Navigation Links
UCSD team discovers specialized, rare heart stem cells in newborns

The first evidence of cardiac progenitor cells ?rare, specialized stem cells located in the newborn heart of rats, mice and humans ?has been shown by researchers at the University of California, San Diego (UCSD) School of Medicine. The cells are capable of differentiation into fully mature heart tissue.

Called isl1+ cells, these cardiac progenitor cells are stem cells that have been programmed to form heart muscle during fetal growth. Until this new discovery, the cells were thought to be absent after birth. However, the UCSD team discovered a small number of the specialized stem cells remained embedded in a region of the newborn heart called the atrium. They also determined that the cells could be expanded into millions of progenitor cells by growing them on a layer of neighboring heart cells called fibroblasts.

Published in the February 10, 2005 issue of the journal Nature, the research identified the isl1+ progenitor cells in the tissue of newborn rats and mice, and then in heart tissue taken from five newborn human babies undergoing surgery for congenital heart defects.

Study author Sylvia Evans, Ph.D., a member of the UCSD Institute of Molecular Medicine (IMM) and professor of pharmacology, and co-first author Alessandra Moretti, Ph.D., IMM member, explained that the cells are programmed to become spontaneously beating cardiac muscle cells simply by exposure to other neighboring heart cells.

And, since these rare cardiac progenitor cells are found in regions of the atrium that are normally discarded during routine cardiac surgery, the discovery raises the possibility that an individual could receive their own cardiac stem cells to correct a wide spectrum of pediatric cardiac diseases, according to co-first authors Moretti and Karl-Ludwig Laugwitz, M.D., a Heisenberg-Scholar of the German Research Foundation.

"Conceptually, these cells could provide a cell-therapy based approach to pediatric cardiac disease, which is new fo
'"/>

Source:University of California, San Diego


Page: 1 2 3

Related biology news :

1. University of Nevada, Reno research team discovers hormone that causes malaria mosquito to urinate
2. MIT chemist discovers secret behind natures medicines
3. Mayo Clinic collaboration discovers protein amplifies DNA injury signals
4. Expedition discovers marine treasures
5. Team discovers possible universal strategy to combat addiction
6. Nobelist discovers antidepressant protein in mouse brain
7. Joslin discovers signs of residual islet cell function in people with long-term type 1 diabetes
8. Contrary to common wisdom, scientist discovers some mammals can smell objects under water
9. U of S Vaccine and Infectious Disease Organization team discovers key step in flu virus replication
10. LSU professor discovers new species
11. Mayo discovers protein as potential tactic to prevent tumors
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: UCSD team discovers specialized rare heart stem cells newborns

(Date:7/7/2015)... , July 7, 2015 NXT-ID, Inc. (NASDAQ: NXTD ... the growing mobile commerce market announces a revised version of one ... The commercial will air on CNBC in New York ... and San Francisco metro areas. ... focuses on Wocket,s ability to replace all the cards in your ...
(Date:7/2/2015)... Fingerprint Cards has received an order ... from the distributor World Peace Industrial Group (WPI), part of ... Asia . Deliveries are planned to take place ... by smartphone manufacturers in Asia . The ... revenue guidance of approximately 2,200 MSEK for 2015. ...
(Date:6/29/2015)... June 24, 2015 Research ... the "Latin America Biomedical Sensors Market - Growth, ... The Latin America Biomedical Sensors market is ... of 2.04% over the period 2014-2020 The ... to the genetic formulation of each individual. These sensors ...
Breaking Biology News(10 mins):Wocket Smart Wallet Commercials Airing on CNBC to Showcase This Summer's Must- Have Tech Product 2Wocket Smart Wallet Commercials Airing on CNBC to Showcase This Summer's Must- Have Tech Product 3FPC Receives Order for Touch Fingerprint Sensors of 268 MSEK 2Latin America Biomedical Sensors Market Report 2015-2020 2
... of memory loss and cognitive decline among older people with ... studied more than 900 men and women aged between 60 ... after the age of 40. They found that brain ... hormone cortisol. Dr Rebecca Reynolds, of the University of ...
... makers in Europe and United States are markedly underestimating ... required to prevent dangerous climate change because they work ... Carney, from The University of Manchester, discovered that the ... authorities has resulted in significant differences over who is ...
... a chronic irregularity of heartbeat which affects ... condition is not acutely life-threatening, it does increase the ... insufficiency, stroke and dementia. In the third of a ... researchers, led by LMU physician PD Dr. Stefan Kb, ...
Cached Biology News:Governments 'misjudging' scale of CO2 emissions 2When the heart gets out of step 2When the heart gets out of step 3
(Date:7/30/2015)... ... 30, 2015 , ... GEA's Pony™ NS2006L is ... up to 1500 bar. The sanitary design gauge of the NS2006L is well ... The Pony™ NS2006L homogenizer is an ideal solution for the processing of ...
(Date:7/29/2015)... Sanofi, un leader mondial ... pour le premier semestre 2015. Le Directeur Général ... Visionner l,interview vidéo et lire la transcription ... Au sommaire de l,interview :  - ... - Diabète - Praluent ...
(Date:7/29/2015)... 2015 US-Australian drug discovery company, Novogen Limited ... is committed to progressing its ground-breaking technology platforms to ... to ensure the Company delivers the best value for ... Ross , said the Company currently had an extensive ... discovery programs and academic partnerships and initiatives, and he ...
(Date:7/29/2015)... MONTREAL , July 29, 2015 /PRNewswire/ - BioAmber Inc. ... Laurin , the Company,s Chief Financial Officer has resigned.  ... former Chief Financial Officer who retired in December 2014, ... search for a permanent successor.     Andy ... Mr. Laurin and ensure a smooth transition.  Andy was ...
Breaking Biology Technology:GEA Announces the Pony™ NS2006L… a Self-contained, High Pressure Lab Homogenizer for Product Development Ensuring Maximum Efficiency and Safety 2Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 2Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 3Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 4Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 5Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 6Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 7Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 8Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 9Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 10BioAmber Announces Change in Chief Financial Officer 2BioAmber Announces Change in Chief Financial Officer 3
... YORK, Dec. 4 Delcath Systems, Inc. (Nasdaq: DCTH ... from his position as a director of the Company, effective December ... to leave the Delcath board is a result of additional commitments ... (Logo: http://www.newscom.com/cgi-bin/prnh/20081118/NY46990LOGO ) , , ...
... - AEterna Zentaris Inc. (NASDAQ: AEZS , ... therapy and oncology, today announced that its President and ... panel discussion titled, "Replacing The Mainstay With Newer And ... Healthcare Conference on Wednesday, December 10, 2008 at 4:30 ...
... Technologies Corporation (NASDAQ:LIFE), a provider of innovative life ... its technology for next-generation genomic analysis, the SOLiD™ ... of the Year for 2008 by The Scientist, ... science industry. In making the announcement of the ...
Cached Biology Technology:Jonathan Lewis, M.D., Ph.D. Steps Down From Delcath Systems Board of Directors 2 Applied Biosystems SOLiD System Named Life Science Innovation of the Year : The Scientist Magazine Cites the Technology's High Throughput, Lower Sequencing Cost, and Rapid Technology Innovation for Unlocking New Approaches to Clinical Research 2 Applied Biosystems SOLiD System Named Life Science Innovation of the Year : The Scientist Magazine Cites the Technology's High Throughput, Lower Sequencing Cost, and Rapid Technology Innovation for Unlocking New Approaches to Clinical Research 3 Applied Biosystems SOLiD System Named Life Science Innovation of the Year : The Scientist Magazine Cites the Technology's High Throughput, Lower Sequencing Cost, and Rapid Technology Innovation for Unlocking New Approaches to Clinical Research 4 Applied Biosystems SOLiD System Named Life Science Innovation of the Year : The Scientist Magazine Cites the Technology's High Throughput, Lower Sequencing Cost, and Rapid Technology Innovation for Unlocking New Approaches to Clinical Research 5