Navigation Links
UNC scientists discover new role for protein as fundamental inhibitor of cell movement

er synched up with the time course of Rac and Cdc42 activation; now we know why ?it was probably CIB1 that was activating PAK1 and not the Ras relatives."

In illustrating the role that CIB1 plays in cell migration and PAK1 activation, the authors used a new method known as RNAi or RNA interference to knock down or reduce CIB1 expression in various cell lines. Cells with less CIB1 had less PAK1 activation and migrated faster. The authors also showed that the more CIB1 these cells had, the less likely they were to move.

The key to understanding CIB1's multifunctional role in humans is that the protein has a relative that behaves in a very similar multifunctional fashion: calmodulin. This was one of the first regulatory proteins ever discovered.

"CIB1 is very similar to the protein calmodulin, which binds to a host of other proteins and regulates numerous cell functions, the fact that CIB1 and calmodulin are so similar could suggest that CIB1 may play multiple roles in multiple cell types."

"Our study of CIB1 is still very much in its early days, but its role in migration is already very clear," Parise said.


'"/>

Source:University of North Carolina School of Medicine


Page: 1 2

Related biology news :

1. Wisconsin scientists grow critical nerve cells
2. UCSB scientists probe sea floor venting to gain understanding of early life on Earth
3. UAB scientists discover the origin of a mysterious physical force
4. Fox Chase Cancer Center scientists identify immune-system mutation
5. Weizmann Institute scientists develop a new approach for directing treatment to metastasized prostate cancer in the bones.
6. U-M scientists find genes that control growth of common skin cancer
7. UCLA scientists transform HIV into cancer-seeking missile
8. RNA project to create language for scientists worldwide
9. Carnegie Mellon scientists develop tool that uses MRI to visualize gene expression in living animals
10. To control germs, scientists deploy tiny agents provocateurs
11. Leprosy microbes lead scientists to immune discovery
Post Your Comments:
(Date:7/31/2014)... the roughly 156,000 gas stations across the United ... of underground gas storage tankscorrosion that could result ... source of drinking water. In recent years, field ... corroding gas storage tank components such as sump ... of gasoline-ethanol blends and the presence of bacteria, ...
(Date:7/31/2014)... vaccine protected 100 percent of animal models against the ... which causes an intestinal disease that kills approximately 30,000 ... in Infection and Immunity . , In ... primates against the purified toxins produced by C. ... infection, a laboratory model that mimics the human disease, ...
(Date:7/31/2014)... to help better identify and treat those with fibromuscular dysplasia ... of medium sized arteries in the body, which can restrict ... In a new report appearing in August 2014 issue of ... that that FMD may not be limited to the arteries ... abnormalities of bones and joints, as well as evidence that ...
Breaking Biology News(10 mins):NIST corrosion lab tests suggest need for underground gas tank retrofits 2C. difficile vaccine proves safe, 100 percent effective in animal models 2Scientists discover biochemical mechanisms contributing to fibromuscular dysplasia 2
... basic recipe for capturing and maintaining indefinitely the most ... including cows, pigs and even humans. Two new studies ... Cell , a Cell Press publication, show that ... this year, which includes inhibitory chemicals, also can be ...
... CITYResearchers have discovered two enzymes that, when combined, could ... these enzymes genetically might lead to targeted therapies aimed ... "We could conceivably reactivate a completely normal gene in ... the growth of a tumor if reactivated," says David ...
... reindeer during the holiday season, caribou are also central to ... many cultures, the caribou could soon become endangered ,by threats ... new book by authors from the Wildlife Conservation Society and ... North: A Shared Future (Dundurn Press Toronto, $50/29.00), the book ...
Cached Biology News:Recipe for capturing authentic embryonic stem cells may apply to any mammal, study suggests 2Recipe for capturing authentic embryonic stem cells may apply to any mammal, study suggests 3Newly found enzymes may play early role in cancer 2Rudolf's kin more than just Santa's ride 2Rudolf's kin more than just Santa's ride 3
(Date:7/31/2014)... New York , July 31, 2014 ... by Transparency Market Research "Electrodes for Medical Devices Market ... Scalp Electrodes, Therapeutic Electrodes - TENS, Pacemakers, Defibrillators, Electrosurgical ... Growth, Trends and Forecast, 2013 - 2019," the global ... 633.6 million in 2012 and is estimated to reach ...
(Date:7/31/2014)... 31, 2014 CollabRx, Inc. (NASDAQ: CLRX), ... decision-making in oncology, today announced that it will hold ... discuss the Company's financial results for the first quarter ... the business in the current fiscal year. , The ... Thursday, August 14, 2014, at 5 p.m. EDT (2 ...
(Date:7/31/2014)... LONDON , July 31, 2014  Smith ... the global medical technology business, today announced its ... of the HAT-TRICK™ Lesser Toe Repair System. Comprised ... includes products for metatarsophalangeal (MTP) ligament repair and ... all-PEEK implant for proximal Inter-phalanges (PIP) fusion, also ...
(Date:7/31/2014)... (PRWEB) July 31, 2014 Held at ... patients with an overview of the disease and its ... drug side effects, as well as updates on the ... to Dr. Sandy Srinivas for organizing this educational opportunity,” ... kidney cancer. “Sandy and her colleagues have put together ...
Breaking Biology Technology:Electrodes for Medical Devices Market Expected to Reach USD 1.45 Billion Globally in 2019: Transparency Market Research 2Electrodes for Medical Devices Market Expected to Reach USD 1.45 Billion Globally in 2019: Transparency Market Research 3Electrodes for Medical Devices Market Expected to Reach USD 1.45 Billion Globally in 2019: Transparency Market Research 4Electrodes for Medical Devices Market Expected to Reach USD 1.45 Billion Globally in 2019: Transparency Market Research 5Electrodes for Medical Devices Market Expected to Reach USD 1.45 Billion Globally in 2019: Transparency Market Research 6CollabRx, Inc. Schedules First Quarter Fiscal Year 2015 Financial Conference Call and Business Update 2Smith & Nephew scores a HAT-TRICK with its entry into the high-growth hammer toe repair market 2Smith & Nephew scores a HAT-TRICK with its entry into the high-growth hammer toe repair market 3Smith & Nephew scores a HAT-TRICK with its entry into the high-growth hammer toe repair market 4
... Michael J. Cronin, Ph.D., J.D., an intellectual property associate with ... the facts in the dispute over three important University ... behind similar disputes - shows a strong likelihood that the ... its patent rights, even if some of its claims are ...
... once said everyone will be famous for 15 minutes, couldn't imagine ... have on his prediction. , ,With these tools, everyone can have ... that. It seems that 15 minutes is about all anyone has ... Silicon Valley. , ,I was reminded of this after coming ...
... - University of Wisconsin System researchers are in ... stimulate economic development, as the result of a new research ... typical home broadband connection. , ,The network, which makes the ... faster than a home broadband connection, is the result of ...
Cached Biology Technology:WARF is likely to hold on to stem cell patent rights 2WARF is likely to hold on to stem cell patent rights 3WARF is likely to hold on to stem cell patent rights 4WARF is likely to hold on to stem cell patent rights 5WARF is likely to hold on to stem cell patent rights 6WARF is likely to hold on to stem cell patent rights 7WARF is likely to hold on to stem cell patent rights 8On the Web, attention spans shrink, the need for value rises 2On the Web, attention spans shrink, the need for value rises 3UW-Madison launches new high-speed research network 2UW-Madison launches new high-speed research network 3
Purified anti-Fanconi anemia D2-Phosphorylated (Ser222)...
A431 cells stimulated with EGF Source: Cell Lysate Form: Ready to Use Application: Western Blotting Control...
... 'The Gene Construction KitTM allows graphic ... drawing options. It has an award winning ... DNA sequences in addition to providing sophisticated ... GCK was named the "Best Plasmid Mapping ...
... collects data from balances and scales with RS232 ... other program. If you can type the weight ... collection process Simple to use parser extracts ... , Add user information , Collect data at ...
Biology Products: