Navigation Links
Unraveling the viral mechanism

ace protein, there are other proteins that make this virus viable," said Chiu. In particular, proteins protruding at one of the twelve vertices of the virus shell contain structures like tails that actually anchor the bacteriophage to the surface of the bacteria itself. The shape of these "tail" structures gives clues about how the virus or phage and cell interact.

Then as Chiu and Jiang used the computer visualization tool to strip away the surface shell entirely, they saw the concentric coil of DNA underneath. They also identified a protein "hub" through which DNA enters and exits the virus.

"It's like a garden hose, in some ways," said Chiu. "You extend it. If you put it away in a heap, then you have trouble using it again. But if you coil the hose orderly, then it is easy to use again. I think the virus does the same thing. The virus genome has to enter the capsid during the birth of the virus and then inject into the cell during infection. It has to come in and get out easily. The hub anchors the tail spikes, but is also a conduit for the DNA to get in and out."

Below is the "portal" that acts as a motor using energy to coil the threads of double-stranded DNA. Using the capabilities of his program, Chiu and colleagues identified 12 protein copies that make up this viral motor.

Chiu anticipates using the same technique to study other spherical viruses as soon as he can obtain the computer power to study larger structures. Soon, he said, he hopes to be able to study the interactions of virus and cell more closely.

Others who participated in his study include Juan Chang (a current graduate student in the SCBMB Program) and Joanita Jakana of BCM, Dr. Peter Weigele and Professor Jonathan King of the Massachusetts Institute of Technology. Jiang is now a faculty with Purdue University.


'"/>

Source:Baylor College of Medicine


Page: 1 2

Related biology news :

1. Unraveling a stomach cancer puzzle
2. Unraveling the mysteries of poison
3. Unraveling where chimp and human brains diverge
4. New binding target for oncogenic viral protein
5. Novel antiviral technology inhibits RSV infection in mice
6. NYU study reveals how brains immune system fights viral encephalitis
7. Antiretroviral therapy may prevent excess risk of some cancers in people with HIV
8. Stopping smallpox in its tracks: A new anti-viral approach
9. Study reveals candidate targets for anti-retroviral therapeutics
10. PHACCS, an online tool for estimating the structure and diversity of uncultured viral communities using metagenomic information
11. Chimp genome reveals a retroviral invasion
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Unraveling the viral mechanism

(Date:8/3/2015)... Calif. , Aug. 3, 2015 Synaptics, ... human interface solutions, today announced that members of the ... at the Pacific Crest Global Technology Leadership Forum on ... The conference will be held at the Sonnenalp Resort ... The presentation may include forward-looking information. An audio ...
(Date:7/31/2015)... 31. juli 2015 Den 10. internationale konference ... BGI fra den 22. - 25. oktober i ... sin 10-års fødselsdag i år. Siden starten i 2006 ... møder på ,omik,-feltet, og er en af de mest ... ICG-10 fokuserer på nylige gennembrud og fremskridt inden for ...
(Date:7/31/2015)... de 2015 BGI llevará a cabo la 10ª ... al 25 de octubre de 2015, en ... su décimo aniversario este año. Desde su inauguración en ... reuniones anuales más influyentes del mundo en los campos ... científicas más dinámicas, entusiastas y amenas. ICG-10 ...
Breaking Biology News(10 mins):Den 10. internationale konference om Genomics (ICG-10) åbner i oktober 2La 10ª Conferencia Internacional sobre Genómica (ICG-10) comienza en octubre 2La 10ª Conferencia Internacional sobre Genómica (ICG-10) comienza en octubre 3
... species of sharks and redfish captured in waters off ... free-swimming fish harbored several drug-resistant bacterial strains. ... and Wildlife Medicine , found antibiotic-resistant bacteria in every ... bacteria in fish at nearly all of the study ...
... - Haze, scientifically known as atmospheric aerosols - microscopic ... major environmental problem because it degrades visibility, affects human ... how the haze is formed is not fully understood, ... and chemistry who has studied air chemistry for more ...
... Eyjafjallajokull volcano woke from its nearly 200-year slumber to change ... transatlantic air travel to a halt for the first time ... these forces of nature contain and of our relative ... Department of Geology & Geophysics has published research in the ...
Cached Biology News:Wild sharks, redfish harbor antibiotic-resistant bacteria 2Research is getting closer to understanding critical nucleus in haze formation, prof says 2LSU professor uses volcanic emissions to study Earth's atmospheric past 2LSU professor uses volcanic emissions to study Earth's atmospheric past 3
(Date:8/4/2015)... ... August 04, 2015 , ... On August 4, 2015, ... diverse selection of entrepreneurs from across the United States to talk about their experiences ... honored to be chosen to be among the attendees. , One of the day’s ...
(Date:8/4/2015)... Aug. 4, 2015   California Cryobank Stem Cell ... of LifeLine Cryogenics, an east coast cord blood and ... York tristate area. LifeLine clients will maintain ... contracts will be honored. Since 1991, LifeLine ... storage of sperm, eggs, embryos, and cord blood stem ...
(Date:8/4/2015)... Biotech Ltd. (Nasdaq: SVA ), a leading provider ... today announced that it will release its unaudited financial ... after market close on Wednesday, August 12, 2015. The Company ... 2015, at 8:00 a.m. EDT (Thursday, August 13, 2015 ... Company,s financial results and provide an update on recent ...
(Date:8/3/2015)... , Aug. 3, 2015  Halozyme Therapeutics, Inc. (NASDAQ: ... Call for the second quarter 2015 on Monday, August ... Helen Torley , president and chief executive officer, ... Halozyme will release financial results for the second quarter ... through the "Investors" section of Halozyme,s corporate website and ...
Breaking Biology Technology:White House Invites uBiome CEO Jessica Richman to First-Ever Startup Demo Day 2FamilyCord Announces Acquisition of LifeLine Cryogenics 2Sinovac to Host Conference Call to Report Second Quarter 2015 Unaudited Financial Results 2Halozyme to Host Second Quarter 2015 Financial Results Conference Call 2
... Isolation from E. coli Using the Eppendorf<sup , ... Plasmid Mini , Kit , , ... Joel Lopez, Melissa Higgins, Chere Griffin and Vince Prezioso, PhD , ... Introduction , Isolation and purification of plasmid DNA from bacteria ...
... or pathogens , Gabriela M. Tobal ,Stratagene ... Stratagene is introducing PCR primer sets ... these primers have been published previously,and are well ... use PCR technology to identify the presence of ...
... New PathDetect reporting system for ... Matthew Hsu Mary Buchanan Chao-Feng Zheng ... plasmid,the pNFAT-Luc reporter plasmid, is designed for studying ... (NFAT) transcription factors. These,interesting proteins, which play an ...
Cached Biology Technology:Comparison of Growth Techniques and Media for the Purpose of Plasmid , Isolation from E. coli Using the Eppendorf , Perfectprep Plasmid Mini , Kit 2Comparison of Growth Techniques and Media for the Purpose of Plasmid , Isolation from E. coli Using the Eppendorf , Perfectprep Plasmid Mini , Kit 3Comparison of Growth Techniques and Media for the Purpose of Plasmid , Isolation from E. coli Using the Eppendorf , Perfectprep Plasmid Mini , Kit 4New PCR Primers for Human Diseases 2New PCR Primers for Human Diseases 3New PCR Primers for Human Diseases 4Cis-Reporting System Monitors Intracellular Calcium Mobilization 2Cis-Reporting System Monitors Intracellular Calcium Mobilization 3Cis-Reporting System Monitors Intracellular Calcium Mobilization 4Cis-Reporting System Monitors Intracellular Calcium Mobilization 5
Chicken Aortic Smooth Muscle Cells (CAOSMC) (>500,000 cells)...
... Start Taq Monoclonal Antibody ... the onset of thermal ... and primer-dimer formation. When ... the antibody is quickly ...
... brings together UV irradiation and antimicrobial stainless ... PCR contamination! Quickly inactivate DNA between ... clean environment with antimicrobial coated stainless steel ... minutes with built-in 30-minute timer ...
... flexible and easy to use ... control all members of the ... features a clear and easy-to-follow ... setup, user-friendly and highly sophisticated ...
Biology Products: