Navigation Links
UC Davis researchers use heated nanoprobes to destroy breast cancer cells in mice

In experiments with laboratory mice that bear aggressive human breast cancers, UC Davis researchers have used hot nanoprobes to slow the growth of tumors -- without damage to surrounding healthy tissue. The researchers describe their work in the March issue of the Journal of Nuclear Medicine.

"We have demonstrated that the system is feasible in laboratory mice. The next step will be clinical testing in patients," said Sally DeNardo, a professor of internal medicine and radiology at UC Davis and lead author of the study.

Many researchers have studied heat as a potential treatment for cancer, but the difficulty of confining heat within the tumor and predicting an effective heat dose has limited its use. The UC Davis research, carried out in collaboration with scientists from Triton BioSystems in Boston, seeks to solve this problem.

The experimental system uses bioprobes created by wedding magnetized iron-oxide nanospheres to radiolabeled monoclonal antibodies. The bioprobes are cloaked in polymers and sugars that render them nearly invisible to the body's immune system.

DeNardo and her colleagues infused trillions of the probes -- more than 10,000 can fit on the end of a straight pin -- into the bloodstreams of laboratory mice bearing human breast tumors. Once in the bloodstream, the probes began to seek out and latch onto receptors on the surface of malignant cells.

Three days later, the team applied an alternating magnetic field to the tumor region, causing the magnetic nanospheres latched onto the tumor cells to change polarity thousands of times per second, instantaneously generating heat. As soon as the AMF stopped, the bioprobes cooled down.

Mice in the study received a series of AMF bursts in a single 20-minute treatment. Dosing was calculated using an equation that included tumor concentration of bioprobes, heating rate of particles at different amplitudes, and the spacing of AMF bursts.

Tumor
'"/>

Source:University of California, Davis - Health System


Page: 1 2

Related biology news :

1. UC Davis study finds HIV hiding from drugs in gut, preventing immune recovery
2. UC Davis researchers move biotechnology closer to replacing electronic pacemakers
3. UC Davis researchers reveal apples protective ways
4. British cattle give TB to badgers, finds UC Davis expert
5. NYU researchers simulate molecular biological clock
6. Vital step in cellular migration described by UCSD medical researchers
7. ASU researchers finds novel chemistry at work to provide parrots vibrant red colors
8. UCSD researchers maintain stem cells without contaminated animal feeder layers
9. Why do insects stop breathing? To avoid damage from too much oxygen, say researchers
10. New protein discovered by Hebrew University researchers
11. First real-time view of developing neurons reveals surprises, say Stanford researchers
Post Your Comments:
(Date:7/9/2014)... Bacteria found in the bladders of healthy women ... form of incontinence, according to researchers from Loyola ... These findings, published July 9, 2014, in the ... , suggest that bacterial communities may play a ... incontinence (UUI) is a common, yet poorly understood, ...
(Date:7/9/2014)... shifts the geographic ranges in which animals can be ... their parasites. Does an increased range for a host ... Not necessarily, says a team of UC Santa Barbara ... a study published in the Journal of Biogeography ... species, the opposite may happen: Hosts may actually lose ...
(Date:7/9/2014)... nature,s ability to split the water molecule during ... artificial photosynthesis for clean, green and renewable energy ... scientists led by researchers with the Lawrence Berkeley ... Accelerator Laboratory. , Working at SLAC,s Linac ... x-ray laser, the researchers were able to take ...
Breaking Biology News(10 mins):Not at home on the range 2Not at home on the range 3Not at home on the range 4Postcards from the photosynthetic edge 2Postcards from the photosynthetic edge 3
... A study supported by the U.S. Department of Health ... findings that suggested the presence of one of several viruses ... The new study also could not find the viruses in ... not have the viruses., The HHS-supported study examined the validity ...
... 22, 2011) -- Maintaining fluid balance in the body ... the mightiest of mammals. By researching recent genomic data, ... intricate process to a turning point in evolution. ... Emeritus, University of Lausanne, along with colleagues Romain A. ...
... E.coli that plays a critical role in defending the ... have the shape of a seahorse by researchers with the ... This discovery holds far more implications for your own health ... protect you from infections by bacteria, viruses, toxins and other ...
Cached Biology News:XMRV, related viruses not confirmed in blood of healthy donors or chronic fatigue syndrome patients 2XMRV, related viruses not confirmed in blood of healthy donors or chronic fatigue syndrome patients 3XMRV, related viruses not confirmed in blood of healthy donors or chronic fatigue syndrome patients 4Fluid equilibrium in prehistoric organisms sheds light on a turning point in evolution 2Close up look at a microbial vaccination program 2Close up look at a microbial vaccination program 3Close up look at a microbial vaccination program 4
(Date:1/15/2014)... PA (PRWEB) January 15, 2014 The Pittcon ... publisher of Food Safety Tech , an e-Journal and ... signed an agreement for the second year for the co-location ... Pittcon 2014. The partnership provides that the registration fee to ...
(Date:1/15/2014)... MINNEAPOLIS , Jan. 15, 2014 ­ RedBrick ... and behavior change technology, today announces that EmblemHealth ... insurer and wellness company, is now providing the RedBrick ... digital coaching program, to all of its members. EmblemHealth ...
(Date:1/15/2014)... The Microcompetition with Foreign DNA theory explains how ... latent viruses is the Epstein Barr Virus (EBV), and one ... is a chronic inflammatory disease that destroys the body’s joints. ... patients have high concentrations of EBV DNA in their bodies ...
(Date:1/15/2014)... 2014 TaiGen Biotechnology Company, Limited ("TaiGen") today announced ... a leading Russian pharmaceutical company, to develop and commercialize ... Federation , Turkey and ... a novel antibiotic for the treatment of bacterial infections ...
Breaking Biology Technology:Pittcon Announces Second Year Partnership With Food Safety Tech 2Pittcon Announces Second Year Partnership With Food Safety Tech 3EmblemHealth Selects RedBrick Health to Power its Next-Generation Health Engagement and Behavior Change System 2EmblemHealth Selects RedBrick Health to Power its Next-Generation Health Engagement and Behavior Change System 3Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 3TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 2TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 3TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 4
... NEW YORK, Jan. 20, 2011 Reportlinker.com announces ... in its catalogue: Hospital General ... This is the most comprehensive ... General Radiology and radiology IT systems (PACS) in ...
... using new image and cell technologies have for the ... invading red blood cells. The researchers, from the Walter ... University of Technology, Sydney (UTS), achieved this long-held aim ... microscopy, a technology platform new to Australia. The ...
... German . Development of efficient battery systems for ... Ulm Helmholtz Institute for Electrochemical Energy Storage (HIU). Today, this ... Helmholtz Institute for Electrochemical Energy Storage in Ulm shall be ... high importance to Germany as a location of technology and ...
Cached Biology Technology:Reportlinker Adds Hospital General Radiology Census 2Malaria parasite caught red-handed invading blood cells 2Malaria parasite caught red-handed invading blood cells 3Start of the Ulm Helmholtz Institute 2Start of the Ulm Helmholtz Institute 3
... Simplify the process and you reduce ... built into the CEQ 8000. Developed using ... and leadership in capillary electrophoresis technology, the ... analysis system. This system automatically fills the ...
The external laser upgrade for the Molecular Imager FX adds a 635 nm external laser; the 555 nm long pass filter is replaced with a 605 nm band pass filter to distinguish Cy5 from 532 nm excitable dy...
... The APO-BRDU Kit is a 2-color ... total cellular DNA to detect apoptotic cells ... instructions and reagents required for measuring apoptosis ... cells for assessing reagent performance; washing, reaction ...
... The BioGenex VISION Sytem is a ... comes with proprietary digital imaging and ... digital image acquisition, analysis, archving/retrieval and ... a state-of-the-art digital imaging system that ...
Biology Products: