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University of Minnesota researchers take new look at cellular suicide

ayed a role in the development of the cancer. Working with cells from the skin of mice, they have now discovered that after they expose cells to damaging amounts of ultraviolet light, a form of JNK initiates both of the cellular processes that culminate in DNA destruction.

In one process, JNK starts a chain reaction that leads to the activation of an enzyme that chops up DNA. In the other process, JNK activates the histone H2AX. The activated enzyme and the activated histone work together to make mincemeat of the DNA. Dong and his colleagues are the first to show that activation of H2AX is necessary for apoptosis to occur by means of the DNA-chopping enzyme. The work was supported by the Hormel Foundation and the National Institutes of Health.


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Source:University of Minnesota


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