Navigation Links
'Underground' tunnels discovered as means for communication between immune system cells

University of Pittsburgh researchers first to report function of tunneling nanotubules

Immune system cells are connected to each other by an extensive network of tiny tunnels that, like a building's hidden pneumatic tube system, are used to shoot signals to distant cells. This surprising discovery, being reported by two University of Pittsburgh School of Medicine researchers in the September issue of the journal Immunity, may explain how an immune response can be so exquisitely swift. The research not only proves cells other than neurons are capable of long-distance communication, but it reveals a hereto-unknown mechanism cells use for exchanging information.

Blood-derived dendritic cells and macrophages, both antigen-presenting cells, make use of these so-called tunneling nanotubules to relay molecular messages, report Simon C. Watkins, Ph.D., and Russell D. Salter, Ph.D. Further research may show there are additional cell types with these microscopic tunnel connections. Thus far, their studies suggest the tunnels do not exist between commonly used fibroblast and tumor cell lines.

Interestingly, if not for a minor mishap while carrying out an experiment, the authors might not have discovered the existence of these physical structures and conducted the studies that revealed their role in intercellular communication.

Using a custom-built, multi-camera live cell microscopic imaging system, they report that, in a matter of seconds, dendritic cells and macrophages can send waves of calcium and other small molecules to cells hundreds of micrometers away. Each nanotubule measures between 35 and 200 nanometers across - 5000 times smaller than the width of a human hair - and at any given time, cells may have up to 75 of these extensions, each of varying lengths.

"Considering their scale, these nanotubules are allowing communication between fairly distant cells. If instead of a culture dish we were talking about a large metropolitan are
'"/>

Source:University of Pittsburgh Medical Center


Page: 1 2 3 4

Related biology news :

1. Newly-discovered class of genes determines ?and restricts ?stem cell fate
2. Newly discovered virus linked to childhood lung disorders and Kawasaki disease
3. New protein discovered by Hebrew University researchers
4. New RNA polymerase discovered in plants
5. Newly discovered pathway might help in design of cancer drugs
6. New tumor-suppressor gene discovered
7. Newly discovered protein an important tool for sleeping sickness research
8. Function of new cancer genes discovered
9. Evidence of 600-million-year old fungi-algae symbiosis discovered in marine fossils
10. Natural tumor suppressor in body discovered by UCSD medical researchers
11. Enzymes newly discovered role may make it target for arthritis treatment
Post Your Comments:
(Date:7/21/2014)... Irvine, Calif., July 21, 2014 Dysfunction in ... about 2,000 genes in the brain,s prefrontal cortex ... complex neuropsychiatric disorders, such as schizophrenia, according to ... gene activity in brain cells that receive this ... deficiencies can affect a variety of behavioral and ...
(Date:7/21/2014)... satellites detected 154 hotspots in areas across Riau province ... had increased again following a decline in rainfall. ... far higher than what had been reported one day ... hotspots were scattered in six regencies and municipalities, most ... and the related haze it creates could potentially spread ...
(Date:7/21/2014)... change, due to greenhouse gasses emitted by livestock. New ... and that beef cattle are responsible for far more ... is published by Climactic Change . , ... to climate change. It is released by vehicles, industry, ... greenhouse gas totals. But methane and nitrous oxide are ...
Breaking Biology News(10 mins):UCI researchers find epigenetic tie to neuropsychiatric disorders 2Climate: Meat turns up the heat 2
... with a large-scale "geoengineering" fix, such as having a ... or building tens of millions of chemical filter systems ... But Richard Turco, a professor in ... a member and founding director of UCLA,s Institute of ...
... Rochester have designed a gene that produces a ... in healthy cells., The findings may help address ... ability to specifically and effectively target cancer cells. ... to insert "self-destruct" codes into the modified gene, ...
... Commonwealth University Life Sciences survey shows that eight in 10 ... who want it, and 54 percent say that the benefits ... about genetic research are varied with a plurality of 38 ... known about how to conduct such research safely. About three ...
Cached Biology News:No quick or easy technological fix for climate change, researchers say 2No quick or easy technological fix for climate change, researchers say 3No quick or easy technological fix for climate change, researchers say 4Modified gene targets cancer cells a thousand times more often than healthy cells 2Modified gene targets cancer cells a thousand times more often than healthy cells 3VCU survey: US public supports genetic research, testing and government spending on research 2VCU survey: US public supports genetic research, testing and government spending on research 3
(Date:7/21/2014)... 21, 2014 With a larger, ... the new Cole-Parmer® Digital Gear Pump Drive ... to operate for automated process applications. , Simply ... The batch count function counts down and displays ... tracks amount dispensed across multiple cycles. View the ...
(Date:7/21/2014)... , July 21, 2014 ... & USA Cancer Biomaker ... Forecasts ResearchMoz presents this most up-to-date ...   to 2018 (Identification, Technologies, Market Analysis, Competitor Profiles, ... Pipeline Analysis. GLOBAL & ...
(Date:7/18/2014)... TARRYTOWN, N.Y. , July 18, 2014 ... report its second quarter 2014 financial and operating results ... markets open.  The Company will host a conference call ... day. Conference Call InformationTo access this ...  A link to the webcast may be accessed from ...
(Date:7/18/2014)... July 18, 2014  Neurotrope, Inc. (OTCQB: NTRP) today ... Directors appointed Co-Chairmen Charles S. Ramat and ... an interim basis, effective immediately. Messrs. Ramat and Freiman ... longer Chief Executive Officer of Neurotrope Bioscience, Inc., (a ... whose employment agreement with Neurotrope Bioscience Inc. terminated as ...
Breaking Biology Technology:New Easy-View Cole-Parmer Digital Gear Pump Drive Makes Performance Monitoring Effortless 2Global & USA Cancer Biomaker Market to 2018 (Identification, Technologies, Market Analysis, Competitor Profiles, Companion Diagnostic Co-Development, Business Strategies, Industry Trends, and Pipeline Analysis) - Market Size, Trends, and Forecasts A 2Global & USA Cancer Biomaker Market to 2018 (Identification, Technologies, Market Analysis, Competitor Profiles, Companion Diagnostic Co-Development, Business Strategies, Industry Trends, and Pipeline Analysis) - Market Size, Trends, and Forecasts A 3Global & USA Cancer Biomaker Market to 2018 (Identification, Technologies, Market Analysis, Competitor Profiles, Companion Diagnostic Co-Development, Business Strategies, Industry Trends, and Pipeline Analysis) - Market Size, Trends, and Forecasts A 4Global & USA Cancer Biomaker Market to 2018 (Identification, Technologies, Market Analysis, Competitor Profiles, Companion Diagnostic Co-Development, Business Strategies, Industry Trends, and Pipeline Analysis) - Market Size, Trends, and Forecasts A 5Global & USA Cancer Biomaker Market to 2018 (Identification, Technologies, Market Analysis, Competitor Profiles, Companion Diagnostic Co-Development, Business Strategies, Industry Trends, and Pipeline Analysis) - Market Size, Trends, and Forecasts A 6Neurotrope Board of Directors Appoints Chairmen Ramat and Freiman as Interim Co-CEOs 2Neurotrope Board of Directors Appoints Chairmen Ramat and Freiman as Interim Co-CEOs 3Neurotrope Board of Directors Appoints Chairmen Ramat and Freiman as Interim Co-CEOs 4
... , , , Multiporator , , , , , ... Transfection Protocol , Protocol No. 4308 915.026 11/2001 , ... , , , ... line), , , ...
... , , , Multiporator / Electroporator 2510 , , , , , ... Transformation Protocol , Protocol No. 4308 915.525 01/2002 , ... , , , ... , Cell type , Bacteria, gram positive, ...
... Multiporator / Electroporator 2510 , , , , , , , ... Protocol No. 4308 915.540 07/2002 , , ... , , Microorganism , ... Cell type , Bacteria, gram positive, , ...
Cached Biology Technology:Sp20-Ag14 2Sp20-Ag14 3Nocardia asteroides 2Pediococcus spp. 2
... fast and reliable automation for today's ... development laboratories. Staccato Mini-Workstations offer the ... basic liquid handling and material management ... either Caliper's time proven CLARA™ assay ...
Experion StdSens chips are the microfluidic chips used to perform standard-sensitivity RNA analysis (nanogram levels) with the Experion automated electrophoresis system. Each chip has the capacity to...
... If particles in the submicron range ... development process, measurement and control of particle ... an analyzer that can reliably detect the ... The N5 Submicron Particle Size Analyzer uses ...
...
Biology Products: