Navigation Links
UCSD medical/bioengineering reseachers show titanium debris satobtage artificial joints

Microscopic titanium particles weaken the bonding of hip, knee, and other joint replacements, according to research published online in Proceedings of the National Academy of Sciences by researchers at the University of California, San Diego (UCSD) School of Medicine and the Jacobs School of Engineering. The team demonstrated that titanium implants are safe in large blocks, but at the microscopic level, wear and tear can generate micrometer-sized particles.

"As replacement joints are becoming increasingly common in aging populations, our results explain how such devices fail and suggest that improvements should be made in artificial joint design," said the study's senior author K.L. Paul Sung, Ph.D., UCSD professor of orthopedic surgery and adjunct professor of cellular bioengineering.

The team measured how titanium particles affected the bonding strength of pins implanted in rat thighs. The pins were shown to come out more easily when the titanium particles were present, with the smallest and largest particles causing the greatest weakening. The researchers demonstrated how different-sized titanium particles affected bone-building cells called osteoblasts and bone-destroying cells called osteoclasts. Microscopic studies revealed osteoblasts did not form proper adhesions, with small- and medium-sized titanium particles concentrated inside cells. Increased production of the protein RANKL by osteoblasts recruited and activated osteoclasts at the insertion sites, further weakening the bone. Larger titanium particles also activated metalloproteinases, which chop up the extracellular matrix that holds cells together.

###

Currently, Sung is leading a team in using nano-technology to improve implant material which has three to five times higher wear resistance and fatigue properties to reduce particle generation from implants.

In addition to Sung, additional authors were first author Moon G. Choi, M.D., UCSD Department of Orthopedic S
'"/>

Source:UCSD


Page: 1 2

Related biology news :

1. Bioartificial kidney under study at MCG
2. Ophthalmologists implant five patients with artificial silicon retina microchip
3. Bad aftertaste? New sensory on/off switch may cure bane of artificial sweetener search
4. Researchers create functioning artificial proteins using natures rules
5. UC Berkeley researchers create a biologically-inspired artificial compound eye
6. Secrets of the sea yield stronger artificial bone
7. Stimulation of the semicircular canals can artificially control human walking and balance
8. Bacteria could make new library of cancer drugs that are too complex to create artificially
9. An artificial cornea is in sight, thanks to biomimetic hydrogels
10. Hair-growth drug artificially lowers PSA levels in prostate cancer screening, study finds
11. Mechanical artificial hearts can remove need for heart transplant by returning heart to normal
Post Your Comments:
(Date:8/27/2014)... trans-fats have largely succeeded in sidelining the use ... for its potential contributions to Americans, health conditions. ... the best way to assuage the nation,s insatiable ... Chemical & Engineering News (C&EN), the weekly ... In the article, Stephen Ritter, a senior correspondent ...
(Date:8/27/2014)... As of seven hours ago the Happy Camp Complex ... Northern California, the July complex had consumed 35,530 as ... seventeen fires on the Happy Camp Ranger District of ... the area on August 11, 2014. All but three ... following is a list of contained fires and their ...
(Date:8/26/2014)... St. Louis have developed algorithms to identify weak spots ... breaking. The technology, which needs to be refined before ... pinpoint minor strains and tiny injuries in the body,s ... is available online Aug. 27 in the Journal ... at the nexus of the physical and life sciences. ...
Breaking Biology News(10 mins):Happy Camp and July Fire Complexes in California 2New technology may identify tiny strains in body tissues before injuries occur 2New technology may identify tiny strains in body tissues before injuries occur 3
... as being in perpetual conflict, but a new study by ... major research universities see religion and science as requiring distinct ... of life, ways of understanding reality, origins of Earth and ... science as being at odds and even in irreconcilable conflict," ...
... in German . Jean-Baptiste Lamarck would ... his belief that acquired traits can be passed on to ... of transformation went onto the ash heap of history. But ... can after all leave traces in the genomes of animals ...
... from the medical and research communities held high-level discussions ... Office of Naval Research (ONR), Sept. 16. "ONR,s ... with the Marine Corps component because of the physical ... Research Rear Adm. Nevin Carr. "This meeting of the ...
Cached Biology News:Science and religion do mix 2Science and religion do mix 3Epigenetic changes don't last 2Epigenetic changes don't last 3Epigenetic changes don't last 4ONR officials meet with Navy Surgeon General to coordinate medical research 2
(Date:8/27/2014)... 2014 WriteResult, LLC – a premier ... again shown superiority when it comes to meeting the ... ePRO portion of their most recent study closeout on-time ... chose WriteResult’s digital writing platform to collect Patient Reported ... to complete drew data from a number of assessments ...
(Date:8/26/2014)... and Bellingham, WA (PRWEB) August 26, 2014 ... engineering, visions for next-generation wearable technology, and inspiration ... numerous highlights at this year’s brighter, busier ... Diego, California, Convention Center. More than 4,400 international ... attended conferences, courses, an exhibition, and industry sessions ...
(Date:8/26/2014)... A new argument has just been added to ... its pedestal as the next big thing in ... as MX2 materials. An international collaboration of researchers ... of Energy (DOE),s Lawrence Berkeley National Laboratory (Berkeley ... ultrafast charge transfer in photo-excited MX2 materials. The ...
(Date:8/26/2014)... ARBOR, Mich. , Aug. 26, 2014 /PRNewswire/ ... the development of breakthrough oral medicines to treat ... of immune modulation, today announced the appointment of ... the company,s scientific advisory board.  Dr. Singh will ... insight to advance Lycera,s multiple ongoing research programs ...
Breaking Biology Technology:A Perfect Record: WriteResult Maintains a 100% On-Time ePRO Record with Latest Irritable Bowel (IBS) Study Data Lock 2Brighter, Busier SPIE Optics + Photonics Draws International Crowd to San Diego 2Brighter, Busier SPIE Optics + Photonics Draws International Crowd to San Diego 3Brighter, Busier SPIE Optics + Photonics Draws International Crowd to San Diego 4Competition for graphene 2Lycera Appoints Harinder Singh, Ph.D., as Chair of Scientific Advisory Board 2Lycera Appoints Harinder Singh, Ph.D., as Chair of Scientific Advisory Board 3
... Logical Therapeutics, Inc., a,biotechnology company focused ... associated with poorly controlled inflammation, announced today,the ... controlled multi-dose,safety and pharmacokinetics study of LT-NS001, ... was conducted from December, 2007,through July, 2008 ...
... Pharmacology Space and Drug Target Knowledge Databases ... Related to Nuclear Receptors and Proteases, ... provider of,knowledge management solutions that accelerate life sciences discovery,announced ... The new offerings include knowledge databases for the important,drug ...
... Board: LFVN), the maker of Protandim(R), the only product,clinically ... announced,that the company,s President & CEO, David Brown, is ... The interview gives viewers an overview of the ... To view the clip in ...
Cached Biology Technology:Logical Therapeutics Inc. Announces Results of Phase 1b Clinical Study of its Naproxen Prodrug 2Aureus Pharma Releases New Unified Knowledge Database 2[video] David Brown, President and CEO of LifeVantage Corporation, Discusses Record Page Views on WallSt.net's 3-Minute Press Show 2
... The Fluorescence Test Plate consists of an ... with Inert Organic Fluorescent Compounds embedded in ... used on BioTeks FLx800 and Synergy Multi-Detection ... for GLP compliance while reducing the need ...
... line is a Greenough stereomicroscope designed for the ... available with a choice of a large working ... (N2GG). This microscope can be easily connected to ... the same time giving you ultimate flexibility. Available ...
... MATra-si Reagent optimized for siRNA applications, contains ... with the nucleic acid of interest. Exploiting ... is then rapidly drawn towards and delivered ... transfection. MATra-si Reagent can be used for ...
...
Biology Products: