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UNC scientists discover new role for protein as fundamental inhibitor of cell movement

er synched up with the time course of Rac and Cdc42 activation; now we know why ?it was probably CIB1 that was activating PAK1 and not the Ras relatives."

In illustrating the role that CIB1 plays in cell migration and PAK1 activation, the authors used a new method known as RNAi or RNA interference to knock down or reduce CIB1 expression in various cell lines. Cells with less CIB1 had less PAK1 activation and migrated faster. The authors also showed that the more CIB1 these cells had, the less likely they were to move.

The key to understanding CIB1's multifunctional role in humans is that the protein has a relative that behaves in a very similar multifunctional fashion: calmodulin. This was one of the first regulatory proteins ever discovered.

"CIB1 is very similar to the protein calmodulin, which binds to a host of other proteins and regulates numerous cell functions, the fact that CIB1 and calmodulin are so similar could suggest that CIB1 may play multiple roles in multiple cell types."

"Our study of CIB1 is still very much in its early days, but its role in migration is already very clear," Parise said.


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Source:University of North Carolina School of Medicine


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