Navigation Links
UC Davis researchers reveal apples' protective ways

Doctors have long been encouraging Americans to add more fruits and vegetables to their daily diets. Now, UC Davis researchers have discovered one way in which flavonoid-rich apples inhibit the kinds of cellular activity that leads to the development of chronic diseases, including heart disease and age-related cancers.

"We've known for a long time that it's the flavonoids in fruits that are protecting the body. We just haven't known exactly how. Now, at least in the case of apples, we have a good idea about what's going on," said Eric Gershwin, professor of allergy, rheumatology and immunology at the UC Davis School of Medicine.

Gershwin and his colleagues found that apple extract was able to protect cells from damage and death by interfering with communication between cells.

The current findings appear in the latest issue of Experimental Biology and Medicine.Earlier studies have shown that flavonoids--which are found in chocolate and green tea, as well as other fruits and vegetables--behave as anti-oxidants, taking up free oxygen radicals that can damage precious DNA. The UC Davis study takes that research further by looking beyond the antioxidant effects of apple flavonoids.

In the current study, Gershwin and his colleagues exposed human endothelial cells to an extract of an apple mash made from different apple varieties. The researchers then challenged these cells by exposing them to tumor necrosis factor (TNF), a compound that usually triggers cell death and promotes inflammation via a mechanism called the "nuclear factor (NF) kappa B pathway." This pathway involves chemical signaling between cells. The apple extract was able to protect the cells from the normal lethal effects of TNF.

"Our study showed that the flavonoids in apples and apple juice can inhibit signals in this pathway that would otherwise damage or kill cells in the body," Gershwin explained.

The method by which apple extract protects cells is diffe rent than that reported for other flavonoid-rich foods. Grape seed extracts, for example, do not affect the NF kappa B pathway, the authors wrote. In addition, they said, other studies indicate that it is not just the flavonoids in the apple extract that are important in protecting cells from genetic damage.

"The differences are likely due to the other biologically active ingredients found in the different fruits," Gershwin said. "We need to know more about how fruits like apples are able to protect us from disease."


'"/>

Source:University of California, Davis - Health System


Related biology news :

1. UC Davis study finds HIV hiding from drugs in gut, preventing immune recovery
2. UC Davis researchers move biotechnology closer to replacing electronic pacemakers
3. British cattle give TB to badgers, finds UC Davis expert
4. UC Davis researchers use heated nanoprobes to destroy breast cancer cells in mice
5. NYU researchers simulate molecular biological clock
6. Vital step in cellular migration described by UCSD medical researchers
7. ASU researchers finds novel chemistry at work to provide parrots vibrant red colors
8. UCSD researchers maintain stem cells without contaminated animal feeder layers
9. Why do insects stop breathing? To avoid damage from too much oxygen, say researchers
10. New protein discovered by Hebrew University researchers
11. First real-time view of developing neurons reveals surprises, say Stanford researchers
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/20/2017)... 20, 2017 Delta (NYSE: DAL ) customers now ... aircraft at Reagan Washington National Airport (DCA). ... Delta launches biometrics to board aircraft at ... Delta,s biometric boarding pass experience ... is now integrated into the boarding process to allow eligible Delta SkyMiles ...
(Date:6/14/2017)... (NYSE: IBM ) is introducing several innovative partner startups ... collaboration between startups and global businesses, taking place in ... nine startups will showcase the solutions they have built with ... France is one of the ... percent increase in the number of startups created between 2012 ...
(Date:5/16/2017)... DALLAS , May 16, 2017   ... for health organizations, and MD EMR Systems ... certified development partner for GE, have established a ... Patient Portal product and the GE Centricity™ products, ... Centricity EMR. These new integrations ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... BARBARA, CALIFORNIA (PRWEB) , ... October 10, 2017 ... ... management, technological innovation and business process optimization firm for the life sciences and ... BoxWorks conference in San Francisco. , The presentation, “Automating GxP Validation ...
(Date:10/9/2017)... (PRWEB) , ... October 09, 2017 , ... The award-winning ... to broadcast first quarter 2018. American Farmer airs Tuesdays at 8:30aET on RFD-TV. ... is faced with the challenge of how to continue to feed a growing nation. ...
(Date:10/9/2017)... ... October 09, 2017 , ... ... the medical journal, Epilepsia, Brain Sentinel’s SPEAC® System which uses the surface ... detecting generalized tonic-clonic seizures (GTCS) using surface electromyography (sEMG). The prospective multicenter ...
(Date:10/7/2017)... Oct. 6, 2017  The 2017 Nobel Prize ... scientists, Jacques Dubochet, Joachim Frank and ... cryo-electron microscopy (cryo-EM) have helped to ... structural biology community. The winners worked with systems ... routinely produce highly resolved, three-dimensional images of protein ...
Breaking Biology Technology: