Navigation Links
UCLA AIDS Institute researchers find a peptide that encourages HIV infection

UCLA AIDS Institute researchers have discovered that when a crucial portion of a peptide structure in monkeys that defends against viruses, bacteria and other foreign invaders is reversed, the peptide actually encourages infection with HIV.

The findings, published in the April issue of AIDS Research and Human Retroviruses, could pave the way for the use of such peptides in gene therapy using HIV-based vectors as the delivery method.

"Although it may seem counterintuitive to value or even study a peptide that increases the ability of HIV-1 to enter a broad range of human cells, retroviral vectors are currently being explored as vehicles for gene therapy," the authors wrote. "In this area, at least, agents that enhance retroviral uptake could contribute to an emerging field of medicine."

"So many people have tried to deliver genes into different kinds of cells," said study co-author Shen Pang, adjunct associate professor at the UCLA School of Dentistry and a member of the UCLA AIDS Institute. "If you know of some method that can enhance gene delivery, you would have a useful tool."

Retrocyclin-1 (RC-100) is a circular peptide that has been shown in previous studies to inhibit the infection of CD4 cells with HIV. RC-111 is also cyclic and has the same amino acid sequence as retrocyclin-1. In both peptides, the amino acids are strung like 18 beads along the molecule's backbone. The amino acids in RC-111, however, are in reverse order.

The researchers had initially wanted to quantify previous research by Dr. Robert I. Lehrer, distinguished professor of medicine in the division of infectious diseases at the David Geffen School of Medicine at UCLA and a co-author of the present study. Unexpectedly, the researchers discovered that while retrocyclin-1 inhibited infection of CD4 cells with HIV-1 by about 95 percent, the RC-111 variant enhanced viral infection five-fold.

There are three structural varieties of peptid
'"/>

Source:University of California - Los Angeles


Page: 1 2

Related biology news :

1. Weizmann Institute scientists develop a new approach for directing treatment to metastasized prostate cancer in the bones.
2. Affymetrix and the Karolinska Institutet Announce Translational Medicine Strategic Alliance
3. BioMed Central welcomes the new National Institutes of Health public access policy
4. Institute for Systems Biology Symposium Addresses Need for Better Computational Tools
5. Virginia Tech, Nanjing Institute researchers discover half-billion year-old fossils
6. UC San Diego partners with Venter Institute to build marine microbial genomics cyberinfrastructure
7. Weizmann Institute suggests that immune cells help to maintain cognition and brain cell renewal
8. Virginia Bioinformatics Institutes launches microbial database
9. Weizmann Institute scientists discover a molecular security mechanism for keeping mutations in check
10. Latest advances in DNA sequencing highlighted at DOE Joint Genome Institute User Meeting
11. NYU researchers simulate molecular biological clock
Post Your Comments:
(Date:12/10/2014)... Research and Markets ( http://www.researchandmarkets.com/research/xclcvw/biometrics_market ... "Biometrics Market in Japan 2014-2018" report to ... The integration of biometrics and ... and upgradation of the driver,s license is one ... Besides the aforementioned projects, biometrics is being used ...
(Date:12/4/2014)... , Dec. 3, 2014  Crossmatch™, a ... announced that its DigitalPersona ® Pro Enterprise ... have been deployed throughout First Bank branch locations ... South Carolina and Virginia. First Bank, ... Southern Pines, North Carolina , selected ...
(Date:11/21/2014)... 2014  Earlier this year Donald Spector , ... one of the most prolific inventors in the world, ... from Smartphones to third party agencies. Spector envisioned this ... of the earliest known patents in this area. Now ... military, child care, elder care and hospital applications. This ...
Breaking Biology News(10 mins):Biometrics Market in Japan 2014-2018: Key Vendors are DDS, Fujitsu, Hitachi and NEC 2First Bank Partners with Crossmatch to Increase Log In Security 2First Bank Partners with Crossmatch to Increase Log In Security 3Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 2Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 3Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 4
... Two scientists from Cold Spring Harbor Laboratory (CSHL) are ... genetic mutation that causes Joubert Syndrome. JBTS, as it ... that is very rare in the general population but ... The study was published in collaboration with Dor Yeshorim, ...
... crops relies on a relatively stable climate, not dramatic ... evolutionary, ecological, genetic and agronomic considerations, Dr. Shahal Abbo, ... Hebrew University of Jerusalem, Israel, and colleagues, demonstrate why ... domestication in the Near East. Rather, the variety of ...
... COLUMBIA, Md. , Jan. 12 Cylex Incorporated® ... Panel approved the creation of new CPT coding based on ... the fact that existing CPT codes insufficiently captured all steps ... , In an effort to keep customers informed of these ...
Cached Biology News:CSHL scientists use next-gen sequencing to rapidly discover genetic cause of devastating disorder 2Stable climate and plant domestication linked 2Cylex(TM) Awarded New CPT Code For Its ImmuKnow(R) Assay 2Cylex(TM) Awarded New CPT Code For Its ImmuKnow(R) Assay 3
(Date:12/15/2014)... 2014  Origin Agritech Limited (NASDAQ GS: SEED) (" Origin ... crop seeds in China , today announced ... 2014 ended September 30, 2014, before the market opens on ... a teleconference on January 8, 2015, at 8:00 a.m. ET ... discuss the results. To participate in the call, please dial ...
(Date:12/13/2014)... The DNA Microarray market market was ... expected to grow at a CAGR of 15.2% ... TOC of the DNA Microarray for an in-depth ... help of various tables and figures. , ... consists of instrument, consumables, and services, where the ...
(Date:12/13/2014)... 2014  Vermillion, Inc. (NasdaqCM: VRML), a bio-analytical solutions company ... Veronica G. H. Jordan , Ph.D., and ... Directors, bringing the total number of directors to eight, ... Jim LaFrance , Chairman, President, and Chief Executive Officer ... the appointments of Veronica and David to our board ...
(Date:12/12/2014)... Graphite Metallizing Corporation, the manufacturer of self-lubricating ... has appointed Kirk Staller as Sales Engineering Representative for ... a B.S. degree from Purdue University and has over ... of it with a manufacturer of centrifugal pumps. He ... , “We are pleased to have Kirk join ...
Breaking Biology Technology:Origin Agritech Limited to Announce Fiscal 2014 Annual Financial Results on January 8th, 2015 2Origin Agritech Limited to Announce Fiscal 2014 Annual Financial Results on January 8th, 2015 3DNA Microarray Market Is Expected to Grow at a CAGR of 15.2% from 2014 to 2019 - A Report by MicroMarket Monitor 2DNA Microarray Market Is Expected to Grow at a CAGR of 15.2% from 2014 to 2019 - A Report by MicroMarket Monitor 3DNA Microarray Market Is Expected to Grow at a CAGR of 15.2% from 2014 to 2019 - A Report by MicroMarket Monitor 4Vermillion Strengthens Board of Directors with Appointments of Veronica Jordan, Ph.D., and David Schreiber 2Vermillion Strengthens Board of Directors with Appointments of Veronica Jordan, Ph.D., and David Schreiber 3Kirk Staller Joins Graphite Metallizing Corporation 2
... WA, and VANCOUVER, Oct. 9 /PRNewswire-FirstCall/ - OncoGenex Pharmaceuticals, ... Cormack, president and chief executive officer of OncoGenex, has ... The Year(R). The Ernst & Young Entrepreneur Of The ... entrepreneurs that are building successful, dynamic businesses. , "I ...
... ... Supersaturation Assessment and Control for the Development and Optimization of Crystallization Processes, a method ... for the production and control of qualitative supersaturation trajectories. , ... (PRWEB) October 9, 2009 -- The quantitative ...
... , ... is announcing its 2010 Best Practices awards program and is opening the call for ... of technology and strategic innovation--initiatives and collaborations that manifestly improve some facet of the ... ...
Cached Biology Technology:OncoGenex Pharmaceuticals CEO Named Canada's Pacific Ernst & Young's Entrepreneur Of The Year(R) in the Health Sciences Category 2OncoGenex Pharmaceuticals CEO Named Canada's Pacific Ernst & Young's Entrepreneur Of The Year(R) in the Health Sciences Category 3Calibration Free Supersaturation Assessment and Control for the Development and Optimization of Crystallization Processes 2The 2010 Bio-IT World Best Practices Call for Entries has been Released -- Highlight your Company's Excellence in Innovation 2The 2010 Bio-IT World Best Practices Call for Entries has been Released -- Highlight your Company's Excellence in Innovation 3
... is the simplest, easiest-to-use system ever for ... handling capabilities,into their labs, or groups in ... applications on a separate instrument. Plate-handling is ... even when you have thousands of samples., ...
Cells are grown in triple flasks, roller bottles, or NUNC Factory. Viability and growth curves are generated from a parallel representative culture....
NovaScreen offers cell biology, cell culture and molecular biology services for companies who lack a cell culture facility....
... Affinity Life Sciences provides cost effective cell ... proteins or monoclonal antibodies. Quality at a ... whether you require research or commercial product, ... production methods such as roller bottles, hollow ...
Biology Products: