Navigation Links
UW-Madison engineers squeeze secrets from proteins

Proteins, one of the basic components of living things, are among the most studied molecules in biochemistry. Understanding how proteins form or "fold" from sequenced strings of amino acids has long been one of the grand challenges of biology.

A common belief holds that the more proteins are confined by their environment, the more stable - or less likely to unfold - they become. Now, as reported on the cover of the March issue of Biophysical Journal, a team of chemical and biological engineers from UW-Madison shows that premise to be untrue. While confinement plays an important role, other factors are also at play.

"Most research in this area looked at proteins in free solution when in fact, most proteins are confined in some way," says Juan de Pablo, a chemical and biological engineer at the University of Wisconsin-Madison. "What we demonstrate for the first time is that the stability of proteins under severe confinement, which is really the relevant way of looking at them for numerous applications, depends on their shape, their size and their interactions with the environment. It is a delicate balance between the energy available to fold the protein and entropy, or it's desire to be in the unfolded state."

De Pablo's research team developed a method to precisely calculate the entropy and determine how much of a protein's stability change upon confinement to attribute to energy and how much to entropy. "This is the important part of the calculation," de Pablo adds.

Protein stability is an incredibly important property in myriad applications, de Pablo says. Consider laundry detergent. A popular ad for detergent once claimed that "protein gets out protein." The idea behind this is that engineered enzymes are at work in the wash breaking down elements of a stain.

"Once a protein is folded, you can actually unfold it or destabilize it, either by heating it up, or by adding solvents to the system, like urea for example, that just
'"/>

Source:University of Wisconsin-Madison


Page: 1 2

Related biology news :

1. UW-Madison scientists zero in on drugs sweet spots
2. Duke engineers develop new 3-D cardiac imaging probe
3. MIT engineers an anti-cancer smart bomb
4. Scientists and engineers apply natures design to human problems
5. Bioengineers create stable networks of blood vessels
6. Rice bioengineers pioneer techniques for knee repair
7. MIT engineers probe spiders polymer art
8. Boston University biomedical engineers win major grant for pursuit of the $1,000 Genome
9. UWs Rosetta software to unlock secrets of many human proteins
10. Scientists reveal molecular secrets of the malaria parasite
11. Marine sponge yields nanoscale secrets
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Madison engineers squeeze secrets from proteins

(Date:7/23/2015)... Inc. (NASDAQ: AWRE ), a leading supplier of biometrics ... quarter ended June 30, 2015.  Revenue for ... of 33% compared to $6.8 million in the same quarter ... was $0.3 million, or $0.01 per diluted share, which compared ... same period a year ago.  Lower revenue ...
(Date:7/20/2015)... -- Acuity Market Intelligence,s latest research "The Global Biometrics ... Privacy" forecasts that between 2014 and 2020 nearly ... to smart mobile devices by 2.2 billion mobile ... to generate more than $67.9 billion in total ...    "Biometrics is at the center ...
(Date:7/9/2015)... 2015  Unchained Labs just can,t get enough ... Avid Nano. Avid Nano designs, develops and manufactures ... Also today, Unchained Labs UNcaged the ... use protein sizing system. The pUNk is a ... size, size distribution, aggregation population and molecular weight. ...
Breaking Biology News(10 mins):Aware, Inc. Reports Second Quarter 2015 Financial Results 2Aware, Inc. Reports Second Quarter 2015 Financial Results 3Aware, Inc. Reports Second Quarter 2015 Financial Results 4Aware, Inc. Reports Second Quarter 2015 Financial Results 5Aware, Inc. Reports Second Quarter 2015 Financial Results 6Biometrics on Smart Mobile Devices to Redefine Digital Identity with 12.9 Billion Biometric App Downloads between 2014 and 2020 2Unchained Labs just can't get enough, acquires Avid Nano, rocks out the new pUNk! 2
... researchers has studied the changes in the make-up of ... malacological fauna are a good indicator of forest recovery. ... that post-fire forestry operations that do not harm these ... of the soil and vegetation structure. The researchers ...
... WI, February 15, 2010 -- Agricultural nonpoint source ... leading sources of pollution in rivers and water ... are making concerted efforts to reduce these pollutions ... As promising and effective BMPs, vegetated buffers are ...
... DNA from royal mummies, research findings suggest that malaria and ... Egyptian pharaoh King Tutankhamun, with other results appearing to identify ... mother, according to a study in the February 17 issue ... B.C.) of the New Kingdom was one of the most ...
Cached Biology News:Presence of snails points to forest recovery 2A review of vegetated buffer efficacy 2Study examines family lineage of King Tut, his possible cause of death 2Study examines family lineage of King Tut, his possible cause of death 3Study examines family lineage of King Tut, his possible cause of death 4Study examines family lineage of King Tut, his possible cause of death 5
(Date:7/29/2015)... July 30, 2015 Sanofi, ... publie ses résultats pour le premier semestre 2015. ... les résultats. Visionner l,interview vidéo et ... Au sommaire de l,interview :  ... Moteurs de croissance - Diabète ...
(Date:7/29/2015)... , July 29, 2015 US-Australian drug ... ) today confirmed it is committed to progressing its ... soon as practicable and to ensure the Company delivers ... Executive Officer, Iain Ross , said the Company ... the lead pre-clinical programs, discovery programs and academic partnerships ...
(Date:7/29/2015)... MONTREAL , July 29, 2015 /PRNewswire/ - BioAmber Inc. ... Laurin , the Company,s Chief Financial Officer has resigned.  ... former Chief Financial Officer who retired in December 2014, ... search for a permanent successor.     Andy ... Mr. Laurin and ensure a smooth transition.  Andy was ...
(Date:7/29/2015)...  AsureQuality and Ubiquitome have agreed to collaborate ... food and primary production sectors. The collaboration will ... the Freedom4. AsureQuality provides quality assurance ... shelf for producers, processors and Competent Authorities around ... control and pest management and surveillance programmes. ...
Breaking Biology Technology:Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 2Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 3Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 4Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 5Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 6Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 7Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 8Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 9Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 10BioAmber Announces Change in Chief Financial Officer 2BioAmber Announces Change in Chief Financial Officer 3AsureQuality and Ubiquitome Partner on Applications for Mobile Molecular Food Safety Testing 2
... September 11 Debiopharm Group,(Debiopharm), a global ... medical conditions, today announced that it,received current ... the chemical, physical and biochemical quality control ... At the same time,certification of the Lausanne ...
... QC, Sept. 10 /PRNewswire-FirstCall/ - Mr. Pierre,Fitzgibbon, President ... or the "Company", TSX: ATB) today announced changes ... the decision by Mr.,Richard Bordeleau, President of the ... order to pursue news challenges. However, Mr. Bordeleau,will ...
... Newswire-FirstCall/ -- China Kangtai,Cactus Biotech, Inc. (OTC Bulletin ... marketer of a variety of cactus-based,consumer products, announced ... new,product: Cactus Health Cigarettes. In order to ... 2008,Beijing Olympiad, and in an effort to take ...
Cached Biology Technology:Debiopharm Receives cGMP Certification for Quality Control of its Drug Products 2Atrium Innovations Announces Management Changes 2China Kangtai Cactus Biotech, Inc. Announces Plans for New Product Launch 2China Kangtai Cactus Biotech, Inc. Announces Plans for New Product Launch 3China Kangtai Cactus Biotech, Inc. Announces Plans for New Product Launch 4
Human Norrin Biotinylated Affinity Purified PAb Protein Family: Other Growth Factors, Other Wnt-related Molecules...
Human VASA Biotinylated Affinity Purified PAb...
Immunogen: Synthetic Peptide: C N(185) D G T E F G G S I Y Q K(197) Storage: -20 C, Avoid Freeze/Thaw Cycles...
interferon-related developmental regulator 2...
Biology Products: