Navigation Links
Unraveling a stomach cancer puzzle

It started several years ago with the observation that a large group of seemingly unconnected genes were behaving differently in patients with stomach cancer. Now a multi-national research team led by the Melbourne Branch of the Ludwig Institute for Cancer Research (LICR) has joined the proverbial dots and identified a potential new target for stomach cancer therapy, according to a paper published today in the prestigious Nature Medicine journal.

The paper's first author, LICR's Dr. Brendan Jenkins, says that this single study has made several substantial contributions to the understanding of Stat3, the protein linking those 'genes behaving badly' and central to development, tissue equilibrium and the immune system. "We showed that, in mice, hyperactive Stat3 shuts down a vital controller of stomach cell growth, called TGF beta, and this allows cancer formation, and this mechanistic link is a world-first. Also, the gene differences identified in human stomach cancers are similar to those we would predict if the same thing, Stat3 hyperactivity shutting down TGF, happens in humans. So this is also the first time a connection between stomach cancer and this signaling pathway has been made."

Team leader Dr. Matthias Ernst, also from LICR, says that these basic research findings may one day impact directly on the treatment of stomach and other cancers. "We've demonstrated that by lowering Stat3 hyperactivity we can suppress stomach cancer formation, importantly without affecting Stat3's other important roles in the body. Add to that the evidence suggesting that Stat3 is also involved in breast, head and neck, and prostate cancers, and we have a compelling case for investigating the development of therapies that target Stat3."


'"/>

Source:Ludwig Institute for Cancer Research


Page: 1

Related biology news :

1. Unraveling the mysteries of poison
2. Unraveling the viral mechanism
3. Unraveling where chimp and human brains diverge
4. Salmonella survives better in stomach due to altered DNA
5. Prehistoric origins of stomach ulcers uncovered
6. Viral DNA sequence a possible trigger for breast cancer
7. Enzyme, lost in most mammals, is shown to protect against UV-induced skin cancer
8. Its not all genetic: Common epigenetic problem doubles cancer risk in mice
9. Columbia research lifts major hurdle to gene therapy for cancer
10. Combination therapy boosts effectiveness of telomere-directed cancer cell death
11. Mitochondrial DNA mutations play significant role in prostate cancer
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/6/2017)... LONDON , April 6, 2017 ... Control, RFID, ANPR, Document Readers, by End-Use (Transportation & ... Energy Facility, Oil, Gas & Fossil Generation Facility, Nuclear ... Healthcare, Educational, Other) Are you looking for ... Authentication sector? ...
(Date:4/3/2017)... , April 3, 2017  Data captured ... engineering platform, detected a statistically significant association ... prior to treatment and objective response of ... potential to predict whether cancer patients will ... treatment, as well as to improve both pre-infusion ...
(Date:3/28/2017)... India , March 28, 2017 ... IP, Biometrics), Hardware (Camera, Monitors, Servers, Storage Devices), Software ... Vertical, and Region - Global Forecast to 2022", published ... Billion in 2016 and is projected to reach USD ... between 2017 and 2022. The base year considered for ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... , ... October 12, 2017 , ... ... two-dimensional representations of a complex biological network, a depiction of a system of ... mess,” said Dmitry Korkin, PhD, associate professor of computer science at Worcester Polytechnic ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... United States multicenter, prospective clinical study that demonstrates the accuracy of the ... of identifying clinically significant acute bacterial and viral respiratory tract infections by ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... platform specifically designed for life science researchers to analyze and interpret datasets, ... Franklin, who made a major contribution to the discovery of the double-helix ...
(Date:10/11/2017)... ... ... wash is a basic first aid supply for any work environment, but most personal eye ... first if a dangerous substance enters both eyes? It’s one less decision, and likely quicker ... eye piece. , “Whether its dirt and debris, or an acid or alkali, getting anything ...
Breaking Biology Technology: