Navigation Links
UBC researchers find stroke death channel

New therapies for stroke patients may soon be possible, thanks to a discovery made by a team of University of British Columbia neuroscience researchers who have found a new stroke death channel ?the conduit through which key chemicals are lost from brain cells during stroke, causing the cell death that disables stroke victims.

The findings were published recently in Science and will be the subject of an editorial in next month's issue of Nature Reviews Neuroscience.

"We've known for 40 years about chemicals flowing out of cells after stroke, but nobody knew the exact process ?so we went looking for the death channel. And we found it," says Roger Thompson, a UBC Psychiatry post-doctoral Fellow who made the discovery, along with graduate student Ning Zhou and Psychiatry Prof. Brian MacVicar, all members of the Brain Research Centre at UBC Hospital and of Vancouver Coastal Health Research Institute.

The researchers found, in animal models, that brain cell membranes were disrupted at the site of gap junction hemichannels. Gap junctions are connections that allow molecules and ions to flow between cells. Junctions are composed of two hemichannels that bridge the intercellular space.

Until now, scientists believed the disruption to occur at the site of glutamate channels. Glutamate is one of the brain's most abundant chemical messengers. However, therapeutic strategies targeted at glutamate channels failed to prevent brain cell death.

"Our discovery was unexpected ?we're now going to change channels and pursue a completely different research direction," says MacVicar, Canada Research Chair in Neuroscience. "This finding offers new possibilities for stroke therapies and reinforces the value of investing in basic science research."

When stroke occurs, hemichannels can form outside the junction and leak chemicals. The process drastically disrupts levels of critical brain cell ingredients such as calcium and potassium, and is a ssociated with rapid cell death.

Every year, 50,000 Canadians suffer a stroke. Another 300,000 people are living with the consequences of stroke, which is the leading cause of adult disability in Canada.

The next step in the investigation will be to determine the cause of the hemichannel malfunction. Scientists can then develop a compound to block brain cell hemichannels from opening, says MacVicar. Therapies for stroke patients may be available within five to 10 years, he adds.


'"/>

Source:University of British Columbia


Related biology news :

1. NYU researchers simulate molecular biological clock
2. Vital step in cellular migration described by UCSD medical researchers
3. ASU researchers finds novel chemistry at work to provide parrots vibrant red colors
4. UCSD researchers maintain stem cells without contaminated animal feeder layers
5. Why do insects stop breathing? To avoid damage from too much oxygen, say researchers
6. New protein discovered by Hebrew University researchers
7. First real-time view of developing neurons reveals surprises, say Stanford researchers
8. Agilent Technologies releases automated literature search tool for biology researchers
9. Self-assembled nano-sized probes allow Penn researchers to see tumors through flesh and skin
10. Yale researchers identify molecule for detecting parasitic infection in humans
11. US life expectancy about to decline, researchers say
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/22/2016)... 2016 http://www.researchandmarkets.com/research/4lmf2s/global_behavioral ... the  "Global Behavioral Biometric Market 2016-2020" ... http://www.researchandmarkets.com/research/4lmf2s/global_behavioral ) has announced the ... Market 2016-2020"  report to their offering. ... http://www.researchandmarkets.com/research/4lmf2s/global_behavioral ) has announced the addition ...
(Date:1/20/2016)... 20, 2016   MedNet Solutions , an innovative ... of clinical research, is pleased to announce the attainment ... are the result of the company,s laser focus on ... , it,s comprehensive, easy-to-use and highly affordable cloud-based ... Key MedNet growth achievements in 2015 include: ...
(Date:1/13/2016)... , January 13, 2016 ... has published a new market report titled - Biometric Sensors ... and Forecast, 2015 - 2023. According to the report, the global ... and is anticipated to reach US$1,625.8 mn by 2023, ... 2023. In terms of volume, the biometric sensors market ...
Breaking Biology News(10 mins):
(Date:2/3/2016)... Feb. 3, 2016   ViaCyte, Inc ., ... first pluripotent stem cell-derived islet replacement therapy for ... development, today announced that ViaCyte and Janssen Biotech, ... Johnson & Johnson, have agreed to consolidate the ... The agreement provides ViaCyte with an exclusive license ...
(Date:2/3/2016)... , Feb. 3, 2016  With the growing ... cliff that is underway, therapies such as monoclonal ... a whole host of indications are in high ... in the development and production of these therapeutics. ... quality and high costs, novel approaches and novel ...
(Date:2/3/2016)... 3, 2016 Harvard Apparatus Regenerative Technology, ... developing bioengineered organ implants for life-threatening conditions of ... CEO Jim McGorry , will present at ... on Tuesday, February 9, 2016 at 8:00 am ... . HART,s presentation will be webcast live and ...
(Date:2/3/2016)... ... 03, 2016 , ... Aerocom, a world-leading supplier of pneumatic ... American healthcare market. , Aerocom Healthcare, LLC will be based in Denver, Colo., ... new pneumatic tube systems or expand existing systems within the U.S. and Canada. ...
Breaking Biology Technology: