Navigation Links
UCLA scientists store materials in cells natural vaults

In the realm of nanotechnology, or study of the tiny, scientists often aim to safely deliver and leave material in the human body without causing harm. A big challenge is how to design a package for this biomaterial that will be compatible with living cells and will not provoke an immune reaction. Previous efforts have relied upon viruses or artificial chemicals to house and deliver drugs or other substances to targeted cells.

RESEARCH: Scientists at the David Geffen School of Medicine at UCLA have exploited thousands of tiny capsules in cells to store vast amounts of biomaterial. Dubbed vaults ?for their high arches reminiscent of cathedral ceilings ?these naturally occurring capsules may prove less likely to elicit an immune response than foreign carriers like viruses.

IMPACT: The UCLA discovery will enable many potential applications, including:

* Therapeutic delivery, such as homing cancer drugs directly to a tumor cell without harming healthy tissue
* Enzyme delivery to replace missing or defective enzymes, such as those that cause Tay Sachs disease
* DNA delivery to correct genetic mutations
* Timed release of drugs, enzymes and DNA
* Extracting and imprisoning cellular toxins into the vault
* Stabilizing proteins in vaults to increase their lifespans

AUTHORS: Leonard Rome, professor of biological chemistry and senior associate dean of research; Bruce Dunn, professor of material science and engineering; Jeffrey Zink, professor of chemistry and biochemistry and Valerie Kickhoefer, first author and associate research biochemist.

JOURNAL: The Proceedings of the National Academy of Sciences
http://www.pnas.org/cgi/content/abstract/0500929102v1


'"/>

Source:University of California - Los Angeles


Page: 1

Related biology news :

1. Wisconsin scientists grow critical nerve cells
2. UCSB scientists probe sea floor venting to gain understanding of early life on Earth
3. UAB scientists discover the origin of a mysterious physical force
4. Fox Chase Cancer Center scientists identify immune-system mutation
5. Weizmann Institute scientists develop a new approach for directing treatment to metastasized prostate cancer in the bones.
6. U-M scientists find genes that control growth of common skin cancer
7. UCLA scientists transform HIV into cancer-seeking missile
8. RNA project to create language for scientists worldwide
9. Carnegie Mellon scientists develop tool that uses MRI to visualize gene expression in living animals
10. To control germs, scientists deploy tiny agents provocateurs
11. Leprosy microbes lead scientists to immune discovery
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: UCLA scientists store materials cells natural vaults

(Date:11/6/2014)... Except when that predator runs so fast that it essentially ... is the fastest creature on Earth. Some of these half-inch-long ... five miles per hour). The fastest human can do about ... tiger beetle, a person would have to hit 480 miles ... At peak speeds, everything becomes a blur. They can,t gather ...
(Date:11/5/2014)... in their ability to identify scents and odors. ... perceptual evaluation of odors, with women outperforming men on ... differences in olfactory detection may play a role in ... perception of smell, which is naturally linked to associated ... suggested to be cognitive or emotional, rather than perceptual. ...
(Date:11/4/2014)... Think about the way our bodies are assembled during ... that they are supposed to become a nerve or ... the correct place and alignment? Researchers at the University ... In a new study, UM researchers describe the signaling ... neighbors, at the head-trunk region. Their discovery may have ...
Breaking Biology News(10 mins):The tiger beetle: Too fast to see 2The female nose always knows: Do women have more olfactory neurons? 2The inside story: How the brain and skull stay together 2
... U.S. Department of Energy (DOE) Joint Genome Institute (JGI) ... winning at the 13th Annual Applied Ergonomics Conference held ... The Ergo Cup highlights ergonomic innovations from institutions and ... in Ergonomics," was for the Ergonomic Program Improvement Initiatives ...
... A preliminary study by New Zealand company Plant ... may help breathing in some types of asthma. ... may reduce lung inflammation with a multi-action assault in ... to enhance the natural defence mechanisms in lung tissue ...
... Ghoneum today will discuss his findings on cancer research and ... event, sponsored by the Egyptian Cultural and Educational Bureau, will ... reception. Ghoneum, an Egyptian-born researcher and professor at Charles ... been studying natural cures for cancer for more than two ...
Cached Biology News:Breathe easy: A natural fruit compound may help asthma 2
(Date:11/26/2014)... 26, 2014 SoundConnect , an ... proud to announce that Darren Suders has joined the ... Darren will drive the partner program through ... , Darren brings more than 10-years of ... roles in channel operations, from policy development, to partner ...
(Date:11/26/2014)... 2014 Theravalues Corporation est fier d,annoncer ... européen au salon Hi Europe 2014 (du 2 ... Curcumine la plus biodisponible actuellement sur ... à des ingrédients approuvés par les règlements européens. ... présent dans la racine de curcuma ( Curcuma ...
(Date:11/26/2014)... 2014  Roka Bioscience, Inc. (NASDAQ: ROKA ), ... for the detection of foodborne pathogens, today announced that ... 26 th Annual Healthcare Conference on December 2, 2014 ... New York Palace in New York, NY ... the Company, its operations, strategies and prospects may be discussed. ...
(Date:11/24/2014)... -- Last week, Representatives Gus Bilirakis (R-FL) ... bold bipartisan step on behalf of patients with ... co-sponsors of the legislation include Representatives McCaul (R-TX) ... makers and innovators to "repurpose" major market drugs ... opens the door to the development of hundreds ...
Breaking Biology Technology:SoundConnect Appoints Director of Channel Development & Sales 2La curcumine présentant la plus haute biodisponibilité bientôt en vente en Europe 2La curcumine présentant la plus haute biodisponibilité bientôt en vente en Europe 3Roka Bioscience to Present at the Piper Jaffray Healthcare Conference 2OPEN Act Introduced to Repurpose Drugs for Rare Diseases 2
... begins its 2005 season, researchers at the University of ... school spirit. The only fans who can appreciate it, however, ... team of UW-Madison chemists led by professor Robert Hamers ... of nanofiber hairs each only 75 nanometers long. With each ...
... since I have had a chance to dig into some more music. ... musician son. As I am hoping that he is the next Jonny ... this summer to a week of rock 'n roll camp. , ,Can ... of the night? This kind of reminded me of the movie "School ...
... of Eau Claire, also operating as ... a channel program that enables resellers and systems ... products and subscription services to customers without major ... able to offer hosted digital signage solutions to ...
Cached Biology Technology:Nanotechnology minimizes UW's beloved mascot 2Historic lists - The greatest rock bands, rock guitarists of all time 2Historic lists - The greatest rock bands, rock guitarists of all time 3Historic lists - The greatest rock bands, rock guitarists of all time 4
... DNA detection has been improved. With Gene Coloring ... can be detected > 20 ng. The excised ... organic solvent extraction or with other commercially available ... DNA excised from agarose gel can be used ...
...
Mouse monoclonal antibody raised against a full length recombinant CSNK2A2. NCBI Entrez Gene ID = CSNK2A2...
... form of cell suicide, which follows a ... of this process is a cascade of ... participate in a series of reactions that ... and result in the cleavage of protein ...
Biology Products: