Navigation Links
UCLA researchers unravel a mystery about DNA

UCLA researchers in collaboration with researchers at Rutgers University have solved longstanding mysteries surrounding DNA transcription, the first step in carrying out instructions contained in our genes. The breakthrough described in an article in the Nov. 17 issue of the journal Science reveals important structural information about the gyrations of DNA during transcription and the effects of those gyrations on the process.

The discoveries, which inform our understanding of the structure and mechanics of RNAP -- an enzyme responsible for making RNA from a DNA or RNA template -- can help set the stage for new opportunities in combating bacterial diseases that kill 13 million people worldwide each year.

The researchers used single-molecule spectroscopy to monitor the transfer of energy between -- and hence the distance separating -- pairs of fluorescent chemical tags attached to key structural elements of RNAP and the DNA double helix during initiation of the transcription process.

The changes in the distances between these tags confirmed that transcription proceeds initially through a "scrunching" mechanism in which, much like a fisherman reeling in a catch, RNAP remains in a fixed position while it pulls the flexible DNA strand of the gene within itself and past the enzyme's reactive center to form the RNA product.

These changes are inconsistent with other theories that had suggested that RNAP moves along the DNA strand as a complete block in a process resembling the movement of an inchworm.

The research team is comprised of Achillefs N. Kapanidis, Emmanuel Margeat, Sam On Ho, Ekaterine Kortkhonjia and Shimon Weiss of the UCLA Department of Chemistry and Biochemistry, the Department of Physiology and the California NanoSystems Institute (CNSI). The team collaborated with Richard H. Ebright, Howard Hughes Medical Institute, Waksman Institute and Department of Chemistry, Rutgers University.

The scrunching mo
'"/>

Source:University of California - Los Angeles


Page: 1 2

Related biology news :

1. NYU researchers simulate molecular biological clock
2. Vital step in cellular migration described by UCSD medical researchers
3. ASU researchers finds novel chemistry at work to provide parrots vibrant red colors
4. UCSD researchers maintain stem cells without contaminated animal feeder layers
5. Why do insects stop breathing? To avoid damage from too much oxygen, say researchers
6. New protein discovered by Hebrew University researchers
7. First real-time view of developing neurons reveals surprises, say Stanford researchers
8. Agilent Technologies releases automated literature search tool for biology researchers
9. Self-assembled nano-sized probes allow Penn researchers to see tumors through flesh and skin
10. Yale researchers identify molecule for detecting parasitic infection in humans
11. US life expectancy about to decline, researchers say
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: UCLA researchers unravel mystery about DNA

(Date:8/22/2014)... DUBLIN , August 22, 2014 ... Markets ( http://www.researchandmarkets.com/research/mtm27l/biometrics_market ) has announced the ... North America 2014-2018"  report to their ... , , ,Biometrics is a technology ... individuals based on their physical or ...
(Date:8/22/2014)... Thomson Reuters , a leading source of information ... the University of California, Riverside in its 2014 list ... our times." , To generate the list, the company ... researchers whose published work has had enormous impact. , ... 3,200 individuals who published the greatest number of highly ...
(Date:8/22/2014)... the 29th Annual International Papillomavirus Conference shows that ... combats three types of human papillomavirus, including the ... cancer. , When tested in several cultured human ... HPV-18 and HPV-11 cells, according to Louise T. ... the findings at the Seattle conference. The National ...
Breaking Biology News(10 mins):Biometrics Market in North America 2014-2018: Key Vendors are 3M Cogent, Cross Match, NEC and Safran SA 2Biometrics Market in North America 2014-2018: Key Vendors are 3M Cogent, Cross Match, NEC and Safran SA 35 UC Riverside scientists among world's most influential scientific minds 2
... 2013) The world,s leading conservation organizations have joined together ... eastern lowland gorilla ( Gorilla beringei graueri ). Found ... Democratic Republic of Congo (DRC), Grauer,s gorilla is not only ... largest primate in the world. With their entire range ...
... advance toward overcoming a major barrier to tapping the ... medicine in developing new and more effective modern drugs. ... Information and Modeling . Andreas Bender and ... modern medicine. In the world,s largest international clinical trial, ...
... World, the first international conference examining the critical link ... the University of Pennsylvania from Wednesday, March 13, through ... Penn Institute for Urban Research (Penn IUR), in partnership ... Steering Committee representing nine schools and six centers, is ...
Cached Biology News:Gorillas caught in the crossfire in the DRC 2Gorillas caught in the crossfire in the DRC 3Penn conference tackles complex relationship between urbanization and food 2
(Date:8/23/2014)... August 23, 2014 Dr. ... LLC announced today that Janet B. Arrowsmith, MD, ... consultant. NDA Partners Premier Experts are top tier ... to bring extraordinary value to the company’s clients. ... solutions to help clients successfully develop their medical ...
(Date:8/22/2014)... August 23, 2014 This is ... state of the Papain industry in Global and ... the industry, including definitions, applications and industry chain ... analysis are provided with a focus on history, ... A comparison between the international and Chinese situation ...
(Date:8/22/2014)... August 22, 2014 Today the Academy of ... United States Court of Appeals for the D.C. Circuit challenging ... published in the Federal Register on June 25, 2014. ... contrary to the text and intent of the FAA Modernization ... Congress’ specific prohibition on any new rules or regulations regarding ...
(Date:8/22/2014)... /PRNewswire/ - BIOREM Inc. (TSXV: BRM) ("Biorem" or "the Company") today announced ... 2014.  Biorem,s complete 2014 second quarter financial statements and MD&A have been ... June 30, , Six-months ended June 30, ( in ... 2013 , 2014 , 2013 Revenue , ... 9,195 Gross profit , 56 , 1,485 , ...
Breaking Biology Technology:Noted Epidemiologist and Former FDA Deputy Director Janet B. Arrowsmith, MD, Joins NDA Partners as a Premier Expert Consultant 2Papain Industry Global & China Development Trend and Proposals Analysis Research Report Available at DeepResearchReports.com 2Papain Industry Global & China Development Trend and Proposals Analysis Research Report Available at DeepResearchReports.com 3AMA Files Petition for Review of FAA’s Interpretive Rule 2Biorem Reports 2014 Second Quarter Results 2Biorem Reports 2014 Second Quarter Results 3
... Accera Inc., a privately,held biotechnology company focused on ... it has appointed William,T. Poncy, M.B.A., as vice ... commercial launch of Ketasyn (AC-1202) as a medical ... Alzheimer,s disease. "Given his strong track record ...
... Assay Development, Biomarker Identification ... and ADME/Tox Applications, ... MCET), entered into a worldwide,exclusive license and technology purchase agreement ... human liver cell lines. Corning paid MultiCell a license ...
... Alliance, the leading,management consulting firm specializing in the pharmaceutical ... as one of the best,places to work in the ... Business Journal, ranking third among midsize companies. The award,was ... annual Best,Places to Work luncheon and awards ceremony on ...
Cached Biology Technology:Accera, Inc. Names William T. Poncy Vice President of Commercial Development 2Accera, Inc. Names William T. Poncy Vice President of Commercial Development 3MultiCell Technologies Signs Worldwide Exclusive License Agreement With Corning Incorporated 2MultiCell Technologies Signs Worldwide Exclusive License Agreement With Corning Incorporated 3Campbell Alliance Named 'Best Place to Work' by Triangle Business Journal 2
... Construction KitTM allows graphic manipulation of DNA ... has an award winning interface design that ... addition to providing sophisticated drawing capabilities for ... the "Best Plasmid Mapping Software" by the ...
... Quality ISO 9001:2000 Certified ... All Precedures Validated, SOP's Training ... Process for All Procedures GLP Documentation Upon ... one stop shopping point for all your ...
...
...
Biology Products: