Navigation Links
UNC launches study of liver injury caused by drugs

The University of North Carolina at Chapel Hill is one of five clinical centers nationwide to receive funds from the National Institutes of Health to study why good medications are sometimes bad for the liver.

During the next seven years, the Drug-Induced Liver Injury Network, or DILIN, will study patients who have suffered severe liver injury caused by prescription and over-the-counter medications, nutritional supplements, alternative medicines and herbals.

Funded by the National Institute of Diabetes and Digestive and Kidney Diseases, DILIN will be the first large-scale investigation of severe liver injury associated with drugs.

Other DILIN centers along with UNC are at the University of Indiana at Indianapolis, University of California at San Francisco, University of Michigan at Ann Arbor and University of Connecticut at Hartford.

Duke University is the project's data coordinating center, collecting information from the five clinical centers.

Drug-induced liver injury is the most common cause of sudden liver failure nationwide and the most common reason why new drugs fail to obtain approval by the U.S. Food and Drug Administration, said Dr. Paul Watkins, DILIN Steering Committee chairman and the study's principal investigator at UNC.

"This is the case even though drugs that cause liver injury are usually entirely safe for the majority of patients taking them," he added. The main purpose of DILIN is to find and study people who have experienced liver injury due to medications, said Watkins, who is Verne S. Caviness distinguished professor of medicine, professor of pharmacotherapy and director of the General Clinical Research Center at UNC. "This is the only way we can identify inherited and other factors that explain why a particular patient is susceptible when most are not," he said.

Researchers will use DNA analysis based on blood samples to identify possible genetic risk factors for such liver injury.

"Once a drug has been associated with severe liver injury, physicians are understandably hesitant to prescribe it, even if it may provide the best benefit for that patient," said Dr. Mark Russo, assistant professor of medicine and DILIN investigator at UNC.

One goal of the network is to develop testing that will identify patients who are at risk and, therefore, should not receive treatment with certain drugs.

Patients diagnosed with potentially severe liver injury due to any medication are eligible if enrolled within six months of the event. These people will be followed over time to find out what happens as a result of their injury. People who have not sustained liver injury but who have taken any of the medications in question also will be enrolled for comparison.

In addition to enrolling patients as they are brought to medical attention, DILIN is establishing a registry of patients who at any time since 1994 developed severe liver injury due to one of four specific drugs. The four are the tuberculosis drug isoniazid, the anti-seizure medications phenytoin and valproic acid, and the antibiotic amoxicillin-clavulanate potassium.

"Eligible patients from anywhere in North Carolina or neighboring states who are willing to come to UNC can be enrolled now," Watkins said. "Overall, we believe that the network will bring greater focus and interest to the study of drug-induced liver injury and will help to develop better ways to prevent, detect and treat this growing problem," Watkins said.

DILIN also may provide important insight into medical problems beyond liver injury induced by drugs, he added.

"Drug-induced liver injury is an ideal model to study how genes and environment interact to produce disease in some but not all people. We hope the factors identified by DILIN research will provide clues to susceptibility to the many diseases that represent an interaction with the environment."


'"/>

Source:University of North Carolina School of Medicine


Related biology news :

1. UCLA launches $20 million stem cell institute to investigate HIV, cancer and neurological disorders
2. DOE JGI launches IMG public online microbial genome data clearinghouse
3. NIEHS launches website with information for assessing environmental hazards from Hurricane Katrina
4. NIH launches comprehensive effort to explore cancer genomics
5. Virginia Bioinformatics Institutes launches microbial database
6. BioMed Central launches Biology Direct
7. Protein structure initiative launches new resources for the scientific community
8. NIH neuroscience microarray consortium launches high-throughput genotyping services
9. UW launches study testing adult stem cells for heart damage repair
10. ESA launches new project to protect biodiversity
11. Africas first large-scale HIV vaccine study launches
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/31/2016)... March 31, 2016   ... or the "Company") LegacyXChange is excited to ... its soon to be launched online site for trading ... ) will also provide potential shareholders a sense ... technology to an industry that is notorious for fraud. ...
(Date:3/23/2016)... Massachusetts , March 23, 2016 /PRNewswire/ ... im Interesse erhöhter Sicherheit Gesichts- und Stimmerkennung ... Xura, Inc. (NASDAQ: MESG ), ... bekannt, dass das Unternehmen mit SpeechPro zusammenarbeitet, ... aus der Finanzdienstleistungsbranche, wird die Möglichkeit angeboten, ...
(Date:3/21/2016)... , March 22, 2016 ... with passcodes for superior security   ... leading provider of secure digital communications services, today announced ... technology and offer enterprise customers, particularly those in the ... recognition and voice authentication within a mobile app, alongside, ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... , ... June 23, 2016 , ... ... pleased to announce the launch of their brand, UP4™ Probiotics, into Target stores ... 35 years, is proud to add Target to its list of well-respected retailers. ...
(Date:6/23/2016)... 23, 2016 Houston Methodist Willowbrook Hospital ... Sports Association to serve as their official health ... Methodist Willowbrook will provide sponsorship support, athletic training ... association coaches, volunteers, athletes and families. ... Sports Association and to bring Houston Methodist quality ...
(Date:6/23/2016)... , June 23, 2016   EpiBiome , a ... $1 million in debt financing from Silicon Valley Bank ... automation and to advance its drug development efforts, as ... facility. "SVB has been an incredible strategic ... services a traditional bank would provide," said Dr. ...
(Date:6/23/2016)... 2016 Apellis Pharmaceuticals, Inc. today announced ... of its complement C3 inhibitor, APL-2. The trials ... dose studies designed to assess the safety, tolerability, ... in healthy adult volunteers. Forty subjects ... single dose (ranging from 45 to 1,440mg) or ...
Breaking Biology Technology: