Navigation Links
UCSD team unmasks family of immune system invaders

ut they don't look anything like the host proteins. In a sense, they take over the host cell's identity like a bad actor."

When spoiled food is eaten, the pathogenic bacteria pass into the intestine and colon, where they meet up with a layer of cells lining these organs called the epithelial cells. The epithelial cells form a protective wall without any doors, a barrier that blocks bacterial entry from the intestine and colon into the rest of the body. However, bacterial pathogens can inject effector proteins into the intestinal epithelial cells, creating a door in the barrier.

"As a result, these bacteria proteins are the bad guys that make you sick," said Alto. "Instead of curing the illness by giving a patient antibiotics, it might be possible to target these effectors, turning their virulant actions into something benign."

The researchers used a molecular "fingerprinting" approach to identify the family of hijackers. Using this molecular fingerprint and computer-aided searches, they discovered a number of proteins having the same molecular pattern ?all were proteins used by pathogenic microorganisms. UCSD researchers were able to determine that additional bacterial proteins used a common strategy to hijack the cells' communication network.

"The novel findings of this research are particularly gratifying since this work not only included scientists from our laboratory, but also other UCSD colleagues as well as investigators from the University of Toronto," said Dixon. "This illustrates how advances in a field like bacterial pathogenesis requires the talents and diverse expertise of many scientists."

Their insights into the mechanisms of bacterial pathogens could lead to novel treatments for diseases such as dysentery. These findings may prove to be especially helpful in fighting bacterial disease in Third-World countries, in children and those with suppressed immune systems, such as HIV/AIDS patients.

C
'"/>

Source:University of California - San Diego


Page: 1 2 3

Related biology news :

1. The biggest family tree ever
2. Researchers identify new catfish family
3. Environment, not genes, key in family relationships
4. New genetic analysis forces re-draw of insect family tree
5. USC team reveals structure of APOBEC family protein
6. Worlds largest flower evolved from family of much tinier blooms
7. A rarity among arachnids, whip spiders have a sociable family life
8. Fox Chase Cancer Center scientists identify immune-system mutation
9. Genetically modified natural killer immune cells attack, kill leukemia cells
10. Studies reveal methods viruses use to sidestep immune system
11. Jumping gene helps explain immune systems abilities
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: UCSD team unmasks family immune system invaders

(Date:5/19/2015)... 19, 2015 Research ... addition of the  "Genetic Testing Market Outlook ... http://photos.prnewswire.com/prnh/20130307/600769) , ,A recent report, Genetic Testing ... of the current and future genetic testing ... their working principles and types are covered ...
(Date:5/14/2015)... , May 14, 2015 Research and Markets ... the "Fingerprint Sensors Market in Smart Mobile Devices ... report believes that 2014 was a watershed year for ... introduction of ,Apple Pay,. Apple gave fingerprint sensors a ... payment service. Fingerprint sensors are a must-have feature in ...
(Date:5/11/2015)... 11, 2015  Synaptics Incorporated (NASDAQ: SYNA ... today announced the appointment of Wajid Ali ... Officer, reporting to Rick Bergman , President ... Financial Officer, Kathleen Bayless , who announced ... Mr. Ali brings extensive financial management expertise to ...
Breaking Biology News(10 mins):Global Genetic Testing Market Outlook 2018 2Global Smart Mobile Devices Fingerprint Sensors Market 2015-2019: Key Vendors are Authentec, Validity Sensors, Fingerprint Cards, Next Biometrics Group. IDEX, and Qualcomm 2Synaptics Appoints Wajid Ali as Senior Vice President and Chief Financial Officer 2
... fish populations leaving them in danger of total collapse, ... measures in place to control fish stocks may not ... research, which is published in today's Nature, involved compiling ... non-exploited fish off the California coast. The research team ...
... Researchers from the University of Pennsylvania School of Veterinary Medicine ... of fish and mammals in the form of a primitive ... system. Their studies link the evolution of the adaptive ... fight infection, to the more primitive innate immunity in fish, ...
... Institut Pasteur has recently shown that the tuberculosis bacillus ... cells. This formidable pathogen is protected against even the ... may remain dormant for years. This discovery, published in ... fighting tuberculosis. Attempts to eradicate the bacillus entirely from ...
Cached Biology News:Commercial fishing causes dangerous fluctuations in fish populations 2'Killer' B cells demonstrate evolutionary link between fish and mammal immune systems 2'Killer' B cells demonstrate evolutionary link between fish and mammal immune systems 3Tuberculosis: The bacillus takes refuge in adipose cells 2
(Date:5/29/2015)... 29, 2015 Delcath Systems, Inc. (NASDAQ: ... device company focused on oncology with an emphasis ... cancers, announces that results of a large, European ... patients with hepatic metastases with the Delcath Hepatic ... an on-line abstract at the American Society of ...
(Date:5/29/2015)... SILVER SPRING, Md. and RESEARCH TRIANGLE ... Therapeutics Corporation (NASDAQ: UTHR ) announced today that ... United Therapeutics, will provide an overview and update on the ... New York City . The ... on Thursday, June 4, 2015, at 11:00 AM Eastern Time, ...
(Date:5/28/2015)... 28, 2015 Research ... the addition of Jain PharmaBiotech,s new report ... and Companies" to their offering. ... This report deals with therapeutic drug monitoring, ... patient care by monitoring drug levels in ...
(Date:5/28/2015)... , May 27, 2015 Research and ... Jain PharmaBiotech,s new report "Cell Therapy - ... This report describes and evaluates cell ... to play an important role in the practice ... the old fashioned bone marrow transplants. Role of ...
Breaking Biology Technology:Positive Data With Delcath's CHEMOSAT Highlighted At ASCO 2015 2Positive Data With Delcath's CHEMOSAT Highlighted At ASCO 2015 3Positive Data With Delcath's CHEMOSAT Highlighted At ASCO 2015 4Positive Data With Delcath's CHEMOSAT Highlighted At ASCO 2015 5Global Therapeutic Drug Monitoring Market 2015-2024 2Global Cell Therapy Market 2015-2020 - Technologies, Markets and Companies 2
... companies with substantial internal mammalian cell culture ... manufacturing capacity. Contract mammalian cell culture manufacturers ... pressure of increased utilization rates. For these ... understanding critical demand drivers, market factors and ...
... 1 Anadys Pharmaceuticals, Inc. (Nasdaq: ANDS ... (FDA) has granted fast track designation to ANA598 for the ... is Anadys, investigational hepatitis C non-nucleoside polymerase inhibitor. Anadys ... ANA598 for the treatment of patients chronically infected with HCV. ...
... business intelligence company, the biofuel market is estimated at 33 billion ... 85% bioethanol and 15% biodiesel. Bioethanol is produced and consumed mainly ... the world leader in biodiesel production and this fuel represents about ... ...
Cached Biology Technology:PharmSource and BioProcess Technology Consultants Announce Publication of New Market Report: Cell Culture Manufacturing Capacity: Trends and Outlook through 2013 2ANA598 Receives Fast Track Designation From the FDA for the Treatment of Chronic Hepatitis C Infection 2ANA598 Receives Fast Track Designation From the FDA for the Treatment of Chronic Hepatitis C Infection 3ANA598 Receives Fast Track Designation From the FDA for the Treatment of Chronic Hepatitis C Infection 4ANA598 Receives Fast Track Designation From the FDA for the Treatment of Chronic Hepatitis C Infection 5CBDM.T, the Market and Business Intelligence Company Reviews the Biofuel Market 2CBDM.T, the Market and Business Intelligence Company Reviews the Biofuel Market 3CBDM.T, the Market and Business Intelligence Company Reviews the Biofuel Market 4
Normal canine serum collected from healthy normal canines....
... fosmid (40kb), and large plasmid insert (10-20kb) ... BAC vector. On command 20-50 fold copy ... DNA purification. Available with blue-white screening (pEZ ... the highest insert stability. Kits include electrocompetent ...
RABBIT ANTI GLYCINE...
... Light Diagnostics Cytomegalovirus (CMV) pp65 Antigenemia Immunofluorescence ... identification of lower matrix protein pp65 of ... Kit Components: Erythrocyte ... bottle containing 220 mL of buffered ammonium ...
Biology Products: