Navigation Links
University of Pittsburgh School of Medicine researchers develop 'off-the-shelf' vascular grafts

University of Pittsburgh School of Medicine investigators have engineered artificial blood vessels from muscle-derived stem cells (MDSCs) and a biodegradable polymer that exhibit extensive remodeling and remain free of blockages when grafted into rats. The results of their study, which is being presented at the Tissue Engineering and Regenerative Medicine International Society (TERMIS) North America Chapter meeting being held June 13 to 16 at the Westin Harbor Castle conference center in Toronto, has potentially significant implications for the treatment of heart and kidney diseases, where there is a critical need for new sources of blood vessels for vascular grafts.

The saphenous vein taken from a patient’s leg continues to be the most commonly used graft for coronary artery bypass grafting even though a significant percentage of vein grafts eventually fail. Arterial grafts are the preferred conduits because they are less prone to becoming obstructed. However, they are in very limited supply, as many patients require multiple grafts. Thus, there is an ongoing search for the ideal small-caliber arterial substitute for revascularization procedures.

The University of Pittsburgh team, led by David A. Vorp, Ph.D., associate professor of surgery and bioengineering and a faculty member of the McGowan Institute for Regenerative Medicine, University of Pittsburgh School of Medicine, developed its vascular graft by “bulk seeding,” or spraying, MDSCs inside a biodegradable porous, tubular polyester urethane scaffold using a rotational vacuum seeding device.

After culturing their vascular constructs for seven days, the investigators then implanted them in the abdominal aortas of rats eight weeks before performing tests to determine how well the grafts had performed. The cell-seeded constructs showed a significantly higher blockage-free rate than unseeded controls (55 percent versus 0 percent). In addition, at eight weeks, there was an extensive r
'"/>

Source:University of Pittsburgh Schools of the Health Sciences


Page: 1 2

Related biology news :

1. University of Manchester makes made-to-measure skin and bones a reality using inkjet printers
2. New protein discovered by Hebrew University researchers
3. Next Generation Body Scanner Launched By The University Of Manchester
4. Roundup®highly lethal to amphibians, finds University of Pittsburgh researcher
5. Green catalyst destroys pesticides and munitions toxins, finds Carnegie Mellon University
6. University of Nevada, Reno research team discovers hormone that causes malaria mosquito to urinate
7. Carnegie Mellon University research reveals how cells process large genes
8. University of Delaware researchers develop cancer nanobomb
9. University of Arizona plant scientists to unravel maize genome
10. Team led by Carnegie Mellon University scientist finds first evidence of a living memory trace
11. University of Utah to help build bionic arm
Post Your Comments:
(Date:7/11/2014)... A new report from the Wildlife Conservation Society ... only help economically valuable species such as lobster, ... also help re-colonize nearby reef areas. , The ... a systematic review of research literature from no-take ... by Dr. Craig Dahlgren, a recognized expert in ...
(Date:7/11/2014)... Mills Canyon fire started near the City of Entiat ... local resources, the fire quickly grew to over 1,000 ... of the fire is under investigation by the Washington ... working with existing local resources in developing fire control ... Service (USFS), Washington State Department of Natural Resources, (WA ...
(Date:7/11/2014)... available in German . ... that uses the refraction of X-rays through a specimen ... with this method are often of much higher quality ... team of Prof. Franz Pfeiffer are particularly interested in ... including X-ray phase-contrast imaging. One main goal is ...
Breaking Biology News(10 mins):Belize's lobster, conch, and fish populations rebuild in no-take zones 2New simple setup for X-ray phase contrast 2
... the planet. They thrive in almost every known environment, ... that provide the capabilities essential for survival. These genetic ... mutation and exchange of genes and other bits of ... which then becomes an intrinsic part of the genome. ...
... URBANA - When University of Illinois researchers surveyed over 3,500 ... accurately, and overweight and obese men were more likely to ... because the first step in dealing with a weight problem ... U of I professor of food science and human nutrition. ...
... Most medical imaging equipment is not designed with overweight and ... be exposed to higher levels of radiation during routine X-ray ... Polytechnic Institute is the first to calculate exactly how much ... results show the internal organs of obese men receive 62 ...
Cached Biology News:Study shows unified process of evolution in bacteria and sexual eukaryotes 2Study shows unified process of evolution in bacteria and sexual eukaryotes 3Misperception of weight is an important barrier to weight loss 2Obese patients face higher radiation exposure from CT scans -- but new technology can help 2
(Date:7/10/2014)... , July 10, 2014 On ... Dmitry Medvedev , presented Russia,s ... BIOCAD . The Company is developing a unique project ... project BIOCAD develops a number of innovative drugs based ... diseases. The ceremony took place at the International Exhibition ...
(Date:7/10/2014)... 2014 /PRNewswire-iReach/ -- Tute Genomics, the leader ... an agreement with Lineagen, Inc., to provide ... Dx PLUS.  Lineagen, focused on the ... currently offers FirstStep Dx PLUS, a ... by healthcare providers as a first-line genetic ...
(Date:7/10/2014)... THOUSAND OAKS, Calif., July 10, 2014   Ceres, ... biotechnology and seed company, announced today financial results for ... an update on its business. Ceres reported ... progress in product performance this growing season in Brazil, ... that affected the company,s sorghum evaluation areas for part ...
(Date:7/10/2014)... Adelaide research may help in the fight against terrorism ... tiny quantities of explosives with the use of light ... Sensors and Actuators B: Chemical , the researchers ... explosives in concentrations as low as 6.3 ppm (parts ... a few minutes. , "Traditionally explosives detection has involved ...
Breaking Biology Technology:Dmitry Medvedev Presented BIOCAD the First National "Industry" Award 2Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 2Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 3Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 4Ceres Announces Fiscal Third Quarter 2014 Financial Results 2Ceres Announces Fiscal Third Quarter 2014 Financial Results 3Ceres Announces Fiscal Third Quarter 2014 Financial Results 4Ceres Announces Fiscal Third Quarter 2014 Financial Results 5Ceres Announces Fiscal Third Quarter 2014 Financial Results 6Ceres Announces Fiscal Third Quarter 2014 Financial Results 7Ceres Announces Fiscal Third Quarter 2014 Financial Results 8Ceres Announces Fiscal Third Quarter 2014 Financial Results 9Detecting trace amounts of explosives with light 2
... - NovaScan, an early-stage medical imaging company developing what ... of breast cancer, had to bypass angel tax credits from ... for its emerging technology. , ,The company instead has raised ... a state loan, and grants. , ,According to CEO Larry ...
... rural Wisconsin, one company is earning their bread and ... Networks, Inc. , a global satellite communications provider, has ... , a satellite-based broadband access provider. , ,IsoTropic operates ... set on 21 acres in rural Wisconsin, and it ...
... Last week, the nation marked the five-year anniversary of ... restrictions have unquestionably set back the progress of this ... Congress passed legislation that would have lifted President Bush's ... ones are suffering from a wide range of debilitating ...
Cached Biology Technology:NovaScan decides against tax credits 2Rural company works to improve broadband 2Stem cell research holds the promise for tomorrow 2Stem cell research holds the promise for tomorrow 3
... is the only PCR system that ensures ... time. It provides accuracy, consistency, and dependability ... the property of the DNA templates. This ... a unique blend of thermostable enzymes that ...
Special grade: for molecular biology Density: 1.000 g/mL (20 C)...
... to meet the needs of ... component-free medium supports fast cell ... densities, while maintaining high cell ... production using the Baculovirus Expression ...
... This CLS number ... number, created to easily ... If showing no availability ... the old Sigma-Aldrich number ...
Biology Products: