Navigation Links
UCLA cancer researchers shake loose hidden biomarker

Using a common chemotherapy agent, researchers at UCLA's Jonsson Cancer Center and the Department of Pathology and Laboratory Medicine found a way to move an important biomarker expressed in prostate cancer, shaking it loose from one location in a cell ?where it could not be accessed by blood ?to another, easier to target area.

The discovery, outlined in the cover article of May 11 edition of the peer-reviewed journal Molecular Cancer Therapeutics, could have important implications for using immunotherapy to treat prostate cancer, said Ayyappan K. Rajasekaran, a Jonsson Cancer Center researcher and senior author of the article.

The method discovered by the research team places the prostate-specific membrane antigen (PSMA) in a location on the cell that would allow blood-borne immunotherapies to access the biomarker, transforming it from a hidden target into an exposed one.

"In prostate cancer cells, PSMA is expressed in the apical region of the cell membrane, which blood can't reach, so injection of immunotherapy into the bloodstream is not effective," said Rajasekaran, also an associate professor of pathology and laboratory medicine. "By using information from very basic studies about how the PSMA protein is targeted in these cells, we identified a way to redirect this protein within the cell. We found that if we disturbed hollow tubular structures called microtubules, part of the cell's framework, we were able to relocate PSMA from its 'hidden' location on the apical membrane to an accessible area in the basolateral surface."

To cause this disturbance and the resulting relocation of PSMA, Rajasekaran and his team employed a commonly used cancer chemotherapy agent, which destroys the microtubules.

"These patients are getting chemotherapy anyway, and once we move the PSMA to a more accessible area on the prostate cancer cell, we might be able to use antibody-based immunotherapies as well, and they could be administered in the b
'"/>

Source:University of California - Los Angeles


Page: 1 2

Related biology news :

1. Viral DNA sequence a possible trigger for breast cancer
2. Enzyme, lost in most mammals, is shown to protect against UV-induced skin cancer
3. Its not all genetic: Common epigenetic problem doubles cancer risk in mice
4. Columbia research lifts major hurdle to gene therapy for cancer
5. Combination therapy boosts effectiveness of telomere-directed cancer cell death
6. Mitochondrial DNA mutations play significant role in prostate cancer
7. New imaging method gives early indication if brain cancer therapy is effective, U-M study shows
8. BRCA1 causes ovarian cancer through indirect, biochemical route
9. Researchers identify target for cancer drugs
10. Weizmann Institute scientists develop a new approach for directing treatment to metastasized prostate cancer in the bones.
11. First atlas of key brain genes could speed research on cancer, neurological diseases
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: UCLA cancer researchers shake loose hidden biomarker

(Date:5/7/2015)... May 7, 2015 Fingerprint ... FPC1022 and FPC1035, FPC,s smallest touch fingerprint sensors ... mainly considered for integration on the backside of ... OEMs increased possibilities to integrate touch fingerprint sensors ... also improves possibilities for module manufacturers to customize ...
(Date:4/27/2015)... -- For more than four decades, AUVSI,s Unmanned Systems ... worldwide event for the unmanned land, sea, and air ... any local, national, or trade news organization interested in ... current applications of unmanned technologies. The conference will explore ... industry, and how it will soon impact the lives ...
(Date:4/21/2015)... BURNABY, Canada , April 21, 2015 ... spending and evolving government policies are boosting access control ...   According to a recently published report ... & Opportunities, 2020 ", the access control systems market ... to nearly USD1.2 billion by 2020.The access control systems ...
Breaking Biology News(10 mins):FPC Introduces its Smallest Touch Fingerprint Sensors to Date 2UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 2UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 3UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 4UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 5Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 2Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 3
... disappearing. These fearsome yet charismatic fish continue to fall ... of extinction as a result. New research shows that ... work shows that the deeper sharks live, the longer ... are just now learning critical details of their behavior, ...
... evolution of human speech was far more complex than is ... specific gene, says Robert Berwick, professor of computational linguistics at ... a session at the annual meeting of the American Association ... session is called Mind of a Toolmaker, and explores the ...
... French . , Sharks are disappearing from the worlds ... by more than half due to increased demand for shark ... and swordfish fisheries, where millions of sharks are taken as ... sharks has been assessed by the World Conservation Union (IUCN), ...
Cached Biology News:New research reveals shark superhighways and hotspots 2New research reveals shark superhighways and hotspots 3New research reveals shark superhighways and hotspots 4MIT: No easy answers in evolution of human language 2MIT: No easy answers in evolution of human language 3Ocean's fiercest predators now vulnerable to extinction 2
(Date:6/2/2015)... ST. LOUIS , June 2, 2015 /PRNewswire/ ... leading Life Science and Technology company, announced today ... XCell Science to launch genetically engineered human ... to advance the research of neurological diseases. These ... portfolio, provide unique and versatile tools for the ...
(Date:6/2/2015)... 2015 /PRNewswire/ -- China Cord Blood Corporation (NYSE: CO ) ... leading provider of cord blood collection, laboratory testing, ... announced that the Special Committee of the Company,s board of ... ( China ) Limited as its independent financial ... its United States legal counsel and ...
(Date:6/2/2015)... AKRON, Ohio , June 2, 2015 ... today pledged its commitment to antibiotic stewardship at the ... and human and animal health organizations and stakeholders at ... next five years to slow the emergence of antibiotic-resistant ... existing antibiotics, and prevent the spread of resistant infections. ...
(Date:6/2/2015)... 2, 2015 MGB Biopharma ... resistance problem  MGB Biopharma, a biopharmaceutical ... to address the major global problem of antibiotic ... stable intravenous (IV) formulation of MGB-BP-3, designed for the ... The intravenous formulation of MGB-BP-3 is ...
Breaking Biology Technology:Sigma-Aldrich to Launch XCell Science Genetically Engineered iPSC-Derived Neural Disease Cells 2Sigma-Aldrich to Launch XCell Science Genetically Engineered iPSC-Derived Neural Disease Cells 3China Cord Blood Corporation's Special Committee Appoints Independent Financial Advisor and Legal Counsel to Evaluate Non-binding "Going Private" Proposal 2China Cord Blood Corporation's Special Committee Appoints Independent Financial Advisor and Legal Counsel to Evaluate Non-binding "Going Private" Proposal 3GOJO Among Leaders At The White House Forum On Antibiotic Stewardship 2GOJO Among Leaders At The White House Forum On Antibiotic Stewardship 3GOJO Among Leaders At The White House Forum On Antibiotic Stewardship 4MGB Biopharma Succeeds in Developing an IV Formulation of MGB-BP-3 for the Treatment of Systemic Susceptible and Resistant Gram-Positive Hospital-Acquired Infections 2MGB Biopharma Succeeds in Developing an IV Formulation of MGB-BP-3 for the Treatment of Systemic Susceptible and Resistant Gram-Positive Hospital-Acquired Infections 3
... To understand friction on a very small scale, a team ... , Friction is a force that affects any application where ... is, the stronger the force. At the nanoscale mere ... tiny devices made from only a small number of atoms ...
... Cornerstone Therapeutics Inc. (Nasdaq: CRTX ), a ... medications for respiratory disorders, today announced that it will ... Thursday, March 26, 2009, to discuss its financial results ... Management will also provide an update on the ...
... Hire - Tony Mallia, Practice DirectorFAIRFAX, Va., Feb. 25 ... to announce the addition to our team of Tony ... the methodology for enterprise engineering, bringing to bear his ... organizations in the federal and financial services sectors. The ...
Cached Biology Technology:Models present new view of nanoscale friction 2Cornerstone Therapeutics to Host Quarter and Year Ended December 31, 2008 Conference Call 2Cornerstone Therapeutics to Host Quarter and Year Ended December 31, 2008 Conference Call 3Cornerstone Therapeutics to Host Quarter and Year Ended December 31, 2008 Conference Call 4Edmond Scientific Company 'Spotlight on the Executive': 2
...
... mouth PYREX Fernbach-style culture flask is designed for ... volume ratio. It can also be used in ... edges to achieve maximal oxygen transfer to culture ... and accepts cotton plugs or No. 13 rubber ...
These are replacement caps for No. CLS6980 5mm PYREX NMR tubes. Proper method to remove caps is to slice them from the tube. Caps come in eight assorted/mixed colors. Packed in bags of 100....
... for nucleic acid electrophoresis in agarose ... Preparation Quantity Equivalency: A final concentration ... stock solution can be made in ... Dye content ~ 75% Special ...
Biology Products: