Navigation Links
UCSD team unmasks family of immune system invaders

ut they don't look anything like the host proteins. In a sense, they take over the host cell's identity like a bad actor."

When spoiled food is eaten, the pathogenic bacteria pass into the intestine and colon, where they meet up with a layer of cells lining these organs called the epithelial cells. The epithelial cells form a protective wall without any doors, a barrier that blocks bacterial entry from the intestine and colon into the rest of the body. However, bacterial pathogens can inject effector proteins into the intestinal epithelial cells, creating a door in the barrier.

"As a result, these bacteria proteins are the bad guys that make you sick," said Alto. "Instead of curing the illness by giving a patient antibiotics, it might be possible to target these effectors, turning their virulant actions into something benign."

The researchers used a molecular "fingerprinting" approach to identify the family of hijackers. Using this molecular fingerprint and computer-aided searches, they discovered a number of proteins having the same molecular pattern ?all were proteins used by pathogenic microorganisms. UCSD researchers were able to determine that additional bacterial proteins used a common strategy to hijack the cells' communication network.

"The novel findings of this research are particularly gratifying since this work not only included scientists from our laboratory, but also other UCSD colleagues as well as investigators from the University of Toronto," said Dixon. "This illustrates how advances in a field like bacterial pathogenesis requires the talents and diverse expertise of many scientists."

Their insights into the mechanisms of bacterial pathogens could lead to novel treatments for diseases such as dysentery. These findings may prove to be especially helpful in fighting bacterial disease in Third-World countries, in children and those with suppressed immune systems, such as HIV/AIDS patients.

C
'"/>

Source:University of California - San Diego


Page: 1 2 3

Related biology news :

1. The biggest family tree ever
2. Researchers identify new catfish family
3. Environment, not genes, key in family relationships
4. New genetic analysis forces re-draw of insect family tree
5. USC team reveals structure of APOBEC family protein
6. Worlds largest flower evolved from family of much tinier blooms
7. A rarity among arachnids, whip spiders have a sociable family life
8. Fox Chase Cancer Center scientists identify immune-system mutation
9. Genetically modified natural killer immune cells attack, kill leukemia cells
10. Studies reveal methods viruses use to sidestep immune system
11. Jumping gene helps explain immune systems abilities
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: UCSD team unmasks family immune system invaders

(Date:8/20/2014)... The National Institutes of Health has awarded the Oklahoma ... continue its research on anthrax and the bacteria,s effects ... Mark Coggeshall, Ph.D., and his colleagues have studied the ... NIH,s Cooperative Centers for Human Immunology. The original funding ... 17 on the heels of the terrorist attacks of ...
(Date:8/20/2014)... causes a burning spiciness that is irresistible to some, ... effect are using their findings to develop a new ... be caused by inflammation or other problems. They reported ... in clinical trials, in ACS, Journal of Medicinal ... decades ago, scientists had pegged a compound called capsaicin ...
(Date:8/20/2014)... gene therapy developed by researchers at the University of ... mice from a life-threatening heart condition caused by muscular ... said Yi Lai, Ph.D., the leading author of the ... of Medicine,s Department of Molecular Microbiology and Immunology. "This ... could lead to a treatment for people with this ...
Breaking Biology News(10 mins):$14.5 million grant awarded to continue anthrax studies 2Gene therapy protects mice from lethal heart condition, MU researchers find 2
... February 5, 2013 What do microbes have to do with ... a microbe and every step in the brewing process helps ... If the Yeast Ain,t Happy, Ain,t Nobody Happy: The Microbiology of ... time someone brews a batch of beer, in a very real ...
... view the causes of obesity may impact the advice ... new study led by researchers at the Johns Hopkins ... between primary care physicians, beliefs about the causes of ... that physicians who believed over consumption of food to ...
... this advance is almost comparable to the leap from ... Cotte and Fatih Toy, have designed a device that ... living biological tissues at the nanoscale. Their research is ... of the Microvision and Microdiagnostics Group in EPFL,s School ...
Cached Biology News:Yeast we can! New report answers questions on microbiology and beer 2Physicians' belief about obesity causes impacts advice and care 2Peering into living cells -- without dye nor fluophore 2
(Date:8/20/2014)... 2014 Clintrax Global, Inc., a worldwide ... Raleigh, NC , recently announced the ... President of Administration. As Vice ... processes, including their alignment with company objectives and ... as an HR executive, specializing in needs assessments, ...
(Date:8/20/2014)... August 20, 2014 High performance ... apply the most complete climate and Earth system ... climate change issues. , Eight national laboratories, including ... the National Center for Atmospheric Research, four academic ... effort. Other participating national laboratories include Argonne, Brookhaven, ...
(Date:8/20/2014)... , Aug. 20, 2014 /PRNewswire-iReach/ -- A ... transformative collaboration between the school,s bioengineering department and ... of the Intel® Software Academic Program, UCSD,s research ... and the human body.  Photo ... study exhibits the work of Dr. Todd ...
(Date:8/19/2014)... Shimadzu Scientific Instruments has introduced two ... adding to the company’s extensive line-up of HPLC ... operating environment, and full automation, the i-Series provides ... conventional to ultra-high-speed analysis. , The ... so users can begin building the lab of ...
Breaking Biology Technology:Clintrax Global, Inc. Announces Addition to Executive Team 2New Project Is the ACME of Addressing Climate Change 2New Project Is the ACME of Addressing Climate Change 3Intel and University of San Diego Bioengineering Department Release Case Study on Health Sciences Research 2Shimadzu’s New i-Series Integrated Liquid Chromatography Systems Provide Laboratories Wider Range of Analytical Capabilities 2Shimadzu’s New i-Series Integrated Liquid Chromatography Systems Provide Laboratories Wider Range of Analytical Capabilities 3
... announced Wednesday that it has begun shipping Gen2 RFID-tagged cases ... Auto-ID research lab in Neenah, Wis., to thank for it. ... of Huggies brand diapers is the company's next step in ... extensive research and testing on the compatibility of Gen2 hardware ...
... wearing paper goggles gasped frequently as they watched a human ... from La Crosse to Madison. , , ... of the applications he's developed at UW-La Crosse. It ... the foundation for educational software on anatomy. It was also ...
... not necessarily their best mind you, growing up was "Aftermath", an ... of BIO 2006- Chicago. , ,As BIO 2006 - Chicago is ... take on the outcome, but so many others have already done ... and some more of the facts emerge (like the final attendance ...
Cached Biology Technology:Neenah lab helps firm ship RFID-tagged products to Wal-Mart 2Next generation simulations? Not on the Internet you're used to 2BIO 2006 aftermath and a taste of bio-generics 2BIO 2006 aftermath and a taste of bio-generics 3BIO 2006 aftermath and a taste of bio-generics 4BIO 2006 aftermath and a taste of bio-generics 5BIO 2006 aftermath and a taste of bio-generics 6BIO 2006 aftermath and a taste of bio-generics 7BIO 2006 aftermath and a taste of bio-generics 8