Navigation Links
UBC researchers find stroke death channel

New therapies for stroke patients may soon be possible, thanks to a discovery made by a team of University of British Columbia neuroscience researchers who have found a new stroke death channel ?the conduit through which key chemicals are lost from brain cells during stroke, causing the cell death that disables stroke victims.

The findings were published recently in Science and will be the subject of an editorial in next month's issue of Nature Reviews Neuroscience.

"We've known for 40 years about chemicals flowing out of cells after stroke, but nobody knew the exact process ?so we went looking for the death channel. And we found it," says Roger Thompson, a UBC Psychiatry post-doctoral Fellow who made the discovery, along with graduate student Ning Zhou and Psychiatry Prof. Brian MacVicar, all members of the Brain Research Centre at UBC Hospital and of Vancouver Coastal Health Research Institute.

The researchers found, in animal models, that brain cell membranes were disrupted at the site of gap junction hemichannels. Gap junctions are connections that allow molecules and ions to flow between cells. Junctions are composed of two hemichannels that bridge the intercellular space.

Until now, scientists believed the disruption to occur at the site of glutamate channels. Glutamate is one of the brain's most abundant chemical messengers. However, therapeutic strategies targeted at glutamate channels failed to prevent brain cell death.

"Our discovery was unexpected ?we're now going to change channels and pursue a completely different research direction," says MacVicar, Canada Research Chair in Neuroscience. "This finding offers new possibilities for stroke therapies and reinforces the value of investing in basic science research."

When stroke occurs, hemichannels can form outside the junction and leak chemicals. The process drastically disrupts levels of critical brain cell ingredients such as calcium and potassium, and is a
'"/>

Source:University of British Columbia


Page: 1 2

Related biology news :

1. NYU researchers simulate molecular biological clock
2. Vital step in cellular migration described by UCSD medical researchers
3. ASU researchers finds novel chemistry at work to provide parrots vibrant red colors
4. UCSD researchers maintain stem cells without contaminated animal feeder layers
5. Why do insects stop breathing? To avoid damage from too much oxygen, say researchers
6. New protein discovered by Hebrew University researchers
7. First real-time view of developing neurons reveals surprises, say Stanford researchers
8. Agilent Technologies releases automated literature search tool for biology researchers
9. Self-assembled nano-sized probes allow Penn researchers to see tumors through flesh and skin
10. Yale researchers identify molecule for detecting parasitic infection in humans
11. US life expectancy about to decline, researchers say
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: UBC researchers find stroke death channel

(Date:9/2/2014)... hot oven, you rapidly pull your hand away. Although ... and responding to such painful stimuli, they are still ... made a surprising discovery about the role of a ... built a structural model of the molecule. These discoveries, ... help direct new strategies to treat pain in people. ...
(Date:9/1/2014)... of research shows an association between TV viewing and ... a new Cornell University study points out that not ... people to eat twice as much as other programs! ... while snacking your mouth will see more action too!" ... article just published in the Journal of the ...
(Date:9/1/2014)... of the U.S. diet showed some modest improvement in ... reduction in the consumption of unhealthy trans fats, but ... rich and the poor. , , An unhealthy diet ... cancers. Eating a healthy diet is an important part ... population trends in diet quality is important because it ...
Breaking Biology News(10 mins):Surprising new role for calcium in sensing pain 2Surprising new role for calcium in sensing pain 3Can action movies make you fat? 2Quality of US diet improves, gap widens for quality between rich and poor 2Quality of US diet improves, gap widens for quality between rich and poor 3
... picture in this kind of article , A detailed ... in activating the Epstein Barr Virus in human cells has ... Laboratory (EMBL) and the Institut de Virologie Moléculaire et Structurale ... in Grenoble. , Like Sleeping Beauty, the Epstein Barr Virus ...
... leading plant science centre have uncovered a gene that could ... able to cope with the changing world climate. Researchers funded ... the John Innes Centre in Norwich have identified the gene ... changes in the length of the day. This is key ...
... avian flu conference last fall believe there is little chance ... enough vaccine or antiviral medication to stop a bird flu ... be spread easily from human to human, according to a ... of the survey will be published in the June 2006 ...
Cached Biology News:Waking a sleeping virus 2Growing crops to cope with climate change 2Medical experts: US unlikely to have enough vaccines to stop avian flu 2
(Date:9/2/2014)... , September 2, 2014 Persistence ... Membrane Technology in Pharmaceutical, Biopharma and Life Sciences: ... by 2019" the global membrane technology market for pharmaceutical, biopharma and ... 2014 and is expected to grow at a CAGR ... estimated value of USD 10,886.0 million in 2019. ...
(Date:9/2/2014)... Myriant Corporation, a global renewable chemicals ... agreement with Azelis Group, a specialty chemicals distribution ... in the Nordics, Benelux, France, Iberia, Italy, the ... industrial and base chemicals markets. , “As a ... chemical portfolio with extensive distribution networks providing Myriant ...
(Date:9/2/2014)... , Sept. 2, 2014  Xencor, Inc. (NASDAQ: ... developing engineered monoclonal antibodies for the treatment of ... today announced the appointment of Debra Zack ... the appointment of Lloyd Rowland , senior ... "Debra,s expertise in biologics clinical ...
(Date:9/2/2014)... 2, 2014 /PRNewswire/ - BIOREM Inc. (TSXV: BRM) ("Biorem" or "the ... orders consist of three large odour control systems for waste ... "These orders are consistent with the market resurgence in ... , President and CEO. "After a difficult period of restraint ... beginning to see sales growth. Our lower cost structure, technology ...
Breaking Biology Technology:Global Membrane Technology Market Will Reach $10,886.0 Million in 2019: Persistence Market Research 2Global Membrane Technology Market Will Reach $10,886.0 Million in 2019: Persistence Market Research 3Global Membrane Technology Market Will Reach $10,886.0 Million in 2019: Persistence Market Research 4Global Membrane Technology Market Will Reach $10,886.0 Million in 2019: Persistence Market Research 5Myriant and Azelis Sign European Distribution Agreement for Bio-Succinic Acid 2Xencor Appoints Debra Zack, M.D., Ph.D., Vice President, Clinical Development and Lloyd Rowland, Senior Vice President, Chief Compliance Officer and General Counsel 2Xencor Appoints Debra Zack, M.D., Ph.D., Vice President, Clinical Development and Lloyd Rowland, Senior Vice President, Chief Compliance Officer and General Counsel 3
... Inc. (Nasdaq: IDEV ) today announced that ... Food and Drug Administration (FDA) for,VALSTAR(R). VALSTAR, a ... only product approved by the FDA for therapy ... the,urinary bladder. VALSTAR was removed from the ...
... Extracranial Resources Benefits Baltimore ... Area and ... Cancer Center at Johns Hopkins Medicine is adding an Elekta,Synergy(R) S ... Johns Hopkins aims to fight cancer with,both intracranial and extracranial resources ...
... Balance of Year, SAN DIEGO, Aug. 17 ... Noble Financial Equity,Conference at 11:30 a.m. EDT on Tuesday, ... South Carolina. William Spencer, Imagenetix,s Chief Executive Officer ... and prospects for the,Company. Commenting on the prospects, Mr. ...
Cached Biology Technology:Indevus Receives Approvable Letter From FDA for VALSTAR(R) for Bladder Cancer Therapy 2Indevus Receives Approvable Letter From FDA for VALSTAR(R) for Bladder Cancer Therapy 3Indevus Receives Approvable Letter From FDA for VALSTAR(R) for Bladder Cancer Therapy 4Johns Hopkins to add Elekta Synergy S(R) to Cancer Treatment Lineup 2Johns Hopkins to add Elekta Synergy S(R) to Cancer Treatment Lineup 3Imagenetix Inc. to Present at Noble Small Cap Financial Conference on August 21, 2007 2