Navigation Links
UCSD Discovery Shows How Embryonic Stem Cells Perform 'Quality Control' Inspections

e system's 'a la carte' process happens is still murky," says Craig. But the a la carte approach provides great diversity from a limited number of choices, whether in the immune system or in a cafeteria. For example, at a cafeteria, one diner could have a meal of mashed potatoes, broccoli and a pork chop, and another French fries, salad and a hamburger, and so on through all the possible combinations of offerings. While the choices aren't as tasty, immune cells select sections of certain genetic instructions in order to make instructions for a protein that will recognize a particular antigen. Machinery snips out unwanted genetic sections and reconnects the leftover ones, creating a unique gene (the cellular equivalent of the diner's meal). Snipping out different sections will lead to a different gene, carrying instructions for a different protein that will recognize a different antigen, and on and on. This a la carte process, known as V(D)J recombination, is similar to the excision of jumping genes, but none had matched one of its characteristic oddities: As the unwanted DNA is being removed, the remaining DNA forms a tiny loop. Unexpectedly, when Hermes is being cut out of the DNA, the leftover DNA also forms a hairpin loop, temporarily doubling back on itself, postdoctoral fellows Liqin Zhou, Ph.D., and Rupak Mitra, Ph.D., discovered in experiments in test tubes and with E. coli bacteria. Although this loop distances Hermes from its well-studied cousins, the Hermes protein still has an important family trait, the researchers report. Colleagues at the National Institutes of Health found that a few key building blocks in the protein's DNA-snipping crevice are identical to those in other jumping genes' proteins, even though the overall sequence is quite different. "Because of its similarities both to V(D)J recombination and to other families of jumping genes, Hermes is the first real link between the two processes," says Craig. "It also is likely to be a good model t
'"/>

Source:


Page: 1 2 3

Related biology news :

1. Fundamental Finding Yields Insight into Stem Cells, Cancer; Opens Door to Drug Discovery
2. Discovery of key proteins shape could lead to improved bacterial pneumonia vaccine
3. Discovery Could Lead To Novel Approaches In HIV Treatment
4. Discovery Promises Simpler Therapy for Sickle Cell Disease
5. Discovery may lead to better Candidiasis drug
6. Protein Discovery Could Unlock The Secret To Better TB Treatment
7. Discovery clarifies role of peptide in biological clock
8. Eliminate Data Analysis Bottlenecks in Drug Discovery
9. Discovery of New Dopamine Action May Yield Alternative Psychiatric Drugs
10. Discovery could be key to bioterrorism defense
11. Discovery of an American salamander where it shouldnt be: Korea
Post Your Comments:
(Date:4/2/2015)... 2015 In the current ... outperforms the strongest competitors, showing outstanding performance in ... system is capable of a throughput of 5.000.000 ... to be ten times faster than most competitors ...      (Photo: http://photos.prnewswire.com/prnh/20150402/738673-a ) ...
(Date:4/1/2015)... 1, 2015   Medisafe ™, the leading global ... iOS and Android smartphones and ... into the platform to allow patients to track and ... first time, patients will be able to visualize in ... important biometrics, such as glucose levels and blood pressure. ...
(Date:3/24/2015)... Mar. 24, 2015 Research and Markets ... "Global Iris Recognition Market 2015-2019" report to ... Iris Recognition market to grow at a CAGR of ... report covers the present scenario and the growth prospects ... 2015-2019. To calculate the market size, the report considers ...
Breaking Biology News(10 mins):DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 2DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 3Medisafe Announces Launch of Biometric Integration, Enabling Patients to Stay Adherent to Their Meds and See Tangible Health Results 2Global Iris Recognition Market 2015-2019 with 3M Cogent, Bioenable Technologies, Cross Match Technology, Iris ID Systems & Safran Dominating 2
... French . , Two McGill researchers have ... Fellowships. Dr. Andrew P. Hendry an associate professor with ... Dr. Karim Nader, an associate professor and Willam Dawson ... the prestigious fellowships from the Natural Sciences and Engineering ...
... emotional toll on our bodies and scientists are working on ... to stress at the cellular level in the brain. ... essential for survival. Using a rat model, Jaideep ... of researchers at the Hotchkiss Brain Institute have discovered that ...
... for pregnant women and their children, and vitamin B12 ... any common multivitamin, say doctors and dietitians with the ... are available for comment in response to a new ... vitamin B12 may increase the risk for neural tube ...
Cached Biology News:2 McGill researchers garner prestigious NSERC Steacie Fellowships 2New and unexpected mechanism identified how the brain responds to stress 2Doctors endorse vegan and vegetarian diets for healthy pregnancies 2
(Date:5/4/2015)... , May 4, 2015   Intrexon Corporation ... first quarter 2015 financial results after the market closes ... conference call that day at 5:30 PM ET to ... The conference call may be accessed by ... to join the "Intrexon Conference Call."  Participants may also ...
(Date:5/1/2015)... OncoTAb, Inc., a University of North ... Pinku Mukherjee, Ph.D. has received the O. Max ... faculty honor. Mukherjee received the award, which recognizes ... research and development of cancer diagnostics and treatments. , ... in my scientific career,” said Mukherjee, OncoTAb Co-founder and ...
(Date:5/1/2015)... 1, 2015 A new report ... drugs will reach $22.4bn in 2019. That revenue forecast ... and Market Prospects 2015-2025 ,  published in ... is to provide forecasts and qualitative analyses of the ... and consultancy in London, UK . ...
(Date:5/1/2015)... and RESEARCH TRIANGLE PARK, N.C. , ... ) announced today that Roger Jeffs , Ph.D., President ... overview and update on the company,s business at the Deutsche ... Boston, Massachusetts . The presentation will ... Eastern Time, and can be accessed via a live webcast ...
Breaking Biology Technology:Intrexon to Announce First Quarter 2015 Financial Results on Monday, May 11, 2015 2OncoTAb CSO Awarded the University of North Carolina’s O. Max Gardner Award 2Antithrombotic Drugs: World Industry and Market Prospects 2015-2025 2Antithrombotic Drugs: World Industry and Market Prospects 2015-2025 3Antithrombotic Drugs: World Industry and Market Prospects 2015-2025 4Antithrombotic Drugs: World Industry and Market Prospects 2015-2025 5
... Middle East,s only forum for the global pharma/biotech industries, Pharmaceutical Manufacturing ... ... April 2008, DUBAI, United Arab Emirates, Sept. 4 The Middle ... and with annual growth in double digits. The market,drivers are: -- ...
... Exists Between Understanding Cholesterol Monitoring Versus ... N.J., Sept. 4, 2007 A recent survey ... spite of concerns about the,serious health risks associated ... coronary heart disease, there is a significant disconnect,between ...
... Calif., Sept. 4 Volcano,Corporation (Nasdaq: VOLC ... measurement (FM) products designed to enhance the diagnosis,and ... today that it,will be participating in the Bear ... The presentation by Scott Huennekens, president and chief ...
Cached Biology Technology:New Survey Reveals Many Adults With High Cholesterol Fail to Take Necessary Steps to Improve Their Condition 2New Survey Reveals Many Adults With High Cholesterol Fail to Take Necessary Steps to Improve Their Condition 3New Survey Reveals Many Adults With High Cholesterol Fail to Take Necessary Steps to Improve Their Condition 4New Survey Reveals Many Adults With High Cholesterol Fail to Take Necessary Steps to Improve Their Condition 5New Survey Reveals Many Adults With High Cholesterol Fail to Take Necessary Steps to Improve Their Condition 6New Survey Reveals Many Adults With High Cholesterol Fail to Take Necessary Steps to Improve Their Condition 7Volcano Corporation Presentation at Bear Stearns Conference to be Webcast 2