Navigation Links
UCR chemist part of team identifying new areas of gene regulation

Researcher Kangling Zhang at the University of California, Riverside is part of a team that has discovered a new way that yeast governs genetic expression and repression, a finding that could be repeated in cells of other organisms.

Zhang, an academic coordinator at the Mass Spectrometry Facility of the Department of Chemistry at UCR, worked with Feng Xu and Michael Grunstein of the Department of Biological Chemistry at the David Geffen School of Medicine at UCLA on a paper titled Acetylation in Histone H3 Globular Domain Regulates Gene Expression in Yeast, which was published today in the journal Cell.

The paper focuses on observations of histones, the proteins that regulate genetic expression and form the major supporting structures housing the cell's DNA. Histones interacting with each other form a 'spool' around which DNA is wrapped in the cell. Grunstein, one of the scientists in the current team, discovered in 1991 that sites of histone acetylation, a modification of the protein, play a fundamental role in the regulation of gene activation and repression.

The key findings of the current paper were the discovery of this acetylation at the core of the histone, rather than at the proteins' ends, which are where most gene regulation is thought to take place. The team used mass spectrometry to show that acetylation at the core of the histone is associated with gene activation by attracting the protein string known as the SWI/SNI chromatin remodeling complex to the location of acetylation.

"In this paper, we used mass spectrometry to identify a novel acetylation site at the lysine 56 of yeast histone H3," said Zhang, referring to the previously unknown location of a chemical opening to allow genetic transfers to occur.

"We found acetylation at this site near the entry-exit points of the DNA superhelix as it wraps around the nucleosome is required for recruiting the nucleosome remodeling complex SWI/SNF and so regulates gene act
'"/>

Source:University of California - Riverside


Page: 1 2

Related biology news :

1. ASU researchers finds novel chemistry at work to provide parrots vibrant red colors
2. Biochemists report discovery of structure of major piece of telomerase; implications for cancer
3. Red delicious, Northern Spy apples have most antioxidants, chemists find
4. Breakthrough in micro-device fabrication combines biology and synthetic chemistry
5. UCR biochemist goes to Washington with high-protein corn
6. NYU chemists use computer simulation to enhance understanding of DNA transcription
7. Male elephants woo females with precise chemistry
8. Computer-chemistry yields new insight into a puzzle of cell division
9. MIT chemist discovers secret behind natures medicines
10. Precision biochemistry tracks DNA damage in fish
11. Smoking changes brain chemistry
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: UCR chemist part team identifying new areas gene regulation

(Date:4/23/2014)... shows that male black widow spiders prefer their female ... of mate preference by male spiders. , ... Maydianne Andrade, a professor in UTSC,s Department of Biological ... wild that males overwhelmingly chose to mate with well-fed, ... tell whether a potential mate is well-fed and unmated ...
(Date:4/23/2014)... Scientists have conclusive evidence that the source of a ... Ocean and called the "bio-duck," is the Antarctic minke ... by submarine personnel in the 1960s who thought it ... recorded at various locations in the Southern Ocean, but ... In February 2013, an international team of researchers deployed ...
(Date:4/23/2014)... group decision increases with the abundance of brains involved ... variety of factors as often happens in life ... groups actually tend to make more accurate decisions while ... pieces of information. , The findings present a significant ... the "wisdom of crowds," wherein individual observations even ...
Breaking Biology News(10 mins):Picky male black widow spiders prefer well-fed virgins 2Scientists identify source of mysterious sound in the Southern Ocean 2Scientists identify source of mysterious sound in the Southern Ocean 3Too many chefs: Smaller groups exhibit more accurate decision-making 2Too many chefs: Smaller groups exhibit more accurate decision-making 3
... herders are facing the challenges of adapting to climate ... for herds to find food and navigate. To help ... them with satellite-based snow maps. "Snow is of ... whether reindeer are able to access the pastures that ...
... ANN ARBOR, Mich. Head and neck cancer patients who ... they were diagnosed had worse survival outcomes than those with ... University of Michigan Comprehensive Cancer Center. "While there has ... be linked to cancer survival, the health habits a person ...
... report finds that man-made toxic chemicals used as flame retardants in consumer products are found in all US coastal ... Click here for more information. , ... , , , ... , , , , ...
Cached Biology News:Satellite snow maps help reindeer herders adapt to a changing Arctic 2Health choices predict cancer survival, U-M study finds 2NOAA report calls flame retardants concern to US coastal ecosystems 2NOAA report calls flame retardants concern to US coastal ecosystems 3NOAA report calls flame retardants concern to US coastal ecosystems 4
(Date:1/15/2014)... and SAN JOSE, California , ... biotechnology company developing antibody-drug conjugates for cancer, today announced the ... of Directors. Dr Reynolds has over 20 years, development experience ... Officer at Seattle Genetics. "I am delighted to ...
(Date:1/15/2014)... Two champions of science, technology, engineering, and ... annual competition for middle and high school students designed ... study. The competition presents students with real-world problems experienced ... Mathematics, and Sciences is a program administered by ...
(Date:1/15/2014)... AudioNotch is the internet's leading provider ... treatment of tinnitus. Patients listen to sound therapy that ... period of weeks to months, their tinnitus volume decreases. , ... Notched Music and Notched White Noise. Now, AudioNotch is pleased ...
(Date:1/14/2014)... 14, 2014  3D Communications, a leading provider of strategic communications services ... media events in the United States and ... Virginia Cox , JD, is returning to the firm,s ... re-joins 3D after more than two years of service as Associate ...
Breaking Biology Technology:Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 2Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 3Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 2Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 3Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 4Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 5Former FDA Associate Commissioner Returns To 3D Communications 2
... investment in science and technology, as well expand ... third Office of Naval Research (ONR)-sponsored International Lecture ... headquarters. "The Arrival of Brazil" lecture featured ... Warfare Center, Carderock; Dr. Eugenius Kaszkurewicz, director of ...
... Oct. 22 Shrink Nanotechnologies, Inc. ("Shrink") (OTC ... nanotechnology company developing products and licensing opportunities in ... and biotechnology research and development tools businesses, announced ... to produce a high content screening tool for ...
... Encorium Group, Inc. (Nasdaq:  ENCO), (the "Company"), ... conducting studies in over 30 countries for many ... today announced that, on October 20, 2010, it ... (the "Panel") has determined to delist the Company,s ...
Cached Biology Technology:ONR lecture focuses on Brazil's growth in global science and technology 2Shrink Nanotechnologies Enters Into Agreement to Produce High Content Screening Software Called 'Stemage' for its StemDisc Stem Cell Culturing Products 2Shrink Nanotechnologies Enters Into Agreement to Produce High Content Screening Software Called 'Stemage' for its StemDisc Stem Cell Culturing Products 3Shrink Nanotechnologies Enters Into Agreement to Produce High Content Screening Software Called 'Stemage' for its StemDisc Stem Cell Culturing Products 4Shrink Nanotechnologies Enters Into Agreement to Produce High Content Screening Software Called 'Stemage' for its StemDisc Stem Cell Culturing Products 5Encorium Announces NASDAQ Panel Decision to Delist Common Stock; Announces Changes to its Board of Directors 2Encorium Announces NASDAQ Panel Decision to Delist Common Stock; Announces Changes to its Board of Directors 3Encorium Announces NASDAQ Panel Decision to Delist Common Stock; Announces Changes to its Board of Directors 4
Features , Designed to assist users in applying domed caps to tube strips and plates , Minimises the pressure required to seal the caps effectively , Enables multiple tubes to be sealed simultaneousl...
Request Info...
Sterile, individually wrapped, 4mm Cuvettes...
versican (H-56)...
Biology Products: