Navigation Links
UAB researchers confirm HIV-1 originated in wild chimpanzees

An international team of scientists, led by researchers at the University of Alabama at Birmingham (UAB), has discovered a crucial missing link in the search for the origin of HIV-1, the virus responsible for human AIDS. That missing link is the natural reservoir of the virus, which the team has found in wild-living chimpanzees in southern Cameroon. The findings provide important clues to how the disease migrated from non-human to human primates, and will be released Thursday (May 25) in ScienceExpress [http://www.sciencemag.org/sciencexpress/recent.dtl] and will be published in an upcoming issue of Science magazine.

Although researchers have long suspected that HIV-1's origins lie in some way with chimpanzee infection through a closely related virus SIVcpz (simian immunodeficiency virus from chimpanzees), only a few captive apes had been found to harbor SIVcpz. In the study, UAB Professor of Medicine Beatrice H. Hahn, M.D., and her team conducted the first-ever molecular epidemiological survey of SIVcpz infection in wild-living chimpanzees in west-central Africa. By analyzing ape fecal samples collected by trackers from the forest floor in remote jungle regions of Cameroon, Hahn and her colleagues were able to detect SIVcpz-specific antibodies and nucleic acids (viral genetic information) in as many as 35 percent of chimpanzees in some ape communities.

The UAB investigators went on to molecularly clone and sequence the complete viral genomes from four individual chimpanzees. According to UAB post-doctoral researcher Brandon Keele, Ph.D., lead author of the report, "this allowed for unprecedented genetic comparisons to be done between HIV-1 and its closest simian virus counterpart." He went on to say that "finding this cluster of naturally infected chimpanzees will allow us to explore the natural history and behavior of SIVcpz in its natural host and help us begin to unravel how and wh y SIVcpz made the jump to humans."


'"/>

Source:University of Alabama at Birmingham


Related biology news :

1. NYU researchers simulate molecular biological clock
2. Vital step in cellular migration described by UCSD medical researchers
3. ASU researchers finds novel chemistry at work to provide parrots vibrant red colors
4. UCSD researchers maintain stem cells without contaminated animal feeder layers
5. Why do insects stop breathing? To avoid damage from too much oxygen, say researchers
6. New protein discovered by Hebrew University researchers
7. First real-time view of developing neurons reveals surprises, say Stanford researchers
8. Agilent Technologies releases automated literature search tool for biology researchers
9. Self-assembled nano-sized probes allow Penn researchers to see tumors through flesh and skin
10. Yale researchers identify molecule for detecting parasitic infection in humans
11. US life expectancy about to decline, researchers say
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/17/2019)... SALT LAKE CITY (PRWEB) , ... September 17, ... ... Group SA, and a group of doctors, scientists and engineers from the Medical ... to present the results of their work to-date in creating a neuroprosthetic system ...
(Date:9/11/2019)... ... September 10, 2019 , ... Newly released ... an unusual collaboration that offers a beautiful and thought-provoking journey through five chapters ... Srinivasan painted to Whittaker’s poems and other times, Whittaker wrote to Srinivasan’s paintings. ...
(Date:8/29/2019)... , ... August 28, 2019 , ... Lajollacooks4u has expanded ... Diego-based team building and cooking events company has seen record growth in 2019, having ... as Amazon, ServiceNow, Vistage and Illumina, have all visited the company’s La Jolla-based venue, ...
Breaking Biology News(10 mins):
(Date:9/17/2019)... ... 2019 , ... Catalent, a global leader in clinical supply ... Pacific (APAC) will present at the upcoming 3rd Annual Accelerating Clinical Trials in ... Thursday, Sept. 26, at 10:10 a.m., Ms. Delaney will present “Singapore: APAC’s Clinical ...
(Date:9/17/2019)... ... September 17, 2019 , ... Tucker, a Labrador retriever, was just a ... Tucker was limping and lame on his right hip and elbow. At one year ... called “the worst case the vet had seen.” He was prescribed pain medications, both ...
(Date:9/17/2019)... ... September 17, 2019 , ... Geneticure, Inc., a Rochester Minnesota ... that the U.S. Patent and Trademark Office (USPTO) and European Patent Office (EPO) ... recommendations for hypertension treatment. , The patent applies to Geneticure’s first pharmacogenomics ...
(Date:9/17/2019)... ... September 17, 2019 , ... Jennifer Hermansky and ... , have been named to Law360’s 2019 Rising Stars. Hermansky and Xie, named an ... attorneys from 1,300 submissions, spanning 39 practice areas. The list highlights attorneys “whose legal ...
Breaking Biology Technology: