Navigation Links
Uniform language for describing genes of pathogenic and beneficial microbes

An international group of scientists has announced a major expansion of a lingua franca used to describe the activities of genes in living organisms. The expansion provides terms that scientists can use to describe the complex events that occur when a pathogenic or beneficial microbe encounters its host. Understanding these events is crucial for developing new interventions for preventing infections by disease-causing microbes while preserving or encouraging the presence of beneficial microbes.

The unified language under development in this effort is called The Gene Ontology (GO). The new terms added to the GO will significantly bolster what is already a powerful tool for scientists to compare the functions of genes and proteins in a wide range of disease-related organisms. The ongoing initiative is part of the Plant-Associated Microbe Gene Ontology (PAMGO) project, a recently-established interest group of the worldwide Gene Ontology Consortium.

The GO Consortium has been working since 2000 to develop a common language of terms that can be used to describe how individual genes function in diverse organisms. The PAMGO project is supported by the National Science Foundation and by the National Research Initiative of the USDA Cooperative State Research, Education and Extension Service.

Candace Collmer, Professor of Biology at Wells College and one of the principal investigators on the project explained: “Microbes that associate with plants or animals can be pathogenic, neutral, or beneficial, but all share many common processes in their interactions with their hosts. For example, all must initially attach to the host. Accordingly, from the very beginning of the PAMGO project, we carefully tailored the new terms so that they would be useful for describing benign as well as pathogenic microbes in plant or animal hosts.?

Brett Tyler, Professor at the Virginia Bioinformatics Institute, and the PAMGO project leader, remarked: “Having a co mmon set of terms to describe genes of pathogenic and beneficial microbes as well as the organisms they come into contact with is a critical step in understanding host-microbe-environment interactions. By providing a precise vocabulary for the functions of these genes, scientists can compare among microbes the many processes that make up the interplay between a microbe and its host.?

Dr. Tyler added: “PAMGO started out with the goal of creating terms to describe how microbes interact with plants. However, we quickly realized that almost all the terms were relevant to microbes that interact with animals and humans, and the response from researchers that study human and animal diseases has been very enthusiastic.?

"A common set of terms for the exchange of information about microbe-host interactions will help researchers communicate information, and expand concepts from the studies of microbes and their hosts," said Maryanna Henkart, Director of the National Science Foundation's Division of Molecular and Cellular Biosciences.

João Setubal, Deputy Director of the Virginia Bioinformatics Institute and one of the scientists on the project, commented “When the PAMGO project began, many GO terms existed for describing biological functions and processes found in microbes, but very few for describing the functions used by microbes in their associations with hosts.?

Trudy Torto-Alalibo, PAMGO Project Coordinator, remarked: “The GO Consortium has been set up in a way that allows all users to actively contribute to the ongoing refinement of the terms. When a scientist submits a new term to PAMGO it enables the entire community to participate in synthesizing a common understanding of how microbes associate with hosts. This is a tremendous open-source resource and a powerful way to advance our understanding of host-pathogen relationships.?

Michelle Gwinn-Giglio, Staff Scientist at The Institute for Genomic Research (TIGR) and a sen ior PAMGO member, remarked: “During the process of developing terms for PAMGO, it was immediately apparent that the mechanisms that microbes use to deal with hosts are really quite universal. The same terms can be used for species ranging from nematode worms to bacteria. Having these terms in place will greatly enhance research in this area.?

In the current update, the PAMGO consortium, in collaboration with Jane Lomax and Amelia Ireland of the GO Consortium’s editorial office at the European Bioinformatics Institute, has released more than 450 new terms for describing gene products involved in microbial-host interactions.


'"/>

Source:Virginia Tech


Related biology news :

1. Uniform tungsten trimers stand and deliver
2. RNA project to create language for scientists worldwide
3. Uniquely human component of language found in gregarious birds
4. Warbling whales speak a language all their own
5. Learning the language of DNA
6. Computer scientists unravel language of surgery
7. Newly-discovered class of genes determines ?and restricts ?stem cell fate
8. Inexpensive, mass-produced genes core of synthetic biology advances at UH
9. First atlas of key brain genes could speed research on cancer, neurological diseases
10. U-M scientists find genes that control growth of common skin cancer
11. Researchers find missing genes of ancient organism
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/1/2016)... 2016  Wocket® smart wallet ( www.wocketwallet.com ) announces the launch of ... Fatone . Las Vegas , where Joey appeared ... Las Vegas , where Joey appeared at the Wocket ... video ad was filmed at the Consumer Electronics Show (CES2016) in ... to meet and greet fans. --> ...
(Date:1/25/2016)... , Jan. 25, 2016  Glencoe Software, the world-leading ... and publication industries, will provide the data management solution ... (NPSC). ... Phenotypic analysis measures the ... organisms, allowing comparisons between states such as health and ...
(Date:1/20/2016)... LONDON , Jan. 20, 2016 A ... positioned to directly benefit from the explosion in genomics ... from Howe Sound Research. A range of dynamic trends ... ...... - personalized medicine - pharmacogenomics - pathogen ... economies with large markets - greater understanding of the ...
Breaking Biology News(10 mins):
(Date:2/11/2016)... , Feb. 11, 2016  Vermillion, Inc. (NASDAQ: ... gynecologic disease, today announced the formation of the Steering ... --> --> Pelvic masses can ... diagnosis and management. Once pregnancy is ruled out, pelvic ... and ovaries, advanced endometriosis, benign ovarian tumors and gastrointestinal ...
(Date:2/11/2016)... New York, NY (PRWEB) , ... ... ... International (BPI), a business-to-business publication dedicated to delivering cutting-edge information focused on ... GE Healthcare Life Sciences to become a premier sponsor of the 2016 ...
(Date:2/11/2016)... ... February 11, 2016 , ... Global Stem Cells Group, ... Bankok,Thailand-based Global Stem Cells Network (GSCN) to distribute exosome injection and other biological ... Mexico, Costa Rica, Dominican Republic, Colombia, Argentina, Nicaragua, Panama, El Salvador, Venezuela, Peru, ...
(Date:2/10/2016)... NX Prenatal Inc., a US based ... for early warning of adverse pregnancy outcomes, announced ... by Dr. Thomas McElrath of Brigham ... Medicine,s (SMFM) annual meeting held in ... The presentation reported initial positive top-line results regarding ...
Breaking Biology Technology: