Navigation Links
UCSD medical/bioengineering reseachers show titanium debris satobtage artificial joints

Microscopic titanium particles weaken the bonding of hip, knee, and other joint replacements, according to research published online in Proceedings of the National Academy of Sciences by researchers at the University of California, San Diego (UCSD) School of Medicine and the Jacobs School of Engineering. The team demonstrated that titanium implants are safe in large blocks, but at the microscopic level, wear and tear can generate micrometer-sized particles.

"As replacement joints are becoming increasingly common in aging populations, our results explain how such devices fail and suggest that improvements should be made in artificial joint design," said the study's senior author K.L. Paul Sung, Ph.D., UCSD professor of orthopedic surgery and adjunct professor of cellular bioengineering.

The team measured how titanium particles affected the bonding strength of pins implanted in rat thighs. The pins were shown to come out more easily when the titanium particles were present, with the smallest and largest particles causing the greatest weakening. The researchers demonstrated how different-sized titanium particles affected bone-building cells called osteoblasts and bone-destroying cells called osteoclasts. Microscopic studies revealed osteoblasts did not form proper adhesions, with small- and medium-sized titanium particles concentrated inside cells. Increased production of the protein RANKL by osteoblasts recruited and activated osteoclasts at the insertion sites, further weakening the bone. Larger titanium particles also activated metalloproteinases, which chop up the extracellular matrix that holds cells together.

###

Currently, Sung is leading a team in using nano-technology to improve implant material which has three to five times higher wear resistance and fatigue properties to reduce particle generation from implants.

In addition to Sung, additional authors were first author Moon G. Choi, M.D., UCSD Department of Orthopedic S
'"/>

Source:UCSD


Page: 1 2

Related biology news :

1. Bioartificial kidney under study at MCG
2. Ophthalmologists implant five patients with artificial silicon retina microchip
3. Bad aftertaste? New sensory on/off switch may cure bane of artificial sweetener search
4. Researchers create functioning artificial proteins using natures rules
5. UC Berkeley researchers create a biologically-inspired artificial compound eye
6. Secrets of the sea yield stronger artificial bone
7. Stimulation of the semicircular canals can artificially control human walking and balance
8. Bacteria could make new library of cancer drugs that are too complex to create artificially
9. An artificial cornea is in sight, thanks to biomimetic hydrogels
10. Hair-growth drug artificially lowers PSA levels in prostate cancer screening, study finds
11. Mechanical artificial hearts can remove need for heart transplant by returning heart to normal
Post Your Comments:
(Date:4/20/2015)... DUBAI , April 20, 2015 ... soars   Glenbeigh Records Management (GRM), ... contract with Dubai Islamic Bank. Having built up an impressive ... is now a leading player within the records management sector ... company expects to double is GCC staffbase and employ a ...
(Date:4/13/2015)... April 13, 2015  higi, a leading cloud-based consumer ... more fully engage with their communities around health and ... protected and secure API.  ... most accessible, affordable, and convenient vehicle to receive validated ... The API will allow higi,s trusted ...
(Date:4/2/2015)... 2, 2015 In the ... far outperforms the strongest competitors, showing outstanding performance ... the system is capable of a throughput of ... up to be ten times faster than most ... performance.      (Photo: http://photos.prnewswire.com/prnh/20150402/738673-a ...
Breaking Biology News(10 mins):Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 2Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 3higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 2higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 3DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 2DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 3
... office on the Texas A&M University campus, Dr. Marty Dickman,s ... pursuit of scientific excellence that,s what,s fun," Dickman said. ... is to understand what the problems are, how things work ... Dickman paused briefly and with gratitude recently to reflect on ...
... Ten researchers at the University of California, Riverside have ... of Science ( AAAS ). Including this year,s fellows, the ... with AAAS Fellow distinction is 190. Election as a ... peers. This year AAAS gave this honor to 503 of ...
... Iowa State University two of them are also affiliated ... been named fellows of the American Association for the Advancement ... their award citations are: Srinivas ... of Computer Engineering, "For distinguished contributions to high performance computational ...
Cached Biology News:Marty Dickman named AAAS Fellow 210 UC Riverside researchers recognized by the American Association for the Advancement of Science 210 UC Riverside researchers recognized by the American Association for the Advancement of Science 3AAAS honors Iowa State, Ames Lab researchers for distinguished science 2
(Date:4/21/2015)... (PRWEB) April 21, 2015 Staying true ... to craft a digital product that makes the world ... with Global Biological Standards Institute (GBSI) to redesign their ... clean, and most importantly, strategy-based. , "Biomedical research is ... - much less to promote it in a narrative ...
(Date:4/21/2015)... , April 21, 2015 ... and development, custom automation, and contract manufacturing, and  ... accessible flow cytometry and cell sorting technology for ... develop a novel flow cytometry platform. ... NanoCellect Biomedical has developed a microchip-based cell sorting ...
(Date:4/21/2015)... , April 21, 2015  Tute Genomics, a leading ... of Josh Forsythe as VP of Marketing. Mr. ... witnessed a significant expansion in its commercial operations over the ... " Josh Forsythe is a tremendous addition ... MD MBA, CEO of Tute Genomics. "Josh,s vast experience commercializing ...
(Date:4/21/2015)... and RESEARCH TRIANGLE PARK, N.C. , ... UTHR ) announced today that it will release ... on Tuesday, April 28, 2015. United Therapeutics ... 2015, at 9:00 a.m. Eastern Time.  The teleconference is ... A rebroadcast of the teleconference will be available for ...
Breaking Biology Technology:Visceral Tells GBSI’s Story Within 30 Seconds of Attention 2Visceral Tells GBSI’s Story Within 30 Seconds of Attention 3NanoCellect And Invetech Announce Collaboration To Develop Novel Flow Cytometry Platform For Cell Sorting And Analysis 2NanoCellect And Invetech Announce Collaboration To Develop Novel Flow Cytometry Platform For Cell Sorting And Analysis 3Tute Genomics Continues Expansion of Genomic Medicine Commercial Operations; Appoints Josh Forsythe as New VP of Marketing 2Tute Genomics Continues Expansion of Genomic Medicine Commercial Operations; Appoints Josh Forsythe as New VP of Marketing 3Tute Genomics Continues Expansion of Genomic Medicine Commercial Operations; Appoints Josh Forsythe as New VP of Marketing 4
... 18 Danaher Corporation (NYSE: DHR ) announced today ... indirect wholly owned subsidiary, to acquire all of the issued and ... pence per share implying an aggregate price of approximately GBP 50 ... The offer enjoys the recommendation of the Board of Genetix who ...
... , Toronto Stock Exchange Symbol: ... (TSX: MS) today provided the following update on corporate developments: ... -----------------, , The Company has completed its substantive review of ... drug candidate for the treatment of multiple sclerosis (MS). BioMS ...
... , , , , ... stem cell based,technology of Cellonis Biotechnologies, Beijing, a Chinese research/medical,team ... 36 year old Norwegian,patient in a hospital in Beijing. The ... stem cells as well as cancer daughter,cells. The amazing outcome ...
Cached Biology Technology:Danaher Offers to Acquire Genetix Group plc for GBP 50 million pounds Sterling (USD $82 million) 2BioMS Medical provides corporate update 2BioMS Medical provides corporate update 3For the First Time, a Glioma - Brain Cancer - may be Eliminated by a Chinese Research/Medical Team, Using a Novel Stem Cell Based Therapy of Cellonis Biotech, Beijing 2For the First Time, a Glioma - Brain Cancer - may be Eliminated by a Chinese Research/Medical Team, Using a Novel Stem Cell Based Therapy of Cellonis Biotech, Beijing 3For the First Time, a Glioma - Brain Cancer - may be Eliminated by a Chinese Research/Medical Team, Using a Novel Stem Cell Based Therapy of Cellonis Biotech, Beijing 4
... is the only PCR system that ensures ... time. It provides accuracy, consistency, and dependability ... the property of the DNA templates. This ... a unique blend of thermostable enzymes that ...
Special grade: for molecular biology Density: 1.000 g/mL (20 C)...
... Designed to meet the needs ... animal component-free medium supports fast ... cell densities, while maintaining high ... protein production using the Baculovirus ...
... This CLS number ... number, created to easily ... If showing no availability ... the old Sigma-Aldrich number ...
Biology Products: