Navigation Links
UCLA AIDS Institute researchers find a peptide that encourages HIV infection

UCLA AIDS Institute researchers have discovered that when a crucial portion of a peptide structure in monkeys that defends against viruses, bacteria and other foreign invaders is reversed, the peptide actually encourages infection with HIV.

The findings, published in the April issue of AIDS Research and Human Retroviruses, could pave the way for the use of such peptides in gene therapy using HIV-based vectors as the delivery method.

"Although it may seem counterintuitive to value or even study a peptide that increases the ability of HIV-1 to enter a broad range of human cells, retroviral vectors are currently being explored as vehicles for gene therapy," the authors wrote. "In this area, at least, agents that enhance retroviral uptake could contribute to an emerging field of medicine."

"So many people have tried to deliver genes into different kinds of cells," said study co-author Shen Pang, adjunct associate professor at the UCLA School of Dentistry and a member of the UCLA AIDS Institute. "If you know of some method that can enhance gene delivery, you would have a useful tool."

Retrocyclin-1 (RC-100) is a circular peptide that has been shown in previous studies to inhibit the infection of CD4 cells with HIV. RC-111 is also cyclic and has the same amino acid sequence as retrocyclin-1. In both peptides, the amino acids are strung like 18 beads along the molecule's backbone. The amino acids in RC-111, however, are in reverse order.

The researchers had initially wanted to quantify previous research by Dr. Robert I. Lehrer, distinguished professor of medicine in the division of infectious diseases at the David Geffen School of Medicine at UCLA and a co-author of the present study. Unexpectedly, the researchers discovered that while retrocyclin-1 inhibited infection of CD4 cells with HIV-1 by about 95 percent, the RC-111 variant enhanced viral infection five-fold.

There are three structural varieties of peptid es, also known as defensins ?alpha, beta and theta, Lehrer said. Humans have only alpha and beta; monkeys have all three.

"Here's a peptide whose normal structure allows it to protect against viruses, yet if you make the same peptide and place its amino acids in a reverse order, that lets the virus in," Lehrer said. "We would like to learn why it happens, but at the moment there's no explanation for this paradoxical result."

Still, the findings seem to show promise in gene therapy.


'"/>

Source:University of California - Los Angeles


Related biology news :

1. Weizmann Institute scientists develop a new approach for directing treatment to metastasized prostate cancer in the bones.
2. Affymetrix and the Karolinska Institutet Announce Translational Medicine Strategic Alliance
3. BioMed Central welcomes the new National Institutes of Health public access policy
4. Institute for Systems Biology Symposium Addresses Need for Better Computational Tools
5. Virginia Tech, Nanjing Institute researchers discover half-billion year-old fossils
6. UC San Diego partners with Venter Institute to build marine microbial genomics cyberinfrastructure
7. Weizmann Institute suggests that immune cells help to maintain cognition and brain cell renewal
8. Virginia Bioinformatics Institutes launches microbial database
9. Weizmann Institute scientists discover a molecular security mechanism for keeping mutations in check
10. Latest advances in DNA sequencing highlighted at DOE Joint Genome Institute User Meeting
11. NYU researchers simulate molecular biological clock
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/21/2016)... 21, 2016 NuData Security announced today that ... of principal product architect and that Jon ... customer development. Both will report directly to ... moves reflect NuData,s strategic growth in its product ... customer demand and customer focus values. ...
(Date:6/9/2016)... TURKU, Finland , June 9, 2016 ... French National Police deploy Teleste,s video security solution to ensure ... France during the major tournament ... and data communications systems and services, announced today that its ... Police Prefecture to back up public safety across ...
(Date:6/2/2016)... , June 2, 2016 ... Manned Platforms, Unmanned Systems, Physical Infrastructure, Support & Other ... provider visiongain offers comprehensive analysis of the ... this market will generate revenues of $17.98 billion in ... acquired DVTEL Inc, a leader in software and hardware ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... A person commits a crime, and the detective ... the criminal down. An outbreak of foodborne illness ... (FDA) uses DNA evidence to track down the bacteria that ... It,s not. The FDA has increasingly used a complex, cutting-edge ... illnesses. Put as simply as possible, whole genome sequencing is ...
(Date:6/23/2016)... 23, 2016   EpiBiome , a precision microbiome ... in debt financing from Silicon Valley Bank (SVB). The ... to advance its drug development efforts, as well as ... "SVB has been an incredible strategic partner to ... traditional bank would provide," said Dr. Aeron Tynes ...
(Date:6/23/2016)... BEACH, Calif. , June 23, 2016  Blueprint ... new biological discoveries to the medical community, has closed ... co-founder Matthew Nunez . "We have ... us with the capital we need to meet our ... will essentially provide us the runway to complete validation ...
(Date:6/23/2016)... ... June 23, 2016 , ... Velocity Products, ... tools designed, tuned and optimized exclusively for Okuma CNC machining centers at The ... of a collaboration among several companies with expertise in toolholding, cutting tools, machining ...
Breaking Biology Technology: