Navigation Links
UNC scientists solve mystery of how largest cellular motor protein powers movement

Scientists now understand how an important protein converts chemical energy to mechanical force, thus powering the process of cell division, thanks to a new structural model by University of North Carolina at Chapel Hill researchers.

The structural model helps solve a scientific mystery: how the protein dynein fuels itself to perform cellular functions vital to life. These functions include mitosis, or cell division into identical cells.

Dynein uses energy derived from ATP, or adenosine triphosphate, a molecule that is the principal form of energy for cells. The lack of a comprehensive and detailed molecular structure for dynein has kept scientists largely in the dark about how the protein converts ATP into mechanical force, said Dr. Nikolay V. Dokholyan, assistant professor of biochemistry and biophysics in the UNC School of Medicine.

Dokholyan said the dynein puzzle is similar to figuring out how auto engines make cars move.

“You have an engine up front that burns gas, but we didn’t know how the wheels are made to move.?

Dr. Timothy Elston, associate professor of pharmacology and director of the School of Medicine’s bioinformatics and computational biology program, explains further. “One of the unknowns about dynein was that the molecular site where chemical energy is initially released from ATP is very far away from where the mechanical force occurs. The mechanical force must be transmitted over a large distance.?

The study was published online Nov. 22 in the Proceedings of the National Academy of Sciences Early Edition. The work was supported in part by grants from the Muscular Dystrophy Association and the American Heart Association.

Using a variety of modeling techniques that allowed resolution at the level of atoms, Adrian W.R. Serohijos, a graduate student in Dokholyan’s lab and first author of the study, identified a flexible, spring-like “coiled-coil?region within dynein. It couples the motor
'"/>

Source:University of North Carolina School of Medicine


Page: 1 2

Related biology news :

1. Wisconsin scientists grow critical nerve cells
2. UCSB scientists probe sea floor venting to gain understanding of early life on Earth
3. UAB scientists discover the origin of a mysterious physical force
4. Fox Chase Cancer Center scientists identify immune-system mutation
5. Weizmann Institute scientists develop a new approach for directing treatment to metastasized prostate cancer in the bones.
6. U-M scientists find genes that control growth of common skin cancer
7. UCLA scientists transform HIV into cancer-seeking missile
8. RNA project to create language for scientists worldwide
9. Carnegie Mellon scientists develop tool that uses MRI to visualize gene expression in living animals
10. To control germs, scientists deploy tiny agents provocateurs
11. Leprosy microbes lead scientists to immune discovery
Post Your Comments:
(Date:5/11/2015)... , May 11, 2015  Through a well-rounded UAS ... had a strong showing at AUVSI,s Unmanned 2015 ... representatives of Ohio,s UAS industry met ... abroad from all points along the UAS ecosystem. ... Coalition,s (DDC) Vice President for Aerospace Rich Knoll . ...
(Date:5/8/2015)... SAN JOSE, Calif. , May 8, 2015 ... human interface solutions, today announced that members of the executive ... J.P. Morgan 43rd Annual Technology, Media and Telecom Conference ... Westin Waterfront Hotel in Boston, MA ... Date: May 27, 2015 Time: 2:45pm ET Location: The New ...
(Date:5/5/2015)... OXFORD, Conn. , May 5, 2015, NXT-ID, ... biometric authentication company focused on the growing mobile commerce market, ... the Company,s Chief Technology Officer, is presenting  at CARTES SECURE ... May 5-7, 2015. The three-day conference ... session David is speaking in is themed Global Fraud: ...
Breaking Biology News(10 mins):Ohio Flies High at Unmanned '15, Sets Stage for Ohio UAS Conference 2Synaptics to Present at Upcoming Investor Conferences 2NXT-ID, Inc.'s CTO, David Tunnell, Presents at CARTES SECURE CONNEXIONS AMERICA 2015 Today in Washington DC. 2NXT-ID, Inc.'s CTO, David Tunnell, Presents at CARTES SECURE CONNEXIONS AMERICA 2015 Today in Washington DC. 3
... weapons used by our immune system to absorb and ... defence mechanism and even multiply within the macrophages. Cell ... a strategy in a recently publication in the journal ... findings reveal that the pathogens escape the 'stomach' of ...
... scientists from Johns Hopkins' Institute for Cell Engineering have discovered ... existing operations. , For more than a century, scientists thought ... them, but in fact, new neurons do form during adulthood ... of the adult brain in mice at the very least. ...
... pharmaceutical potential in a species of red seaweed that ... of Fiji in the south Pacific Ocean. , Some ... cancer cells, bacteria and the HIV virus, according to ... two of them exhibit anti-bacterial activity towards antibiotic-resistant Staphylococcus ...
Cached Biology News:Dangerous tricksters: Some bacterie use immune cells to reproduce 2Dangerous tricksters: Some bacterie use immune cells to reproduce 3New neurons take baby steps in the adult brain 2Seaweed yields new compounds with pharmaceutical potential 2Seaweed yields new compounds with pharmaceutical potential 3Seaweed yields new compounds with pharmaceutical potential 4
(Date:5/21/2015)... VANCOUVER , May 21, 2015 /PRNewswire/ - ... a clinical stage regenerative medicine company focused on ... an upcoming poster presentation at the International Society ... treatment for chronic Achilles tendinosis currently in a ... on May 29 th from 5:30 PM ...
(Date:5/20/2015)... 2015 This year has been one ... US Patented Pearl’s Premium Ultra Low Maintenance Lawn ... country that are coming out of record bad weather. ... of major global concerns related to water, health, and ... the alternative to the standard, water-wasting, chemical-treated standard lawn. ...
(Date:5/20/2015)... Agricultural firm H.J. Baker & Bro., ... of Tiger-Sul. Since the purchase of Tiger Industries ... May 2005, H.J. Baker has leveraged the innovation of ... comprehensive portfolio of product offerings and solutions expertise. The ... the innovation of Tiger-Sul, transforming the company into a ...
(Date:5/20/2015)... May 19, 2015 Research and Markets ... of the "Bone Morphogenetic Proteins Market (Types ... Reconstructive and Oral - Maxillofacial) - Global Industry ... - 2022" report to their offering. ... studied based on the types of recombinant BMPs, ...
Breaking Biology Technology:RepliCel to Present Unique Autologous Cell Treatment for Achilles Tendinosis at International Society for Cellular Therapy Conference 2RepliCel to Present Unique Autologous Cell Treatment for Achilles Tendinosis at International Society for Cellular Therapy Conference 3Breakthrough 4th Generation Low Maintenance Lawn Seed Offers Solution to California Drought 2Agricultural Firm H.J. Baker & Bro., Inc., Celebrates 10 Years Since Acquisition Of Tiger-Sul 2Agricultural Firm H.J. Baker & Bro., Inc., Celebrates 10 Years Since Acquisition Of Tiger-Sul 3Global Bone Morphogenetic Proteins Market Industry Analysis 2014 - 2022 2
... Manufacturing, looks at the sustainability performance of 17 ... It has been published by researchers from Queen,s ... researchers from the Euromed Management School Marseille, and ... (IZT) in Berlin. The report details how ...
... wrought when freezing rain collects on roads, power lines, and ... of Pittsburgh-led team demonstrates in the Nov. 3 edition of ... of Di Gao, a chemical and petroleum engineering professor in ... ice on solid surfaces and can be easily applied. ...
... ViroPharma Incorporated (Nasdaq: VPHM ) today announced ... healthcare investment conferences. , Vincent Milano, president and ... Oppenheimer 20th Annual Healthcare Conference at 4:30 P.M. EST ... being held at the Waldorf=Astoria in New York City. ...
Cached Biology Technology:North America automobile sector bottom of 'world sustainability league' 2North America automobile sector bottom of 'world sustainability league' 3Pitt-led researchers create nanoparticle coating to prevent freezing rain buildup 2ViroPharma to Present at Three November Healthcare Conferences 2
... PTC-100 thermal cycler holds 96 x 0.2 ... Bonnet heated lid incorporates a thumbwheel to ... PCR vessels for oil-free cycling. Peltier heat ... calibration and ramping rates of up to ...
... Super Sensitive MultiLink IHC Detection ... secondary antibodies, labeled with multiple ... the bound primary antibody, and ... Streptavidin-Enzyme conjugate. This kit is ...
... performance on minimum space. Thanks to a ... and cooling rates have been achieved that, ... maximum capacity of 48 x 0.2ml tubes, ... much more expensive 96 well instruments. Alternatively, ...
Sf21 Insect Cells (Live) in Max-XP Medium...
Biology Products: