Navigation Links
UCLA discovery will aid in treatment of patients with a deadly brain cancer

a, but it was not clear what characteristics made them respond to these drugs. There had to be critical molecular factors that determined response, Mischel said.

He and his team set out to find the molecular determinants that indicated which patients would respond best to EGFR blockers. Previous UCLA research in brain and other cancers suggested that the key might be the interaction of the PTEN protein and a mutant protein called EGFRvIII. About half of patients with amplified EGFR also have this mutant protein.

The UCLA team and their collaborators studied a subset of 26 glioblastoma patients who either responded very well or very poorly to EGFR blocking drugs and developed a way to test their brain tumor tissue for the presence of both the mutant and PTEN proteins. Mischel's team found that patients with both genetic variations were 51 times more likely to respond to EGFR blockers. They also lived five times longer after initiating therapy than those without the variation, surviving 253 days versus 50 days.

To confirm their promising work, Mischel and his team obtained tissue samples from 33 brain cancer patients treated at another facility without knowing who the responders were. They were able to independently replicate their results, confirming that those with both genetic variations were more likely to respond to EGFR blocking drugs.

The study shows that glioblastoma patients can respond to targeted agents, and suggests that patients likely to benefit from treatment can be identified by molecular testing. The study also raised the possibility that patients whose tumors lack the genetic variations in the molecular signature could possibly be treated with drugs to make them more sensitive to EGFR blockers.

Of the 8,000 to 10,000 glioblastoma patients diagnosed each year, about 10 to 20 percent have the combination of the mutant and PTEN proteins, Mischel said. The next step is a prospective study, determining the molecular
'"/>

Source:University of California - Los Angeles


Page: 1 2 3

Related biology news :

1. Protein discovery could unlock the secret to better TB treatment
2. Purdue proves concept of using nano-materials for drug discovery
3. UCSD discovery may help extend life of natural pesticide
4. Leprosy microbes lead scientists to immune discovery
5. Biochemists report discovery of structure of major piece of telomerase; implications for cancer
6. Researchers make surprise discovery that some neurons can transmit three signals at once
7. Important discovery about second most fatal cancer
8. Harmless virus may hold key to more effective HIV drug discovery
9. Fundamental discovery -- Bone fracture
10. Genetic discovery could lead to drought-resistant plants
11. Gene discovery sheds light on causes of rare disease, cancer
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: UCLA discovery will aid treatment patients with deadly brain cancer

(Date:8/28/2014)... systems are good examples of complex systems. Their ... networkincluding water for cooling, transport to supply fuel, ... step in the network chain is interconnected with ... dependent. A team of UK-based scientists has studied ... The findings have been published in EPJ B ...
(Date:8/28/2014)... More than 25 million kilometres of new roads will ... will slice into Earth,s last wildernesses, where they bring ... , Now, an ambitious study has created a ... to try to balance the competing demands of development ... an ,environmental-values, layer that estimates that natural importance of ...
(Date:8/28/2014)... to alert the world to Global Warming, has called ... stored underground. He says that Carbon Capture, combined with ... to avoid global warming getting out of control over ... York) made the call during his presentation to the ... are meeting to discuss Carbon Capture and Storage. ...
Breaking Biology News(10 mins):Inter-dependent networks stress test 2Study shows where on the planet new roads should and should not go 2Study shows where on the planet new roads should and should not go 3Global warming pioneer calls for CO2 to be taken from atmosphere and stored underground 2
... TALLAHASSEE, Fla. -- One of the world,s most ... brain evolution of modern humans and their ancestors, according ... The Taung fossil the first australopithecine ever discovered ... Falk and a group of anthropological researchers. Their findings, ...
... Sustainability has become a major focus for federal, ... This National Research Council symposium will showcase ... identify opportunities to help promote practices that would ... will highlight science and technology research contributions to ...
... from the European Alps suggests that population declines to ... the long-term effects of recent climate warming on mountain ... from the Department of Conservation Biology, Vegetation and Landscape ... modeling tool to predict migration of mountain plants which ...
Cached Biology News:Anthropologist finds explanation for hominin brain evolution in famous fossil 2European mountain plant population shows delayed response to climate change 2
(Date:8/28/2014)... month, executives from clinical trial marketing firm BBK Worldwide will ... Patient-Centered Clinical Trials 2014 , to be held at the ... 4-5. Patient recruitment experts Bonnie A. Brescia , ... insights on the benefits of employing an effective patient engagement ... to mobile apps – can be used to drive study ...
(Date:8/28/2014)... TALLAHASSEE, Fla. Exciting new work by a Florida ... molecular system that can take your temperature, emit white ... , And, the molecule looks like a butterfly. , ... and Biomedical Engineering in the FAMU-FSU College of Engineering, ... ago, but has continued to discover that his creation ...
(Date:8/28/2014)... 28, 2014 PrimeSource Building Products, ... selected SoundConnect to support their communication ... audio and web conferencing platform GlobalMeet powered by ... employees’ needs. SoundConnect delivers award winning “results ... Building Products will be utilizing GlobalMeet powered ...
(Date:8/27/2014)... Green & Grow Inc. (GGI) has raised an ... Otter Capital as a significant new partner. Otter Capital’s ... Agriplier™ technology, building on recent compelling field trial results ... meeting, we have been impressed with Otter Capital’s knowledge ... Sobba, President and CEO of GGI. “We look forward ...
Breaking Biology Technology:BBK Worldwide Leads Sessions at Key September Events 2Novel 'butterfly' molecule could build new sensors, photoenergy conversion devices 2PrimeSource Chooses SoundConnect as Collaboration Provider 2Green & Grow Inc. Secures $6M Series B Funding from Otter Capital 2Green & Grow Inc. Secures $6M Series B Funding from Otter Capital 3
... Research Society awarded Walter A. de Heer, professor of physics ... its annual fall meeting in Boston today. De Heer was ... science and technology of epitaxial graphene." The MRS Medal recognizes ... years. The MRS Medal is awarded for a specific outstanding ...
... Physicians at Thomas Jefferson University Hospital reported today ... fully automated interpretation of coronary CT angiography (cCTA) by ... artery disease (CAD) in the major coronary arteries as ... Chicago at the Radiological Society of North America (RSNA) ...
... tiny, hair-like blood vessels in the back of our ... vessels like those that bring blood to the heart respond ... revealed that otherwise healthy people exposed to high levels of ... higher risk of heart disease. Previous studies linked pollution ...
Cached Biology Technology:Georgia Tech's Walt de Heer awarded Materials Research Society Medal 2Rcadia COR Analyzer System Safely Rules Out Coronary Artery Disease in Main Coronary Arteries and Branch Vessels 2Photos of tiny blood vessels in the eye link air pollution to heart disease 2
Gridded Cell Culture Petri Dish (20 mm molded in base), tissue-culture treated...
Chicken Anti-Human DNA-directed RNA Polymerase II 7.6 Kd Polypeptide (POLR2L Polyclonal AntibodyOther Sub-Family: not assigned-Other Applications: ELISA, Western Blot...
... RPMI 1640 with 2 mM L-glutamine and harvested ... order to keep the antigens in their native ... cells are arrayed on a 12-well (5 mm) ... treated to enhance cellular attachment and to minimize ...
...
Biology Products: