Navigation Links
Unexpressed But Indispensable -- The DNA Sequences That Control Development

Amidst the hoopla over the exact number of genes we have in our genome—more than a fruitfly, fewer than a rice plant—a more fundamental genetic truth has often been obscured. The expression of 20,000?0,000 genes is under the control of an uncounted host of non-coding sequences, which bind transcription factors and thereby regulate when and where genes are expressed. Unlike coding sequences, whose signatures are easy to spot, the characteristic features of non-coding regulatory elements are largely unknown, making their discovery by simple sequence analysis difficult. In this issue, Greg Elgar and colleagues attack this problem by comparing the non-coding sequences of the human and the pufferfish.

Since the last common ancestor of these two species existed 450 million years ago, the authors reasoned that non-coding sequences conserved between them are likely to be fundamental to vertebrate development. Through sequence alignment with increasingly strict criteria, they identified 1,373 highly conserved non-coding elements (CNEs), with an average length of about 200 base pairs. The average sequence match is 84%: not perfect, but much higher than for coding regions shared by humans and pufferfish. A quick check showed that virtually all the sequences also occurred in rodents, chickens, and zebrafish, but not in the nematode, fruitfly, or even the sea squirt, a primitive non-vertebrate chordate.

CNEs are not spread uniformly throughout the genome. Instead, they are bunched together in fewer than 200 clusters, most of them in close proximity to genes implicated in transcriptional regulation or development. This clustering of CNEs suggests they may not only attract transcription factors, but may also influence the local topology of the DNA, thereby controlling access to their associated gene. Several clusters also appear in regions without any known genes—the identification of these clusters might lead to the discovery of new developmentally significant gene
'"/>

Source:PLoS


Page: 1 2

Related biology news :

1. UCSD Discovery Shows How Embryonic Stem Cells Perform Quality Control Inspections
2. Controlling protein diversity
3. Stealth Worms May Improve Insect Pest Control
4. Controlling wildlife trade key to preventing health crises, study says
5. Control measures fail to stop spread of new H5N1 virus
6. Controlling antibiotics and antibiotic resistance in hospitals
Post Your Comments:
(Date:12/10/2014)... , Dec. 9, 2014  Valencell, a leader ... is seeing a staggering demand from its licensees for ... Company revealed, is not solely coming from fitness and ... well. "A wearable is only as useful ... accuracy is the ultimate driver in long-term mass consumer ...
(Date:12/10/2014)... Dec. 08, 2014 Research and Markets ... of the "Biometrics Market in Japan 2014-2018" ... http://photos.prnewswire.com/prnh/20130307/600769 The integration ... as rural banking and upgradation of the driver,s ... in the market. Besides the aforementioned projects, biometrics ...
(Date:12/5/2014)... , Dec. 4, 2014  Tute Genomics, a leader ... million in Series A1 funding led by UK-based Eurovestech. ... participated in the investment round. "We are ... community adopts next-generation sequencing and seeks new approaches for ... Reid Robison , MD MBA, and CEO of Tute ...
Breaking Biology News(10 mins):Wearable Technology Products Demand Highly Accurate Biometric Technology 2Biometrics Market in Japan 2014-2018: Key Vendors are DDS, Fujitsu, Hitachi and NEC 2Tute Genomics Raises $2.3 Million to Scale Up Cloud-Based Genome Analytics and Accelerate Personalized Medicine 2Tute Genomics Raises $2.3 Million to Scale Up Cloud-Based Genome Analytics and Accelerate Personalized Medicine 3
... Harvard bioengineer and an MIT aeronautical engineer have created a ... blood sample, potentially allowing doctors to quickly determine whether cancer ... described in the March 17 online edition of the journal ... also detect viruses such as HIV. It could eventually be ...
... PhD, has been named the first recipient of the ... Foundation for Eye Research (AFER) to a clinician-scientist under ... and Psychiatry at Stanford University, is being recognized for ... approaches to study neuronal function. "It is ...
... -- A nanotechnology-based biosensor being developed by Kansas State ... cells and pathogens, leading to increased food safety and ... chemistry, Hyderabad, India, is developing the biosensor with Jun ... E. coli , but Syed said the same ...
Cached Biology News:MIT: New blood-testing device can quickly spot cancer cells, HIV 2K-State chemists' biosensor may improve food, water safety and cancer detection 2
(Date:12/24/2014)... 24, 2014 The report expects global ... by 2019. It also provides a carefully analyzed data ... challenges for the market. , Full Copy of Report ... the global market for cell expansion will keep witnessing ... expects this growth to be driven by rapid technological ...
(Date:12/24/2014)... 23, 2014 China Biologic Products, Inc. ... leading fully integrated plasma-based biopharmaceutical company in ... majority-owned subsidiary, Shandong Taibang Biological Products Co. Ltd., ... the China Food and Drug Administration (the "CFDA") ... previously disclosed in the Company,s public filings, the ...
(Date:12/24/2014)... , December 23, 2014 ... Algeria , out today and available for free download ... actors driving change and growth in the sector today. ... scored notable successes has been in developing a homegrown pharmaceutical ... percent local production still remains some way off. A cursory ...
(Date:12/24/2014)... Fla. , Dec. 23, 2014  Rock Creek ... that it has filed a Clinical Trial Application (CTA) ... Healthcare products Regulatory Agency (MHRA) seeking regulatory approval to ... lead molecule, Anatabine Citrate. Contingent on the ... conduct a Phase I trial to assess the safety, ...
Breaking Biology Technology:The Cell Expansion Market is Expected to Reach $14.8 billion by 2019 - New Research Report by MarketsandMarkets 2The Cell Expansion Market is Expected to Reach $14.8 billion by 2019 - New Research Report by MarketsandMarkets 3China Biologic Receives GMP Certification for New Coagulation Factor Facility 2China Biologic Receives GMP Certification for New Coagulation Factor Facility 3PharmaBoardroom Releases New Algeria Pharmaceuticals Report 2PharmaBoardroom Releases New Algeria Pharmaceuticals Report 3Rock Creek Pharmaceuticals Files Clinical Trial Application in the UK for Clinical Trials of Anatabine Citrate Formulations 2Rock Creek Pharmaceuticals Files Clinical Trial Application in the UK for Clinical Trials of Anatabine Citrate Formulations 3
... Sept. 24 (Nasdaq: MATK ) --,Martek ... into a,multi-year sole source supply agreement with Grupo ... infant formulas produced by Grupo Ricap in,Mexico. Grupo ... and,Martek,s life,sDHA & life,sARA(TM) will initially be available ...
... For the ... Bioprocess Industry, ... industry first -- an online interactive design tool that,provides step-by-step ... The GORE(TM) STA-PURE(SM) Bioprocess Configurator is unique to the,bioprocess industry. ...
... Corporation,(Nasdaq: NEOG ) announced today that its revenues ... 31, increased 26% from the previous year,s first,quarter to ... year,s $3,011,000 to $3,733,000, or to $0.25 per share ... Neogen,s first quarter revenues, net income, and earnings ...
Cached Biology Technology:Martek to be the Sole Source Supplier of DHA and ARA for Infant Formulas Produced By Grupo Ricap 2Gore's Legacy of Innovation Extends From Products to Processes 2Gore's Legacy of Innovation Extends From Products to Processes 3Neogen Reports 26% Increase in Revenues 2Neogen Reports 26% Increase in Revenues 3Neogen Reports 26% Increase in Revenues 4Neogen Reports 26% Increase in Revenues 5Neogen Reports 26% Increase in Revenues 6
Request Info...
... 2D polyacrylamide gel electrophoresis (2D-PAGE) with biological ... core technology platform for proteomic analysis. 2D-PAGE ... samples limited only in the dynamic range ... proteins. Quantitative image based analysis of separated ...
... Polymerase is ideal for high-fidelity amplification ... such as cloning and mutagenesis. ... proprietary enzyme preparation containing recombinant DNA ... (3'Cut Site5' exonuclease) activity. Platinum ...
... PLAU N-term Antibody This antibody is generated ... synthetic peptide selected within aa 50~150 of ... in PBS with 0.09% (W/V) sodium azide. ... G column and eluted out with both ...
Biology Products: