Navigation Links
UCSD researchers develop 'smart petri dish'

ure analogous to the way that semiconductors transmit electricity through computer chips. By attaching rat liver cells to the polystyrene within the crystals and measuring the scattering of light with a sensitive spectrometer, they were able to detect small changes in the shapes of the cells as they reacted to toxic doses of cadmium chloride and acetaminophen.

"As these cells shrivel up in response to a toxin, they scatter light better, much like fog on a car windshield, allowing us to quickly detect which drugs may have adverse side effects when taken in combination with another," says Sailor. "You're not supposed to drink alcohol when taking acetaminophen, because the combination of the two is much more toxic to your liver than either drug individually. This is known as an adverse drug-drug interaction and it is very expensive and time-consuming to screen a new drug candidate with all the possible combinations of drugs that a patient may be taking. The Smart Petri Dish allows us to perform a large number of such toxicity assays simultaneously, in order to provide an early indication of the particular physiological or pharmacological conditions that need more in-depth study."

"Although we performed these experiments on rat cells, this technology can be easily extended to human cells," says Sangeeta Bhatia, a professor of bioengineering at UCSD now at MIT, who also participated in the study. "This is important because we know that the enzymes that metabolize drugs--the P450 family--are very different in animal and humans. This is one of the reasons many drugs clear animal testing but end up toxic in patients. This type of sensor could help us predict human liver responses without patient exposure."

"Because the Smart Petri Dish gives a continuous readout of cell damage," she adds, "this type of sensor could also be very useful for understanding more about the way environmental toxicants such as water contaminants or viruses like hepatitis
'"/>

Source:University of California - San Diego


Page: 1 2 3

Related biology news :

1. NYU researchers simulate molecular biological clock
2. Vital step in cellular migration described by UCSD medical researchers
3. ASU researchers finds novel chemistry at work to provide parrots vibrant red colors
4. UCSD researchers maintain stem cells without contaminated animal feeder layers
5. Why do insects stop breathing? To avoid damage from too much oxygen, say researchers
6. New protein discovered by Hebrew University researchers
7. First real-time view of developing neurons reveals surprises, say Stanford researchers
8. Agilent Technologies releases automated literature search tool for biology researchers
9. Self-assembled nano-sized probes allow Penn researchers to see tumors through flesh and skin
10. Yale researchers identify molecule for detecting parasitic infection in humans
11. US life expectancy about to decline, researchers say
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: UCSD researchers develop smart petri dish

(Date:4/20/2015)... Huntington Memorial Hospital is the first facility ... miniaturized, wireless monitoring sensor to manage heart failure (HF). ... FDA-approved heart failure monitoring device that has been proven ... to manage heart failure. The CardioMEMS HF ... pulmonary artery (PA) during a non-surgical procedure to directly ...
(Date:4/14/2015)... NEW YORK , April 14, 2015 /PRNewswire/ ... Fast IDentity Online (FIDO ® ) Alliance tm ... standards-based specifications. FIDO members commit to share technology ... authentication methods that are interoperable, more secure and ... specifications enable biometric identity verification that protects sensitive ...
(Date:4/13/2015)... 2015  higi, a leading cloud-based consumer engagement platform ... engage with their communities around health and wellness, announced ... secure API.  ... affordable, and convenient vehicle to receive validated health information ... The API will allow higi,s trusted partners, on ...
Breaking Biology News(10 mins):Huntington Memorial Hospital Becomes First in the San Gabriel Valley to Offer Patients a New Heart Failure Monitoring Solution 2Huntington Memorial Hospital Becomes First in the San Gabriel Valley to Offer Patients a New Heart Failure Monitoring Solution 3HYPR Corp. Joins the FIDO Alliance 2HYPR Corp. Joins the FIDO Alliance 3higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 2higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 3
... researchers have discovered a novel molecular mechanism that can ... progression of some cancers. In the March 23 online ... scientists from the University of Montreal explain how they ... of inflammatory cytokines that normally activate the immune system, ...
... diagnosis is critical in treating Lyme disease. However, ... initially misdiagnosed because currently available serological tests have ... of infection. Misdiagnosed patients may go untreated and ... face longer and more invasive treatments, as well ...
... National Renewable Energy Laboratory (NREL) recently convened the ... with a mission to enable securitization of solar ... marketplace. SAPC,s primary efforts center on the ... documents relevant to residential and commercial deployment, and ...
Cached Biology News:University of Montreal researchers discover how drug prevents aging and cancer progression 2Penn Researchers attach Lyme disease antibodies to nanotubes, paving way for diagnostic device 2Penn Researchers attach Lyme disease antibodies to nanotubes, paving way for diagnostic device 3Penn Researchers attach Lyme disease antibodies to nanotubes, paving way for diagnostic device 4NREL assembles industry working group to advance solar securitization 2
(Date:4/21/2015)... 2015 Leading-edge research into ... will be presented at the 2nd International ... and clinicians from academia, industry and government ... Invibio Biomaterial Solutions. The world-leading solutions provider ... manufacturing and R&D for medical-device manufacturers, holds ...
(Date:4/21/2015)... Whether it’s used for troubleshooting in a factory, ... Kessler CineDrive in a cinematic studio setting, or ... is designed to help any shooter create vivid high-speed ... the TS5-H offers the same convenient touchscreen controls and streamlined ... According to Tom Boldt for Fastec, “We believe that compelling ...
(Date:4/20/2015)... Stent retriever thrombectomy, an endovascular technique ... brain reduced disability after stroke, according to a ... of the Society of Vascular and Interventional Neurology ... step forward that will change the way we ... Jovin, who is associate professor of Neurology and ...
(Date:4/20/2015)... Champaign, IL (PRWEB) April 20, 2015 ... establishment of its 12th clinical research site: PMG Research ... has assumed operation of the clinical research department at ... footprint outside the Southeast to a second region within ... 150 multi-specialty physician practice enhances PMG’s access to an ...
Breaking Biology Technology:2nd International PEEK Meeting: Invibio Biomaterial Solutions spearheads medical research for implantable PEEK polymer devices 22nd International PEEK Meeting: Invibio Biomaterial Solutions spearheads medical research for implantable PEEK polymer devices 3Fastec Imaging Releases the TS5-H High Definition High-Speed Camera 2Fastec Imaging Releases the TS5-H High Definition High-Speed Camera 3SVIN President Tudor Jovin, MD, Co-Leads Groundbreaking Stroke Study In The New England Journal Of Medicine 2SVIN President Tudor Jovin, MD, Co-Leads Groundbreaking Stroke Study In The New England Journal Of Medicine 3PMG Research Announces the Formation of its 12th Site in Champaign-Urbana, IL 2PMG Research Announces the Formation of its 12th Site in Champaign-Urbana, IL 3
... Oct. 29 Vical Incorporated,(Nasdaq: VICL ) today ... three months and nine months ended September 30, 2008,before ... conduct a,conference call and webcast to discuss the financial ... on Wednesday, November 5. The call is,open on a ...
... Clearance from ... Development Progress Triggered $1M Milestone Payment from Cook Medical - ... 4:30 p.m. Eastern Time -, REDWOOD CITY, Calif., October 28 ... its fiscal 2009 first quarter ended September 30, 2008., "We had ...
... $490 Million, Up 14 Percent over Third Quarter 2007 ... Sales and Earnings Guidance, Introduces 2009 Adjusted Net ... Oct. 28 Cephalon, Inc. (Nasdaq:,CEPH) today reported third quarter ... for the third quarter of 2007, and at the high,end ...
Cached Biology Technology:Vical Announces News Release and Conference Call Schedule For Third Quarter 2008 Financial Results 2Vical Announces News Release and Conference Call Schedule For Third Quarter 2008 Financial Results 3Cardica Announces Fiscal 2009 First Quarter Financial Results 2Cardica Announces Fiscal 2009 First Quarter Financial Results 3Cardica Announces Fiscal 2009 First Quarter Financial Results 4Cardica Announces Fiscal 2009 First Quarter Financial Results 5Cardica Announces Fiscal 2009 First Quarter Financial Results 6Cephalon Reports Another Strong Quarter 2Cephalon Reports Another Strong Quarter 3Cephalon Reports Another Strong Quarter 4Cephalon Reports Another Strong Quarter 5Cephalon Reports Another Strong Quarter 6Cephalon Reports Another Strong Quarter 7Cephalon Reports Another Strong Quarter 8Cephalon Reports Another Strong Quarter 9Cephalon Reports Another Strong Quarter 10Cephalon Reports Another Strong Quarter 11Cephalon Reports Another Strong Quarter 12Cephalon Reports Another Strong Quarter 13Cephalon Reports Another Strong Quarter 14Cephalon Reports Another Strong Quarter 15Cephalon Reports Another Strong Quarter 16Cephalon Reports Another Strong Quarter 17Cephalon Reports Another Strong Quarter 18Cephalon Reports Another Strong Quarter 19
5,6 Carboxyfluorescein is conjugated to BSA (bovine serum albumin) protein through amide bonds....
2,4,6-Trinitrophenyl hapten is conjugated to Bovine Serum Albumin protein through lysine by amide bonds....
... Edwards (1996) • Provides key ... immunoassays, including RIA, ELISA and ... the photoluminescent and chemiluminescent labels ... also given on assay design ...
EoProbe Eosinophil Staining Kit, 1 Kit...
Biology Products: