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Ultra low-dose estrogen shown safe for post-menopausal women

e women who took estradiol compared to the women who took placebo. The current study was a pre-planned secondary investigation.

Yaffe speculates that the differences in health and cognition outcomes between these two studies and the WHI studies could be related to three factors: dose, type of estrogen, and means of delivery.

The women in the WHI studies received .625 milligrams per day of conjugated estrogen ?a mixture of estrogen from several different sources ?in pill form. In contrast, the women studied by Yaffe and her associates received a daily dose of estradiol ?pure human estrogen ?that was over 44 times smaller and delivered through a skin patch.

"The different between a patch and a pill is significant because medications taken in pill form are processed through the liver before they reach the bloodstream," explains Yaffe. "It's thought that estrogen in pill form might stimulate the liver to produce substances that can lead to clotting or other adverse side effects. With a patch, you bypass the liver and go straight to the blood."

Yaffe notes that since the WHI results were announced in 2004, "the field of estrogen research has been stymied. Hopefully, this study will start to turn the tide."


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Source:University of California - San Francisco


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