Navigation Links
UC Davis researchers move biotechnology closer to replacing electronic pacemakers

UC Davis researchers have successfully used a custom designed protein and gene delivery system to restore normal heart rhythms in pigs with electronic pacemakers, reducing their dependence on implanted devices. This work suggests that scientists are one step closer to making bioengineering a reality in treating the more than 2.2 million Americans affected by irregular heartbeats.

The UC Davis study, which was co-authored by an international team that included scientists from the University of Hong Kong and Johns Hopkins University, is published in the current issue of the journal Circulation, (which is available online and will appear in print on September 5). The same issue also includes a similar but independent research effort by scientists from Columbia University and State University of New York at Stony Brook.

"Our study offers positive and direct evidence in living models that bioengineered cells can replace the electronic pacemaker," said Ronald Li, who leads the research team and is an associate professor of cell biology and human anatomy at the UC Davis School of Medicine. More than 250,000 people in the United States get artificial pacemakers implanted each year. Researchers believe this biological approach would provide a more permanent, reliable and less invasive alternative to implanted electronic devices. "Our hope is to one day replace electronic pacemakers in people," Li said.

Li and his colleagues have been working for years to develop biological alternatives to drugs and electronic devices for treating heart arrhythmias ?heartbeats that are irregular in rhythm, rate or sequence. The sinoatrial (SA) node, a patch of cells called the pacemaker, generates cardiac rhythms for coordinated contractions and blood pumping. Malfunctions due to aging or diseases can lead to a range of potentially lethal arrhythmias, such as slow heart rates or rhythms called bradycardias.

In the current study, the researchers delivered a
'"/>

Source:University of California, Davis - Health System


Page: 1 2 3

Related biology news :

1. UC Davis study finds HIV hiding from drugs in gut, preventing immune recovery
2. UC Davis researchers reveal apples protective ways
3. British cattle give TB to badgers, finds UC Davis expert
4. UC Davis researchers use heated nanoprobes to destroy breast cancer cells in mice
5. NYU researchers simulate molecular biological clock
6. Vital step in cellular migration described by UCSD medical researchers
7. ASU researchers finds novel chemistry at work to provide parrots vibrant red colors
8. UCSD researchers maintain stem cells without contaminated animal feeder layers
9. Why do insects stop breathing? To avoid damage from too much oxygen, say researchers
10. New protein discovered by Hebrew University researchers
11. First real-time view of developing neurons reveals surprises, say Stanford researchers
Post Your Comments:
(Date:11/12/2014)... 2014 Crossmatch™, a leading provider of biometric ... fingerprint readers have been deployed throughout Montparnasse Pasteleria, ... Mexico . The bakery chain implemented the Crossmatch ... caused by employees clocking in for each other. ... Montparnasse relied on paper timecards and a mechanical time ...
(Date:11/7/2014)... led by Dr. Debra Auguste, associate professor, biomedical ... The City College of New York, have identified ... for one of the most aggressive forms of ... have a high mortality rate owing to aggressive ... therapeutic options. However, Professor Auguste,s team, discovered the ...
(Date:11/6/2014)... a team of Florida State University biologists could lead ... to and survive environmental swings such as droughts or ... of the journal The Plant Cell , sheds ... proteins) is organized in a cell and how plants ... on and others are turned off. , "If you ...
Breaking Biology News(10 mins):Montparnasse Pasteleria Achieves Time and Attendance Transparency with Crossmatch U.are.U Fingerprint Readers 2Maize analysis yields whole new world of genetic science 2
... Polar Regions and the deep sea is the focus ... involving over 200 international scientists. The CAREX (Coordination ... roadmap outlines priorities for future research into life in ... Life has evolved thousands of strategies to adapt and ...
... nearly 390,000 chemical compounds had led scientists to a ... the brain with effects promising for new drugs for ... which blocks formation of cholesterol in the brain, in ... G. Kazantsev and colleagues previously discovered that blocking cholesterol ...
... lifted off on board India,s Polar Satellite Launch Vehicle ... on 20 April 2011. The X-SAT, developed ... collaboration with DSO National Laboratories, was launched from the ... India. The wholly made-in-Singapore satellite was one ...
Cached Biology News:Life in extreme environments paves the way for international collaboration 2Singapore's first locally made satellite launched into space 2
(Date:11/22/2014)... Frederick, MD (PRWEB) November 21, 2014 ... sample management solutions provider, has released Limfinity® version ... more installation projects of Limfinity® than ever in ... majority configuration and minority framework enhancement. Limfinity® version ... goes far above and beyond bug fixes! , ...
(Date:11/22/2014)... Quebec , November 21, 2014 ... wechselt als Chief Commercial Officer zu KLOX ... SVP der Unternehmensentwicklung und Chief Financial Officer bestellt    ... Europa mit der Vermarktung seines jüngst zugelassenen Behandlungssystems zur ... Inc. ("KLOX" bzw. das "Unternehmen") ist sehr erfreut, die ...
(Date:11/21/2014)... Los Angeles, CA (PRWEB) November 20, 2014 ... “A Short Walk to the Other Side” ... was an “Award-Winning Finalist in the “Fiction: Short Story” ... . , Jeffrey Keen, President and CEO of USA ... entries from mainstream and independent publishers, including Simon & ...
(Date:11/21/2014)... Angeles, CA (PRWEB) November 21, 2014 ... it that makes Albert Einstein so instantly recognizable? Why ... African-born physicist, mathematician, astronomer and author Hilton Ratcliffe seeks ... they have nothing at all to do with science. ... Muse Harbor Publishing , November 21, 2014), Ratcliffe puts ...
Breaking Biology Technology:RURO Announces Limfinity® version 5.1.4 2KLOX Technologies meldet Neubesetzung von Führungspositionen 2KLOX Technologies meldet Neubesetzung von Führungspositionen 3KLOX Technologies meldet Neubesetzung von Führungspositionen 4KLOX Technologies meldet Neubesetzung von Führungspositionen 5Mystic Ink 's Short Story Collection “A Short Walk to the Other Side” Honoring Ray Bradbury Praised As Award-Winning Finalist In USA Best Book Awards 2Mystic Ink 's Short Story Collection “A Short Walk to the Other Side” Honoring Ray Bradbury Praised As Award-Winning Finalist In USA Best Book Awards 3Mystic Ink 's Short Story Collection “A Short Walk to the Other Side” Honoring Ray Bradbury Praised As Award-Winning Finalist In USA Best Book Awards 4“Stephen Hawking Smoked My Socks” Sparks Controversy in Science World 2“Stephen Hawking Smoked My Socks” Sparks Controversy in Science World 3“Stephen Hawking Smoked My Socks” Sparks Controversy in Science World 4
... in silicon ever produced are shown to have the same ... Science . This means electrical interconnects in silicon can be ... law holds true at the atomic-scale. UNSW researchers will use ... in realising a scalable quantum computer. The narrowest ...
... This press release is available in Spanish . ... Sebastian and Japan, a relay reaction of hydrogen atoms at ... of manipulating matter could open up new ways to exchange ... Frederiksen, presently working in the Donostia International Physics Center (DIPC) ...
... for the Kansas City Royals, will receive the 47th annual Hutch ... Major League Baseball player who best exemplifies the honor, courage and ... field. Baseball Hall of Famer Cal Ripken Jr. ... presentation on Feb. 1 at Safeco Field in Seattle, Fred Hutchinson,s ...
Cached Biology Technology:Down to the wire: Silicon links shrink to atomic scale 2Relay race with single atoms: New ways of manipulating matter 2Royals Batter Billy Butler Named Hutch Award Winner 2
... These versatile vacuum cups provide flexible ... curved, or irregular surfaces. ,PFG: Flat ... Bellows cup ,PCG: Multiple Bellows cup ... from 25 to 200 mm , ...
XA7 B6...
... linear motor and ballscrew technologies, ... Cartesian solutions that include all ... and motors., , XY ... through high-flex cabling for power, ...
Total Proteins from over 50 different human Alzheimer, Diabetic, Liver Cirrhosis, and Lupus diseased tissues are available....
Biology Products: