Navigation Links
UCSD medical/bioengineering reseachers show titanium debris satobtage artificial joints

Microscopic titanium particles weaken the bonding of hip, knee, and other joint replacements, according to research published online in Proceedings of the National Academy of Sciences by researchers at the University of California, San Diego (UCSD) School of Medicine and the Jacobs School of Engineering. The team demonstrated that titanium implants are safe in large blocks, but at the microscopic level, wear and tear can generate micrometer-sized particles.

"As replacement joints are becoming increasingly common in aging populations, our results explain how such devices fail and suggest that improvements should be made in artificial joint design," said the study's senior author K.L. Paul Sung, Ph.D., UCSD professor of orthopedic surgery and adjunct professor of cellular bioengineering.

The team measured how titanium particles affected the bonding strength of pins implanted in rat thighs. The pins were shown to come out more easily when the titanium particles were present, with the smallest and largest particles causing the greatest weakening. The researchers demonstrated how different-sized titanium particles affected bone-building cells called osteoblasts and bone-destroying cells called osteoclasts. Microscopic studies revealed osteoblasts did not form proper adhesions, with small- and medium-sized titanium particles concentrated inside cells. Increased production of the protein RANKL by osteoblasts recruited and activated osteoclasts at the insertion sites, further weakening the bone. Larger titanium particles also activated metalloproteinases, which chop up the extracellular matrix that holds cells together.

###

Currently, Sung is leading a team in using nano-technology to improve implant material which has three to five times higher wear resistance and fatigue properties to reduce particle generation from implants.

In addition to Sung, additional authors were first author Moon G. Choi, M.D., UCSD Department of Orthopedic S urgery; and Hae S. Koh, M.D., UCSD Department of Orthopedic Surgery; Daniel Kluess, M.S. and Daniel O'Connor, M.A., UCSD Department of Bioengineering; Anshu Mathur, Ph.D., George Truskey, Ph.D., Department of Biomedical Engineering, Duke University; Janet Rubin, M.D., Department of Medicine, Emory University School of Medicine and Veterans Administration Medical Center, Atlanta; and David X.F. Zhou, Ph.D., UCSD Department of Bioengineering.


'"/>

Source:UCSD


Related biology news :

1. Bioartificial kidney under study at MCG
2. Ophthalmologists implant five patients with artificial silicon retina microchip
3. Bad aftertaste? New sensory on/off switch may cure bane of artificial sweetener search
4. Researchers create functioning artificial proteins using natures rules
5. UC Berkeley researchers create a biologically-inspired artificial compound eye
6. Secrets of the sea yield stronger artificial bone
7. Stimulation of the semicircular canals can artificially control human walking and balance
8. Bacteria could make new library of cancer drugs that are too complex to create artificially
9. An artificial cornea is in sight, thanks to biomimetic hydrogels
10. Hair-growth drug artificially lowers PSA levels in prostate cancer screening, study finds
11. Mechanical artificial hearts can remove need for heart transplant by returning heart to normal
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/18/2017)... Minn. , Jan. 18, 2017 ... technology company that supports the entire spectrum of ... has been another record-breaking year for the organization ... market interest in MedNet,s eClinical products and services. ... the tremendous marketplace success of iMedNet ...
(Date:1/12/2017)... , Jan. 12, 2017  New research undertaken by ... office of the future.  1,000 participants were simply asked which ... months which we may consider standard issue.  Insights on what ... 2017 were also gathered from futurists and industry leaders including ... James Canton .  Some of ...
(Date:1/11/2017)... NEW BRUNSWICK, N.J. , Jan. 11, 2017  Michael Johnson, ... from Foundation Venture Capital Group, Inc., has been named to the ... Johnson, 27,  was one of 600 people in 20 fields ... only four percent of the 15,000 applicants were selected. ... He is currently a PhD ...
Breaking Biology News(10 mins):
(Date:1/18/2017)... , Jan. 18, 2017   Parent Project ... fight to end Duchenne muscular dystrophy (Duchenne) , ... the New Jersey Institute of Technology (NJIT) and Talem ... exploration of robotic technology to assist people living ... incorporate NJIT,s technology – an embedded computer, software, a ...
(Date:1/18/2017)... , ... January 18, 2017 , ... ... Dr. Dante Leven successfully implanted SpineFrontier’s A-CIFT™ Solofuse-P™. The operation took place on ... Valley Stream, NY. The procedure was an anterior cervical discectomy and fusion on ...
(Date:1/18/2017)... ... January 18, 2017 , ... Announced in December ... Institutes (MII). U.S. Secretary of Commerce Penny Pritzker has announced the award of ... of Defense has announced the award of a new Advanced Regenerative Manufacturing Institute ...
(Date:1/18/2017)... ... 2017 , ... Researchers from a new study are stating that if levels of ... cancer treatment, this indicates there is still remaining prostate cancer cells that are more likely ... test has always been an indicator of whether a man’s prostate cancer is growing ...
Breaking Biology Technology: