Navigation Links
UCSD medical/bioengineering reseachers show titanium debris satobtage artificial joints

Microscopic titanium particles weaken the bonding of hip, knee, and other joint replacements, according to research published online in Proceedings of the National Academy of Sciences by researchers at the University of California, San Diego (UCSD) School of Medicine and the Jacobs School of Engineering. The team demonstrated that titanium implants are safe in large blocks, but at the microscopic level, wear and tear can generate micrometer-sized particles.

"As replacement joints are becoming increasingly common in aging populations, our results explain how such devices fail and suggest that improvements should be made in artificial joint design," said the study's senior author K.L. Paul Sung, Ph.D., UCSD professor of orthopedic surgery and adjunct professor of cellular bioengineering.

The team measured how titanium particles affected the bonding strength of pins implanted in rat thighs. The pins were shown to come out more easily when the titanium particles were present, with the smallest and largest particles causing the greatest weakening. The researchers demonstrated how different-sized titanium particles affected bone-building cells called osteoblasts and bone-destroying cells called osteoclasts. Microscopic studies revealed osteoblasts did not form proper adhesions, with small- and medium-sized titanium particles concentrated inside cells. Increased production of the protein RANKL by osteoblasts recruited and activated osteoclasts at the insertion sites, further weakening the bone. Larger titanium particles also activated metalloproteinases, which chop up the extracellular matrix that holds cells together.

###

Currently, Sung is leading a team in using nano-technology to improve implant material which has three to five times higher wear resistance and fatigue properties to reduce particle generation from implants.

In addition to Sung, additional authors were first author Moon G. Choi, M.D., UCSD Department of Orthopedic S
'"/>

Source:UCSD


Page: 1 2

Related biology news :

1. Bioartificial kidney under study at MCG
2. Ophthalmologists implant five patients with artificial silicon retina microchip
3. Bad aftertaste? New sensory on/off switch may cure bane of artificial sweetener search
4. Researchers create functioning artificial proteins using natures rules
5. UC Berkeley researchers create a biologically-inspired artificial compound eye
6. Secrets of the sea yield stronger artificial bone
7. Stimulation of the semicircular canals can artificially control human walking and balance
8. Bacteria could make new library of cancer drugs that are too complex to create artificially
9. An artificial cornea is in sight, thanks to biomimetic hydrogels
10. Hair-growth drug artificially lowers PSA levels in prostate cancer screening, study finds
11. Mechanical artificial hearts can remove need for heart transplant by returning heart to normal
Post Your Comments:
(Date:9/2/2014)... the University of Warwick in the UK and the ... Journal Early Human Development , has found that ... birth and the use of mechanical ventilation are key ... Mathematic abilities are crucial for lifelong academic attainment. Impairments ... Earlier studies of children who are born very preterm ...
(Date:9/2/2014)... that migrate by night tend to fly faster in ... destinations. This seasonal difference in flight speed is especially ... says researcher Cecilia Nilsson of Lund University in Sweden, ... , Nilsson, in a group led by professor ... three years the speed by which birds flew over ...
(Date:9/2/2014)... spiky legs and their propensity for eating anything, including ... And now research from North Carolina State University finds ... across the eastern United States. , "The good news ... kind of threat to humans," says Dr. Mary Jane ... author of a paper about the research. , The ...
Breaking Biology News(10 mins):Mechanical ventilation a key indicator for pre-term children's math problems 2Migrating birds sprint in spring, but take things easy in autumn 2Researchers find Asian camel crickets now common in US homes 2
... researchers and their colleagues have identified the gene that is ... called paraganglioma (PGL). The gene, called hSDH5, is required for ... in the chemical reactions that take place within cells to ... published in the journal Science , to be released ...
... that reveal some of the attributes of the long-lived leaves ... relatively large and are constructed of tough tissues," said Marler. ... leaf form are substantial." Green leaves must pay back ... to supply the energy needed to maintain its live tissues ...
... KNOXVILLE, Tenn. Consider the case of the three-spine ... in fresh water might appear to be the same, ... diverse collection of very specialized individuals. Understanding ... is the goal of a group of scientists meeting ...
Cached Biology News:Scientists discover gene mutation responsible for hereditary neuroendocrine tumor 2Scientists discover gene mutation responsible for hereditary neuroendocrine tumor 3High construction cost for cycads 2The value of variation: Ecologists consider the causes and consequences 2
(Date:9/2/2014)... (PRWEB) September 02, 2014 PMG ... its 11th clinical research site: PMG Research of Rocky ... and operation of the clinical research department at ... PMG’s presence in eastern North Carolina. This new site ... the patients in Rocky Mount and the surrounding communities, ...
(Date:9/1/2014)... Reportlinker.com announces that a new market ... India Solid Waste Management Vehicles Market Forecast ... In India ... responsible for complete handling and regulation of solid ... 135,000 MT solid waste is generated daily in ...
(Date:8/31/2014)... September 01, 2014 Available spectra ... needs for research and cultivation of a wide ... Valoya’s proprietary LEDs with proven patented and pending ... uncompromised light uniformity in critical applications in contrast ... LEDs. , “Our customers have a large variety ...
(Date:8/29/2014)... Aug. 29, 2014  Pfenex Inc. (NYSE MKT: ... development of high-value and difficult to manufacture proteins ... and reported financial results for the second quarter ... successful completion of our initial public offering, we ... biosimilar product candidates, derived from our proprietary protein ...
Breaking Biology Technology:PMG Research Announces the Formation of its Eleventh Site 2PMG Research Announces the Formation of its Eleventh Site 3India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 2India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 3India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 4India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 5India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 6India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 7India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 8Pfenex Reports Second Quarter 2014 Results and Provides Business Update 2Pfenex Reports Second Quarter 2014 Results and Provides Business Update 3Pfenex Reports Second Quarter 2014 Results and Provides Business Update 4Pfenex Reports Second Quarter 2014 Results and Provides Business Update 5Pfenex Reports Second Quarter 2014 Results and Provides Business Update 6Pfenex Reports Second Quarter 2014 Results and Provides Business Update 7Pfenex Reports Second Quarter 2014 Results and Provides Business Update 8
... has closed the nominations for the 2011 Life Science ... 2011, hundreds of scientists on The Science Advisory Board® ... the ballot to determine the recipients of the prestigious ... survey, will be available to fill out between September ...
... Mass. and TORONTO, Sept. 21, 2011 Generex Biotechnology ... Express, Inc. ( www.antigenexpress.com ), today announced that its ... in Phase II development for the treatment of breast ... Scientific American , in a story titled "A ...
... Wales, Sept. 21, 2011 Genesis Biosciences, a ... and antimicrobial product development, announced today that Casey ... operations. Additionally, Mauricio Amaya and Amit Choksi have ... respectively, and Prasanth Maddipati joins Genesis as a ...
Cached Biology Technology:BioInformatics LLC Announces the Nominees for the 2011 Life Science Industry Awards® 2BioInformatics LLC Announces the Nominees for the 2011 Life Science Industry Awards® 3BioInformatics LLC Announces the Nominees for the 2011 Life Science Industry Awards® 4Antigen Express' AE37 Cancer Vaccine Featured in Scientific American 2Antigen Express' AE37 Cancer Vaccine Featured in Scientific American 3Antigen Express' AE37 Cancer Vaccine Featured in Scientific American 4Genesis Biosciences Announces New Hire and Promotions on Operational and Scientific Staff 2Genesis Biosciences Announces New Hire and Promotions on Operational and Scientific Staff 3Genesis Biosciences Announces New Hire and Promotions on Operational and Scientific Staff 4
... Monoclonal Mouse Antibody to Cytokeratin 5 / ... a high molecular weight, basic type of ... the superficial cell layers of stratified epithelia ... and in mesothelial cells and mesothelioma. Cytokeratin ...
Bovine Coronary Artery Endothelial Cells (BCAEC) (>500,000 cells)...
Bovine Renal Artery Endothelial Cells (BRAEC) (>500,000 cells)...
Bovine Aortic Smooth Muscle Cells (BAOSMC) (>500,000 cells)...
Biology Products: