Navigation Links
Unexpected lock and key mechanism found for the assembly of tumor blood vessels

A critical lock and key mechanism that allows the final step in the completion of new blood vessel formation has been identified by a University of California, San Diego (UCSD) School of Medicine team in research that promises to lead to a new way to halt tumor growth by cutting off the tumor blood supply.

The research team led by Judith Varner, Ph.D., Associate Professor of Medicine at UCSD and a member of the Rebecca and John Moores UCSD Cancer Center, made the surprising discovery that a receptor-ligand pair previously identified as key regulators of immune cell function puts the finishing touches on newly constructed blood vessels by allowing the two cell layers of blood vessels to recognize and "lock" together.

The study, which appears in the June 2005 issue of the Journal of Clinical Investigation, is the first to show how the two cell layers of blood vessels recognize and bind to each other during angiogenesis, which is the formation of new blood vessels.

The work also could yield new ways to diagnose and combat cancer. In fact, together with Barbara Parker, M.D., UCSD Professor of Clinical Medicine at the Moores UCSD Cancer Center, the researchers currently are conducting tests with breast cancer patients to see if measuring the activity of the receptor, or "lock," called integrin, could help diagnose the cancer earlier. They are also currently planning cancer clinical trials with an FDA approved drug directed against the integrin.

Angiogenesis has been an intensely studied field of cancer research for the past 10 years. Since cancer cells literally hijack the body's normal angiogenesis process to initiate blood vessel growth to fuel the growth of tumors, researchers believe that blocking angiogenesis may choke off a tumor's blood supply and kill the cancerous cell.

Varner and her team found that a specific integrin protein called alpha4beta1 was produced at high levels in one part of a developing blood vessel, the inte
'"/>

Source:University of California - San Diego


Page: 1 2 3

Related biology news :

1. A new mechanism of regulating RNA degradation
2. Plants, animals share molecular growth mechanisms
3. PET/MRI scans may help unravel mechanisms of prenatal drug damage
4. Researchers discover molecular mechanism that desensitizes us to cold
5. Chemists identify immune system mechanism for methamphetamine binges
6. Key mechanism in genetic inheritance during cell division identified
7. Researchers unlock mechanism creating jigsaw puzzle-like plant cells
8. Mouse gene shows new mechanism behind cardiac infarction in man
9. UCSD research reveals mechanism involved with type of fatal epilepsy
10. Ancient immune defense mechanism is no match for HIV-1
11. Malaria mechanism revealed

Post Your Comments:
(Date:11/23/2009)...des "incontrovertible evidence" that the volcanic ...out 73,000 years ago deforested much of central In...ers report. , The volcano ejected an estimated 8...aving a crater (now the world,s largest volcanic l... wide. Ash from the event has been found in India,...
(Date:11/23/2009)...USDOE and USDA study concluded that 50 million U.S...asture could be converted from current uses to the...ass, from which biomass could be harvested for use...ction of a perennial grass monoculture from which ...ally is expected to require nitrogen fertilizer. ,...
(Date:11/23/2009)...eal in unprecedented detail how the ribosome inter... and guide them toward their destination in biolog...exible fitting (MDFF) to examine the interaction o...rs. , The first study, in Proceedings of the N...e signaling between the ribosome and an elongation...
Breaking Biology News(10 mins):Supervolcano eruption -- in Sumatra -- deforested India 73,000 years ago 2Switchgrass produces biomass efficiently 2Computational microscope peers into the working ribosome 2Computational microscope peers into the working ribosome 3Exenatide Once Weekly Provided Sustained Improvements in Glycemic Control With Weight Loss Over Two Years 3A DURATION 1 Interim Long Term Data Present 4551 1Exenatide Once Weekly Provided Sustained Improvements in Glycemic Control With Weight Loss Over Two Years 3A DURATION 1 Interim Long Term Data Present 4551 2Exenatide Once Weekly Provided Sustained Improvements in Glycemic Control With Weight Loss Over Two Years 3A DURATION 1 Interim Long Term Data Present 4551 3Exenatide Once Weekly Provided Sustained Improvements in Glycemic Control With Weight Loss Over Two Years 3A DURATION 1 Interim Long Term Data Present 4551 4Exenatide Once Weekly Provided Sustained Improvements in Glycemic Control With Weight Loss Over Two Years 3A DURATION 1 Interim Long Term Data Present 4551 5Exenatide Once Weekly Provided Sustained Improvements in Glycemic Control With Weight Loss Over Two Years 3A DURATION 1 Interim Long Term Data Present 4551 6Exenatide Once Weekly Provided Sustained Improvements in Glycemic Control With Weight Loss Over Two Years 3A DURATION 1 Interim Long Term Data Present 4551 7Study Shows GSKs Novel Diabetes Treatment SYNCRIA 28R 29 28albiglutide 29 Improves Glucose Control and Reduces Weight 4549 1Study Shows GSKs Novel Diabetes Treatment SYNCRIA 28R 29 28albiglutide 29 Improves Glucose Control and Reduces Weight 4549 2Study Shows GSKs Novel Diabetes Treatment SYNCRIA 28R 29 28albiglutide 29 Improves Glucose Control and Reduces Weight 4549 3Orange County Laser Surgeon Nissan Pilest Tapped as Keynote Speaker at Fraxel 26amp 3B Thermage User Forum Held at Beckman Laser Institute 12498 1Orange County Laser Surgeon Nissan Pilest Tapped as Keynote Speaker at Fraxel 26amp 3B Thermage User Forum Held at Beckman Laser Institute 12498 2Orange County Laser Surgeon Nissan Pilest Tapped as Keynote Speaker at Fraxel 26amp 3B Thermage User Forum Held at Beckman Laser Institute 12498 3
... In recent years, a growing scarcity of energy com...ey geopolitical risks and threats, such as conflic...nalism. However, a study released this week by Ric...uggests that, taken individually, many of the risk...rophic than they seem at first glance. The executi...
... Fishery biologist Sandy Sutherland looks through ...h earbones, known as otoliths, each showing annual...o determine the age of the fish, then moves on to ...nd is one of a small team at NOAAs Northeast Fishe...itical to stock assessments needed to manage the n...
... This press release is available in German . , ...cost us in the long term" How much do national eco...nd" And what price will we have to pay if we do no...nomics of Ecosystems and Biodiversity - project is...ukhdev, who is head of Deutsche Bank,s Global Mark...
Other Biology News:Baker Institute study, conference weigh risks for global energy markets 2Saltwater sleuths: Seeking clues to help determine the ages of fish and shellfish populations 2Saltwater sleuths: Seeking clues to help determine the ages of fish and shellfish populations 3Saltwater sleuths: Seeking clues to help determine the ages of fish and shellfish populations 4Biodiversity as a natural resource 2
(Date:11/24/2009)..., SEATTLE,Nov.24/PRNewswire/--BlueMarbleEnerg...icDevelopmentAuthority(OPDA)wererecentlyawarded$2m...zationBoard(CERB)inaprivate/publicpartnershiptocon...ryinLincolnCounty,WA. ,, "Thisinvestmentwillsig...ingover70greenjobstoLincolnCounty,"saidBlueMarbleE...
(Date:11/24/2009)..., TSXVENTURE:HTL , TORONTO,Nov.24/PRNews...erlyCalottoCapitalInc.,aleadingproviderofadvancedl...fertilityclinicmarkets,todayreportedoperationaland...,2009. , ,Q32009Highlights,-Revenuewas$1.46milli...ginwas66.3percentcomparedwith66.1percentinQ3,2008,...
(Date:11/24/2009)..., REDWOODCITY,Calif.,Nov.24/PRNewswire-FirstC...cedthatRandyScott,GenomicHealth,sExecutiveChairman...onferenceinNewYorkCityonTuesday,December1,2009at10...hivedwebcastofthepresentation,visittheInvestorRela...stor.genomichealth.com .Pleaseconnecttothewebsitea...
(Date:11/24/2009)... Chemical Abstracts Servic..., reports that China,s patent office is now the wo...tions in chemistry. China trailed Japan,s patent o...n (WIPO), and the United States Patent and Tradema...ed the USPTO in 2005, WIPO in 2006, and exceeded J...
Breaking Biology Technology:Blue Marble Energy, OPDA Awarded $2M by WA's Community Economic Revitalization Board 2Hamilton Thorne announces third quarter results 2Hamilton Thorne announces third quarter results 3Hamilton Thorne announces third quarter results 4Hamilton Thorne announces third quarter results 5Hamilton Thorne announces third quarter results 6Hamilton Thorne announces third quarter results 7Genomic Health to Present at Piper Jaffray Health Care Conference 2China Leads All Nations in Publication of Chemical Patents According to CAS, the World's Most Authoritative Publisher of Chemical Information 2China Leads All Nations in Publication of Chemical Patents According to CAS, the World's Most Authoritative Publisher of Chemical Information 3
...uticals,Inc. (Nasdaq: ANDS ), a clinical-stage bi...ient care by developing novel medicines in the are... financial results and,highlights for the third qu...make rapid progress in both of our hepatitis C,dev...ident and CEO of,Anadys. "We completed our first c...
...all/ - Oncolytics Biotech Inc. (TSX:,ONC, NASDAQ: ... Phase I,Study to Evaluate Systemic Wild-Type Reov...n Patients with Advanced Malignancies" will be ava...al of Immunotherapy, the official,journal of the I...cer,(iSBTc). The principal investigator for the tr...
...ne today announced,that researchers will present e... at the Annual Meeting of the American College of ...oscone Center in San Francisco, California., "Med...ns for patients,struggling with systemic autoimmun...ice president, clinical development, respiratory,i...
Other Biology Technology:Anadys Pharmaceuticals Reports Third Quarter 2008 Financial Results and Highlights 2Anadys Pharmaceuticals Reports Third Quarter 2008 Financial Results and Highlights 3Anadys Pharmaceuticals Reports Third Quarter 2008 Financial Results and Highlights 4Anadys Pharmaceuticals Reports Third Quarter 2008 Financial Results and Highlights 5Anadys Pharmaceuticals Reports Third Quarter 2008 Financial Results and Highlights 6Anadys Pharmaceuticals Reports Third Quarter 2008 Financial Results and Highlights 7Anadys Pharmaceuticals Reports Third Quarter 2008 Financial Results and Highlights 8Oncolytics Biotech Inc. Collaborators to Present Combination REOLYSIN(R) and Docetaxel Results at iSBTc Annual Meeting 2Oncolytics Biotech Inc. Collaborators to Present Combination REOLYSIN(R) and Docetaxel Results at iSBTc Annual Meeting 3MedImmune Presents Data Highlighting its Progressive Inflammatory Disease Portfolio at the 72nd Annual Meeting of the American College of Rheumatology 2MedImmune Presents Data Highlighting its Progressive Inflammatory Disease Portfolio at the 72nd Annual Meeting of the American College of Rheumatology 3
...llow 5-minute cloning and subsequent sequencing of...rs with primer sites located as close as 33 base p...imizes the amount of vector DNA that needs to be r...ctors are available. The pCR4-TOPO vector provides...
Transfer & Blot Paper from NuSep Ltd
Dynabeads M-450 Epoxy from Dynal Biotech
GIBCO Earles Balanced Salt Solution (EBSS) (1X); liquid from Invitrogen
Biology Products: