Navigation Links
UC Davis researchers move biotechnology closer to replacing electronic pacemakers

UC Davis researchers have successfully used a custom designed protein and gene delivery system to restore normal heart rhythms in pigs with electronic pacemakers, reducing their dependence on implanted devices. This work suggests that scientists are one step closer to making bioengineering a reality in treating the more than 2.2 million Americans affected by irregular heartbeats.

The UC Davis study, which was co-authored by an international team that included scientists from the University of Hong Kong and Johns Hopkins University, is published in the current issue of the journal Circulation, (which is available online and will appear in print on September 5). The same issue also includes a similar but independent research effort by scientists from Columbia University and State University of New York at Stony Brook.

"Our study offers positive and direct evidence in living models that bioengineered cells can replace the electronic pacemaker," said Ronald Li, who leads the research team and is an associate professor of cell biology and human anatomy at the UC Davis School of Medicine. More than 250,000 people in the United States get artificial pacemakers implanted each year. Researchers believe this biological approach would provide a more permanent, reliable and less invasive alternative to implanted electronic devices. "Our hope is to one day replace electronic pacemakers in people," Li said.

Li and his colleagues have been working for years to develop biological alternatives to drugs and electronic devices for treating heart arrhythmias ?heartbeats that are irregular in rhythm, rate or sequence. The sinoatrial (SA) node, a patch of cells called the pacemaker, generates cardiac rhythms for coordinated contractions and blood pumping. Malfunctions due to aging or diseases can lead to a range of potentially lethal arrhythmias, such as slow heart rates or rhythms called bradycardias.

In the current study, the researchers delivered a
'"/>

Source:University of California, Davis - Health System


Page: 1 2 3

Related biology news :

1. UC Davis study finds HIV hiding from drugs in gut, preventing immune recovery
2. UC Davis researchers reveal apples protective ways
3. British cattle give TB to badgers, finds UC Davis expert
4. UC Davis researchers use heated nanoprobes to destroy breast cancer cells in mice
5. NYU researchers simulate molecular biological clock
6. Vital step in cellular migration described by UCSD medical researchers
7. ASU researchers finds novel chemistry at work to provide parrots vibrant red colors
8. UCSD researchers maintain stem cells without contaminated animal feeder layers
9. Why do insects stop breathing? To avoid damage from too much oxygen, say researchers
10. New protein discovered by Hebrew University researchers
11. First real-time view of developing neurons reveals surprises, say Stanford researchers
Post Your Comments:
(Date:4/22/2014)... Gables, Fla. (April 21, 2014) -- There are all ... their feathers and spread their colorful tails; satin bowbirds ... with blue and shiny objects; and European bitterling males ... species has evolved a unique method to communicate with ... "Signaling can have profound fitness implications ...
(Date:4/22/2014)... 2014 Scientists from the Florida campus of The ... that plays a critical but previously unknown role in ... showed a novel role for a protein known as ... eLife , a publisher supported by the Howard ... Wellcome Trust. , "This is a critical building block ...
(Date:4/22/2014)... International Science Consortium Ltd.,s nanotechnology expert will present a ... hazard assessment" at the 7th International Nanotoxicology Congress ... Turkey. , Dr. Monita Sharma will outline a ... National Academy of Sciences, " Toxicity Testing in the ... recommends use of non-animal methods involving human cells and ...
Breaking Biology News(10 mins):Best practices in communication for the animal world 2Best practices in communication for the animal world 3Scientists identify critical new protein complex involved in learning and memory 2
... air quality apparently affects the running times of women in ... environmental engineer Linsey Marr. Marr,s findings come from a ... air pollutant concentrations in seven marathons over a period of ... finishing times were compared with the course record and contrasted ...
... for Microbiology (ASM) Roche Diagnostics Alice C. Evans Award ... Science Director, Walter Reed Army Institute of Research, ... scientists. This award recognizes contributions toward the full participation ... in honor of Alice C. Evans, the first woman ...
... monkeys, mothers who weigh more and have had previous ... babies than mothers who weigh less and are less ... of California, Davis are using this natural variation in ... mother,s milk sends a reliable signal to infants about ...
Cached Biology News:Women more affected than men by air pollution when running marathons 2Baby monkeys receive signals through their mother's breast milk 2
(Date:1/15/2014)... 2014  Bill Jacobs Automotive, a group of car dealerships headquartered ... the Heartland Blood Center and offering free oil change coupons ... place Saturday, Jan. 18 at the Bill Jacobs Cadillac and ... (Photo: http://photos.prnewswire.com/prnh/20140115/MN46637 )  The Bill Jacobs ...
(Date:1/15/2014)... Westlake Village, Calif. (PRWEB) January 15, 2014 ... cancer treatment and management through the genomic analysis of ... will offer Therapy Finder™, a web-based cancer decision support ... a reporting option with Cynvenio’s ClearID™ genomic test, Therapy ...
(Date:1/15/2014)... A study has been launched to test whether technology ... help to tackle the problem of obesity.  This unique healthcare ... based in Stowmarket) and academics at University Campus Suffolk is ... which is inspired by equipment used to collect data about ...
(Date:1/15/2014)... (PRWEB) January 15, 2014 DTS Language ... its Online Web Portal for Life Science organizations who need ... specify the subject matter of their documents in advance with ... help reduce time-to-delivery of translations, often a critical factor in ...
Breaking Biology Technology:Join the Bill Jacobs Auto blood drive and receive a free oil change 2Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 2Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 2Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 4DTS Improves Efficiency for Life Science Document Translations 2
... Reliable, PCR-based mycoplasma detection , Douglas ... , Stratagene introduces the Mycoplasma PCR Primer Set ... method which specifically amplifies an 874-bp,PCR product from ... contains an internal,control template that serves as a ...
... kit for site-directed mutagenesis of,large plasmids ... Holly Hogrefe ,Jeff Braman ,Stratagene , The ... exceeding 80%. We have created a new ... QuikChange XL,site-directed mutagenesis kit ...
... transduction research and drug screening , , ... Inc. , , Stratagene has successfully expressed and ... constitutively active mutant (MEK1 CA ),using the ESP ... MEKs, produced in yeast, are full length and ...
Cached Biology Technology:A New PCR-based Mycoplasma Detection Method 2A New PCR-based Mycoplasma Detection Method 3A New PCR-based Mycoplasma Detection Method 4A New PCR-based Mycoplasma Detection Method 5A New PCR-based Mycoplasma Detection Method 6High-Efficiency Site-Directed Mutagenesis of Large Plasmid Vectors 2High-Efficiency Site-Directed Mutagenesis of Large Plasmid Vectors 3High-Efficiency Site-Directed Mutagenesis of Large Plasmid Vectors 4Production of Full-Length, Biologically Active MEK1WT and MEK1CA 2Production of Full-Length, Biologically Active MEK1WT and MEK1CA 3Production of Full-Length, Biologically Active MEK1WT and MEK1CA 4Production of Full-Length, Biologically Active MEK1WT and MEK1CA 5
... Blocker Array II can be used ... against various proteins and sera that are ... carriers. The array contains spots for 19 ... Application: Determination of antibody crossreactivity and species ...
... Tecans new HydroFlex platform provides excellent ... range of 96-well format applications, including ... protein arrays, and vacuum filtration-to-waste, such ... outstanding on-line control features set new ...
... and Accurate Results Laser Capture Microdissection ... sensitivity and accuracy of molecular assays by ... and multi-cellular structures isolated from whole tissue ... microdissection-developed in 1996 at the National Institutes ...
...
Biology Products: