Navigation Links
UCLA study uncovers clues for why Graves' disease attacks the eyes

UCLA researchers have uncovered new clues that may explain why Graves?disease (GD) attacks the muscle tissue behind the eyes, often causing them to bulge painfully from their sockets, as in the late actor Marty Feldman.

Scientists at UCLA’s Jules Stein Eye Institute and Harbor-UCLA Medical Center discovered defects in the infection-fighting T-cells of GD patients?immune systems. Reported March 1 in the Journal of Immunology, their study may deepen understanding of how the autoimmune disorder damages the body and offer a new target for treating the disfiguring disease.

Earlier research found that GD patients?immune systems produce an antibody that other people do not. Not recognizing the patient’s thyroid as "self," the antibody mistakenly mounts an attack against the organ, causing inflammation and damage to the body, including eye tissue.

In the current study, UCLA researchers discovered that T-cells taken from GD patients contain an abnormal surplus of the receptor targeted by this antibody. An antibody must latch to a specific receptor ?like a key into a lock -- in order to elicit a cellular response. The receptors mobbed the patients?immune systems, even on T-cells that normally would not produce them.

"We didn’t know why GD patients?cells created a new antibody, but had a hunch that that it sprang from an immune abnormality," explained Dr. Raymond Douglas, first author and assistant professor of ophthalmology at the Jules Stein Eye Institute. "Because T-cells are the generals of the immune system and lead the attack in any immune response, we assumed that they played a key role in this antibody’s development."

The team tested GD patients?blood for the antibody and compared their findings to samples from healthy people, with about 100 subjects in each group. The new antibody was found in almost all of the GD patients?blood.

The new antibody binds to the excess receptors on the T-cells, mimic
'"/>

Source:University of California - Los Angeles


Page: 1 2

Related biology news :

1. Bioartificial kidney under study at MCG
2. W.M. Keck Foundation funds study of friendly microbes
3. Yellowstone microbes fueled by hydrogen, according to U. of Colorado study
4. Genome-wide mouse study yields link to human leukemia
5. Clam embryo study shows pollutant mixture adversely affects nerve cell development
6. New imaging method gives early indication if brain cancer therapy is effective, U-M study shows
7. Same mutation aided evolution in many fish species, Stanford study finds
8. Sequencing of marine bacterium will help study of cell communication
9. Genetically modified rice in China benefits farmers health, study finds
10. A new study examines how shared pathogens affect host populations
11. NYU study reveals how brains immune system fights viral encephalitis
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: UCLA study uncovers clues for why Graves disease attacks the eyes

(Date:7/11/2014)... Salk Institute for Biological Studies, BGI, and other ... and reliability of the existing targeted gene correction ... which could significantly increased gene-correction efficiency in human ... online in Cell Stell Cell provides ... therapy. , The combination of stem cells and ...
(Date:7/11/2014)... July 11, 2014 Researchers have pioneered ... images. The new technology, called Virtual Finger, allows ... structures like neurons and synapses using the flat ... technology makes 3D imaging studies orders of magnitude ... an unprecedented level across many areas of experimental ...
(Date:7/11/2014)... the normal circumstances, astrocytes participate in normal ... and exhibit therapeutic and repairing effects on ... have found that nerve cells differentiated from ... reduced viability, which produces influences on subsequent ... General Hospital, Hebei United University, China demonstrated ...
Breaking Biology News(10 mins):A new genome editing method brings the possibility of gene therapies closer to reality 2Virtual finger enables scientists to navigate and analyze complex 3D images 2
... 19, 2012 /PRNewswire-iReach/ -- Global Information ... of forthcoming conferences and networking events in the ... events provide a platform for researchers and decision ... latest findings and learn about significant developments in ...
... have discovered the unexpected way in which a key cell ... said, offers insight into the processes that take place within ... from spinal cord injury to cancer. The research focused ... cell. Like other cells in the immune system, its job ...
... Va.The Office of Naval Research,s (ONR) biennial 2012 Naval ... Oct. 22-24, officials announced Jan. 19. "The chief ... Navy and Marine Corps, vision for 2025," said Rear ... is to bring the right people together to deliver ...
Cached Biology News:2012 Biotechnology and Pharmaceuticals: Forthcoming Conferences and Exhibitions 22012 Biotechnology and Pharmaceuticals: Forthcoming Conferences and Exhibitions 32012 Biotechnology and Pharmaceuticals: Forthcoming Conferences and Exhibitions 4UCSF team uncovers how immune cells move against invaders 2ONR sets date for 2012 Naval S&T Partnership Conference 2
(Date:7/10/2014)... July 10, 2014   Ceres, Inc . (Nasdaq: ... company, announced today financial results for the three months ... its business. Ceres reported that the company ... performance this growing season in Brazil, which concluded in ... company,s sorghum evaluation areas for part of the growing ...
(Date:7/10/2014)... of Adelaide research may help in the fight against ... detect tiny quantities of explosives with the use of ... journal Sensors and Actuators B: Chemical , the ... detect explosives in concentrations as low as 6.3 ppm ... only a few minutes. , "Traditionally explosives detection has ...
(Date:7/10/2014)... A new study published today in the journal ... has found that time of day and sleep deprivation ... could be crucial when looking at the best time ... and heart disease, and for administering medicines effectively. , ... of Cancer Research, London, investigated the links between sleep ...
(Date:7/10/2014)... the fractional quantum Hall effect in bilayer graphene and ... tuned by an electric field. , The fractional ... to thin sheets are exposed to large magnetic fields, ... of individual electrons behave as a single system. However, ... established, many details of this collective behavior remain not ...
Breaking Biology Technology:Ceres Announces Fiscal Third Quarter 2014 Financial Results 2Ceres Announces Fiscal Third Quarter 2014 Financial Results 3Ceres Announces Fiscal Third Quarter 2014 Financial Results 4Ceres Announces Fiscal Third Quarter 2014 Financial Results 5Ceres Announces Fiscal Third Quarter 2014 Financial Results 6Ceres Announces Fiscal Third Quarter 2014 Financial Results 7Ceres Announces Fiscal Third Quarter 2014 Financial Results 8Ceres Announces Fiscal Third Quarter 2014 Financial Results 9Detecting trace amounts of explosives with light 2Time of day crucial to accurately test for diseases, new research finds 2Columbia researchers observe tunable quantum behavior in bilayer graphene 2Columbia researchers observe tunable quantum behavior in bilayer graphene 3
... there's always one person in a crowd who is proud ... me. I'm compulsive about reading the job classifieds. , ,Don't ... the difference between the ubiquitous "excellent communication skills" and the ... quick scan every day, even if it happens to be ...
... a maker of automotive and ... bought Pro-Tel Inc. for an ... a contracting company founded in ... 70 employees. Its repair and ...
... Gas & Electric has released its 2005 Greater ... and updated listings covering 394 organizations. , ,The directory, ... offers an overview of the high-tech firms, professional organizations, ... in Dane County, as well as an array of ...
Cached Biology Technology:Is IT leadership a position or an attitude? 2Is IT leadership a position or an attitude? 32005 Madison-area tech directory includes more companies, resources 22005 Madison-area tech directory includes more companies, resources 3
... and G. Butcher (1998). • The major ... research in the immunology area. There is ... proteins and in their function as antigen-presenting ... with the prospect of tackling biochemical and ...
VACUGENE PUMP 110V, 1 EA. Category: Nucleid Acid Detection Systems....
Rat whole blood (Sprague-Dawley, averaging 7-8 weeks of age, either sex) is collected at the time of slaughter and refrigerated within 6 hours, and processed and frozen within 24 hours. The serum is ...
... mutS and ES1301 mutS are mismatch repair ... these strains prevents repair of the newly ... mutation efficiencies and making them helpful in ... Sites II Mutagenesis Systems. Both ES1301 and ...
Biology Products: