Navigation Links
University of Pittsburgh School of Medicine researchers develop 'off-the-shelf' vascular grafts

University of Pittsburgh School of Medicine investigators have engineered artificial blood vessels from muscle-derived stem cells (MDSCs) and a biodegradable polymer that exhibit extensive remodeling and remain free of blockages when grafted into rats. The results of their study, which is being presented at the Tissue Engineering and Regenerative Medicine International Society (TERMIS) North America Chapter meeting being held June 13 to 16 at the Westin Harbor Castle conference center in Toronto, has potentially significant implications for the treatment of heart and kidney diseases, where there is a critical need for new sources of blood vessels for vascular grafts.

The saphenous vein taken from a patient’s leg continues to be the most commonly used graft for coronary artery bypass grafting even though a significant percentage of vein grafts eventually fail. Arterial grafts are the preferred conduits because they are less prone to becoming obstructed. However, they are in very limited supply, as many patients require multiple grafts. Thus, there is an ongoing search for the ideal small-caliber arterial substitute for revascularization procedures.

The University of Pittsburgh team, led by David A. Vorp, Ph.D., associate professor of surgery and bioengineering and a faculty member of the McGowan Institute for Regenerative Medicine, University of Pittsburgh School of Medicine, developed its vascular graft by “bulk seeding,” or spraying, MDSCs inside a biodegradable porous, tubular polyester urethane scaffold using a rotational vacuum seeding device.

After culturing their vascular constructs for seven days, the investigators then implanted them in the abdominal aortas of rats eight weeks before performing tests to determine how well the grafts had performed. The cell-seeded constructs showed a significantly higher blockage-free rate than unseeded controls (55 percent versus 0 percent). In addition, at eight weeks, there was an extensive r
'"/>

Source:University of Pittsburgh Schools of the Health Sciences


Page: 1 2

Related biology news :

1. University of Manchester makes made-to-measure skin and bones a reality using inkjet printers
2. New protein discovered by Hebrew University researchers
3. Next Generation Body Scanner Launched By The University Of Manchester
4. Roundup®highly lethal to amphibians, finds University of Pittsburgh researcher
5. Green catalyst destroys pesticides and munitions toxins, finds Carnegie Mellon University
6. University of Nevada, Reno research team discovers hormone that causes malaria mosquito to urinate
7. Carnegie Mellon University research reveals how cells process large genes
8. University of Delaware researchers develop cancer nanobomb
9. University of Arizona plant scientists to unravel maize genome
10. Team led by Carnegie Mellon University scientist finds first evidence of a living memory trace
11. University of Utah to help build bionic arm
Post Your Comments:
(Date:10/29/2014)... their food, but they also need protection from its harmful ... of molecules in plants that shields them from sun damage. ... American Chemical Society , one team reports on the mechanics ... and colleagues at Purdue University note that the harsh ultraviolet ... to plant DNA and, as a result, hinder plant growth. ...
(Date:10/29/2014)... their types and numbers of bugs and bacteria ... the difference between a closed case and an ... a more than $866,000 U.S. Department of Justice ... changing populations. The microbial communities may provide crucial ... race, socioeconomic relations and more, said Eric Benbow, ...
(Date:10/29/2014)... MA and Hebei, China — BGI Tech and Hebei ... of the Jujube genome. Jujube is the most economically ... genome is particularly difficult to sequence due the high ... the first time that a genome in the Rhamnaceae ... recently published in Nature Communications . ...
Breaking Biology News(10 mins):MSU partners with Detroit to investigate death scenes 2BGI Tech and Hebei Agricultural University complete the genome sequencing of the jujube tree 2
... OAK RIDGE, Tenn. -- A tree outside Oak ... the inspiration for a discovery that may ultimately lead ... and more. Just as a breeze causes leaves, ... at the molecular level perform hundreds of chemical processes ...
... -- The Techna Institute, an innovation hub poised to ... new healthcare technologies, launches today at University Health Network ... Dr. Christopher Paige, VP, Research at UHN ... research and development. Technological innovation holds the key to ...
... MEDFORD/SOMERVILLE, Mass. A new approach to studying ... assistant professor of biomedical engineering in Tufts University,s,School of ... March of Dimes Foundation. Kuo,s research could yield ... that occur in utero, such as clubfoot, which requires ...
Cached Biology News:ORNL fundamental discovery casts enzymes in new light 2UHN, University of Toronto launch Techna innovation hub to get health technologies to patients faster 2Tufts University researcher develops living tissue 2
(Date:10/27/2014)... 27, 2014 Pressure BioSciences, Inc. (OTCQB: ... in the development and sale of high pressure-based ... market, today announced that Professor Ruedi Aebersold ... highly reproducible, and robust method to allow – ... analysis on small needle biopsy samples by mass ...
(Date:10/27/2014)... 27, 2014 Investor-Edge has initiated ... NBIX ), Insmed Inc. (NASDAQ: ... ), Dyax Corporation (NASDAQ: DYAX ), and ... companies can be accessed at: http://investor-edge.com/register . ... ended at 4,483.72, up 0.69%, the Dow Jones Industrial ...
(Date:10/26/2014)... The report "Protective Coatings Market by ... Trends & Forecast to 2019", defines and segments the ... volume consumed and value generated. The protective coatings consumption ... to 6,701.3 KT by 2019, at a CAGR of ... data tables and 22 figures spread through 219 slides ...
(Date:10/25/2014)... (PRWEB) October 23, 2014 ... specialty pharmaceutical company devoted to bringing new products ... in 2015. , ViaDerma has developed an innovative, ... for rapid mass transfer of pharmaceutical active ingredients ... to provide immediate localized therapy. The transdermal delivery ...
Breaking Biology Technology:Breakthrough Method to Permit Quantification of Thousands of Proteins in Needle Biopsy Samples in 12 hours Presented at Major International Scientific Meeting; Method Enabled by Pressure BioSciences' PCT Sample Preparation Platform 2Breakthrough Method to Permit Quantification of Thousands of Proteins in Needle Biopsy Samples in 12 hours Presented at Major International Scientific Meeting; Method Enabled by Pressure BioSciences' PCT Sample Preparation Platform 3Breakthrough Method to Permit Quantification of Thousands of Proteins in Needle Biopsy Samples in 12 hours Presented at Major International Scientific Meeting; Method Enabled by Pressure BioSciences' PCT Sample Preparation Platform 4Breakthrough Method to Permit Quantification of Thousands of Proteins in Needle Biopsy Samples in 12 hours Presented at Major International Scientific Meeting; Method Enabled by Pressure BioSciences' PCT Sample Preparation Platform 5Pre-market Equity Watch on Biotech Industry - Neurocrine Biosciences, Insmed, BioCryst Pharma, Dyax, and Oncothyreon 2Pre-market Equity Watch on Biotech Industry - Neurocrine Biosciences, Insmed, BioCryst Pharma, Dyax, and Oncothyreon 3Pre-market Equity Watch on Biotech Industry - Neurocrine Biosciences, Insmed, BioCryst Pharma, Dyax, and Oncothyreon 4Pre-market Equity Watch on Biotech Industry - Neurocrine Biosciences, Insmed, BioCryst Pharma, Dyax, and Oncothyreon 5Protective Coatings Market Poised to Reach $18,431.8 Million by 2019 - Report by MarketsandMarkets 2Protective Coatings Market Poised to Reach $18,431.8 Million by 2019 - Report by MarketsandMarkets 3Protective Coatings Market Poised to Reach $18,431.8 Million by 2019 - Report by MarketsandMarkets 4ViaDerma, Inc. Announces Plans to Pursue Out-Licensing Partnerships in 2015 2ViaDerma, Inc. Announces Plans to Pursue Out-Licensing Partnerships in 2015 3
... Controls Inc., a maker of ... supplies, has bought Pro-Tel Inc. ... ,Pro-Tel is a contracting company ... has about 70 employees. Its ...
... Madison, Wis. Madison Gas & Electric has ... High-Tech Companies with expanded and updated listings covering ... its 18th year of publication, offers an overview of ... University of Wisconsin research programs in Dane County, as ...
... featured speaker at the Digital Healthcare Conference 2005 ... all of the new medical discoveries and treatments that ... enough information to give the best care? , ,Its ... vice president of information services at the University of ...
Cached Biology Technology:2005 Madison-area tech directory includes more companies, resources 22005 Madison-area tech directory includes more companies, resources 3Michael Rosencrance deals with medical overload through human-centric IT 2Michael Rosencrance deals with medical overload through human-centric IT 3
...
... Dyad instrument is the most advanced thermal ... world-class thermal performance, the Dyad also boasts ... as point-and-click navigation via touch pad or ... easily and economically expanded to a four-bay ...
...
Kit for testing the ability of a compound to simulate lipolysis in cultured human adipocytes. Kit contains controls, buffers and reagents for detecting glycerol and non-esterified free fatty acids. A...
Biology Products: