Navigation Links
UCLA scientists find male gene in brain area targeted by Parkinson's

UCLA scientists have discovered that a sex gene responsible for making embryos male and forming the testes is also produced by the brain region targeted by Parkinson's disease. Published in the Feb. 21 edition of Current Biology, the new research may explain why more men than women develop the degenerative disorder, which afflicts roughly 1 million Americans.

"Men are 1.5 times more likely to develop Parkinson's disease than women," said Dr. Eric Vilain, associate professor of human genetics at the David Geffen School of Medicine at UCLA. "Our findings may offer new clues to how the disorder affects men and women differently, and shed light on why men are more susceptible to the disease."

In 1990, British researchers identified SRY as the gene that determines gender and makes embryos male. Located on the male sex chromosome, SRY manufactures a protein that is secreted by cells in the testes.

Now, in an unexpected discovery, Vilain's team became the first to trace the SRY protein to a region of the brain called the substantia nigra, which deteriorates in Parkinson's disease.

Parkinson's disease occurs when cells in the substantia nigra begin to malfunction and die. These brain cells produce a neurotransmitter called dopamine that communicates with the brain areas controlling movement and coordination.

As the cells die off, they produce less dopamine. This slows the delivery of messages from the brain to the rest of the body, leaving the person unable to initiate or control their physical movements. The condition eventually leads to paralysis.

"For the first time, we've discovered that the brain cells that produce dopamine depend upon a sex-specific gene to function properly," Vilain said. "We've also shown that SRY plays a central role not just in the male genitals, but also in regulating the brain."

Vilain's lab used a rat model to study the effect of SRY on the brain. When the researchers lowered the level of
'"/>

Source:University of California - Los Angeles


Page: 1 2

Related biology news :

1. Wisconsin scientists grow critical nerve cells
2. UCSB scientists probe sea floor venting to gain understanding of early life on Earth
3. UAB scientists discover the origin of a mysterious physical force
4. Fox Chase Cancer Center scientists identify immune-system mutation
5. Weizmann Institute scientists develop a new approach for directing treatment to metastasized prostate cancer in the bones.
6. U-M scientists find genes that control growth of common skin cancer
7. UCLA scientists transform HIV into cancer-seeking missile
8. RNA project to create language for scientists worldwide
9. Carnegie Mellon scientists develop tool that uses MRI to visualize gene expression in living animals
10. To control germs, scientists deploy tiny agents provocateurs
11. Leprosy microbes lead scientists to immune discovery
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: UCLA scientists find male gene brain area targeted Parkinson

(Date:9/30/2014)... tetrachloroethylene (PCE) in drinking water may increase the ... a new study led by a Boston University ... published in the journal Environmental Health , ... among 1,766 women in Cape Cod, Ma., where ... the early 1980s by the installation of vinyl-lined ...
(Date:9/30/2014)... and farm runoff in Hawaii is causing tumors in ... The study, published Tuesday in the peer-reviewed open-access journal ... ends up in algae that the turtles eat, promoting ... and internal organs. , Scientists at Duke University, the ... Administration (NOAA) conducted the study to better understand the ...
(Date:9/30/2014)... IVF? Here,s some hope: A new research report published ... Journal , explains how scientists developed a synthetic ... induced embryo development in human and mouse eggs similar ... sperm cell during fertilization. , "We believe that the ... in our understanding of human fertilization by providing a ...
Breaking Biology News(10 mins):Contaminated water linked to pregnancy complications, BU study finds 2Pollution linked to lethal sea turtle tumors 2Pollution linked to lethal sea turtle tumors 3Synthetic sperm protein raises the chance for successful in vitro fertilization 2
... This release is available in German . , ... membrane for the absorption of viruses like hepatitis C, herpes, ... germs. However, certain viruses, such as the human immunodeficiency virus ... membrane. Just how this infiltration occurs on a molecular level ...
... fish that sees simultaneously above and below the water line ... allows organisms to adapt to their environment. Gregory L. ... sharp divide between the upper and lower sections of the ... related to guppies. The findings were published today online in ...
... 20, 2011 Whether engaging experts from the outside to ... AIDS, leaders around the globe acknowledge the need to innovate ... facing business and society today. NineSigma, the leading provider of ... the imperative to innovate for organizations is greater than ever, ...
Cached Biology News:Scavenger cells accomplices to viruses 2UBC graduate student discovers key to 'bifocals' in mangrove fish species 2NineSigma Declares "Innovate or Die" Is the Mantra for Business Success 2NineSigma Declares "Innovate or Die" Is the Mantra for Business Success 3NineSigma Declares "Innovate or Die" Is the Mantra for Business Success 4
(Date:10/1/2014)... In response to its clients’ evolving ... training and consumer engagement challenges, digital agency ... to turn their clients’ visions into reality. New ... app creations, are now featured on its website ... Toyota, StudioPMG created a robust cross-platform mobile application ...
(Date:10/1/2014)... The U.S. Department of Labor has awarded ... as part of the Trade Adjustment Assistance Community College ... by the Department of Labor and Department of Education. ... E. Perez and Secretary of Education Arne Duncan announced ... to nearly 270 colleges across the country. , ...
(Date:9/30/2014)... German . , ... demonstrated a new kind of building block for digital ... could be based on three-dimensional arrangements of nanometer-scale magnets ... the semiconductor industry CMOS fabrication of silicon chips ... at the University of Notre Dame are exploring "magnetic ...
(Date:9/30/2014)... YORK , Sept. 30, 2014 ... to kill nematodes. Nematodes are microscopic parasitic roundworms, ... water, and inside other plants and animals. Nematicides ... volatility or other properties promoting migration through the ... more than 1,000 plant-parasitic nematodes. With more than ...
Breaking Biology Technology:Digital Agency Studio PMG Launches New Case Studies on Website 2U.S. Dept. of Labor Awards SIUE Nearly $10-Million Grant 2U.S. Dept. of Labor Awards SIUE Nearly $10-Million Grant 3U.S. Dept. of Labor Awards SIUE Nearly $10-Million Grant 4A new dimension for integrated circuits: 3-D nanomagnetic logic 2A new dimension for integrated circuits: 3-D nanomagnetic logic 3Nematicides Market by Types (Fumigants, Organophosphates, Carbamate and Bio-Nematicides), Applications (Agrochemicals, Industrial, and Others), and Geography (North America, Europe, Asia-Pacific & ROW) - Global Trends & Forecasts to 2019 2
... improved throughput ... and walk-away time -, HOPKINTON, ... today launched a new high throughput RNA,assay for automatically assessing the ... was expected by the,research community, was launched on schedule and runs ...
... Agendia BV, a world leader in,the rapidly evolving field ... Hessel J. H. M. Lindenbergh as Chairman of its,Supervisory ... the managing board of ING,Group N.V.. Currently, Mr. Lindenbergh ... and board member of the Royal Numico, Petroplus,International and ...
... SAN JOSE, Calif., Sept. 13 Micrus,Endovascular Corporation (Nasdaq: ... Meeting of Stockholders will be broadcast live over the,Internet ... time (9:00,a.m. Pacific time). Those listening to the meeting ... to ask questions during the,meeting. What: Micrus ...
Cached Biology Technology:Caliper Life Sciences Introduces High Throughput RNA Assay to Improve Workflow in Gene Expression Studies 2Agendia BV Appoints Mr. Hessel Lindenbergh as Chairman of its Supervisory Board 2Micrus Endovascular to Webcast Fiscal 2007 Annual Meeting of Stockholders 2
Request Info...
Purified anti-eIF-4E...
Peptide-affinity Purified Polyclonal Antibody to SMAD7 Peptide with sequence SSCPCWLEVIFNSR, from C Terminus of the protein sequence according to NP_005895....
Purified anti-PXR...
Biology Products: