Navigation Links
UW scientists unravel critical genetic puzzle for flu virus replication

one cell and go on to infect other cells.

What Kawaoka found was that the viruses were assembling their infectious genetic elements in a systematic fashion. Virologists have long debated whether the RNA segments in flu viruses assembled at random into the virions or were somehow incorporated into the infectious particle in an organized way.

The RNA segments, according to Kawaoka, form in a distinct pattern abutting the membrane of the virus. They are always arranged in a circle of seven surrounding another segment for a total of eight RNA fragments.

"It was not really known whether the fragments were coming as a set," explains Kawaoka, whose team conducted the work using a long-studied influenza A virus, the family responsible for regular influenza outbreaks, including such medical calamities as the 1918 influenza pandemic.

The fact that the virus requires a systematic -- as opposed to a random -- method of assembly opens the door to the development of new antiviral drugs and the harnessing of benign influenza viruses as gene vectors to optimize vaccine production, Kawaoka says.

"We need to have more antivirals for influenza," according to Kawaoka, "and as these segments get incorporated into the particle as a set, it suggests these elements could be a target for disruption. There must be a genetic element in each of the eight segments that allows them to interact."

What's more, scientists have been exploring the possibility of using strains of influenza to ferry genes from one virus to another to speed and optimize vaccine production. More efficient methods of vaccine production will be critical should a global outbreak such as the "Spanish " flu pandemic of 1918 recur. That pandemic killed an estimated 30-50 million people.

Knowing how influenza A viruses package their genetic contents, and knowing that they do so systematically, suggests it may be possible, by manipulating key genetic elements, to quickly
'"/>

Source:University of Wisconsin-Madison


Page: 1 2 3

Related biology news :

1. Wisconsin scientists grow critical nerve cells
2. UCSB scientists probe sea floor venting to gain understanding of early life on Earth
3. UAB scientists discover the origin of a mysterious physical force
4. Fox Chase Cancer Center scientists identify immune-system mutation
5. Weizmann Institute scientists develop a new approach for directing treatment to metastasized prostate cancer in the bones.
6. U-M scientists find genes that control growth of common skin cancer
7. UCLA scientists transform HIV into cancer-seeking missile
8. RNA project to create language for scientists worldwide
9. Carnegie Mellon scientists develop tool that uses MRI to visualize gene expression in living animals
10. To control germs, scientists deploy tiny agents provocateurs
11. Leprosy microbes lead scientists to immune discovery
Post Your Comments:
(Date:8/1/2014)... The Journal of Nutrition Education and Behavior (JNEB) ... Material (GEM) awards, which were presented at the Society ... Education Impact: Local to Global," in Milwaukee, Wisconsin, June ... recognize the authors of the best article and best ... members of the JNEB Journal Committee and Board of ...
(Date:8/1/2014)... 2014Biologists at The Scripps Research Institute (TSRI) have identified ... process in brown fat cells. , The study, ... of the Proceedings of the National Academy of ... "brown fat thermogenesis," which is of great interest to ... may also protect against diabetes. , "This finding offers ...
(Date:8/1/2014)... Provider Binary Biometrics is pleased to welcome Kevin Morris ... its mobile service capabilities and add more daily appointments, which will allow the ... new cities such as, but not limited to, Daytona Beach ... Deltona , Edgewater , Holly Hill ... , Oak Hill , Orange City , ...
Breaking Biology News(10 mins):Scripps Research Institute scientists find new calorie-burning switch in brown fat 2Scripps Research Institute scientists find new calorie-burning switch in brown fat 3Binary Biometrics, Founded by James Timothy White, Expands Services to 13+ Locations With the Addition of Owner/Operator Kevin Morris 2Binary Biometrics, Founded by James Timothy White, Expands Services to 13+ Locations With the Addition of Owner/Operator Kevin Morris 3
... biological structures, like the brain or the eye, are ... have proposed various ways that so-called ,irreducibly complex, structures ... a new study proposes an alternative route. ... intricate, say authors Dan McShea and Wim Hordijk, some ...
... dioxide removal could be used under certain requirements to ... would not replace the bulk of actual emissions reductions. ... separate emissions control from the time and location of ... climate protection," says lead-author Elmar Kriegler. "You don,t have ...
... are adding statistical nuance to our understanding of how ... statistical model of Arctic temperature and how it relates ... cores, and lake sediments, Martin Tingley, a research associate ... Peter Huybers, Professor of Earth and Planetary Sciences, have ...
Cached Biology News:Study proposes alternative way to explain life's complexity 2Study proposes alternative way to explain life's complexity 3CO2 removal can lower costs of climate protection 2CO2 removal can lower costs of climate protection 3New research helps place modern temperatures into a more complete statistical framework 2
(Date:8/1/2014)... Glencoe Software, Inc. is pleased ... ( http://glencoesoftware.com/data-inpress.html ), a suite of data ... into on-line publications.  The suite comprises Glencoe ... Photo - http://photos.prnewswire.com/prnh/20140731/132410   ... The DataViewer is a browser-based ...
(Date:7/31/2014)... Today BioSpace , the leading life sciences employment and news website, ... sciences community in Illinois , Indiana ... Michigan , Minnesota , Missouri ... and Wisconsin . BioMidwest is a leader ... on BioSpace originating in this region in 2013. The life sciences sector ...
(Date:7/31/2014)... The ability to see through organs and even the ... well as fine-grained cellular structures has been a long-time ... Press July 31st in the journal Cell ... simple methods for making opaque organs, bodies, and human ... connections intact. The protocols could pave the way for ...
(Date:7/31/2014)... York , July 31, 2014 ... Transparency Market Research "Quantum Dots Market - Global Industry ... 2023," the market was valued at USD 88.5 million ... million by 2023, growing at a CAGR of 53.8% ... Quantum Dots Market Report at  http://www.transparencymarketresearch.com/quantum-dots.html ...
Breaking Biology Technology:Glencoe Software Launches Data InPress 2Glencoe Software Launches Data InPress 3Midwest Biotech Leaders Featured On BioSpace Map 2See-through organs and bodies will accelerate biomedical discoveries 2Global Quantum Dots Market is Expected to Reach USD 8,246.8 Million in 2023: Transparency Market Research 2Global Quantum Dots Market is Expected to Reach USD 8,246.8 Million in 2023: Transparency Market Research 3Global Quantum Dots Market is Expected to Reach USD 8,246.8 Million in 2023: Transparency Market Research 4
... for optimal image clarity , Eagle Eye ... Jane Moores ,Stratagene , A new optical filter has been ... Still Video System that increases contrast and sensitivity when imaging,silver-stained ... II Still Video System,is currently sold with an optical filter ...
... quantities of pure high-kb DNA , Jeff Braman Scott ... kits are,designed to isolate up to 20 and 350 g, respectively, ... kits can also easily purify very,large plasmids, including cosmid DNA. , ... SuperCos I clone containing a 40-kb , ...
... pcmv-script PCR cloning kit , , Tanya Hosfield ... Cloning Systems, Inc. , , Stratagene has expanded the ... a new vector for high-efficiency cloning of PCR,fragments and ... kit uses a PCR cloning method ...
Cached Biology Technology:Eagle Eye Optical Filter Optimized for Imaging Silver-Stained,Gels 2Eagle Eye Optical Filter Optimized for Imaging Silver-Stained,Gels 3Easy Cosmid DNA Purification with StrataPrep Kits 2Mammalian Expression Vector for Efficient Cloning of PCR Fragments 2Mammalian Expression Vector for Efficient Cloning of PCR Fragments 3Mammalian Expression Vector for Efficient Cloning of PCR Fragments 4
Fingerprinting II Informatix optional matrix types module, is an optional module that adds external similarity and distance matrix functions to the Fingerprinting II Informatix software package....
... Zyagen tissue microarrays are derived from ... to rigorous quality control procedures to ensure ... are manually assembled in one block, sectioned ... mounted on coated slides. Sections are large ...
... Zyagen tissue microarrays are derived from Paraffin ... rigorous quality control procedures to ensure the ... manually assembled in one block, sectioned at ... on coated slides. Sections are large (3-5 ...
... 2-D standards consist of seven reduced, denatured ... carbonic anhydrase, rabbit muscle GAPDH, bovine muscle ... with pIs ranging from 4.5 to 8.5 ... 76,000. These 2-D standards provide calibrated references ...
Biology Products: