Navigation Links
UCLA scientists discover immune response to HIV differs, even in identical twins

In findings illustrating the difficulty of developing an AIDS vaccine, UCLA AIDS Institute researchers report the immune systems in two HIV-positive identical twins responded to the infection in different ways.

Detailed in the Dec. 5 issue of the peer-reviewed Journal of Virology (http://jvi.asm.org), the findings show that the body's defenses against the virus are random rather than genetically determined.

The researchers followed the cases of male twins who were infected shortly after their 1983 births in Los Angeles by blood transfusions administered from the same donor at the same time. Infected with the same strain of the virus, the twins continue to live in the Los Angeles area and grew up exposed to the same environmental forces.

Yet their T-cell receptors (TCR) reacted differently in each twin, showing that the body's defense response was random--and unpredictable. TCRs play an important role in the immune system by binding viruses and other antigens to receptors on their surface, killing the invader. HIV escapes this action by changing shape so that it does not fit into those receptors.

"These boys are as similar as two humans can be, yet we see differences in how they fight the virus," said Dr. Paul Krogstad, professor of pediatrics and pharmacology, and one of the researchers. "That's one more thing that makes it difficult to develop a vaccine for everyone."

When a virus invades a body, the cellular immune response targets small parts of proteins in the virus. This targeting mechanism itself is genetically determined. ". The virus tries to escape that immune response by mutating and changing shape.

The twins' targeting of the HIV was remarkably similar 17 years after infection yet their overall TCR characteristics were highly divergent. The finding, demonstrates that the interaction between their immune systems and the virus was random and unpredictable--indicating that a
'"/>

Source:University of California - Los Angeles


Page: 1 2

Related biology news :

1. Wisconsin scientists grow critical nerve cells
2. UCSB scientists probe sea floor venting to gain understanding of early life on Earth
3. UAB scientists discover the origin of a mysterious physical force
4. Fox Chase Cancer Center scientists identify immune-system mutation
5. Weizmann Institute scientists develop a new approach for directing treatment to metastasized prostate cancer in the bones.
6. U-M scientists find genes that control growth of common skin cancer
7. UCLA scientists transform HIV into cancer-seeking missile
8. RNA project to create language for scientists worldwide
9. Carnegie Mellon scientists develop tool that uses MRI to visualize gene expression in living animals
10. To control germs, scientists deploy tiny agents provocateurs
11. Leprosy microbes lead scientists to immune discovery
Post Your Comments:
(Date:2/5/2015)... Jan. 28, 2015 Research and Markets ... of the "Global Biometrics Market (2014-2020): Market ... Countries " report to their offering. , ... Asia-Pacific is anticipated to overtake ... to increasing government spending towards IT security, government ...
(Date:2/5/2015)... 3, 2015 Despite a lack of ... such as consumer electronics, automotive, storage and telecommunication ... technology (SMT) screen printers. Innovations in electronics and ... push the adoption curve up. Meanwhile, sale volumes ... glue dispensers are indispensable in the production of ...
(Date:1/22/2015)... Valid S.A. ("Company") (BM&FBOVESPA: VLID3 ON), is pleased to inform ... State of Washington,s Department of Licensing, in the ... issuance system for driver,s licenses and identification cards to its ... development will start in January 2015, with enrollment and card ...
Breaking Biology News(10 mins):Global Biometrics Market (2014-2020): Market Forecast By Technologies, Applications, End Use, Regions and Countries 2Global Biometrics Market (2014-2020): Market Forecast By Technologies, Applications, End Use, Regions and Countries 3End-user Demand Spurs Global SMT Screen Printers and Glue Dispensers Market 2End-user Demand Spurs Global SMT Screen Printers and Glue Dispensers Market 3Valid USA Signs Contract For Washington Driver's License Issuance 2
... University of Illinois scientists have learned that a specific ... health. "In experiments with mice, we knocked out ... body to make arachidonic acid. Without arachidonic acid, the ... itchy, they scratched themselves continuously, and they developed a ...
... A team of researchers from the United States and Europe ... a role in the etiology of common forms of kidney ... variations in DNA sequences in more than 65,000 individuals of ... be more frequent among people with poor kidney function or ...
... Just one "pulse" of artificial light at night disrupts ... by Dr. Rachel Ben-Shlomo of the University of Haifa-Oranim ... Charalambos P. Kyriacou of the University of Leicester. "Damage ... is therefore important to understand the causes of this ...
Cached Biology News:U of I study: Lack of omega-6 fatty acid linked to severe dermatitis 2International research team discovers novel genes influencing kidney disease risk 2
(Date:3/5/2015)... Minn. (PRWEB) March 05, 2015 Plant ... Pasadena this summer at the Annual Meeting of The ... starting to be released online now at APSnet.org/meet ... announced for the meeting, to be held August 1-5, ... announced Special Sessions, Field Trips, Workshops, and committee meetings, ...
(Date:3/5/2015)... 2015 Bi-Biomics today announced a ... stain additive. The improvement in histological quality provided ... present in all daughter cells. , After processing ... was analyzed at 1000-1600x using light microscopy. ... in all daughter cells displayed predominant binary features ...
(Date:3/5/2015)... TORONTO , March 5, 2015 /PRNewswire/ - Aptose Biosciences ... new therapeutics and molecular diagnostics that target the underlying ... Rice , Ph.D., Chairman, President and Chief Executive Officer, ... on Tuesday, March 10 th at 9:30 a.m. ... Niguel, CA. Dr. Rice will provide a ...
(Date:3/5/2015)... 2015 Research and Markets ( http://www.researchandmarkets.com/research/4ld5nw/mature_biotech ... Biotech Outlook 2015: New Therapy Ventures Pave the Way ... All biotech companies - Gilead (GILD), Amgen (AMGN), ... have given a positive return and hence increased the ... to select therapy/niche indication where the high treatment cost ...
Breaking Biology Technology:American Phytopathological Society Announces Annual Meeting Daily Schedule 2Aptose Biosciences to Present at the 27th Annual ROTH Conference 2Aptose Biosciences to Present at the 27th Annual ROTH Conference 3Mature Biotech Outlook 2015: New Therapy Ventures Pave the Way for Success 2Mature Biotech Outlook 2015: New Therapy Ventures Pave the Way for Success 3
... 8 Transgenomic, Inc. (OTC Bulletin Board: TBIO) announced today ... in a family of mutation detection kits the company plans ... HS DHPLC platform. SURVEYOR Scan technology is a ... reaction and hybridization to form heteroduplex DNA molecules in samples ...
... , NEW YORK, Dec. ... report is available in its catalogue: , ... , http://www.reportlinker.com/p0164370/Microplate-Instrumentation--Supplies---A-Global-Market-Perspective.html , Playing a ... process, microplate technology has come to replace conventional micro ...
... ... , AMSTERDAM, December 8 ... Strategic Decision-Support,Tool , Elsevier, a world-leading publisher of ... purchased its new SciVal Spotlight tool. The institutions, including,National Chiao Tung University ...
Cached Biology Technology:Transgenomic Announces the Commercial Launch of SURVEYOR(R) Scan K-RAS Mutation Detection Kit 2Transgenomic Announces the Commercial Launch of SURVEYOR(R) Scan K-RAS Mutation Detection Kit 3Transgenomic Announces the Commercial Launch of SURVEYOR(R) Scan K-RAS Mutation Detection Kit 4Reportlinker Adds Microplate Instrumentation & Supplies - A Global Market Perspective 2Reportlinker Adds Microplate Instrumentation & Supplies - A Global Market Perspective 3Reportlinker Adds Microplate Instrumentation & Supplies - A Global Market Perspective 4Reportlinker Adds Microplate Instrumentation & Supplies - A Global Market Perspective 5Reportlinker Adds Microplate Instrumentation & Supplies - A Global Market Perspective 6Reportlinker Adds Microplate Instrumentation & Supplies - A Global Market Perspective 7Reportlinker Adds Microplate Instrumentation & Supplies - A Global Market Perspective 8SciVal Spotlight Gaining Momentum Across the Globe as More Universities Seek Multidisciplinary View of Research Performance 2SciVal Spotlight Gaining Momentum Across the Globe as More Universities Seek Multidisciplinary View of Research Performance 3
... Immunogen: Synthetic peptide derived from the ... 36 protein This peptide sequence is ... another Zymed polyclonal Connexin 36 antibody Cat. ... Connexin 36. Reactivity: Mouse (positive control: ...
Request Info...
...
...
Biology Products: