Navigation Links
Unique dual target specificity of kinase inhibitor key for success against cancer

Scientists have identified a new molecule that inhibits proliferation of a broad range of lethal malignant glioma cells in vitro and in vivo. The findings, published in the May issue of Cancer Cell, shed light on which PI3 kinase family members are most likely to play a role in cancer progression. This study reinforces the concept that successful small molecule kinase inhibitors must display a broad reactivity to effectively attenuate the complex signaling pathways involved in malignant transformation and to thwart to the ability of cancer cells to adapt to stress.

Lipid kinases belonging to the PI3 kinase family, made up of different isoforms, promote cell growth and survival. Aberrant regulation and activation of PI3 kinases has been implicated in several human malignancies. Although the specific mechanisms and PI3K-associated molecules involved in cancer are not clear, this kinase family represents a rational and promising target for design of new cancer therapeutics. Dr. William A. Weiss, from the Department of Neurology at the University of California, San Francisco and coworkers sought to identify which PI3 kinase isoforms are critical for growth and progression of malignant glioma cells. UCSF colleagues Zachary Knight and Kevan Shokat synthesized and characterized a series of novel inhibitors that span the different PI3 kinase isoforms (described in the May issue of Cell). Qi-Wen Fan in the Weiss lab screened these agents in glioma cell lines. One compound, PI-103, uniquely and potently blocked the growth of glioma cells.

The cellular activity of PI-103 was traced to its ability to cooperatively inhibit both the p110á subunit of PI3 kinase and a downstream molecule called mTOR that also plays a critical role in cell growth. Although both of these molecules are members of the same signaling cascade, the researchers found that they must be concurrently inhibited because of a regulatory feedback loop that renders a monospecific inhibitor ineffect
'"/>

Source:Cell Press


Page: 1 2

Related biology news :

1. Breast Cancer May Be Uniquely Sensitive To Inhibitors Of PI3K Pathway
2. Unique library of plant genes germinates, takes root at UNC
3. Invitrogen Launches i-Path -- A Unique Systems Biology Platform at BIO 2005
4. Uniquely human component of language found in gregarious birds
5. Unique equine cataract surgery offered on routine basis
6. Unique soybean lines hold promise for producing allergy-free soybeans
7. Unique gene regulation gives chilly bugs survival advantage at bottom of the world
8. Unique tomatoes tops in disease-fighting antioxidants
9. New binding target for oncogenic viral protein
10. Ancient olfaction protein is shared by many bugs, offering new pest control target
11. A bacterial genome reveals new targets to combat infectious disease
Post Your Comments:
(Date:8/27/2014)... of Utah biologist agan Sekercioglu, who campaigns to save ... highest science prize, which is similar to the U.S. ... researchers picked for 2014 the top awards by TUBITAK, ... researchers won the Science Award and two including ... to the Science Award but for scientists who are ...
(Date:8/27/2014)... what is described by the Volunteer Wildfire Services of ... Cape provincial government warned residents in certain parts of ... veld fires. A high veld fire danger rating ... coast in the Great Kei and Mnquma area. ... thunderstorms. The thunderstorms bring lightning strikes and subsequent ...
(Date:8/27/2014)... . , Charcot-Marie-Tooth ... affecting the peripheral nervous system. Researchers from the Department ... Medicine and University Medical Centre Gttingen have discovered that ... with the disease. These cells enwrap the nerve fibres ... the rapid transfer of electrical impulses. If Schwann cells ...
Breaking Biology News(10 mins):University of Utah biologist wins Turkey's top science prize 2Potential therapy for incurable Charcot-Marie-Tooth disease 2
... development and software company, has secured an exclusive ... deal has potential to enhance various forms of ... Proteomics is the scientific next step in vital ... founded in 2006 in Cleveland near Case Western ...
... In one of the most comprehensive studies of its kind, ... with the Harvard School of Global Health have found that people ... ischemic heart disease and tend to live longer than others. ... Colorado mountains helps reduce the risk of dying from heart ...
... ORLANDO, Fla. The American Association for Cancer Research ... Education Award for Undergraduate Students at the AACR 102nd Annual ... The primary purpose of the AACR-Thomas J. Bardos Science Education ... the undergraduate level to enter the field of cancer research. ...
Cached Biology News:Case Western Reserve and NeoProteomics announce exclusive option 2Study shows living at high altitude reduces risk of dying from heart disease 2AACR awards AACR-Thomas J. Bardos Science Education Award for Undergraduate Students 2AACR awards AACR-Thomas J. Bardos Science Education Award for Undergraduate Students 3
(Date:8/27/2014)... 2014 Remcom announces an update to ... features for the biomedical industry. The central biomedical ... Sensor, exclusive to the Bio-Pro version of the software. ... developed to calculate the biological effects of electromagnetic fields. ... to all versions to expand engineers’ post-processing options. , ...
(Date:8/27/2014)... Hunting Valley, Ohio (PRWEB) August 27, 2014 ... five students from Cleveland's University School ... at Case Western Reserve University’s School of ... program provides students with an unparalleled professional experience ... with the School of Medicine faculty and students ...
(Date:8/26/2014)...  NeuroSigma, Inc., a Los Angeles ... today announced that it has filed a registration statement ... Commission relating to a proposed initial public offering of ... offered and the price range for the proposed offering ... will act as the book-running manager for the proposed ...
(Date:8/26/2014)... , Aug. 26, 2014 An analysis ... structures of all Mers CoV virus strains ... structures back to 2012.  This conservation and sharing of ... a Synthetic Mers CoV Blocker-Vaccine™ candidate, as it did for ... vaccine, both of which have been found to be ...
Breaking Biology Technology:Remcom Announces Enhanced Biological Thermal Sensor and Other Biomedical Features in XFdtd EM Simulation Software Update 2Remcom Announces Enhanced Biological Thermal Sensor and Other Biomedical Features in XFdtd EM Simulation Software Update 3Students at Cleveland's University School Conduct Biomedical Research at Case Western Reserve University’s School of Medicine 2
... 28 Neurotech Pharmaceuticals, Inc. today announced that the ... biologic effect in two Phase 2 clinical trials for ... developing condition that causes the progressive degeneration of rod ... time diminishes night and peripheral vision and eventually leads ...
... SpyGlass(R) Direct Visualization System can now be used ... NATICK, Mass., May 28 Boston Scientific Corporation ... it has received 510(k) clearance from the U.S. ... SpyScope(R) Access and Delivery Catheter for diagnostic and ...
... presenting at the Global Crop Protection Summit and exposition on 15-17th ... ... London, UK (PRWeb UK) - Pira International and ... Protection Summit in Edinburgh, Scotland on 15 - 17 September 2009. ...
Cached Biology Technology:Results From Neurotech's NT-501 Phase 2 Retinitis Pigmentosa Studies Demonstrate Consistent Biological Effect on Photoreceptors 2Results From Neurotech's NT-501 Phase 2 Retinitis Pigmentosa Studies Demonstrate Consistent Biological Effect on Photoreceptors 3Results From Neurotech's NT-501 Phase 2 Retinitis Pigmentosa Studies Demonstrate Consistent Biological Effect on Photoreceptors 4Results From Neurotech's NT-501 Phase 2 Retinitis Pigmentosa Studies Demonstrate Consistent Biological Effect on Photoreceptors 5FDA Clears Boston Scientific's SpyScope(R) Access and Delivery Catheter for Use in Endoscopic Procedures Throughout Pancreatico-Biliary System 2FDA Clears Boston Scientific's SpyScope(R) Access and Delivery Catheter for Use in Endoscopic Procedures Throughout Pancreatico-Biliary System 3FDA Clears Boston Scientific's SpyScope(R) Access and Delivery Catheter for Use in Endoscopic Procedures Throughout Pancreatico-Biliary System 4Call for papers for Pira International's Global Crop Protection Summit 2009 2
... Ham's F-12 was developed for culturing hybrid ... The modification consists of doubling the amino ... The salt concentrations have been altered as ... sulfate per liter, which may render it ...
... peptide whose sequence corresponds to residues 1-18 from rat rab 3D. ... M(1) - A - S - A - S - E ... R - D - A - A - D - Q ... and control experiments with the polyclonal antibody that reacts with this ...
... Bisulfite Kit enables complete conversion of ... than 6 hours. The highly sensitive ... DNA degradation and a spin-column-based purification ... and reliable results for all downstream ...
... or individual RNA sequences from high throughput synthesis ... RNAs from LC Sciences. These products provide a ... of DESIGNED sequences delivered in a microtube as ... a single verified RNA sequence. This is a ...
Biology Products: