Navigation Links
Uncovering DNA's 'sweet' secret

m, why are they optimal, why are they better than others," he said.

Although homo-DNA was first synthesized in 1992, a detailed picture ofthe molecule's structure had been lacking. Egli's high resolution structure is now able to provide answers to some of the lingering questions about why DNA is made the way it is.

While the homo-DNA structure shows a number of similarities with DNA, it is much more stable than DNA. However, it has a more haphazard appearance than normal DNA, looking more like a "slowly writhing ribbon" than the tightly twisted ladder of DNA.

"The reason that DNA was 'picked' is not because it's thermodynamically extremely stable," Egli said. "There are others - including homo-DNA - that are actually superior in that regard."

Egli's structure also shows that homo-DNA has more flexibility in how the bases (rungs of the ladder) bind. The bases in normal DNA adhere to a somewhat strict binding scheme - guanine (G) binds with cytosine (C) and adenine (A) binds with thymine (T). In this "Watson-Crick" basepairing, the G:C bonds are much stronger than A:T or any other bonds.

"In homo-DNA, the Watson-Crick base pairing rules are changed," Eglisaid. "For example, G:C is similar to G:G or A:A, so you have a much more versatile pairing system in homo-DNA. Therefore, the nature of the sugar in the backbone affects the pairing rules."

But despite homo-DNA's apparent versatility in base pairing and its thermodynamic stability, other features of the molecule's architecture probably preclude it from being a viable genetic system

For example, it cannot pair with other nucleic acids - unlike DNA and RNA which can and must pair with each other. Also the steep angle, or inclination, between the sugar backbone and the bases of homo-DNA requires that the pairing strands align strictly in an antiparallel fashion - unlike DNA which can adopt a parallel orientation. Finally,the irregular spaces between the "run
'"/>

Source:Vanderbilt University Medical Center


Page: 1 2 3

Related biology news :

1. Uncovering sex-change secrets of black sea bass
2. Insight into DNAs weakest links may yield clues to cancer biology
3. Brown-Harvard team solves mobile DNAs surgical sleight-of-hand
4. Climatologists discover deep-sea secret
5. Think fast! Rice undergrad unlocks nerve speed secret
6. UVa researchers seek to unlock broccolis cancer fighting secret
7. Scientists identify prions infectious secret
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Uncovering DNA sweet secret

(Date:4/14/2015)... April 14, 2015  HYPR Corp. today announced ... ® ) Alliance tm , an industry consortium ... commit to share technology and collaborate to deliver ... interoperable, more secure and private, and easier to ... verification that protects sensitive user information and eliminates ...
(Date:4/9/2015)... April 9, 2015 Synaptics Inc. (NASDAQ: SYNA ... today that it will report financial results for the ... 2015, after the close of market. The company will ... at 2:00 p.m. PT (5:00 p.m. ET), during which ... participate on the live call, analysts and investors should ...
(Date:4/2/2015)... , April 2, 2015 According ... 2015 attributed to somewhat higher than 125 MSEK. This ... year-end report 2014 that revenues for Q1 2015 would ... company reported for Q4 2014. The operating result for ... negative. The complete interim report will as previously communicated ...
Breaking Biology News(10 mins):HYPR Corp. Joins the FIDO Alliance 2HYPR Corp. Joins the FIDO Alliance 3Synaptics to Report Third Quarter Results on April 23 2Fingerprint Cards Revises Revenues for Q1 2015 2
... University biologist has been awarded over $2.3 million from ... of the human pathogen chlamydia in hopes of finding ... disease in the United States. David E. Nelson, ... Arts and Sciences, Department of Biology, and researchers in ...
... invading virus hijacks a cell,s workings by imitating a ... cell signals, the virus destroys a defensive protein designed ... cell cultures, may represent a broader targeting strategy used ... for developing more effective treatments for infectious diseases. ...
... buzz of the golden-winged warbler,s song might not sound like ... population of this little, gray songbird with bright yellow patches ... since 1966. And, as of yet, it remains unprotected by ... dire situation for the warbler, and Ronald Canterbury wants people ...
Cached Biology News:In search for a vaccine, IU biologist receives $2.3 million to explore chlamydia genomics 2In search for a vaccine, IU biologist receives $2.3 million to explore chlamydia genomics 3To drive infections, a hijacking virus mimics a cell's signaling system 2UC research: Saving habitat key to songbird's survival 2
(Date:4/16/2015)... Portage Biotech Inc. ("Portage" or "the Company" )) (OTC ... announce that the Company will be presenting  at the ... held in London, UK . Portage,s ... James Mellon , a director of Portage, will provide ... at its subsidiaries, Portage Pharmaceuticals Ltd. ("PPL"), and Biohaven ...
(Date:4/16/2015)... , April 16, 2015 /CNW/ - Bioenterprise Corporation is pleased ... office in Charlottetown , PEI.  Bioenterprise ... Edward Island ADAPT Council for the commercialization of agricultural ... to working with PEI ADAPT.  They have been at ... than a decade," explains Dave Smardon , President ...
(Date:4/16/2015)... A new infographic compiles useful information about Research ... learn how Apple’s new framework can change the way ... since Apple made Research Kit available to ... for developing medical research apps that Apple announced on ... collect secure clinical data and communicate via subjects’ smartphones. ...
(Date:4/16/2015)... Calif. , April 16, 2015  Scientists from ... "New Drugs on the Horizon," at the American Association ... Philadelphia, PA on Sunday, April 19, 2015 ... Ph.D., Cleave,s Director of Biology, will present new in ... a first-in-class, oral inhibitor of p97, a critical enzyme ...
Breaking Biology Technology:Portage to Present at Master Investor 2015 in London, UK 2Portage to Present at Master Investor 2015 in London, UK 3Portage to Present at Master Investor 2015 in London, UK 4Bioenterprise Corporation Expands into the Maritimes 2Infographic Illustrates Potential for Research Kit to Impact Clinical Research 2Infographic Illustrates Potential for Research Kit to Impact Clinical Research 3Cleave Biosciences to Participate in Special Session "New Drugs on the Horizon" at AACR Annual Meeting 2015 2Cleave Biosciences to Participate in Special Session "New Drugs on the Horizon" at AACR Annual Meeting 2015 3
... 3 Caliper Life,Sciences, Inc. (Nasdaq: CALP ... 26th Annual Healthcare Conference will be webcast on ... Hrusovsky, President and CEO of,Caliper, will be providing ... can be accessed at, http://www.metameetings.com/webcasts/jpmorgan/healthcare08/ . An archived,presentation ...
... MEDX ) announced today that it is scheduled ... 10:30 a.m. ET on Tuesday, January,8, 2008. The event ... the,Investor Relations section of the Medarex Web site at ... be available following the event., About Medarex, ...
... Mass., Jan. 3 Mersana, a cancer therapeutics,company, ... as Chairman of,the Company,s Board of Directors. Mr. ... a significant record of accomplishment over a,30-year industry ... welcome Boyd Clarke as Chairman of our Board,of ...
Cached Biology Technology:Mersana Therapeutics Appoints C. Boyd Clarke Chairman of the Board of Directors 2
... • Enzyme concentration - 5 units/µL ... in higher yields ,• Leaves an 'A' ... DNA polymerase which exhibits very high activity ... applications. To ensure the quality of the ...
Our original highly-purified, robust Taq Polymerase which delivers consistently high yields and minimal background...
... Polymerase is the most thoroughly characterized enzyme ... to its overall utility and efficacy. , ... for PCR applications. , It is ... ,, AmpliTaq DNA Polymerase is a 94 ...
... a versatile and easy-to use enzyme, with ... Taq DNA Polymerase is prepared from a ... the DNA polymerase I gene from Thermococcus ... 5'-3' DNA polymerase activity. Its inherent 3'-5' ...
Biology Products: