Navigation Links
USC researchers track down the stem cells that create feathers

The stem cells that produce bird feathers have been visualized and analyzed for the first time, signifying the initial step in a scientific journey that may ultimately shed light on human organ regeneration.

The research, published in the December 15 issue of the journal Nature, was performed by a group of prominent stem-cell researchers from the Keck School of Medicine of the University of Southern California.

"What we found is that feather stem cells are distributed in a ring configuration around the inner wall of the vase-shaped feather follicle. This is different from hair stem cells, which are located in a bulge outside the follicle," explains Cheng-Ming Chuong, M.D., Ph.D., professor of pathology at the Keck School and principal investigator on this study.

Feather stem cells are of interest to scientists because of their profound regenerative abilities. A bird in nature molts twice a year. With more than 20,000 feathers on the average bird, Chuong notes, that means there are a lot of active, ongoing regenerative events in an adult bird.

Chuong and his USC colleagues identified epithelial stem cells within a chicken-feather follicle by giving the chickens water containing a non-radioactive label that was then incorporated and retained only in the putative epithelial stem cells. They showed that these cells were pluripotent-retaining the ability to differentiate into many different cell types-by taking the purported stem cells from quail-feather follicles and transplanting them into a chicken host. (Quail cells can be differentiated from chicken cells by cellular markers.) This demonstrated that only the labeled cells were pluripotent.

These stem cells, the researchers found, are well protected in the follicular base of each individual feather follicle. As they proliferate and differentiate, their progeny is displaced upward to create a feather. When the bird molts, the quill of the feather is dislodged from the follicle wi th a tapered proximal opening-the very feature that has historically made feathers so useful as writing implements-leaving behind a ring of stem cells for the creation of the next generation of feathers.

"The unique topological arrangement of stem cells, proliferating cells, and differentiating cells within the feather follicle allows for continuous growth, shedding, and regeneration of the entire organ," Chuong says.

Feathers are also of great interest to scientists due to their diverse shapes, each with its unique functional morphology. For example, the radially symmetric downy feathers found on chicks and on the trunks of adults are designed for warmth, while the bilaterally symmetric feathers found on the adult wing are designed for taking flight.

What Chuong and his colleagues found, to their surprise, was that the orientation of the ring of feather stem cells is related to the type of feather being generated: the stem cell ring is horizontally placed in radially symmetric downy feathers, but is tilted in bilaterally symmetric feathers, with the lower end of the ring on the anterior side of the follicle, where the rachis-the backbone of the feather-arises. In the Nature paper, Chuong postulates that it is this simple tilting that can transform feathers from radially symmetric to bilaterally symmetric morphologies by producing molecular gradients and/or asymmetric cell behaviors.

While this insight into the formation and regeneration of feathers is fascinating, it is the potential for application to human stem-cell studies that really motivates Chuong and his team.

"What we are really learning about is how stem cells are assembled into organs in nature. In this way, we can take advantage of the distinct patterns of the feather as a model to understand the fundamental principles of organ formation and regeneration," Chuong notes. "Nature is the best teacher for tissue engineering. What we decipher from our animal models ca n then be applied to help human stem cells and adult human organs to regenerate-and regenerate properly."


'"/>

Source:University of Southern California


Related biology news :

1. NYU researchers simulate molecular biological clock
2. Vital step in cellular migration described by UCSD medical researchers
3. ASU researchers finds novel chemistry at work to provide parrots vibrant red colors
4. UCSD researchers maintain stem cells without contaminated animal feeder layers
5. Why do insects stop breathing? To avoid damage from too much oxygen, say researchers
6. New protein discovered by Hebrew University researchers
7. First real-time view of developing neurons reveals surprises, say Stanford researchers
8. Agilent Technologies releases automated literature search tool for biology researchers
9. Self-assembled nano-sized probes allow Penn researchers to see tumors through flesh and skin
10. Yale researchers identify molecule for detecting parasitic infection in humans
11. US life expectancy about to decline, researchers say
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/30/2016)... CHICAGO , Nov. 30, 2016  higi ... a new partnership initiative targeting national brands, industry ... and reward their respective audiences for taking steps ... Since its inception in 2012, higi has built ... US, impacting over 38 million people who have ...
(Date:11/24/2016)... -- Cercacor today introduced Ember TM Sport Premium ... measure hemoglobin, Oxygen Content, Oxygen Saturation, Perfusion Index, ... approximately 30 seconds. Smaller than a smartphone, using only ... key data about their bodies to help monitor these ... Hemoglobin carries oxygen to muscles. When hemoglobin and ...
(Date:11/17/2016)... Nov. 17, 2016 Global Market Watch: ... (Disease-Based Banks, Population-Based Banks and Academics) market is to witness ... Private Biobanks shows the highest Compounded Annual Growth Rate (CAGR) ... region during the analysis period 2014-2020. North America ... 9.95% followed by Europe at 9.56% ...
Breaking Biology News(10 mins):
(Date:12/2/2016)... ... , ... DrugDev believes the only way to achieve real change ... three tenets were on display at the 2nd Annual DrugDev User Summit (hosted by ... and site organizations to discuss innovation and the future of clinical research. , ...
(Date:12/2/2016)... ... December 02, 2016 , ... Robots will storm the Prudential Center in Boston, ... The event, which is held on the United Nations International Day of Persons with ... into the workplace. Suitable Technologies is partnering with NTI to showcase how technology can ...
(Date:12/2/2016)... leader in rapid infectious disease tests, introduced the Company,s newest product, the INSTI HIV ... http://photos.prnewswire.com/prnh/20161201/444905 ) Continue Reading ... ... , bioLytical was invited by the Clinton Health ... Self Test to 350 pharmacy representatives in Nairobi and Mombasa, ...
(Date:11/30/2016)... , November 30, 2016 ... a few players hold a dominant share in the ... River Laboratories International, Inc., and Merck KGaA, held a ... 2015. Transparency Market Research observes that these companies are ... on development products that are do not require rabbit ...
Breaking Biology Technology: