Navigation Links
UCF nanoparticle offers promise for treating glaucoma

A unique nanoparticle made in a laboratory at the University of Central Florida is proving promising as a drug delivery device for treating glaucoma, an eye disease that can cause blindness and affects millions of people worldwide.

“The nanoparticle can safely get past the blood-brain barrier making it an effective non-toxic tool for drug delivery,” said Sudipta Seal, an engineering professor with appointments in UCF’s Advanced Materials Processing and Analysis Center and the Nanoscience Technology Center.

The findings will be published in an article appearing in the June 28 issue of the Journal of Physical Chemistry C.

Seal and his colleagues from North Dakota State University note in the article that while barely 1-3 percent of existing glaucoma medicines penetrate into the eye, earlier experiments with nanoparticles have shown not only high penetration rates but also little patient discomfort. The miniscule size of the nanoparticles makes them less abrasive than some of the complex polymers now used in most eye drops.

Seal and his team created a specialized cerium oxide nanoparticle and bound it with a compound that has been shown to block the activity of an enzyme (hCAII) believed to play a central role in causing glaucoma.

The disease involves abnormally high pressure of the fluid inside the eye, which, if left untreated, can result in damage to the optic nerve and vision loss. High pressure occurs, in part, because of a buildup of carbon dioxide inside the eye, and the compound blocks the enzyme that produces carbon dioxide.

Seal and a team of collaborators including Sanku Mallik, of North Dakota State University, developed the research on using nanoparticles as a delivery mechanism for the compound after supervising a student summer project at UCF. Duke University undergraduate Serge Reshetnikov spent a summer studying nanoscience on UCF’s Orlando campus as part of a Research Experience for Under graduates (REU) project funded by the National Science Foundation. Reshetnikov started looking into the possibilities of using nanoparticles as drug delivery tools. Subsequent research with his advisors led to the specific application for glaucoma.

In their paper on the research, which was also supported by the National Science Foundation, Seal and Mallik note the results are “very promising” and that their nanoparticle configuration offers seemingly limitless possibilities as a non-toxic drug delivery tool.


'"/>

Source:University of Central Florida


Related biology news :

1. Breakthrough method in nanoparticle synthesis paves the way for new pharmaceutical and biomedical applications
2. Probing the promise and perils of nanoparticles
3. Novel gene-silencing nanoparticles shown to inhibit Ewings sarcoma
4. Using nanoparticles, in vivo gene therapy activates brain stem cells
5. NJIT study shows nanoparticles could damage plant life
6. Jefferson researchers find nanoparticle shows promise in reducing radiation side effects
7. Targeted drug delivery achieved with nanoparticle-aptamer bioconjugates
8. Gold nanoparticles could improve antisense cancer drugs
9. MIT nanoparticles may help detect, treat tumors
10. Quantum dots reviewed -- Could these nanoparticles hold the cure to cancer?
11. Electric jolt triggers release of biomolecules, nanoparticles

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/22/2016)...  The American College of Medical Genetics and Genomics was ... as one of the fastest-growing trade shows during the Fastest ... in Las Vegas . ... in each of the following categories: net square feet of ... attendees. The 2015 ACMG Annual Meeting was ranked 23 out ...
(Date:6/22/2016)... -- On Monday, the Department of Homeland Security (DHS) ... for the Biometric Exit Program. The Request for Information ... explains that CBP intends to add biometrics to confirm ... States , in order to deter visa overstays, ... Logo - http://photos.prnewswire.com/prnh/20160622/382209LOGO ...
(Date:6/20/2016)... June 20, 2016 Securus Technologies, a ... solutions for public safety, investigation, corrections and monitoring ... involved, it has secured the final acceptance by ... for Managed Access Systems (MAS) installed. Furthermore, Securus ... to be installed by October, 2016. MAS distinguishes ...
Breaking Biology News(10 mins):
(Date:12/6/2016)... Laurel, NJ (PRWEB) , ... December 06, 2016 ... ... white paper on December 1, 2016 asking the Federal Drug Administration (FDA) to ... the study of OA, OARSI is concerned about the growing population of OA ...
(Date:12/6/2016)... ... December 06, 2016 , ... ... today announced it has acquired the assets of Theorem Clinical Research - ... focuses on clinical trial drug packaging, labeling, storage, reconciliation, and distribution for ...
(Date:12/6/2016)... , Dec. 6, 2016  SRI International ... $150 million from the National Institutes of Health,s ... the Division of AIDS (NIAID-DAIDS) to support the ... non-vaccine pre-exposure (PreP) agents. Under the seven-year contract, ... product development services for candidate HIV-prevention products that ...
(Date:12/5/2016)... 5, 2016 Axovant Sciences Ltd. (NYSE: ... on the treatment of dementia, today announced that data ... of Alzheimer,s disease will be presented at the 2016 ... December 9, 2016 in San Diego ... both simple and complex measures of activities of daily ...
Breaking Biology Technology: