Navigation Links
UCLA imaging study of children with autism finds broken mirror neuron system

New imaging research at UCLA detailed Dec. 4 as an advance online publication of the journal Nature Neuroscience shows children with autism have virtually no activity in a key part of the brain's mirror neuron system while imitating and observing emotions.

Mirror neurons fire when a person performs a goal-directed action and while he or she observes the same action performed by others. Neuroscientists believe this observation-execution matching system provides a neural mechanism by which others' actions, intentions and emotions can be understood automatically.

Symptoms of autism include difficulties with social interaction -- including verbal and nonverbal communication -- imitation and empathy. The new findings dramatically bolster a growing body of evidence pointing to a breakdown of the brain's mirror neuron system as the mechanism behind these autism symptoms.

"Our findings suggest that a dysfunctional mirror neuron system may underlie the social deficits observed in autism," said Mirella Dapretto, lead author and assistant professor in residence of psychiatry and biobehavioral sciences at the Semel Institute for Neuroscience and Human Behavior at UCLA and the David Geffen School of Medicine at UCLA. "Together with other recent data, our results provide strong support for a mirror neuron theory of autism. This is exciting because we finally have an account that can explain all core symptoms of this disorder."

Conducted at the Semel Institute's Ahmanson-Lovelace Brain Mapping Center, the research used functional magnetic resonance imaging (fMRI) to measure brain activity in 10 high-functioning children with autism while they imitated and observed 80 photos depicting different emotions such as anger, fear, happiness or sadness. In addition, the brain activity of 10 typically developing children was studied while performing the same tasks.

Separately, symptom severity of each child with autism was tested using two independent measures (the Autism Diagnostic Observation Schedule -- Generic, and the Autism Diagnostic Interview).

The study shows that unlike typically developing children, children with autism have virtually no activity in the pars opercularis of the inferior frontal gyrus, identified by previous research as a key part of the mirror neuron system. Importantly, the level of mirror neuron activity seen in children with autism was inversely related to symptom severity in the social domain.

Children with autism also showed reduced activity in the emotion centers of the brain, consistent with the hypothesis that this mirroring mechanism may play a crucial role for understanding how others feel and for empathizing with them.

All of the children rehearsed the tasks prior to the fMRI scans to assure researchers they could perform the tasks. Both groups performed equally well. Normal brain activity in areas of the brain involving sight and facial movements indicated that the children with autism remained on task during the fMRI scans.


'"/>

Source:University of California - Los Angeles


Related biology news :

1. New imaging method gives early indication if brain cancer therapy is effective, U-M study shows
2. Duke engineers develop new 3-D cardiac imaging probe
3. Confocal imaging promises early detection of skin cancer
4. Newer imaging techniques may lead to over-treatment
5. Researchers use 3-D imaging system to unveil swimming behavior of microscopic plankton
6. Microscopic brain imaging in the palm of your hand
7. New imaging technology shown to detect pancreatic inflammation in type 1 diabetes
8. Purdues gold nanorods brighten future for medical imaging
9. PET imaging reveals the immune system at work
10. New technique puts brain-imaging research on its head
11. T-rays: New imaging technology spotlighted by American Chemical Society
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/30/2017)... YORK , March 30, 2017 Trends, ... type (physiological and behavioral), by technology (fingerprint, AFIS, iris ... voice recognition, and others), by end use industry (government ... and immigration, financial and banking, and others), and by ... Europe , Asia Pacific , ...
(Date:3/27/2017)... 2017  Catholic Health Services (CHS) has been ... (HIMSS) Analytics for achieving Stage 6 on the ... In addition, CHS previously earned a place in ... electronic medical record (EMR). "HIMSS Analytics ... EMR usage in an outpatient setting.  This recognition ...
(Date:3/23/2017)... , March 23, 2017 The report "Gesture Recognition and ... Industry, and Geography - Global Forecast to 2022", published by MarketsandMarkets, the market ... CAGR of 29.63% between 2017 and 2022. Continue ... ... ...
Breaking Biology News(10 mins):
(Date:4/27/2017)... ... April 27, 2017 , ... The Council for Agricultural ... to Jayson Lusk, a consummate communicator who promotes agricultural science and technology in ... as he explains how innovation and growth in agriculture are critical for food ...
(Date:4/26/2017)... ... April 26, 2017 , ... Looking for gift ... cooking events company, offers one-of-a-kind gifts, ranging from gourmet cooking experiences to Farmer’s ... and guests leave inspired with new cooking tips and techniques, thanks to Chef ...
(Date:4/26/2017)... ... April 25, 2017 , ... LABS, Inc. (LABS) announced in ... to its extensive test menu: Nucleic Acid Testing (NAT) for ZIKV; and Enzyme Immunoassays ... able to offer NAT screening for blood donors under an Investigational New Drug (IND) ...
(Date:4/26/2017)... , ... April 26, 2017 , ... ... and drive high-level conversations among healthcare industry stakeholders, the discussion surrounding the topic ... taking place May 15-18, 2017 in Los Angeles, Calif. Hosted by the Workgroup ...
Breaking Biology Technology: