Navigation Links
UF Researchers Map Bacterial Proteins That Cause Tooth Loss

The human mouth teems with millions of enamel-eroding, gum-inflaming microbes.

One of these, Porphyromonas gingivalis, is a bacterial homesteader that stakes a claim deep within the spaces between teeth and gums. It’s also the leading cause of tooth loss ?secreting proteins that destroy the soft tissues and bone that support teeth to cause periodontal disease.

Now scientists have identified the thousands of proteins the bacterium produces, shedding light on how it interacts with healthy cells in order to thrive, according to dental researchers from the University of Florida and the University of Washington. They describe their findings in the current issue of the journal Proteomics.

“Determining which proteins are expressed in greater levels in the mouth has allowed us to gain clues as to how P. gingivalis might be causing disease, and what we might be able to do with drugs or vaccines to prevent it,?said Richard Lamont, Ph.D., a professor of oral biology at UF’s College of Dentistry and study investigator.

The National Institute of Dental and Craniofacial Research estimates 80 percent of adult Americans have some form of periodontal disease, their symptoms ranging from mild gum irritation to complete tooth loss.

People with periodontal disease also are at increased risk of stroke and heart attack, and the disease makes it difficult to control blood sugar levels in people with diabetes. If that’s not bad enough, pregnant women with periodontal disease are seven times more likely to deliver low-birth-weight, preterm babies. Proteins are important to study because they are the foundation of the cellular structure of every living organism, Lamont said. They carry on the day-to-day biology of life, going about their business as enzymes and antibodies. They can also cause disease.

“The genes themselves are only important in that they encode the proteins,?Lamont said. “It’s the proteins that are most responsible for disease,
'"/>

Source:University Of Florida Health Science Center


Page: 1 2 3

Related biology news :

1. Researchers discover way to make cells in the eye sensitive to light
2. Researchers find how protein allows insects to detect and respond to pheromones
3. Researchers Uncover Key Step In Manufacture of Memory Protein
4. Researchers reveal the infectious impact of salmon farms on wild salmon
5. Researchers identify target for cancer drugs
6. Researchers discover molecule that causes secondary stroke
7. Researchers find missing genes of ancient organism
8. Researchers trace evolution to relatively simple genetic changes
9. Researchers add new tool to tumor-treatment arsenal
10. VCU Researchers Identify Networks Of Genes Responding To Alcohol In The Brain
11. Researchers develop rapid diagnostic tool for pathogen identification
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Researchers Map Bacterial Proteins That Cause Tooth Loss

(Date:7/10/2014)... 8, 2014 Fingerprint Cards, ... design win (DW). An Asian OEM has selected FPC1021 for ... start in August 2014.   FPC is proud ... has a planned date for start of mass production in ... of SEK 5M, for delivery in the first half of ...
(Date:7/10/2014)... the large, mainly tropical flowering plant family Melastomataceae (Meadow Beauty ... rely on bees for their pollination. Only about 100 are ... flowers of Axinaea appear in clusters of few ... different species are pink, yellow, orange or red. The stamens ... of their bulbous appendages. The pollination mechanism of Axinaea ...
(Date:7/10/2014)... your popcorn or soap might not be ape friendly, and ... an analysis in the Cell Press journal Current Biology ... oil has already led to the conversion of Southeast Asian ... particular. If guidelines are not put in place very soon, ... Asia into Africa will be bad news for great apes ...
Breaking Biology News(10 mins):FPC Wins DW and Initial Ramp Order for FPC1021 Touch Sensor for Flagship Smartphone from Asian OEM 2Novel type of bird pollination mechanism discovered in South America 2Hunger for vegetable oil means trouble for Africa's great apes 2
... than a dozen countries joined together to sequence the tomato ... The Tomato Genomics Consortium directed the research effort, which ... Foundation and the USDA,s Agriculture Research Services. The OU ... Emeritus in the College of Arts and Sciences, was one ...
... 2012) -- A detailed analysis of more than 4 ... help electricity producers slash as much as 30 percent ... dioxide from power plant emissions. The research by ... Lawrence Berkeley National Laboratory (LBNL) and the Electric Power ...
... Madrid, May, 31st, 2012.- Madrid will become ... during the Biomedical Innovation Conference 2012, focused on ... Madrid-MIT M+Vision Consortium. This new organization has been ... and the regional Government of the Comunidad de ...
Cached Biology News:New materials could slash energy costs for CO2 capture 2New materials could slash energy costs for CO2 capture 3MADRID-MIT M+Vision Consortium hosts Biomedical Innovation Conference 2012 2
(Date:7/10/2014)... (PRWEB) July 10, 2014 OMICS Group’s ... techniques during 18-20 August, 2014 at Double Tree by ... the recent developments in Analytical & Bioanalytical research methods ... , Speaking on this occasion, Dr. Srinubabu Gedela, MD ... Acta conference is a remarkable one in bringing a ...
(Date:7/10/2014)... July 10, 2014  Franciscan St. Anthony ... capnography for respiratory monitoring outside the operating ... leaders in embracing state-of-the-art patient safety technology. ... are breathing and can alert medical caregivers ... the amount of carbon dioxide the patient ...
(Date:7/10/2014)... Utah , July 10, 2014 /PRNewswire-iReach/ ... annotation and interpretation, today announced an agreement ... (NGS) analytics for Lineagen,s NextStep Dx ... of neurodevelopmental and neurological disorders, currently offers ... microarray (CMA) testing service used by healthcare ...
(Date:7/10/2014)... According to the International Atomic Energy Agency (IAEA) ... terrorists acquiring sufficient quantities of plutonium or highly ... explosive device. The IAEA also notes that most ... quantities, which can be challenging to detect with ... study appearing this week in the Journal ...
Breaking Biology Technology:A Critical Review of Analytical Techniques for Improved Living Standards 2A Critical Review of Analytical Techniques for Improved Living Standards 3A Critical Review of Analytical Techniques for Improved Living Standards 4Franciscan St. Anthony Health-Crown Point Underscores Patient Safety Commitment Through Expanded Use of Capnography 2Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 2Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 3Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 4Sensitive detection method may help impede illicit nuclear trafficking 2
... ... ... , ... ...
... ... preemergence herbicide gives corn and soybean growers the opportunity to produce higher yields and ... plants have less pressure and improved yield potential. , ... Philadelphia, PA (PRWEB) March 9, 2010 -- As ...
... ... ... ... ...
Cached Biology Technology:Netsmart Technologies Selected by Douglas Gardens Community Mental Health to Provide Behavioral Health Software Solution 2Netsmart Technologies Selected by Douglas Gardens Community Mental Health to Provide Behavioral Health Software Solution 3Netsmart Technologies Selected by Douglas Gardens Community Mental Health to Provide Behavioral Health Software Solution 4Netsmart Technologies Selected by Douglas Gardens Community Mental Health to Provide Behavioral Health Software Solution 5Preemergence Herbicides from FMC Boost Early Season Plant Health in Corn and Soybeans and Help Optimize Yields for 2010 2Preemergence Herbicides from FMC Boost Early Season Plant Health in Corn and Soybeans and Help Optimize Yields for 2010 3SPO Medical Secures Agreement in Sleep Apnea Market 2SPO Medical Secures Agreement in Sleep Apnea Market 3SPO Medical Secures Agreement in Sleep Apnea Market 4SPO Medical Secures Agreement in Sleep Apnea Market 5SPO Medical Secures Agreement in Sleep Apnea Market 6
MOUSE ANTI RAT RT1Ac Immunogen: PHA activated rat lymphocytes...
MOUSE ANTI RABBIT T LYMPHOCTYES Immunogen: Rabbit Thymocytes...
... (100+kb), fosmid (40kb), and large plasmid insert ... othe BAC vector. On command 20-50 fold ... recombinant DNA purification. Available with blue-white screening ... for the highest insert stability. Kits include ...
... cloning of BAC (100+kb), fosmid (40kb), and ... stability than any othe BAC vector. On ... yields and easy recombinant DNA purification. Available ... (pSMART VC) vectors for the highest insert ...
Biology Products: