Navigation Links
UCF nanoparticle offers promise for treating glaucoma

A unique nanoparticle made in a laboratory at the University of Central Florida is proving promising as a drug delivery device for treating glaucoma, an eye disease that can cause blindness and affects millions of people worldwide.

“The nanoparticle can safely get past the blood-brain barrier making it an effective non-toxic tool for drug delivery,” said Sudipta Seal, an engineering professor with appointments in UCF’s Advanced Materials Processing and Analysis Center and the Nanoscience Technology Center.

The findings will be published in an article appearing in the June 28 issue of the Journal of Physical Chemistry C.

Seal and his colleagues from North Dakota State University note in the article that while barely 1-3 percent of existing glaucoma medicines penetrate into the eye, earlier experiments with nanoparticles have shown not only high penetration rates but also little patient discomfort. The miniscule size of the nanoparticles makes them less abrasive than some of the complex polymers now used in most eye drops.

Seal and his team created a specialized cerium oxide nanoparticle and bound it with a compound that has been shown to block the activity of an enzyme (hCAII) believed to play a central role in causing glaucoma.

The disease involves abnormally high pressure of the fluid inside the eye, which, if left untreated, can result in damage to the optic nerve and vision loss. High pressure occurs, in part, because of a buildup of carbon dioxide inside the eye, and the compound blocks the enzyme that produces carbon dioxide.

Seal and a team of collaborators including Sanku Mallik, of North Dakota State University, developed the research on using nanoparticles as a delivery mechanism for the compound after supervising a student summer project at UCF. Duke University undergraduate Serge Reshetnikov spent a summer studying nanoscience on UCF’s Orlando campus as part of a Research Experience for Under graduates (REU) project funded by the National Science Foundation. Reshetnikov started looking into the possibilities of using nanoparticles as drug delivery tools. Subsequent research with his advisors led to the specific application for glaucoma.

In their paper on the research, which was also supported by the National Science Foundation, Seal and Mallik note the results are “very promising” and that their nanoparticle configuration offers seemingly limitless possibilities as a non-toxic drug delivery tool.


'"/>

Source:University of Central Florida


Related biology news :

1. Breakthrough method in nanoparticle synthesis paves the way for new pharmaceutical and biomedical applications
2. Probing the promise and perils of nanoparticles
3. Novel gene-silencing nanoparticles shown to inhibit Ewings sarcoma
4. Using nanoparticles, in vivo gene therapy activates brain stem cells
5. NJIT study shows nanoparticles could damage plant life
6. Jefferson researchers find nanoparticle shows promise in reducing radiation side effects
7. Targeted drug delivery achieved with nanoparticle-aptamer bioconjugates
8. Gold nanoparticles could improve antisense cancer drugs
9. MIT nanoparticles may help detect, treat tumors
10. Quantum dots reviewed -- Could these nanoparticles hold the cure to cancer?
11. Electric jolt triggers release of biomolecules, nanoparticles

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/28/2017)... 28, 2017 The report "Video ... Monitors, Servers, Storage Devices), Software (Video Analytics, VMS), and ... Global Forecast to 2022", published by MarketsandMarkets, the market ... is projected to reach USD 75.64 Billion by 2022, ... The base year considered for the study is 2016 ...
(Date:3/24/2017)... The Controller General of Immigration from Maldives Mr. Mohamed Anwar ... prestigious international IAIR Award for the most innovative high security ePassport and ... ... Maldives Immigration Controller General, Mr. Mohamed ... the right) have received the IAIR award for the "Most innovative high ...
(Date:3/23/2017)... report "Gesture Recognition and Touchless Sensing Market by Technology (Touch-based and Touchless), Product ... by MarketsandMarkets, the market is expected to be worth USD 18.98 billion by ... Continue Reading ... ...      (Logo: http://photos.prnewswire.com/prnh/20160303/792302) ...
Breaking Biology News(10 mins):
(Date:7/26/2017)... ... July 26, 2017 , ... Franz Inc ., an ... technology for Knowledge Graphs, today announced Gruff v7.0 , the industry’s leading ... users and graph experts the ability to visually build queries and explore connections ...
(Date:7/26/2017)... /PRNewswire/ - Caprion Biosciences Inc., a world leading specialty CRO announced ... predictive of early stage (latent) Mycobacterium tuberculosis (Mtb) infection using ... (MRM-MS) platform. ... Caprion Biosciences Inc. (CNW Group/Caprion Biosciences) ... The new data, recently published in ...
(Date:7/26/2017)... ... July 25, 2017 , ... Proscia Inc. , a ... be a featured panelist at 2017 MedCity CONVERGE. His talk, “The Davids vs. the ... medical technology, and emerging technology (AI, VR, Big Data) sectors are taking aim at ...
(Date:7/26/2017)... ... 25, 2017 , ... In this webinar , which ... considerations needed for designing ideal guide RNAs and DNA oligo or plasmid repair ... double-strand breaks in genomic DNA has greatly simplified strategies for precise gene editing ...
Breaking Biology Technology: