RESEARCH: Scientists at the David Geffen School of Medicine at UCLA have exploited thousands of tiny capsules in cells to store vast amounts of biomaterial. Dubbed vaults ?for their high arches reminiscent of cathedral ceilings ?these naturally occurring capsules may prove less likely to elicit an immune response than foreign carriers like viruses.
IMPACT: The UCLA discovery will enable many potential applications, including:
* Therapeutic delivery, such as homing cancer drugs directly to a tumor cell without harming healthy tissue
* Enzyme delivery to replace missing or defective enzymes, such as those that cause Tay Sachs disease
* DNA delivery to correct genetic mutations
* Timed release of drugs, enzymes and DNA
* Extracting and imprisoning cellular toxins into the vault
* Stabilizing proteins in vaults to increase their lifespans
AUTHORS: Leonard Rome, professor of biological chemistry and senior associate dean of research; Bruce Dunn, professor of material science and engineering; Jeffrey Zink, professor of chemistry and biochemistry and Valerie Kickhoefer, first author and associate research biochemist.
JOURNAL: The Proceedings of the National Academy of Sciences