Navigation Links
UCLA scientists uncover mechanism of response to targeted therapy

ff the independent blood supply that cancers need to grow and flourish. The CCI-779 would stop the growth of the cancer, and the chemotherapy would be used to kill the cancer cells or the angiogenesis inhibitor could be administered to cut off the blood supply to the tumor, stopping the flow of oxygen and nutrients that the tumor needs to survive.

Standard of care for kidney cancer is almost always removal of part or the entire kidney, so that tissue could be tested for the molecular signature that indicates response to CCI-779. Doctors could then decide on what treatment to use in those likely to respond to the drug.

A secondary study finding determined that the drug's efficacy can be monitored quickly using positron emission tomography (PET). Because HIF also regulates glucose transport in cells, UCLA researchers theorized that the kidney cancer cells, with their high levels of HIF, would take in a standard PET imaging probe at high levels. If that proved true, the PET scan would show that the cancer cells had increased levels of the probe. Using laboratory animals, researchers determined that kidney cancer cells were indeed better at taking up the probe, allowing the cancer cells to be monitored by PET scanning. Just 24 hours after treatment with CCI-779, intake of the PET probe levels dropped in the cancer cells, meaning HIF levels were falling and the drug was working.

"If we can use PET scanning to follow response, patients won't need repeated invasive tests," Thomas said. "This would save them from getting an added surgical procedure. And we can see, in a very short time, probably in less than a week, whether the drug is working."

The study was a collaboration of researchers from the Jonsson Cancer Center, the Crump Institute for Molecular Imaging, the Howard Hughes Medical Institute and the UCLA departments of pathology, urology, medicine and molecular and medical pharmacology.


'"/>

Source:University of California - Los Angeles


Page: 1 2 3

Related biology news :

1. Wisconsin scientists grow critical nerve cells
2. UCSB scientists probe sea floor venting to gain understanding of early life on Earth
3. UAB scientists discover the origin of a mysterious physical force
4. Fox Chase Cancer Center scientists identify immune-system mutation
5. Weizmann Institute scientists develop a new approach for directing treatment to metastasized prostate cancer in the bones.
6. U-M scientists find genes that control growth of common skin cancer
7. UCLA scientists transform HIV into cancer-seeking missile
8. RNA project to create language for scientists worldwide
9. Carnegie Mellon scientists develop tool that uses MRI to visualize gene expression in living animals
10. To control germs, scientists deploy tiny agents provocateurs
11. Leprosy microbes lead scientists to immune discovery
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: UCLA scientists uncover mechanism response targeted therapy

(Date:1/22/2015)... Technology Showcase, Hall E -   EyeLock Inc. , ... it will showcase its EyeLock ID technology integrated in a ... Energy,s Oak Ridge National Laboratory (ORNL) at the ... identity authentication technology is being used to validate the driver ...
(Date:1/22/2015)... POINT ROBERTS, Washington , January 20, 2015 ... technology and tech stocks, releases video from the CES 2015 ... security consultant Apollo Robbins . Apollo shows ... Wocket™ biometric smart wallet, a product of NXT-ID, Inc. (NASDAQ: ...
(Date:1/22/2015)... 2015   EyeLock, Inc. , a market leader of iris-based ... Gerber to the new role of Senior Vice President ... development of mobile platforms and wearable solutions for EyeLock,s technologies. ... in the semiconductor industry to his role at EyeLock, with ...
Breaking Biology News(10 mins):EyeLock Debuts First Iris Authentication Technology Embedded in 3D Printed Automobile 2EyeLock Debuts First Iris Authentication Technology Embedded in 3D Printed Automobile 3Apollo Robbins Talks about the Illusion of Personal Safety and How Easily Your Wallet is Stolen; If a Wocket Wallet is Stolen the Thief Can't do Anything With it! 2Apollo Robbins Talks about the Illusion of Personal Safety and How Easily Your Wallet is Stolen; If a Wocket Wallet is Stolen the Thief Can't do Anything With it! 3EyeLock Names Steve Gerber as Senior Vice President of Mobile and Wearables 2
... to restore vision through the use of a component ... University professor and scientific director of the Ligon Research ... has attracted additional funding for therapy development. The ... affiliate, National Neurovision Research Institute, to RetroSense Therapeutics, LLC, ...
... miniaturized lizards have been identified in Madagascar. These lizards, just tens ... enough to stand on the head of a match, rank among ... found in the Feb. 15 issue of the open access journal ... of the Zoological State Collection of Munich in Germany, also conducted ...
... Invasive species which have the potential to destroy biodiversity ... in the same way as wanted criminals, according to ... Geographic profiling (GP) was originally developed as a statistical ... linked crimes (for example murder, rape or arson) to ...
Cached Biology News:Wayne State-licensed technology receives grant from the Foundation Fighting Blindness 2Fighting crimes against biodiversity 2
(Date:1/22/2015)... | RBJ today announces the firm brokered a long-term lease ... leading biopharmaceutical company, at Two Ledgemont Center in ... , president, and Brian Cohen , senior vice president, ... at 95 Hayden Ave. Photo - http://photos.prnewswire.com/prnh/20150122/170765 ...
(Date:1/22/2015)... The laboratory information management systems market is a ... technological advancements due to factors such as rising pressure ... healthcare systems, and increasing government support for adoption of ... players in the market focus on technological advancements to ...
(Date:1/22/2015)... Crystal Diagnostics (CDx) Xpress System, a rapid ... AOAC-PTM Certifications for the six non-O157 Shiga toxin-producing E. coli ... to as STEC or the “Big-6”) as well as Escherichia ... per 325 g of raw ground beef and raw beef ...
(Date:1/22/2015)... Boston, MA (PRWEB) January 22, 2015 ... systems, is pleased to announce an exciting product from a ... of motion analysis solutions over the past 15 years, with ... industries. Most recently, their 3D IMU system (inertial measurement unit), ...
Breaking Biology Technology:Transwestern?RBJ Advises Shire in 202,000 SF Lease, Creating Boston's Largest Suburban Biotech Campus 2Laboratory Information Management Systems Market is Expected to Reach $1,323.6 Million by 2019 - New Research Report by MarketsandMarkets 2Laboratory Information Management Systems Market is Expected to Reach $1,323.6 Million by 2019 - New Research Report by MarketsandMarkets 3Laboratory Information Management Systems Market is Expected to Reach $1,323.6 Million by 2019 - New Research Report by MarketsandMarkets 4Crystal Diagnostics Awarded AOAC-PTM Accreditation for the Rapid Detection of “Big 6” E.coli Food Pathogens 23D Motion Capture Just Got Easy 2
... advantage of available technology for identity management, says a study ... Federal Trade Commission, 27 million Americans have been victims of ... last year. While not all stolen identities may ever be ... pressing worry for many individuals and institutions. , ,David Meunier, ...
... The focus of last week's Fusion2006 was ... by the advice that presenters delivered, private-sector CIOs would ... new technology. If there was a dominant theme of ... managers should practice linkage - linkage with their CEOs ...
... the first round of the Governor's Business Plan Contest, ... 188 submissions by a panel of judges based on ... with concentrations in the Madison and Milwaukee areas. , ... in 2004, the first contest. But Mark Bugher, chairman ...
Cached Biology Technology:IT can't be separate from core business 2
... This CLS number is a ... match Cornings product number. If showing ... the old Sigma-Aldrich number (C6671) or ... tissue-culture treated yes Surface area 148 ...
... XpressPack™ Colorimetric Detection System is intended for ... DNA generated by an in-house validated in ... target of interest. • ... is a hybridization capture assay designed to ...
... Novagens PhageMaker System is optimized for maximum packaging ... with any bacteriophage l vector. Using a test ... 10^7 pfu/g arms (> 4 x 10^8 pfu/g ... one-tube system is extremely easy to use; simply ...
BD BioCoat Laminin 150 mm Culture Dishes...
Biology Products: