Navigation Links
UNC plant researchers discover proteins interact to form hair-trigger protection against invaders

Experimenting with Arabidopsis, a fast-growing cousin of the humble mustard plant, scientists at the University of North Carolina at Chapel Hill got a big surprise while investigating how plants respond to attacks from disease organisms such as bacteria and viruses.

"Contrary to what we thought we'd find, our experiments showed that at least three different proteins work in concert with one another in tug-of war or teeter totter-fashion to keep plant defenses in a state of constant readiness," said Dr. Jeffrey L. Dangl, John N. Couch professor of biology in UNC's College of Arts and Sciences.

Previously, he and others believed that the proteins -- RAR1, SGT1 and HSP90 -- were required for what is called signal transduction -- relaying like Paul Revere the message that an enemy had arrived, Dangl said. Instead, they are needed to form an even earlier disease surveillance antenna or hair trigger. When disease invaders pull that trigger, infected plants cells quickly commit suicide, often preventing the invader from destroying the entire plant.

The new discovery appears to be a universal mechanism for defense by all plants against not only bacteria and viruses, but also parasitic fungi, insects and worms, he said.

"This work is important because every year, these organisms cause us to lose some 30 percent of our grain, fruit and vegetable crops after all the human, water and soil energy has already gone into producing them," Dangl said. "The hope is that we might be able to manipulate plants' immune systems to make them more resistant to pathogens using fewer expensive and polluting chemicals."

A report on the findings appears in this week's edition (June 24) of Science Express, the online, early-release version of the journal Science. Other authors are postdoctoral fellow Dr. Ben F. Holt III and Ph.D. student Youssef Belkhadir, both in biology.

"Plants use resistance proteins to defend themselves against pathogen attack b y initiating a defense response," Holt said. "The proteins RAR1, HSP90 and SGT1 were previously thought to work together to help resistance proteins in this function. To our surprise, we found that SGT1 can actually work against, or antagonize, the other two proteins to disable resistance protein function."

The researchers also showed why they antagonized each other, he said. RAR1 and HSP90 can prevent resistance proteins from disappearing, while SGT1 helps them disappear. The result is that the system remains poised for an immediate response to bacteria and other attackers.

"By controlling disappearance of resisting proteins, RAR1, HSP90 and SGT1 control whether or not the plant is about to recognize that it is under pathogen attack," Holt said. "So the emerging story is that RAR1 and HSP90 keep resistance proteins ready to perceive pathogen signals, and SGT1 probably pulls against these two to send resistance proteins to their destruction."

The National Science Foundation supported the research through its Arabidopsis 20-10 Project, which aims to describe the functions of all 28,000 genes in the model plant.

Scientists study Arabidopsis, also known as thale cress or mouse-eared cress, because it is small and can produce five to six generations a year rather than just one or two like most crop plants. That rapid reproduction allows them to study the plant's genetics faster than they could with other species.

Understanding Arabidopsis completely will teach scientists an enormous amount about all other flowering plants, which are closely related genetically, Dangl said. The new genomics technology, developed by Patrick Brown and David Botstein at Stanford University, has been applied to yeast, fruit flies and humans but not to plants in a large, systematic way. Arabidopsis was the first plant for which scientists succeeded in mapping its entire genetic composition.

Dangl is also with UNC's Curriculum in Genetics, Depart ment of Microbiology and Immunology and Carolina Center for Genome Sciences.


'"/>

Source:University of North Carolina at Chapel Hill


Related biology news :

1. Key molecule in plant photo-protection identified
2. Transplantation Of Monkey Embryonic Stem Cells Reverses Parkinson Disease In Primates
3. Emory Eye Center Implants Its First Retinal Chips In Patients With Retinitis Pigmentosa
4. Circles Of DNA Might Help Predict Success Of Stem Cell Transplantation
5. Antibodies from plants protect against anthrax
6. New RNA polymerase discovered in plants
7. Implanted Devices Detect High-Risk Heart Failure Patients
8. Ophthalmologists implant five patients with artificial silicon retina microchip
9. World-first Living Donor Islet Cell Transplant A Success; Procedure Offers Promise For Diabetics
10. Polymers with copper show promise for implanted sensors
11. Transgenic plants remove more selenium from polluted soil than wild plants, new tests show
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/22/2016)... ANGELES , June 22, 2016 /PRNewswire/ ... identity management and verification solutions, has partnered ... edge software solutions for Visitor Management, Self-Service ... provides products that add functional enhancements ... partnership provides corporations and venues with an ...
(Date:6/15/2016)... 15, 2016 Transparency Market ... Recognition Market by Application Market - Global Industry Analysis Size ... to the report, the  global gesture recognition market ... and is estimated to grow at a CAGR ... 2024.  Increasing application of gesture recognition ...
(Date:6/2/2016)... The Department of Transport Management (DOTM) of ... project, for the , Supply and Delivery of ... Infrastructure , to Decatur , ... Management Solutions. Numerous renowned international vendors participated in the tendering ... selected for the most compliant and innovative solution. The contract ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... -- Regular discussions on a range of subjects including policies, debt ... said Poloz. Speaking at a lecture to the ... pointed to the country,s inflation target, which is set by ... "In certain areas there needs to ... goals, why not sit down and address strategy together?" ...
(Date:6/23/2016)... (PRWEB) , ... June 23, 2016 , ... ... is pleased to announce the launch of their brand, UP4™ Probiotics, into Target ... over 35 years, is proud to add Target to its list of well-respected ...
(Date:6/23/2016)... , ... June 23, 2016 , ... ... YM (Yeast and Mold) microbial test has received AOAC Research Institute approval 061601. ... microbial tests introduced last year,” stated Bob Salter, Vice President of Regulatory and ...
(Date:6/23/2016)... (PRWEB) , ... June 23, 2016 , ... STACS DNA ... Technical Leader at the Arkansas State Crime Laboratory, has joined STACS DNA as a ... STACS DNA team,” said Jocelyn Tremblay, President and COO of STACS DNA. “In further ...
Breaking Biology Technology: