Navigation Links
UCLA researchers develop T-cells from human embryonic stem cells

Researchers from the UCLA AIDS Institute and the Institute for Stem Cell Biology and Medicine have demonstrated for the first time that human embryonic stem cells can be genetically manipulated and coaxed to develop into mature T-cells, raising hopes for a gene therapy to combat AIDS.

The study, to be published the week of July 3 in the online edition of the Proceedings of the National Academy of Sciences, found that it is possible to convert human embryonic stem cells into blood-forming stem cells that in turn can differentiate into the helper T-cells that HIV specifically targets. T-cells are one of the body's main defenses against disease.

The results mark the first time that scientists have been able to derive T-cells out of human embryonic stem cells, said Zoran Galic, assistant research biologist, and lead researcher on the study.

"This tells you that you may be able to use human embryonic stem cells to treat T cell and other blood diseases. This could be a very important weapon in the fight against AIDS," Galic said.

The study is available at http://www.pnas.org/papbyrecent.shtml.

In their study, the researchers cultured human embryonic stem cells, which were incubated on mouse bone marrow support cells, which in turn converted them into blood forming cells. Those cells were then injected into a human thymus gland that had been implanted in a mouse, and the thymus then changed those blood-forming cells into T-cells. Located just above the heart in humans, the thymus is the organ where T-cells develop. It gradually shrinks in adults, weakening the immune system over time.

These results indicate that it is possible to decipher the signals that control the development of embryonic stem cells into mature T-cells, said study co-author Jerome Zack, associate director of the UCLA AIDS Institute, and professor of medicine and of microbiology,
immunology and molecul
'"/>

Source:University of California - Los Angeles


Page: 1 2

Related biology news :

1. NYU researchers simulate molecular biological clock
2. Vital step in cellular migration described by UCSD medical researchers
3. ASU researchers finds novel chemistry at work to provide parrots vibrant red colors
4. UCSD researchers maintain stem cells without contaminated animal feeder layers
5. Why do insects stop breathing? To avoid damage from too much oxygen, say researchers
6. New protein discovered by Hebrew University researchers
7. First real-time view of developing neurons reveals surprises, say Stanford researchers
8. Agilent Technologies releases automated literature search tool for biology researchers
9. Self-assembled nano-sized probes allow Penn researchers to see tumors through flesh and skin
10. Yale researchers identify molecule for detecting parasitic infection in humans
11. US life expectancy about to decline, researchers say
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: UCLA researchers develop cells from human embryonic stem cells

(Date:8/5/2015)... VIEW, Calif. , Aug. 5, 2015 ... exhibits continuous growth in applications, penetration into newer sectors, ... after year. The global biosensors space has seen the ... exited the market so far. (Photo - ... Frost & Sullivan, Analysis of the Global Biosensors ...
(Date:8/3/2015)... Calif. , Aug. 3, 2015 Synaptics, ... human interface solutions, today announced that members of the ... at the Pacific Crest Global Technology Leadership Forum on ... The conference will be held at the Sonnenalp Resort ... The presentation may include forward-looking information. An audio ...
(Date:7/31/2015)... SHENZHEN, China , 31 de julho de 2015 ... Genômica (ICG-10, www.icg-10.org ) será realizada pela BGI de ... China . A conferência está ... inauguração em 2006, a ICG se tornou uma das ... e um dos encontros científicos mais dinâmicos, entusiastas e ...
Breaking Biology News(10 mins):Innovative Biosensors Incite Use in Non-Traditional Applications 2Innovative Biosensors Incite Use in Non-Traditional Applications 3Innovative Biosensors Incite Use in Non-Traditional Applications 4A 10a. Conferência Internacional sobre Genômica (ICG-10) será em outubro 2A 10a. Conferência Internacional sobre Genômica (ICG-10) será em outubro 3
... promising new anticancer agents could have unforeseen risks in ... School of Medicine in St. Louis. The anticancer drugs ... antagonists interfere with a biochemical process that promotes ... that interfering with this biochemical process in mice with ...
... CAMBRIDGE, Mass., June 23, 2008 Biologists at Harvard ... weapons: When threatened, these species puncture their own skin ... as claws capable of wounding predators. The unusual ... James Hanken, and Farish A. Jenkins, Jr., in a ...
... to set the agenda for urgent research in the field ... on 26 October 2008, at the European Heart House, headquarters ... Fibrillation (AF) affects several million people in the European Union. ... that one in four 40 year olds will develop AF ...
Cached Biology News:Certain anticancer agents could be harmful to patients with heart disease 2Certain anticancer agents could be harmful to patients with heart disease 3When threatened, a few African frogs can morph toes into claws 2EHRA-AFNET summit on AF 2
(Date:9/2/2015)... , Sept. 2, 2015 Aytu BioScience, ... developing treatments for urological and related conditions, announced today ... planned private placement convertible note financing, raising a total ... tranches totaling $3.175 million. Josh ... from this private placement are intended to be used ...
(Date:9/2/2015)... , September 2, 2015 ... ("BioLight" or the "Company"), a firm that invests ... and cancer diagnostics, announced today that presentations highlighting ... will be delivered at the Ophthalmology Futures European ... Society of Cataract & Refractive Surgeons ("ESCRS"), both ...
(Date:9/2/2015)... , September 2, 2015 ... des Wettbewerbs BeHEARD von 2015 bekanntgeben zu können. ... Rare Genomics Institute. Biovista unterstützt mit ... für die Behandlung anderer Krankheiten als denen, für ... Laffoon und sein Team bei der Wylder ...
(Date:9/2/2015)... Whitehouse, NJ (PRWEB) , ... September 02, 2015 ... ... key Technical Services Staff members will be attending Pharma Ed Resources upcoming ... and respected group of industry leading speakers, this timely conference will provide Updates ...
Breaking Biology Technology:Aytu BioScience Completes $5.175 Million Private Placement 2Aytu BioScience Completes $5.175 Million Private Placement 3Presentations to Highlight BioLight's IOPtiMate[TM] System at Upcoming European Ophthalmology Conferences 2Presentations to Highlight BioLight's IOPtiMate[TM] System at Upcoming European Ophthalmology Conferences 3Biovista sponsert die Forschung von Wylder Nation Foundation zum Thema Mangel an saurer Sphingomyelinase 2Whitehouse Laboratories to Participate in Pharm Ed Resources Extractables, Leachables, & Elemental Impurities Educational Seminar 2Whitehouse Laboratories to Participate in Pharm Ed Resources Extractables, Leachables, & Elemental Impurities Educational Seminar 3
... CORD:USE Cord Blood Bank, a public cord blood banking facility, ... month their plans to open a family cord blood bank to ... privately bank their baby,s cord blood.  The Team of experts in ... , Joanne Kurtzberg , John Wagner , Eliane ...
... ... Complete Set of Intuitive Gene-Building Tools , ... (PRWEB) June 17, 2010 -- DNA2.0 , the leading gene synthesis and ... sequences: Gene Designer 2.0 . Building on the success of the original Gene Designer, ...
... ... (hECM) produced under proprietary conditions of hypoxia and suspension have demonstrated its ability to diminish ... and in vivo. , ... SAN DIEGO, CA (PRWEB) June 17, 2010 - Histogen, Inc., a regenerative medicine company developing ...
Cached Biology Technology:Leading Cord Blood Experts Clarify Their Support of CORD:USE Family Cord Blood Bank 2DNA2.0 Introduces Powerful, Free Gene Design Software 2DNA2.0 Introduces Powerful, Free Gene Design Software 3DNA2.0 Introduces Powerful, Free Gene Design Software 4Human Embryonic-Like Extracellular Matrix Significantly Inhibits Tumor Growth and Cancer Cell Proliferation 2Human Embryonic-Like Extracellular Matrix Significantly Inhibits Tumor Growth and Cancer Cell Proliferation 3
... a combination of an orbital shaker and ... while providing gentle, thorough mixing without foaming. ... used for a variety of applications including ... immunoblots, staining/destaining, chromatography, etc. The VSN-5 Nutating ...
... for the rapid purification of linear 100 bp ... DNA band is excised from an,agarose gel and ... base of the column are a series of ... back while allowing DNA to selectively pass through ...
...
... The Synaptic Vesicles Isolation Kit provides ... an enriched synaptic vesicle fraction. The ... lysis of the synaptosomes, and differential ... gradient. The kit also contains an ...
Biology Products: