Navigation Links
'Underground' tunnels discovered as means for communication between immune system cells

University of Pittsburgh researchers first to report function of tunneling nanotubules

Immune system cells are connected to each other by an extensive network of tiny tunnels that, like a building's hidden pneumatic tube system, are used to shoot signals to distant cells. This surprising discovery, being reported by two University of Pittsburgh School of Medicine researchers in the September issue of the journal Immunity, may explain how an immune response can be so exquisitely swift. The research not only proves cells other than neurons are capable of long-distance communication, but it reveals a hereto-unknown mechanism cells use for exchanging information.

Blood-derived dendritic cells and macrophages, both antigen-presenting cells, make use of these so-called tunneling nanotubules to relay molecular messages, report Simon C. Watkins, Ph.D., and Russell D. Salter, Ph.D. Further research may show there are additional cell types with these microscopic tunnel connections. Thus far, their studies suggest the tunnels do not exist between commonly used fibroblast and tumor cell lines.

Interestingly, if not for a minor mishap while carrying out an experiment, the authors might not have discovered the existence of these physical structures and conducted the studies that revealed their role in intercellular communication.

Using a custom-built, multi-camera live cell microscopic imaging system, they report that, in a matter of seconds, dendritic cells and macrophages can send waves of calcium and other small molecules to cells hundreds of micrometers away. Each nanotubule measures between 35 and 200 nanometers across - 5000 times smaller than the width of a human hair - and at any given time, cells may have up to 75 of these extensions, each of varying lengths.

"Considering their scale, these nanotubules are allowing communication between fairly distant cells. If instead of a culture dish we were talking about a large metropolitan are
'"/>

Source:University of Pittsburgh Medical Center


Page: 1 2 3 4

Related biology news :

1. Newly-discovered class of genes determines ?and restricts ?stem cell fate
2. Newly discovered virus linked to childhood lung disorders and Kawasaki disease
3. New protein discovered by Hebrew University researchers
4. New RNA polymerase discovered in plants
5. Newly discovered pathway might help in design of cancer drugs
6. New tumor-suppressor gene discovered
7. Newly discovered protein an important tool for sleeping sickness research
8. Function of new cancer genes discovered
9. Evidence of 600-million-year old fungi-algae symbiosis discovered in marine fossils
10. Natural tumor suppressor in body discovered by UCSD medical researchers
11. Enzymes newly discovered role may make it target for arthritis treatment
Post Your Comments:
(Date:7/31/2015)... SHENZHEN, China , 31. Juli 2015 Die ... ) wird von BGI veranstaltet und findet vom ... Shenzhen, China , statt. ... Jubiläum. Seit ihrem Start 2006 ist die ICG ... Bereich „omik" geworden. Sie ist eines der dynamischsten, ...
(Date:7/27/2015)... SAN JOSE, Calif. , July 27, 2015 ... leading developer of human interface solutions, today announced ... ClearPad ® touchscreen solution for its stylish ... controller for its proven reliability, low power and ... with a wet finger. Huawei designers also required ...
(Date:7/21/2015)... 21, 2015 Today, ZTE announced its Android ... well as expected revenues in 2015 that relate to sales of ... guidance of approximately 2,200 MSEK for 2015. Jörgen Lantto, ... smartphone manufacturer in China and we are ... 5 for Axon , its ...
Breaking Biology News(10 mins):Die 10. internationale Konferenz zu Genomik (ICG-10) beginnt im Oktober 2Die 10. internationale Konferenz zu Genomik (ICG-10) beginnt im Oktober 3Synaptics Touchscreen Solution Powers New Huawei Watch 2Synaptics Touchscreen Solution Powers New Huawei Watch 3FPC's Touch Fingerprint Sensor FPC1025 in ZTE's Smartphone Axon 2
... infant follow-on formulas are better reconstituted with fruit juice ... to prevent growth of meningitis bacteria, according to recent ... in the Society for Applied Microbiology journal, Letters ... do not grow in wheat-based infant formula stored at ...
... − Obstructive sleep apnea decreases blood flow to the ... harms the brain,s ability to modulate these changes and ... published by The American Physiological Society. The findings may ... likely to suffer strokes and to die in their ...
... 5, 2009) - This month,s issue of ... two articles detailing experimental methods for the analysis of ... of proteins. Homologous recombination is an important mechanism ... occurs, a Displacement Loop, or "D-loop," is formed as ...
Cached Biology News:Study helps explain connection between sleep apnea, stroke and death 2Study helps explain connection between sleep apnea, stroke and death 3Methods for studying DNA repair and protein modification are featured in CSH Protocols 2
(Date:8/3/2015)... , August 3, 2015 ... Study on 3D Cell Culture: Asia ... Persistence Market Research, the global 3D cell culture market was valued ... to expand at a CAGR of 29.1% to account ... Full Report with TOC:  http://www.persistencemarketresearch.com/market-research/3d-cell-cultures-market.asp 3D ...
(Date:7/31/2015)... ... July 31, 2015 , ... ... market analysis and premium industry insights on the global resorcinol industry. The report ... collective study of vivid market scenarios and analysis of primary and secondary inputs ...
(Date:7/30/2015)... 30, 2015 AACC welcomed thousands of ... AACC Annual Meeting & Clinical Lab Expo in ... The meeting showcased revolutionary advancements in clinical testing ... healthcare providers to diagnose patients quickly and accurately ... As of Wednesday, July 29, ...
(Date:7/30/2015)... -- According to a new market research ... PKPD, Trial Design, Toxicity Prediction, In-house, Contract Service), by ... End Users - Global Forecast to 2020", published by ... 2,107.99 million by 2020 from USD 1,034.93 million in ... Browse more than 75 market ...
Breaking Biology Technology:Global 3D Cell Culture Market Will Reach US$ 2,717.6 Million by 2020: Persistence Market Research 2Global 3D Cell Culture Market Will Reach US$ 2,717.6 Million by 2020: Persistence Market Research 3Global 3D Cell Culture Market Will Reach US$ 2,717.6 Million by 2020: Persistence Market Research 4Resorcinol Market to Grow at 6% CAGR to 2019 Says New Research Report at ReportsnReports.com 2Resorcinol Market to Grow at 6% CAGR to 2019 Says New Research Report at ReportsnReports.com 3Resorcinol Market to Grow at 6% CAGR to 2019 Says New Research Report at ReportsnReports.com 4Innovative Research on Cancer, Heart Disease, and Infectious Diseases Draws More than 17,500 Attendees to 2015 AACC Annual Meeting 2Innovative Research on Cancer, Heart Disease, and Infectious Diseases Draws More than 17,500 Attendees to 2015 AACC Annual Meeting 3Innovative Research on Cancer, Heart Disease, and Infectious Diseases Draws More than 17,500 Attendees to 2015 AACC Annual Meeting 4Biosimulation Market Worth 2,107.99 Million USD by 2020 2Biosimulation Market Worth 2,107.99 Million USD by 2020 3Biosimulation Market Worth 2,107.99 Million USD by 2020 4
... innovation is in large measure the ability to tune ... to a gathering of southeastern Wisconsin technology professionals. , ... and author of "Art of the Start" and several ... presentation to members of eInnovate. He poked some good-natured ...
... any industry trade show, but Doug Tucker didn't come to BIO ... Chicago show floor, the size of three football fields, hosted countries, states ... our end-user customers in the form of physicians, etc., to be in ... is a probably a better way for us to look at the ...
... A stem cell scientist from Harvard University dropped ... noted, with a hint of admiration, that it was abuzz ... around the Wisconsin exhibit than anywhere else I've been on ... appreciated, but foot traffic at a trade show even ...
Cached Biology Technology:Beating back the bozos is an innovation must, says Kawasaki 2As BIO shows mass of competition, hunt for partners is on 2As BIO shows mass of competition, hunt for partners is on 3In competitive biotech world, Wisconsin can't afford to fall behind 2In competitive biotech world, Wisconsin can't afford to fall behind 3
Used in May-Grunwald Giemsa stain....
Normal Bovine Serum; U.S. sourced, ideal for those who seek an uncompromising quality. Low Hemoglobin levels; U.S. sourced, ideal for those who seek an uncompromising quality. Low Hemoglobin lev...
...
...
Biology Products: