Navigation Links
UGA study explains peaks and troughs of dengue epidemics

o other regions where all four dengue strains circulate.

The researchers compared the data with results from mathematical models that explore ?both independently and collectively ?the role factors such as temporary cross-immunity and variation in serotype virulence play in epidemics. They found that cross-immunity alone is enough to create the patterns that are observed in nature.

The study is a major departure from other theories about what drives dengue epidemics. The conventional wisdom is that an amplification of the severity of disease caused by repeat infections with different strains, a phenomenon known as antibody-dependent enhancement, drives the boom and bust cycles of dengue epidemics.

"Temporary cross-immunity has been ignored by the epidemiological community," said study co-author Pejman Rohani, associate professor of ecology and UGA Biomedical and Health Sciences Institute researcher.

"It's discussed in the scientific literature," Wearing added, "but no one ever considers it an important factor in generating the epidemiological cycles."

Cross-immunity, which lasts from two to nine months, results when overall antibody levels created by the body in response to infection by one serotype are high enough to protect against infection by related serotypes. After this period, however, antibody levels drop to levels that are no longer neutralizing but instead are exploited by the dengue virus to enhance replication and cause more severe illness.

"You can't deny the empirical fact that people who get severe dengue may well have had cases before," Rohani said. "But our work suggests it's not the mechanism that's underlying the big-picture pattern that we see."

Several factors are contributing to an increase in dengue epidemics. Global warming is allowing the species primarily responsible for spreading dengue (Aedes aegypti, also known as the yellow fever mosquito) to expand its range. Population g
'"/>

Source:University of Georgia


Page: 1 2 3

Related biology news :

1. Bioartificial kidney under study at MCG
2. W.M. Keck Foundation funds study of friendly microbes
3. Yellowstone microbes fueled by hydrogen, according to U. of Colorado study
4. Genome-wide mouse study yields link to human leukemia
5. Clam embryo study shows pollutant mixture adversely affects nerve cell development
6. New imaging method gives early indication if brain cancer therapy is effective, U-M study shows
7. Same mutation aided evolution in many fish species, Stanford study finds
8. Sequencing of marine bacterium will help study of cell communication
9. Genetically modified rice in China benefits farmers health, study finds
10. A new study examines how shared pathogens affect host populations
11. NYU study reveals how brains immune system fights viral encephalitis
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: UGA study explains peaks and troughs dengue epidemics

(Date:4/17/2014)... on a novel method to help kidney stone ... effective treatment possible., Kidney stones represent a major ... If left untreated, apart from being particularly painful, ... complications. In many patients treated successfully, stone recurrence ... pathological approach to diagnosis and treatment needs to ...
(Date:4/17/2014)... have detected new early-warning signs of the potential loss ... far-reaching implications for the diagnosis and treatment of diabetic ... Americans. , "We had not expected to see such ... said Ann Elsner, professor and associate dean in the ... study. "We set out to study the early signs, ...
(Date:4/17/2014)... immune system may fight cancers and viral infections. The ... treat illness. , The research, in mice, suggests that ... specialized squads of defenders that patrol only one ... the body. , Scientists at Washington University School of ... skin and uterus each has dedicated immune cells, which ...
Breaking Biology News(10 mins):New technique detects microscopic diabetes-related eye damage 2New technique detects microscopic diabetes-related eye damage 3Some immune cells defend only 1 organ 2
... in Plant Science Automated conserved ... promoter evolution among grasses Within the genome of ... undergo little change in position and sequence over millions of ... these evolutionarily stable sequences, so-called conserved noncoding sequences (CNSs), are ...
... Investigators at Rollins School of Public Health at Emory ... Technology, have received a $4 million grant over four ... (Health and Exposome Research Center: Understanding Lifetime Exposures). The ... the United States. The HERCULES Center is ...
... or harsh treatments because science fails to identify ... the disease. Researchers at Case Western Reserve University ... that allows patients to safely choose to do ... drastic measures. The project is one of ...
Cached Biology News:Frontiers news briefs: May 23 2Frontiers news briefs: May 23 3Emory, Georgia Tech receive first human exposome center grant in US 2Emory, Georgia Tech receive first human exposome center grant in US 3Using big data to identify prostate cancers and best treatments 2Using big data to identify prostate cancers and best treatments 3
(Date:1/15/2014)... TAIPEI , Jan. 15, 2014 TaiGen Biotechnology ... an exclusive agreement with R-Pharm, a leading Russian pharmaceutical ... in the Russian Federation , ... Commonwealth Independent States (CIS). Nemonoxacin is a novel antibiotic for ...
(Date:1/14/2014)... Washington, DC (PRWEB) January 14, 2014 ... session for Thursday, January 23, 2014 at 2pm EST ... Actionable Knowledge.” The topic focuses on how technology can ... mission critical decisions for government agencies. The online webinar ...
(Date:1/14/2014)... leading provider of strategic communications services to corporations and organizations preparing ... the United States and Europe , ... returning to the firm,s Washington, D.C. office. ... two years of service as Associate Commissioner for the Office of ...
(Date:1/14/2014)... NY (PRWEB) January 14, 2014 EquitiesIQ, ... Alliqua, Inc. (OTCQB: ALQA). Alliqua is an emerging biomedical ... serve the wound care market. , Free report download: ... restructured with a seasoned management team and Board, which ...
Breaking Biology Technology:TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 2TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 3TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 4Webcast - Natural Language Processing: Converting Raw Data into Actionable Knowledge – Hosted by Carahsoft and CDS Federal Services 2Former FDA Associate Commissioner Returns To 3D Communications 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 3
... , , ... By Susan Catalano, Ph.D., Acumen Pharmaceuticals, Sylvia de Bruin, Joe Bosworth, ... Corporation, , 1311 Orleans Drive, Sunnyvale, CA 94089. , ... G-protein coupled receptors (GPCRs are the largest class of pharmaceutical ...
... and Ario de Marco , EMBL Protein Expression ... , Introduction ,Immobilized Metal ion Affinity ... that allows the fast separation of His-tagged proteins ... resins but all of them show some affinity ...
... , ,,Application Guide, ,I. Description ,II. Product ... User ,IV. Protocol for Extraction of DNA from ... from Plant ,VI. Quantification of Amplified Products ... References , Contact Information , , ,Application Guide, , ...
Cached Biology Technology:High-content screening of GPCR activation with MetaXpress, AcuityXpress and the Transfluor assay system 2High-content screening of GPCR activation with MetaXpress, AcuityXpress and the Transfluor assay system 3High-content screening of GPCR activation with MetaXpress, AcuityXpress and the Transfluor assay system 4High-content screening of GPCR activation with MetaXpress, AcuityXpress and the Transfluor assay system 5High-content screening of GPCR activation with MetaXpress, AcuityXpress and the Transfluor assay system 6High-content screening of GPCR activation with MetaXpress, AcuityXpress and the Transfluor assay system 7High-content screening of GPCR activation with MetaXpress, AcuityXpress and the Transfluor assay system 8High-content screening of GPCR activation with MetaXpress, AcuityXpress and the Transfluor assay system 9High-content screening of GPCR activation with MetaXpress, AcuityXpress and the Transfluor assay system 10High-content screening of GPCR activation with MetaXpress, AcuityXpress and the Transfluor assay system 11Double-Affinity Purification of GST-His Tagged Proteins Using Vivapure 8-to-96 Well Cobalt-Chelate Kit 2Double-Affinity Purification of GST-His Tagged Proteins Using Vivapure 8-to-96 Well Cobalt-Chelate Kit 3Double-Affinity Purification of GST-His Tagged Proteins Using Vivapure 8-to-96 Well Cobalt-Chelate Kit 4Protocol for GenomePlex Whole Genome Amplification from Plant 2Protocol for GenomePlex Whole Genome Amplification from Plant 3Protocol for GenomePlex Whole Genome Amplification from Plant 4Protocol for GenomePlex Whole Genome Amplification from Plant 5Protocol for GenomePlex Whole Genome Amplification from Plant 6
... Microarrays designed for genome-wide microRNA expression profiling ... Paraflo microfluidic on-chip synthesis platform. These microarrays ... microRNA Expression Profiling Service. Probe ... all known cow microRNAs (108 unique mature ...
... for genome-wide microRNA expression profiling and ... Paraflo microfluidic on-chip synthesis platform. These ... our comprehensive microRNA Expression Profiling Service. ... Viruses microRNA Microarray contains all known ...
...
... The Agilent 6850 Networked GC is an excellent ... footprint of a standard dual-channel GC, this one-channel ... GCs in the space of one. You get ... routine GC analyses in an instrument that has ...
Biology Products: