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UCSD study finds anthrax toxins also harmful to fruit flies

such as the anthrax lethal factor toxin that have multiple host target proteins may be used to simultaneously reduce or eliminate the activities of several related proteins that perform overlapping functions in other diseases or biological processes. Such experimental tools could accelerate progress in various areas of biomedical research.

Guichard first conceived this study in 2002, to apply her experience in molecular genetic studies to research that had medical application. At that time, after the spate of anthrax-laced letters in 2001, anthrax became a charged topic in the research community and the general public.

"Anthrax is still a hot subject because of its possible use as a weapon of bioterrorism and remains a health threat in third world countries," Guichard said. "Anthrax infections can be cured by antibiotics when detected early. But after a certain point, the toxins released in the bloodstream can kill the patient even after antibiotic treatment. The more we understand about how the toxins function, the better we'll be able to design effective co-operative or "adjunctive" therapies."


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Source:University of California - San Diego


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