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UCSD discovery may help extend life of natural pesticide

ski, coauthors and entomologists at the University of Georgia, showed that the glycolipid receptor is present in the tobacco hornworm, an insect pest that is susceptible to Bt toxins used commercially in plants.

"It will now be possible to monitor insect populations near fields where Bt is used and catch insect resistance in its early stages by looking for changes in glycolipids," said Aroian. "If changes are detected, switching to another pesticide, perhaps even another variety of Bt that works through a different mechanism, could prevent the resistance genes from becoming widespread."

According to the researchers, prior work indicates that there are other receptors that also contribute to Bt resistance. Combining pesticides that work through different receptors or designing pesticides that can work through more than one receptor type could thwart the development of resistance.

"This paper presents an intriguing question," said Griffitts. "In light of findings by insect biologists that certain proteins function as important Bt toxin receptors in some cases, how might glycolipid and protein receptors cooperate to engage this intoxication program? If the field can figure this out, it might allow for the engineering of toxins that can utilize either type of receptor alternatively, such that host resistance would require the mutation of both receptor types. This means that resistance would be exponentially less probable."


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Source:University of California - San Diego


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