Navigation Links
UBC researchers find stroke death channel

New therapies for stroke patients may soon be possible, thanks to a discovery made by a team of University of British Columbia neuroscience researchers who have found a new stroke death channel ?the conduit through which key chemicals are lost from brain cells during stroke, causing the cell death that disables stroke victims.

The findings were published recently in Science and will be the subject of an editorial in next month's issue of Nature Reviews Neuroscience.

"We've known for 40 years about chemicals flowing out of cells after stroke, but nobody knew the exact process ?so we went looking for the death channel. And we found it," says Roger Thompson, a UBC Psychiatry post-doctoral Fellow who made the discovery, along with graduate student Ning Zhou and Psychiatry Prof. Brian MacVicar, all members of the Brain Research Centre at UBC Hospital and of Vancouver Coastal Health Research Institute.

The researchers found, in animal models, that brain cell membranes were disrupted at the site of gap junction hemichannels. Gap junctions are connections that allow molecules and ions to flow between cells. Junctions are composed of two hemichannels that bridge the intercellular space.

Until now, scientists believed the disruption to occur at the site of glutamate channels. Glutamate is one of the brain's most abundant chemical messengers. However, therapeutic strategies targeted at glutamate channels failed to prevent brain cell death.

"Our discovery was unexpected ?we're now going to change channels and pursue a completely different research direction," says MacVicar, Canada Research Chair in Neuroscience. "This finding offers new possibilities for stroke therapies and reinforces the value of investing in basic science research."

When stroke occurs, hemichannels can form outside the junction and leak chemicals. The process drastically disrupts levels of critical brain cell ingredients such as calcium and potassium, and is a ssociated with rapid cell death.

Every year, 50,000 Canadians suffer a stroke. Another 300,000 people are living with the consequences of stroke, which is the leading cause of adult disability in Canada.

The next step in the investigation will be to determine the cause of the hemichannel malfunction. Scientists can then develop a compound to block brain cell hemichannels from opening, says MacVicar. Therapies for stroke patients may be available within five to 10 years, he adds.


'"/>

Source:University of British Columbia


Related biology news :

1. NYU researchers simulate molecular biological clock
2. Vital step in cellular migration described by UCSD medical researchers
3. ASU researchers finds novel chemistry at work to provide parrots vibrant red colors
4. UCSD researchers maintain stem cells without contaminated animal feeder layers
5. Why do insects stop breathing? To avoid damage from too much oxygen, say researchers
6. New protein discovered by Hebrew University researchers
7. First real-time view of developing neurons reveals surprises, say Stanford researchers
8. Agilent Technologies releases automated literature search tool for biology researchers
9. Self-assembled nano-sized probes allow Penn researchers to see tumors through flesh and skin
10. Yale researchers identify molecule for detecting parasitic infection in humans
11. US life expectancy about to decline, researchers say
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/2/2017)... -- Who risk to be deprived of its imprint ... https://www.reportbuyer.com/product/4313699/ WILL APPLE AND SAMSUNG CONFRONT ... sensors using capacitive technology represent a fast growing market, ... an increase of 360% of the number of fingerprint ... sensor market between 2014 and 2017 (source : N+1 ...
(Date:2/28/2017)... LOS ANGELES , Feb. 28, 2017   ... identity verification software globally, announces significant enhancements to new ... in May 2016. New products include mobile and desktop ... and DocX TM - a real time manual ... Acuant,s core idScan® technology provides the fastest and most ...
(Date:2/27/2017)... 2017   Strategic Cyber Ventures , the industry,s ... a $3.5 million investment in  Polarity , the first ... is DC based and is led by cybersecurity veterans ... Ron Gula , also a longtime cybersecurity veteran ... this series A round of funding. This new funding ...
Breaking Biology News(10 mins):
(Date:3/23/2017)... , March 23, 2017 Kineta, Inc., ... of novel therapies in immuno-oncology, today announced the ... small molecule compounds that activate interferon response factor ... and demonstrate immune-mediated tumor regression in a murine ... study who demonstrated complete tumor regression to initial ...
(Date:3/23/2017)... (PRWEB) , ... March 23, 2017 , ... ... monitoring solutions, today announced the hire of Dr. Sigmund “Sig” Floyd as Vice ... applications, strategic partnerships and joint development activities. , “Dr. Floyd’s career has spanned ...
(Date:3/22/2017)... -- Good Start Genetics, a leading family genomics company, ... covered lives mark through its most recent payor addition, ... . With newly signed contracts nationally and others in ... acceptance based on the quality of its science, the ... industry-leading customer care and support and its published cost-effectiveness ...
(Date:3/22/2017)... , March 22, 2017 /PRNewswire/ - FACIT ... (the "Company" or "Propellon"), a start-up created by ... anti-cancer therapeutics. FACIT,s investment, combined with non-dilutive capital, ... program. The seed funding enables Propellon to accelerate ... the Company for financing and/or entering a strategic ...
Breaking Biology Technology: