Navigation Links
UCSD study clarifies insulin's role in blocking release of energy in patients with type II diabetes

Type II diabetes using medicines called insulin sensitizers, so that the body becomes more sensitive to using its own insulin, rather than compensating for insulin resistance by making more.

In order to understand the mechanisms of insulin resistance present in Type II diabetes, the researchers used a new breed of cellular enzyme reporter to track PKA. The reporter is a “marker?protein, created with special fluorescent tags so that scientists can physically view the protein under a microscope and watch how the live cell activates PKA in real time. The PKA is normally activated inside the adipocyte cell, the major site of energy storage in the body where many aspects of metabolism are controlled. There, energy is stored in the form of triglycerides, commonly known as fat. If a person is obese, excess triglycerides are stored in the adipocytes. The new study shows that insulin weakens the normal linkage between catecholamine receptors and the turn-on of PKA.

“If insulin levels get too high for too long a time ?which happens in many patients with type II diabetes –the normal catecholamine signal that triggers fat breakdown and energy release can be drowned out. This can lead to excessive energy storage in the adipocyte,?said Hupfeld. “This may be one reason why chronic obesity and Type II diabetes are often seen together.?/p>

“By correcting this hormonal imbalance, researchers may at some point improve treatment options for both obesity and Type II diabetes,?said Hupfeld.


'"/>

Source:UCSD


Page: 1 2

Related biology news :

1. Bioartificial kidney under study at MCG
2. W.M. Keck Foundation funds study of friendly microbes
3. Yellowstone microbes fueled by hydrogen, according to U. of Colorado study
4. Genome-wide mouse study yields link to human leukemia
5. Clam embryo study shows pollutant mixture adversely affects nerve cell development
6. New imaging method gives early indication if brain cancer therapy is effective, U-M study shows
7. Same mutation aided evolution in many fish species, Stanford study finds
8. Sequencing of marine bacterium will help study of cell communication
9. Genetically modified rice in China benefits farmers health, study finds
10. A new study examines how shared pathogens affect host populations
11. NYU study reveals how brains immune system fights viral encephalitis
Post Your Comments:
(Date:10/10/2008)...al School in Plymouth, UK, have carried out resear... a day recommended to children from health experts... childhood obesity. , Their research has been pu...rchives of Diseases in Childhood." , The results... the development of over 200 children in Plymouth ...
(Date:10/10/2008)... will be the focus of the Society for Nutrition Ed...event is just one small step in fighting world hun...he world and requires immediate attention in order...hunger and deficiencies. The Society for Nutrition...blic to get involved and make a difference in thei...
(Date:10/9/2008)...swire-FirstCall/ -- Synaptics(R),Incorporated (Nas...ce,solutions for mobile computing, communications,...t will report financial results for the first quar...fter the close of market. The,company will host a ...estors at 2:00 p.m. PT (5:00 p.m. ET) during which...
(Date:10/9/2008)...lecular Biology Laboratory (EMBL) have generated a...elopmental blueprint of a vertebrate. With a newly...st time track all cells for the first 24 hours in ...d into a three-dimensional, digital representation...t online issue of Science , grants many new insig...
Breaking Biology News(10 mins):Recommendations for children's exercise lacking say experts 2World Food Day brings attention to food security around the globe 2Synaptics to Report First Quarter Results on October 23 2Digital zebrafish embryo provides the first complete developmental blueprint of a vertebrate 2Cynthia Steedman Earns Health Care Fraud Investigator Accreditation 2678 1Cynthia Steedman Earns Health Care Fraud Investigator Accreditation 2678 2Doctors Groups Offer ADHD Guide for Parents 2675 1Doctors Groups Offer ADHD Guide for Parents 2675 2Doctors Groups Offer ADHD Guide for Parents 2675 3Kaiser Permanente Named Green Electronics Champion by EPA Green Electronics Council 2671 1Kaiser Permanente Named Green Electronics Champion by EPA Green Electronics Council 2671 2Kaiser Permanente Named Green Electronics Champion by EPA Green Electronics Council 2671 3Tobacco Free Kids Applauds Tyra Banks for Exposing the Ugly Truth About Smoking 2667 1Tobacco Free Kids Applauds Tyra Banks for Exposing the Ugly Truth About Smoking 2667 2
...iew of published data on use of human growth hormo...ynthetic hormone was associated with small changes...er clinically important outcomes. , Further, peop...de effects such as soft tissue swelling, joint pai...reast development. They were also somewhat more l...
...ternational research team has found evidence of th...illion years. , Upright stumps of fossilised trees...tate New York, more than a century ago. However, u...ooked like. , Two years ago, two fossils were f...s, with their trunk, branches, twigs and crown sti...
...hod of mass-producing disease-fighting antibodies ...esearch group at The University of Texas at Austin...d the new antibody-production approach to improve ...gs. Drug companies have used those more time- and...or treating rheumatoid arthritis, cancer and other...
...Xie, Ph.D., Associate Investigator, and Zhigang Ji...ie Lab, have published results showing that the mi...enewal of germline stem cells and somatic stem cel... Maintains Drosophila Ovarian Stem Cells," was pub... , MicroRNAs are single-stranded small RNA molec...
Other Biology News:Growth hormone is not the anti-aging bullet for healthy adults 2Growth hormone is not the anti-aging bullet for healthy adults 3Cheaper, better disease treatments expected from faster approach to developing antibodies 2
(Date:10/10/2008)...hed the Sixth Milestone in its Ofatumumab ...N, Denmark, October 10 /- G...d the sixth milestone for,ofatumumab (HuMax-CD20(R...SmithKline (GSK). A milestone payment of approxima...) was triggered by the first patient,receiving tre...
(Date:10/10/2008)...Oct. 10 /Xinhua-- Beike,Biotechnology...bal leader in,stem cell research and treatment thr...as signed eight separate mutual cooperation agreem...anding stem cell research organizations.,As part o...em Cell Expert,Advisory Committee" and a separate ...
(Date:10/10/2008)...RNewswire/ -- Twenty of Britain,s most,innovative ...bit their,ideas at the fifth annual SETsquared Par...eld at One Great George Street, London, from 8am o...m of technology innovators,in electronics, informa...Six companies will give 10-minute presentations to...
(Date:10/10/2008)...Newswire/ -- Takeda Pharmaceutical Company,Limited...earch and,Development Center, Inc., a wholly owned...ation that the U.S. Food and Drug Administration (...e alogliptin New Drug Application,(NDA) by the Pre...r 27,2008., "In our most recent discussion with ...
Breaking Biology Technology:Genmab Reaches Milestone in Ofatumumab Collaboration 2Stem Cell Leader Beike Signs 8 New Cooperation Agreements, Establishes Safety Monitoring Boards 2Stem Cell Leader Beike Signs 8 New Cooperation Agreements, Establishes Safety Monitoring Boards 3Creators of Britain's Innovation Economy to Showcase the Technologies of the Future at the Fifth SETsquared Partnership Showcase 2008 2Creators of Britain's Innovation Economy to Showcase the Technologies of the Future at the Fifth SETsquared Partnership Showcase 2008 3FDA Continues Review of Takeda's New Drug Application for Alogliptin (SYR-322), a DPP-4 Agent for Type 2 Diabetes 2
...st technology workplace -- from kids right out of ...ond -- found ourselves in a new and unpleasant pla... jobs that we wouldnt have remotely considered in ... may even have stayed at a less-than-sensational c...the job market has slowly improved, many of us hav...
... a pop biotech quiz to see if you know your biotec...iotech companies? How many of these companies sti...ndependent? ,While Im willing to bet that most o... right in the first question, very few will get al...nentech Biogen Genex The Genetics Institute Ce...
...onic stem cells in a UW-Madison lab. Photo courtes...tion on California,s ballot this November may affe...c stem cell research, experts say. If passed, the ...osition 71, will provide $3 billion in tax-free st...searchplacing the Golden State at the forefront of...
... has received a three-year Phase II small business...n from the National Institute for Environmental He...ment of a personal monitor for the measurement of ...onitors are designed to be small, sensitive, inexp...children. , ,Collaborators on the grant include th...
Other Biology Technology:Ten reasons to flee your Midwest technology employer 2Ten reasons to flee your Midwest technology employer 3Ten reasons to flee your Midwest technology employer 4Ten reasons to flee your Midwest technology employer 5The birth of biotech: San Francisco, Boston, Geneva or Chicago? 2The birth of biotech: San Francisco, Boston, Geneva or Chicago? 3The birth of biotech: San Francisco, Boston, Geneva or Chicago? 4The birth of biotech: San Francisco, Boston, Geneva or Chicago? 5The birth of biotech: San Francisco, Boston, Geneva or Chicago? 6The birth of biotech: San Francisco, Boston, Geneva or Chicago? 7Referendum may pull California to the forefront of stem cell research 2Referendum may pull California to the forefront of stem cell research 3Referendum may pull California to the forefront of stem cell research 4Referendum may pull California to the forefront of stem cell research 5
...ins on a 1x3 inch nitrocellulose-coated glass slid...ccording to Gene Ontology classification, are arra...itional control proteins and a specific chip layou...Ichip protein microarrays are high-density protein...
...ained in standard 96-well microtiter plates. Each ...000 clones per plate. After positive identificatio...bplate is screened with a single 96-well PCR to id... well are then plated on LB/Amp agar and the resul...
... designed for flexibility and routine operation. W...on lens, true hyperbolic quadrupole and high-speed...idest range of sample types and applications. New ...nts unique ShieldTorch System, which enables the 7...
...plate luminescence reader that is designed for the...minescence labels: Reporter gene assays luciferas...ce substrates (luminol, acridinium esters, dioxeta...s (cytotoxity and proliferation, intracellular Ca2...
Biology Products: