Navigation Links
UCF nanoparticle offers promise for treating glaucoma

A unique nanoparticle made in a laboratory at the University of Central Florida is proving promising as a drug delivery device for treating glaucoma, an eye disease that can cause blindness and affects millions of people worldwide.

“The nanoparticle can safely get past the blood-brain barrier making it an effective non-toxic tool for drug delivery,” said Sudipta Seal, an engineering professor with appointments in UCF’s Advanced Materials Processing and Analysis Center and the Nanoscience Technology Center.

The findings will be published in an article appearing in the June 28 issue of the Journal of Physical Chemistry C.

Seal and his colleagues from North Dakota State University note in the article that while barely 1-3 percent of existing glaucoma medicines penetrate into the eye, earlier experiments with nanoparticles have shown not only high penetration rates but also little patient discomfort. The miniscule size of the nanoparticles makes them less abrasive than some of the complex polymers now used in most eye drops.

Seal and his team created a specialized cerium oxide nanoparticle and bound it with a compound that has been shown to block the activity of an enzyme (hCAII) believed to play a central role in causing glaucoma.

The disease involves abnormally high pressure of the fluid inside the eye, which, if left untreated, can result in damage to the optic nerve and vision loss. High pressure occurs, in part, because of a buildup of carbon dioxide inside the eye, and the compound blocks the enzyme that produces carbon dioxide.

Seal and a team of collaborators including Sanku Mallik, of North Dakota State University, developed the research on using nanoparticles as a delivery mechanism for the compound after supervising a student summer project at UCF. Duke University undergraduate Serge Reshetnikov spent a summer studying nanoscience on UCF’s Orlando campus as part of a Research Experience for Under graduates (REU) project funded by the National Science Foundation. Reshetnikov started looking into the possibilities of using nanoparticles as drug delivery tools. Subsequent research with his advisors led to the specific application for glaucoma.

In their paper on the research, which was also supported by the National Science Foundation, Seal and Mallik note the results are “very promising” and that their nanoparticle configuration offers seemingly limitless possibilities as a non-toxic drug delivery tool.


'"/>

Source:University of Central Florida


Related biology news :

1. Breakthrough method in nanoparticle synthesis paves the way for new pharmaceutical and biomedical applications
2. Probing the promise and perils of nanoparticles
3. Novel gene-silencing nanoparticles shown to inhibit Ewings sarcoma
4. Using nanoparticles, in vivo gene therapy activates brain stem cells
5. NJIT study shows nanoparticles could damage plant life
6. Jefferson researchers find nanoparticle shows promise in reducing radiation side effects
7. Targeted drug delivery achieved with nanoparticle-aptamer bioconjugates
8. Gold nanoparticles could improve antisense cancer drugs
9. MIT nanoparticles may help detect, treat tumors
10. Quantum dots reviewed -- Could these nanoparticles hold the cure to cancer?
11. Electric jolt triggers release of biomolecules, nanoparticles

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/26/2016)... 2016 Research and Markets has ... Market 2016-2020"  report to their offering.  , ,     ... The analysts forecast the global multimodal biometrics market ... the period 2016-2020.  Multimodal biometrics is ... as the healthcare, BFSI, transportation, automotive, and government ...
(Date:4/14/2016)... TEL AVIV, Israel , April 14, 2016 /PRNewswire/ ... in Behavioral Authentication and Malware Detection, today announced the ... has already assumed the new role. Goldwerger,s ... for BioCatch, on the heels of the deployment of ... In addition, BioCatch,s behavioral biometric technology, which discerns unique ...
(Date:3/29/2016)... 29, 2016 LegacyXChange, Inc. (OTC: ... and SelectaDNA/CSI Protect are pleased to announce our successful ... a variety of writing instruments, ensuring athletes signatures against ... collectibles from athletes on LegacyXChange will be assured of ... DNA. Bill Bollander , CEO states, ...
Breaking Biology News(10 mins):
(Date:5/20/2016)... , ... May 20, 2016 , ... Korean researchers say ... it may offer a new way to treat the disease. Surviving Mesothelioma has just ... , Scientists from several Korean institutions based their mesothelioma study on the fact ...
(Date:5/19/2016)... 2016 There is no saying ... the relentless pressures in pricing and lack in consumer ... circle though - numerous opportunities are up for grabs ... ActiveWallSt.com,s presents four names in this sector: Portola Pharmaceuticals ... (NASDAQ: VTAE ), Anthera Pharmaceuticals Inc. (NASDAQ: ...
(Date:5/18/2016)... Irvine, Calif. (PRWEB) , ... May 18, 2016 , ... ... had awarded the Luis Villalobos Award to Cognition Therapeutics at the annual ACA Summit ... innovative company that is financed by one of ACA’s member angel groups. It is ...
(Date:5/18/2016)... ... May 18, 2016 , ... ... a direct result of asthma complications.* Costing more than $56 billion in direct ... , “For too many, the suffering associated with uncontrolled asthma can ...
Breaking Biology Technology: