Navigation Links
UWM brain research supports drug development from jellyfish protein

With the research support from the University of Wisconsin-Milwaukee, a Wisconsin biotech company has found that a compound from a protein found in jellyfish is neuro-protective and may be effective in treating neurodegenerative diseases.

Testing of aequorin has yielded promising results, said Mark Y. Underwood of Quincy Bioscience located in Madison. Researcher James Moyer, Jr., an assistant professor at UW-Milwaukee, subjected brain cells to the "lab" equivalent of a stroke, and more than half treated with aequorin survived without residual toxicity.

Why does it work? Diseases like Alzheimer's are associated with a loss of "calcium-binding" proteins that protect nerve cells, said Moyer. Calcium is necessary for communication between neurons in the brain, and learning and memory are not possible without it. But too much of it leads to neuron death, interfering with memory and contributing to neurodegenerative diseases.

"There are ways in which cells control the influx of calcium, such as sequestering it by binding it with certain proteins," said Moyer. "If it weren't for these proteins, the high level of calcium would overwhelm the neuron and trigger a cascade of events ultimately leading to cell death."

Calcium-binding proteins decline with age, however, limiting the brain's ability to control or handle the amount of calcium "allowed in."

Aequorin, the jellyfish protein, appears to be a viable substitute.

Moyer, like Underwood, is interested in the "calcium hypothesis of aging and dementia," which is just one of many theories that attempts to explain what is going on in neuron degeneration.

He became interested in aequorin as an undergraduate at UW-Milwaukee, after reading an article that linked the stings of jellyfish with the symptoms of multiple sclerosis, a disease of the central nervous system that his mother has.

Aequorin was discovered in the 1960s and has been used in research for a
'"/>

Source:University of Wisconsin - Milwaukee


Page: 1 2

Related biology news :

1. Controversial drug shown to act on brain protein to cut alcohol use
2. Mouse brain cells rapidly recover after Alzheimers plaques are cleared
3. Mouse brain tumors mimic those in human genetic disorder
4. New imaging method gives early indication if brain cancer therapy is effective, U-M study shows
5. First atlas of key brain genes could speed research on cancer, neurological diseases
6. NYU study reveals how brains immune system fights viral encephalitis
7. Stem cells from brain transformed to produce insulin at Stanford
8. Birds brains reveal source of songs
9. Loves all in the brain: fMRI study shows strong, lateralized reward, not sex, drive
10. Revolutionary nanotechnology illuminates brain cells at work
11. A puzzle piece found in unraveling the wiring of the brain
Post Your Comments:
(Date:8/22/2014)... an injury can probably remember the after-effects, including pain, ... is fighting back against the injury. When tissue in ... aid in tissue regeneration. An inflammatory response acts as ... the body to heal after injuries such as wounds ... healing in situations in which foreign material is introduced, ...
(Date:8/22/2014)... comprehensive study of captive black rhino reproduction in ... success of breeding programmes. , Researchers from Chester ... of Liverpool carried out a six-year study which ... , Dr Katie Edwards led the research as ... Liverpool. She says: "Although some black rhinoceros breed ...
(Date:8/22/2014)... will finally be able to purchase fuel cell cars ... vehicles, most of the cars will run on hydrogen ... to global warming. , Now scientists at Stanford University ... ordinary AAA battery to produce hydrogen by water electrolysis. ... electrodes that split liquid water into hydrogen and oxygen ...
Breaking Biology News(10 mins):Tissue regeneration using anti-inflammatory nanomolecules 2Hormone analysis helps identify horny rhinos 2Stanford scientists develop a water splitter that runs on an ordinary AAA battery 2Stanford scientists develop a water splitter that runs on an ordinary AAA battery 3
... release is available in German . ... travel of tomorrow is meant to become quieter, cleaner and ... to accomplish just that as part of the EU ... technical aspects of air travel to the test, evaluating and ...
... available in French . Quebec ... in which a breastfed premature infant remains in skin-to-skin ... in an incubator -- has lasting positive impact on ... issue of Acta Paediatrica. Very premature infants who benefited ...
... November 11-14, 2012 WHERE: The Knoxville ... 2012 is the 60th Annual Meeting of the Entomological Society ... attend. The theme is "A Global Society for a Global ... 2,500 presentations on subjects such as bed bugs, honey bees, ...
Cached Biology News:Fraunhofer supports continuation of 'Clean Sky' program 2Preemies' brains reap long-term benefits from Kangaroo Mother Care 2
(Date:8/22/2014)... (August 22nd), in the scientific journal PLoS ... establish the effect of serotonin on sensitivity to ... optical techniques., "Serotonin is a small molecule known ... brain functions, from the control of sleep and ... This neurotransmitter is also popularly thought to contribute ...
(Date:8/22/2014)... , Aug. 22, 2014 Research ... "Global and China Gel Permeation Chromatography (GPC) Industry ... The Global and China Gel Permeation Chromatography (GPC) ... the current state of the global gel permeation chromatography ... The report provides a basic overview of the industry ...
(Date:8/22/2014)... SC (PRWEB) August 22, 2014 ... indisputable acknowledgement is a national disgrace. Furthermore, every ... in establishing the current, deplorable state of unorganized ... "5 great mistakes," to merely serve as a ... the extent of colossal failure(s) that have accumulated ...
(Date:8/21/2014)... 2014 2014 Deep Research ... a professional and in-depth research report on ... basic Seaweed Fertilizer information, including Seaweed Fertilizer ... as well as industry overview. This research ... market as well as global industry analysis ...
Breaking Biology Technology:From happiness to pain: Understanding serotonin's function 2Global and China Gel Permeation Chromatography (GPC) Industry Report 2014 25 Great Mistakes in Healthcare and How to Fix Them by Dr. Ira Williams 2Internationals Seaweed Fertilizer Industry 2014 Development Trend Analysis in New Research Study at DeepResearchReports.com 2Internationals Seaweed Fertilizer Industry 2014 Development Trend Analysis in New Research Study at DeepResearchReports.com 3
... 15 Senetek PLC,(OTC Bulletin Board: SNKTY), a Life ... the science of healthy aging, today,announced an agreement with ... Sciences in Poznan, Poland for the exclusive rights to ... therapeutic technology for,the potential use against a broad range ...
... 15 bwin, the world,s,leading online gaming company, and ... Harvard Medical School Teaching Affiliate, have,just signed an agreement ... to use scientific evidence to create the safest,possible online ... longitudinal study. , ...
... ProGenTech Limited was a winner of the Red Herring 100 Award, ... Asia. , The Red Herring ... top 100 out of more than 1,000,closely evaluated companies that are ... "It is truly an honor to be recognized by ...
Cached Biology Technology:Senetek PLC Acquires Rights to Additional Anticancer RNAi Technology 2bwin and Harvard Medical School Faculty Sign 5-Year Research Cooperation Agreement 2Red Herring Awards ProGenTech Limited for the 2008 Red Herring Asia 100 2
... Adapted to Sf-900 ... were isolated from Spodoptera ... insect cells (1). The ... to serum-free suspension culture ...
... BAC (100+kb), fosmid (40kb), and large plasmid ... any othe BAC vector. On command 20-50 ... easy recombinant DNA purification. Available with blue-white ... vectors for the highest insert stability. Kits ...
MAGP-2 (C-19)...
... Immunogen: Synthetic peptide derived from ... junctophilin-2. Specificity: Specific for the ... controls: mouse skeletal muscle homogenates frozen ... Western blotting Immunohistochemistry(froz) ImmunofluorescenceStorage: Store at ...
Biology Products: