Navigation Links
Unraveling the mysteries of poison

Researchers from the Max Planck Institite for Biophysical Chemistry and other German and French colleagues have combined magnetic resonance spectroscopy (solid-state NMR) with special protein synthesis procedures to uncover how potassium channels and toxins combine and change in structure. This work could make it possible to develop medications for high blood pressure and many other diseases connected to potassium channel failure (Nature, April 13, 2006).

Our body's cells have membranes, and "ion channels" are embedded in them. Ion channels are special proteins which let only certain ions through the membrane. The channels build an electro-chemical gradient, allowing nerve and heart muscle cell signals to pass. The nerve or heart muscle cell is excited, and the ion channel structure changes, developing pores which let the ions through. Different channels are open to different specific ions; for example, potassium channels only allow potassium ions through. Poisonous animals use very specific toxins to target channels; the toxins block the channels and make it impossible for electric signals to move through the membrane ?often killing the cell.

These kind of interactions had not been well investigated at a structural level ?even though scientists had made great strides studying ion channels, using x-ray crystallography. Scientists from the Max Planck Institute for Biophysical Chemistry in Göttingen, working together with researchers from the Institute for Neural Signal Processing in Hamburg and French colleagues from the University of Marseille, combined a new method of solid-state NMR with particular protein synthesis procedures and looked at the example of poison from the north African scorpion Androctonus mauretanicus mauretanicus, to determine how bacterial potassium channels interact with toxins at an atomic level.

The researchers first examined the electrophysiological characteristics of the "poisoned" channel protein. The scientists "s
'"/>

Source:Max-Planck-Gesellschaft


Page: 1 2

Related biology news :

1. Unraveling a stomach cancer puzzle
2. Unraveling the viral mechanism
3. Unraveling where chimp and human brains diverge
4. ORNL, UC Berkeley unravel real-world clues to Earths mysteries
5. Tufts researchers shine light on firefly mysteries
6. How satellite tracking revealed the migratory mysteries of endangered Atlantic loggerhead turtles
7. Two central mysteries in genome inheritance solved at UCSD
8. Theory of oscillations may explain biological mysteries
9. Stanford snake venom study shows that certain cells may eliminate poison
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Unraveling the mysteries poison

(Date:7/21/2014)... Their scruffy beards weren,t ironic, but there are reasons ... the Ice Age. , According to research from the ... liked living in Greater Cincinnati long before it was ... age. A study led by Brooke Crowley, an assistant ... enjoyed the area so much they likely were year-round ...
(Date:7/21/2014)... July 21, 2014 Dysfunction in dopamine signaling ... genes in the brain,s prefrontal cortex and may ... disorders, such as schizophrenia, according to UC Irvine ... in brain cells that receive this neurotransmitter showed ... affect a variety of behavioral and physiological functions ...
(Date:7/21/2014)... and Aqua satellites detected 154 hotspots in areas across ... land fires had increased again following a decline in ... report was far higher than what had been reported ... , The hotspots were scattered in six regencies and ... areas. Smoke and the related haze it creates could ...
Breaking Biology News(10 mins):Mammoth and mastodon behavior was less roam, more stay at home 2Mammoth and mastodon behavior was less roam, more stay at home 3UCI researchers find epigenetic tie to neuropsychiatric disorders 2
... State University and the University of Chicago has uncovered clues ... N4, injects an unusual substance -- an RNA polymerase protein ... The results, which are published in the current issue of ... of the infection strategies used by viruses that attack bacterial ...
... as an homage to achievement in the field of coral ... link between corals of the Pacific and Atlantic. Dr. Ann ... McNeill of the University of Miami named a new species ... some six million years old after renowned coral reef ...
... was managing several ecosystem research projects on Galveston Island when the 2008 hurricane season began in June 2008. Then ... Click here for more information. , ... , , , , ... , , , , ...
Cached Biology News:Researchers study virus with unusual properties 2Researchers study virus with unusual properties 3Isopora or isn't it? 2Dune and dirty: Hurricane teaches lessons through ecosystem research 2Dune and dirty: Hurricane teaches lessons through ecosystem research 3Dune and dirty: Hurricane teaches lessons through ecosystem research 4Dune and dirty: Hurricane teaches lessons through ecosystem research 5Dune and dirty: Hurricane teaches lessons through ecosystem research 6
(Date:7/21/2014)... a chain of carbon atoms can turn it from ... University scientists. , Stretching the material known as carbyne ... by just 3 percent can begin to change its ... mechanically activated nanoscale electronics and optics. , The finding ... appears in the American Chemical Society journal Nano ...
(Date:7/21/2014)... 21, 2014 Sleep disturbances such ... closely correlated with depression. According to a study ... "About three quarters of depressed patients have insomnia ... of young depressed adults and 10% of older ... cause huge distress, have a major impact on ...
(Date:7/18/2014)... , July 18, 2014  Neogen Corporation (Nasdaq: ... , Neogen,s chief operating officer and president, has resigned, ... work as a consultant going forward on special projects. ... has been in this position since September 2013. On ... James Herbert , who has been Neogen,s chief ...
(Date:7/18/2014)... Cambridge, MA (PRWEB) July 18, 2014 ... in Budapest with US offices in Cambridge, MA, ... a combination Assay and Software product that leverages ... use on the Illumina® MiSeq sequencing platform. The ... with The Children’s Hospital of Philadelphia (CHOP) and ...
Breaking Biology Technology:Carbyne morphs when stretched 2Carbyne morphs when stretched 3Open Label Data on Enhanced Sleep Released by JayMac Pharmaceuticals, LLC 2Open Label Data on Enhanced Sleep Released by JayMac Pharmaceuticals, LLC 3Omixon Launches Holotype HLA for NGS-based HLA Genotyping 2Omixon Launches Holotype HLA for NGS-based HLA Genotyping 3
... Contributed by James V. Anderson and Charles L. Guy, The,University of Florida, Institute ... Introduction , ... , Glucose Regulated Proteins) are ER-luminal proteins ... 1 BiPs are associated with the transport and folding process , ...
... Contributed by Alan T. Bakalinsky Department of Food Science and Technology, ... , Abstract , ... cerevisiae were , compared to those of ... supported previous genetic findings that two of the wine strains are aneuploid , ...
... Marie Nguyen and William Strong, Bio-Rad Laboratories, Inc.,6000 James ... , Introduction , ... is an established technique employed for protein separation. However, ... manual steps and several , hours to ...
Cached Biology Technology:A Rapid Method for the Purification of Analytical Grade Proteins From Plants Using Preparative SDS-PAGE and Preparative IEF 2A Rapid Method for the Purification of Analytical Grade Proteins From Plants Using Preparative SDS-PAGE and Preparative IEF 3A Rapid Method for the Purification of Analytical Grade Proteins From Plants Using Preparative SDS-PAGE and Preparative IEF 4A Rapid Method for the Purification of Analytical Grade Proteins From Plants Using Preparative SDS-PAGE and Preparative IEF 5Electrophoretic Karyotypes of Wine Strains of Saccharomyces cerevisiae 2Electrophoretic Karyotypes of Wine Strains of Saccharomyces cerevisiae 3Electrophoretic Karyotypes of Wine Strains of Saccharomyces cerevisiae 4Electrophoretic Karyotypes of Wine Strains of Saccharomyces cerevisiae 5Electrophoretic Karyotypes of Wine Strains of Saccharomyces cerevisiae 6Performance Comparison of the Experion Automated Electrophoresis System and a Competing Automated System for Protein Analysis, Rev A 2Performance Comparison of the Experion Automated Electrophoresis System and a Competing Automated System for Protein Analysis, Rev A 3Performance Comparison of the Experion Automated Electrophoresis System and a Competing Automated System for Protein Analysis, Rev A 4Performance Comparison of the Experion Automated Electrophoresis System and a Competing Automated System for Protein Analysis, Rev A 5Performance Comparison of the Experion Automated Electrophoresis System and a Competing Automated System for Protein Analysis, Rev A 6Performance Comparison of the Experion Automated Electrophoresis System and a Competing Automated System for Protein Analysis, Rev A 7Performance Comparison of the Experion Automated Electrophoresis System and a Competing Automated System for Protein Analysis, Rev A 8Performance Comparison of the Experion Automated Electrophoresis System and a Competing Automated System for Protein Analysis, Rev A 9Performance Comparison of the Experion Automated Electrophoresis System and a Competing Automated System for Protein Analysis, Rev A 10Performance Comparison of the Experion Automated Electrophoresis System and a Competing Automated System for Protein Analysis, Rev A 11Performance Comparison of the Experion Automated Electrophoresis System and a Competing Automated System for Protein Analysis, Rev A 12Performance Comparison of the Experion Automated Electrophoresis System and a Competing Automated System for Protein Analysis, Rev A 13
... CHEMICON's Cell Transformation Detection Assay is an ... is considered the most stringent assay for ... this assay, cells (pre-treated with carcinogens or ... in soft agar medium for 21-28 days. ...
The Saturn 2200 answers your GC/MS questions with the CP-3800 GC and the 2000 Series Ion Trap MS! These components create a platform for the worlds most versatile GC and flexible MS. Both deliver une...
... Kit uses a simplified procedure and streamlines ... The kit is based on the three ... and sodium bisulfite where cytosine is converted ... innovative in-column desulphonation reaction eliminates several precipitation ...
... Invitrogen makes blotting of E-PAGE Gels ... pre-cut fiber blotting pad and several types ... perfectly fit 8.6 cm x 13.5 cm ... PVDF membranes are designed for western transfer ...
Biology Products: