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University of Pittsburgh School of Medicine researchers develop 'off-the-shelf' vascular grafts

emodeling of the MDSC-seeded polymer by surrounding tissue, exhibiting tissue formation that is consistent with a mature artery.

According to Dr. Vorp, these findings in a rat demonstrate the feasibility of developing MDSC-seeded tissue-engineered vascular grafts for eventual human application. “The next step is to demonstrate the use of the tissue-engineered blood vessel in a larger animal model, such as a pig, which has a coagulation system more similar to that in humans. The advantage of our approach is that the graft could utilize the patient’s own stem cells and be ready for implantation almost immediately or, at most, after a relatively short culture period. This suggests that we could make these available ‘off-the-shelf,’ which is an essential element for clinical translation,” he explained.


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Source:University of Pittsburgh Schools of the Health Sciences


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