Navigation Links
UF scientists restore sight to chickens with blinding disease

University of Florida scientists have delivered a gene through an eggshell to give sight to a type of chicken normally born blind.

The finding, reported Tuesday (May 23) in the online journal Public Library of Science-Medicine, proves in principle that a similar treatment can be developed for an incurable form of childhood blindness.

"We were able to restore function to the photoreceptor cells in the retinas of an avian model of a disease that is one of the more common causes of inherited blindness in human infants," said Sue Semple-Rowland, Ph.D., an associate professor of neuroscience with UF's Evelyn F. and William L. McKnight Brain Institute. "The vision capabilities of the treated animals far exceeded our expectations."

The bird -- a type of Rhode Island Red chicken -- carries a genetic defect that prevents it from producing an enzyme essential for sight. The condition closely models a genetic disease in humans that causes Leber congenital amaurosis type 1, or LCA1. About 2,000 people in the United States are blind because they have a disease that falls in the LCA family.

"Enabling chickens that can't see to peck and eat after treatment is stunning," said Dr. Jean Bennett, a professor of ophthalmology and cell and developmental biology at the University of Pennsylvania who was not involved in the study but who participated in a landmark gene transfer experiment five years ago that restored vision to blind Briard dogs. "This is proof of concept using a unique vector, animal model and approach. One would hope this could happen in a human."

Semple-Rowland, a College of Medicine faculty member, has worked since 1986 to first discover the malfunctioning gene, known as GC1, and then to develop a viral therapy to treat it.

"I will always remember the first animal that we successfully treated," said Semple-Rowland, who is also a member of the UF Center for Vision Research and the UF Genetics Institute. "I thought I saw sig
'"/>

Source:University of Florida


Page: 1 2 3

Related biology news :

1. Wisconsin scientists grow critical nerve cells
2. UCSB scientists probe sea floor venting to gain understanding of early life on Earth
3. UAB scientists discover the origin of a mysterious physical force
4. Fox Chase Cancer Center scientists identify immune-system mutation
5. Weizmann Institute scientists develop a new approach for directing treatment to metastasized prostate cancer in the bones.
6. U-M scientists find genes that control growth of common skin cancer
7. UCLA scientists transform HIV into cancer-seeking missile
8. RNA project to create language for scientists worldwide
9. Carnegie Mellon scientists develop tool that uses MRI to visualize gene expression in living animals
10. To control germs, scientists deploy tiny agents provocateurs
11. Leprosy microbes lead scientists to immune discovery
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: scientists restore sight chickens with blinding disease

(Date:8/27/2014)... New York, NY (June, 2014) Outstanding basic ... treatments, and a dedication to patient care have ... of Columbia University Medical Center (CUMC) and NewYork-Presbyterian ... Grant from the National Cancer Institute (NCI). The ... only two NCI-designated Comprehensive Cancer Centers in New ...
(Date:8/27/2014)... that piglets can be weaned later with no negative ... the study at the University,s Roseworthy campus, published in ... important finding for pig producers. It allows improvements in ... "Sows don,t usually start their oestrous cycles again during ... been weaned," says Ms Alice Weaver, PhD candidate with ...
(Date:8/26/2014)... Researchers at Washington University in St. Louis have developed ... bones prone to tearing or breaking. The technology, which ... patients, one day may help pinpoint minor strains and ... problems occur. , The research is available online Aug. ... Interface , which publishes research at the nexus of ...
Breaking Biology News(10 mins):Herbert Irving Comprehensive Cancer Center awarded $18 million grant 2Herbert Irving Comprehensive Cancer Center awarded $18 million grant 3Herbert Irving Comprehensive Cancer Center awarded $18 million grant 4Piglet weaning age no bar to litter frequency 2New technology may identify tiny strains in body tissues before injuries occur 2New technology may identify tiny strains in body tissues before injuries occur 3
... at the edge of Alaska,s tundra are growing faster, suggesting ... rapidly warming climate, says a new study. While forests ... attributed to global warming, some white spruce trees in the ... last hundred years, especially since 1950, the study has found. ...
... bike path in Montana to a backwater underneath a ... June to capture high-resolution images for the first Nearby ... in their efforts to document global biodiversity as they ... week of Dec. 19-26., The GigaBlitz is organized ...
... University of Sheffield comparing rats and mice with their ... an important milestone in the evolution of mammals from ... tracking, the research team, which was led by Professor ... shed light on how rodents such as mice and ...
Cached Biology News:Trees on tundra's border are growing faster in a hotter climate 2Trees on tundra's border are growing faster in a hotter climate 3Trees on tundra's border are growing faster in a hotter climate 4GigaBlitz event seeks citizen scientists to capture images of nearby biodiversity 2GigaBlitz event seeks citizen scientists to capture images of nearby biodiversity 3Whiskers marked milestone in evolution of mammals from reptiles 2
(Date:8/27/2014)... 2014 Reportbuyer.com has added a new ... - A Rational View https://www.reportbuyer.com/product/1595336/The-Graphene-Opportunity---A-Rational-View.html ... A similar amount of hype currently surrounds ... microelectronics to water treatment, but is graphene the ... the Graphene Opportunity Report, authored by Tim ...
(Date:8/27/2014)... MONMOUTH JUNCTION, N.J. , Aug. 27, 2014 /PRNewswire/ ... developing innovative drug delivery technologies, today announced that it ... New Jersey Business & Industry Association,s 2014 Awards ... Finalists were selected by an independent panel of judges ... member company volunteers. Award winners will be honored at ...
(Date:8/27/2014)... State College, PA (PRWEB) August 27, 2014 ... Electromagnetic Simulation Software with new features for the ... release is an enhanced Biological Thermal Sensor, exclusive to ... is a specialty version of XFdtd, developed to calculate ... MATLAB® export functionality has been added to all versions ...
(Date:8/26/2014)... WA (PRWEB) August 26, 2014 ... for next-generation wearable technology, and inspiration for the ... at this year’s brighter, busier SPIE Optics ... Convention Center. More than 4,400 international scientists, engineers, ... courses, an exhibition, and industry sessions sponsored by ...
Breaking Biology Technology:The Graphene Opportunity - A Rational View 2The Graphene Opportunity - A Rational View 3The Graphene Opportunity - A Rational View 4Tris Pharma Selected as an award winner in the New Jersey Business & Industry Association's 2014 Awards for Excellence 2Remcom Announces Enhanced Biological Thermal Sensor and Other Biomedical Features in XFdtd EM Simulation Software Update 2Remcom Announces Enhanced Biological Thermal Sensor and Other Biomedical Features in XFdtd EM Simulation Software Update 3Brighter, Busier SPIE Optics + Photonics Draws International Crowd to San Diego 2Brighter, Busier SPIE Optics + Photonics Draws International Crowd to San Diego 3Brighter, Busier SPIE Optics + Photonics Draws International Crowd to San Diego 4
... NEW YORK, April 7 /PRNewswire-Asia-FirstCall/ -- Biostar Pharmaceuticals,Inc. ("Biostar" or the "Company") ... December 31, 2008. , , Highlights for Year Ended ... year were $33.9 million, up from $15.9 million, ... year increased 69% to $6,690,542 as compared to, ...
... ( http://www.volersystems.com ) has launched a "Quality System for ... concept and design to production of devices for human ... from investing in key programs that are critical to ... medical devices. During the economic recovery to come, Voler ...
... CARMEL, Israel, April 7 InSightec Ltd. announced,today that ... label,change for the company,s ExAblate(R) 2000 MR-guided Focused Ultrasound,(MRgFUS) ... fibroids. Under the new labeling, the agency allows,physicians to ... its previous,restriction to only treat up to half the ...
Cached Biology Technology:Biostar Pharmaceuticals, Inc. Reports Record Revenues and Earnings for 2008 2Biostar Pharmaceuticals, Inc. Reports Record Revenues and Earnings for 2008 3Biostar Pharmaceuticals, Inc. Reports Record Revenues and Earnings for 2008 4Biostar Pharmaceuticals, Inc. Reports Record Revenues and Earnings for 2008 5Biostar Pharmaceuticals, Inc. Reports Record Revenues and Earnings for 2008 6Voler Systems Continues Investments and Expands Services 2FDA Approves Label Change for Non-Invasive Fibroid Treatment 2FDA Approves Label Change for Non-Invasive Fibroid Treatment 3
... from Paraffin embedded tissue blocks, which are ... ensure the highest quality. Tissues of each ... sectioned at a thickness of 5 microns ... large (3-5 mm in diameter) in comparison ...
... tissue microarrays are derived from Paraffin embedded ... quality control procedures to ensure the highest ... assembled in one block, sectioned at a ... coated slides. Sections are large (3-5 mm ...
... Zyagen tissue microarrays are derived from ... to rigorous quality control procedures to ensure ... are manually assembled in one block, sectioned ... on coated slides. Sections are large (3-5mm ...
... are derived from Paraffin embedded tissue blocks, ... procedures to ensure the highest quality. Tissues ... one block, sectioned at a thickness of ... Sections are large (3-5mm in diameter) in ...
Biology Products: